Mogat2

Functionⁱ

Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.3 Publications

Catalytic activityⁱ

Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.

Enzyme regulationⁱ

Inhibited by oleic acid and sphingosine, while it is stimulated by phosphatidylcholine, phosphatidylserine and phosphatidic acid.1 Publication

pH dependenceⁱ

Optimum pH is 7.0.1 Publication

Pathwayⁱ: triacylglycerol biosynthesis

This protein is involved in the pathway triacylglycerol biosynthesis, which is part of Glycerolipid metabolism.
View all proteins of this organism that are known to be involved in the pathway triacylglycerol biosynthesis and in Glycerolipid metabolism.

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase
Biological process	Glycerol metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

Reactomeⁱ	R-MMU-75109 Triglyceride biosynthesis
UniPathwayⁱ	UPA00282

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 2-acylglycerol O-acyltransferase 2 (EC:2.3.1.22) Alternative name(s): Acyl-CoA:monoacylglycerol acyltransferase 2 Short name: MGAT2 Diacylglycerol acyltransferase 2-like protein 5 Monoacylglycerol O-acyltransferase 1-like Monoacylglycerol O-acyltransferase 2
Gene namesⁱ	Name:Mogat2 Synonyms:Dgat2l5, Mgat1l
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:2663253 Mogat2

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	23 – 43	HelicalSequence analysisAdd BLAST		21
Transmembraneⁱ	212 – 232	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL3603729

ChEMBLⁱ

CHEMBL3603729

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000249063	1 – 334	2-acylglycerol O-acyltransferase 2Add BLAST		334

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q80W94
PaxDbⁱ	Q80W94
PeptideAtlas More...PeptideAtlasⁱ	Q80W94
PRIDEⁱ	Q80W94

PTM databases

iPTMnetⁱ	Q80W94
PhosphoSitePlusⁱ	Q80W94

Expressionⁱ

Tissue specificityⁱ

Mainly expressed in small intestine. Detected in the small intestine in a proximal-to-distal gradient that correlated with fat absorption pattern. Present not only in the villi, but also in the crypt regions of the small intestine, which suggests that expression occurs prior to the maturation of enterocytes. Not detectable in other sections of the digestive tract, including stomach, cecum, colon and rectum, or other tissues such as kidney, liver and adipocytes (at protein level). Also detected in kidney, adipose and stomach. Expressed at very low level in liver, skeletal muscle and spleen. Not expressed in brain, heart, lung, skin, testis and thymus.3 Publications

Inductionⁱ

Up-regulated in mice fed a high fat diet, implicating a role in diet-induced obesity (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000052396
CleanExⁱ	MM_MOGAT2
Genevisibleⁱ	Q80W94 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000064041

STRINGⁱ

10090.ENSMUSP00000064041

Chemistry databases

BindingDBⁱ

Q80W94

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q80W94
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the diacylglycerol acyltransferase family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0831 Eukaryota ENOG410XTG3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00750000117391
HOGENOMⁱ	HOG000179738
HOVERGENⁱ	HBG065791
InParanoidⁱ	Q80W94
KEGG Orthology (KO) More...KOⁱ	K14457
OMAⁱ	RLGFIKI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BGQ
PhylomeDBⁱ	Q80W94
TreeFamⁱ	TF314707

Family and domain databases

InterProⁱ	View protein in InterPro IPR007130 DAGAT
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03982 DAGAT, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q80W94-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVEFAPLLVP WERRLQTFAV LQWVFSFLAL AQLCIVIFVG LLFTRFWLFS 
        60         70         80         90        100
VLYATWWYLD WDKPRQGGRP IQFFRRLAIW KYMKDYFPVS LVKTAELDPS 
       110        120        130        140        150
RNYIAGFHPH GVLAAGAFLN LCTESTGFTS LFPGIRSYLM MLTVWFRAPF 
       160        170        180        190        200
FRDYIMSGGL VSSEKVSADH ILSRKGGGNL LAIIVGGAQE ALDARPGAYR 
       210        220        230        240        250
LLLKNRKGFI RLALMHGAAL VPIFSFGENN LFNQVENTPG TWLRWIQNRL 
       260        270        280        290        300
QKIMGISLPL FHGRGVFQYS FGLMPFRQPI TTIVGKPIEV QMTPQPSREE 
       310        320        330 
VDRLHQRYIK ELCKLFEEHK LKFNVPEDQH LEFC

