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UniProtKB - Q80W94 (MOGT2_MOUSE)
Protein
2-acylglycerol O-acyltransferase 2
Gene
Mogat2
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity).
By similarity3 PublicationsCatalytic activityi
- EC:2.3.1.221 PublicationThis reaction proceeds in the forwardCurated direction.
- (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol = 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol = 1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-decanoylglycerol = 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
Activity regulationi
Inhibited by oleic acid and sphingosine, while it is stimulated by phosphatidylcholine, phosphatidylserine and phosphatidic acid.1 Publication
pH dependencei
Optimum pH is 7.0.1 Publication
: triacylglycerol biosynthesis Pathwayi
This protein is involved in the pathway triacylglycerol biosynthesis, which is part of Glycerolipid metabolism.View all proteins of this organism that are known to be involved in the pathway triacylglycerol biosynthesis and in Glycerolipid metabolism.
GO - Molecular functioni
- 2-acylglycerol O-acyltransferase activity Source: MGI
- acetyltransferase activity Source: MGI
GO - Biological processi
- diacylglycerol biosynthetic process Source: MGI
- glycerol metabolic process Source: UniProtKB-KW
- intestinal absorption Source: MGI
- lipid metabolic process Source: MGI
- monoacylglycerol biosynthetic process Source: UniProtKB
- monoacylglycerol metabolic process Source: MGI
- triglyceride biosynthetic process Source: MGI
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Glycerol metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
BRENDAi | 2.3.1.22, 3474 |
Reactomei | R-MMU-75109, Triglyceride biosynthesis |
UniPathwayi | UPA00282 |
Names & Taxonomyi
Protein namesi | Recommended name: 2-acylglycerol O-acyltransferase 2Curated (EC:2.3.1.221 Publication)Alternative name(s): Acyl-CoA:monoacylglycerol acyltransferase 2 Short name: MGAT2 Diacylglycerol acyltransferase 2-like protein 5 Monoacylglycerol O-acyltransferase 1-like Monoacylglycerol O-acyltransferase 2 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2663253, Mogat2 |
VEuPathDBi | HostDB:ENSMUSG00000052396 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Other locations
- perinuclear region By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
- perinuclear endoplasmic reticulum membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 23 – 43 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 212 – 232 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000249063 | 1 – 334 | 2-acylglycerol O-acyltransferase 2Add BLAST | 334 |
Proteomic databases
MaxQBi | Q80W94 |
PaxDbi | Q80W94 |
PeptideAtlasi | Q80W94 |
PRIDEi | Q80W94 |
ProteomicsDBi | 295580 |
PTM databases
iPTMneti | Q80W94 |
PhosphoSitePlusi | Q80W94 |
Expressioni
Tissue specificityi
Mainly expressed in small intestine. Detected in the small intestine in a proximal-to-distal gradient that correlated with fat absorption pattern. Present not only in the villi, but also in the crypt regions of the small intestine, which suggests that expression occurs prior to the maturation of enterocytes. Not detectable in other sections of the digestive tract, including stomach, cecum, colon and rectum, or other tissues such as kidney, liver and adipocytes (at protein level). Also detected in kidney, adipose and stomach. Expressed at very low level in liver, skeletal muscle and spleen. Not expressed in brain, heart, lung, skin, testis and thymus.3 Publications
Inductioni
Up-regulated in mice fed a high fat diet, implicating a role in diet-induced obesity (at protein level).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000052396, Expressed in epithelium of small intestine and 151 other tissues |