Length:334

Mass (Da):38,591

Last modified:June 1, 2003 - v1

Checksum:ⁱBFC7C84A22B607BD

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY157609 mRNA Translation: AAO23673.1 AK133854 mRNA Translation: BAE21888.1 BC052831 mRNA Translation: AAH52831.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21478.1
NCBI Reference Sequences More...RefSeqⁱ	NP_803231.1, NM_177448.4
UniGeneⁱ	Mm.208030

Genome annotation databases

Ensemblⁱ	ENSMUST00000064231; ENSMUSP00000064041; ENSMUSG00000052396
GeneIDⁱ	233549
KEGGⁱ	mmu:233549
UCSC genome browser More...UCSCⁱ	uc009ilf.2 mouse

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length
Q80W94	UPI0005ABAAD3		MOUSE		348
UPI000A3126A5		MUSPA		334
UPI000A31B3C9		MUSCR		334
UPI000B90A96C		ACAPL		343
UPI0005778012		Bison bison bison		334
+144

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY157609 mRNA Translation: AAO23673.1 AK133854 mRNA Translation: BAE21888.1 BC052831 mRNA Translation: AAH52831.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21478.1
NCBI Reference Sequences More...RefSeqⁱ	NP_803231.1, NM_177448.4
UniGeneⁱ	Mm.208030

3D structure databases

ProteinModelPortalⁱ	Q80W94
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000064041

STRINGⁱ

10090.ENSMUSP00000064041

Chemistry databases

BindingDBⁱ	Q80W94
ChEMBLⁱ	CHEMBL3603729

PTM databases

iPTMnetⁱ	Q80W94
PhosphoSitePlusⁱ	Q80W94

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q80W94
PaxDbⁱ	Q80W94
PeptideAtlas More...PeptideAtlasⁱ	Q80W94
PRIDEⁱ	Q80W94

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000064231; ENSMUSP00000064041; ENSMUSG00000052396
GeneIDⁱ	233549
KEGGⁱ	mmu:233549
UCSC genome browser More...UCSCⁱ	uc009ilf.2 mouse

Organism-specific databases

CTDⁱ	80168
MGIⁱ	MGI:2663253 Mogat2

Phylogenomic databases

eggNOGⁱ	KOG0831 Eukaryota ENOG410XTG3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00750000117391
HOGENOMⁱ	HOG000179738
HOVERGENⁱ	HBG065791
InParanoidⁱ	Q80W94
KEGG Orthology (KO) More...KOⁱ	K14457
OMAⁱ	RLGFIKI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BGQ
PhylomeDBⁱ	Q80W94
TreeFamⁱ	TF314707

Enzyme and pathway databases

UniPathwayⁱ	UPA00282
Reactomeⁱ	R-MMU-75109 Triglyceride biosynthesis

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q80W94
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000052396
CleanExⁱ	MM_MOGAT2
Genevisibleⁱ	Q80W94 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR007130 DAGAT
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03982 DAGAT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MOGT2_MOUSE
Accessionⁱ	Q80W94Primary (citable) accession number: Q80W94
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
	Last sequence update:	June 1, 2003
	Last modified:	June 7, 2017
	This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families

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Supporting data

UniProtKB - Q80W94 (MOGT2_MOUSE)

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2-acylglycerol O-acyltransferase 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: triacylglycerol biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

Enzyme regulationⁱ

pH dependenceⁱ

Pathwayⁱ: triacylglycerol biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