Genevisiblei | Q80W94, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 231424, 1 interactor |
STRINGi | 10090.ENSMUSP00000064041 |
Chemistry databases
BindingDBi | Q80W94 |
Miscellaneous databases
RNActi | Q80W94, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q80W94 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the diacylglycerol acyltransferase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0831, Eukaryota |
GeneTreei | ENSGT01030000234582 |
HOGENOMi | CLU_023995_0_1_1 |
InParanoidi | Q80W94 |
OMAi | PFYRDYI |
OrthoDBi | 1347007at2759 |
PhylomeDBi | Q80W94 |
TreeFami | TF314707 |
Family and domain databases
InterProi | View protein in InterPro IPR007130, DAGAT |
Pfami | View protein in Pfam PF03982, DAGAT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q80W94-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVEFAPLLVP WERRLQTFAV LQWVFSFLAL AQLCIVIFVG LLFTRFWLFS
60 70 80 90 100
VLYATWWYLD WDKPRQGGRP IQFFRRLAIW KYMKDYFPVS LVKTAELDPS
110 120 130 140 150
RNYIAGFHPH GVLAAGAFLN LCTESTGFTS LFPGIRSYLM MLTVWFRAPF
160 170 180 190 200
FRDYIMSGGL VSSEKVSADH ILSRKGGGNL LAIIVGGAQE ALDARPGAYR
210 220 230 240 250
LLLKNRKGFI RLALMHGAAL VPIFSFGENN LFNQVENTPG TWLRWIQNRL
260 270 280 290 300
QKIMGISLPL FHGRGVFQYS FGLMPFRQPI TTIVGKPIEV QMTPQPSREE
310 320 330
VDRLHQRYIK ELCKLFEEHK LKFNVPEDQH LEFC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY157609 mRNA Translation: AAO23673.1 AK133854 mRNA Translation: BAE21888.1 BC052831 mRNA Translation: AAH52831.1 |
CCDSi | CCDS21478.1 |
RefSeqi | NP_803231.1, NM_177448.4 |
Genome annotation databases
Ensembli | ENSMUST00000064231; ENSMUSP00000064041; ENSMUSG00000052396 |
GeneIDi | 233549 |
KEGGi | mmu:233549 |
UCSCi | uc009ilf.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY157609 mRNA Translation: AAO23673.1 AK133854 mRNA Translation: BAE21888.1 BC052831 mRNA Translation: AAH52831.1 |
CCDSi | CCDS21478.1 |
RefSeqi | NP_803231.1, NM_177448.4 |
3D structure databases
AlphaFoldDBi | Q80W94 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 231424, 1 interactor |
STRINGi | 10090.ENSMUSP00000064041 |
Chemistry databases
BindingDBi | Q80W94 |
ChEMBLi | CHEMBL3603729 |
PTM databases
iPTMneti | Q80W94 |
PhosphoSitePlusi | Q80W94 |
Proteomic databases
MaxQBi | Q80W94 |
PaxDbi | Q80W94 |
PeptideAtlasi | Q80W94 |
PRIDEi | Q80W94 |
ProteomicsDBi | 295580 |
Protocols and materials databases
Antibodypediai | 31177, 153 antibodies from 28 providers |
DNASUi | 233549 |
Genome annotation databases
Ensembli | ENSMUST00000064231; ENSMUSP00000064041; ENSMUSG00000052396 |
GeneIDi | 233549 |
KEGGi | mmu:233549 |
UCSCi | uc009ilf.2, mouse |
Organism-specific databases
CTDi | 80168 |
MGIi | MGI:2663253, Mogat2 |
VEuPathDBi | HostDB:ENSMUSG00000052396 |
Phylogenomic databases
eggNOGi | KOG0831, Eukaryota |
GeneTreei | ENSGT01030000234582 |
HOGENOMi | CLU_023995_0_1_1 |
InParanoidi | Q80W94 |
OMAi | PFYRDYI |
OrthoDBi | 1347007at2759 |
PhylomeDBi | Q80W94 |
TreeFami | TF314707 |
Enzyme and pathway databases
UniPathwayi | UPA00282 |
BRENDAi | 2.3.1.22, 3474 |
Reactomei | R-MMU-75109, Triglyceride biosynthesis |
Miscellaneous databases
BioGRID-ORCSi | 233549, 1 hit in 73 CRISPR screens |
PROi | PR:Q80W94 |
RNActi | Q80W94, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000052396, Expressed in epithelium of small intestine and 151 other tissues |
Genevisiblei | Q80W94, MM |
Family and domain databases
InterProi | View protein in InterPro IPR007130, DAGAT |
Pfami | View protein in Pfam PF03982, DAGAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MOGT2_MOUSE | |
Accessioni | Q80W94Primary (citable) accession number: Q80W94 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | June 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families