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Protein

2-acylglycerol O-acyltransferase 2

Gene

Mogat2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.3 Publications

Catalytic activityi

Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.

Enzyme regulationi

Inhibited by oleic acid and sphingosine, while it is stimulated by phosphatidylcholine, phosphatidylserine and phosphatidic acid.1 Publication

pH dependencei

Optimum pH is 7.0.1 Publication

Pathwayi: triacylglycerol biosynthesis

This protein is involved in the pathway triacylglycerol biosynthesis, which is part of Glycerolipid metabolism.
View all proteins of this organism that are known to be involved in the pathway triacylglycerol biosynthesis and in Glycerolipid metabolism.

GO - Molecular functioni

  • 2-acylglycerol O-acyltransferase activity Source: MGI
  • acetyltransferase activity Source: MGI

GO - Biological processi

  • diacylglycerol biosynthetic process Source: MGI
  • glycerol metabolic process Source: UniProtKB-KW
  • intestinal absorption Source: MGI
  • lipid metabolic process Source: MGI
  • monoacylglycerol metabolic process Source: MGI
  • triglyceride biosynthetic process Source: MGI

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processGlycerol metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-75109 Triglyceride biosynthesis
UniPathwayiUPA00282

Names & Taxonomyi

Protein namesi
Recommended name:
2-acylglycerol O-acyltransferase 2 (EC:2.3.1.22)
Alternative name(s):
Acyl-CoA:monoacylglycerol acyltransferase 2
Short name:
MGAT2
Diacylglycerol acyltransferase 2-like protein 5
Monoacylglycerol O-acyltransferase 1-like
Monoacylglycerol O-acyltransferase 2
Gene namesi
Name:Mogat2
Synonyms:Dgat2l5, Mgat1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2663253 Mogat2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3603729

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002490631 – 3342-acylglycerol O-acyltransferase 2Add BLAST334

Proteomic databases

MaxQBiQ80W94
PaxDbiQ80W94
PeptideAtlasiQ80W94
PRIDEiQ80W94

PTM databases

iPTMnetiQ80W94
PhosphoSitePlusiQ80W94

Expressioni

Tissue specificityi

Mainly expressed in small intestine. Detected in the small intestine in a proximal-to-distal gradient that correlated with fat absorption pattern. Present not only in the villi, but also in the crypt regions of the small intestine, which suggests that expression occurs prior to the maturation of enterocytes. Not detectable in other sections of the digestive tract, including stomach, cecum, colon and rectum, or other tissues such as kidney, liver and adipocytes (at protein level). Also detected in kidney, adipose and stomach. Expressed at very low level in liver, skeletal muscle and spleen. Not expressed in brain, heart, lung, skin, testis and thymus.3 Publications

Inductioni

Up-regulated in mice fed a high fat diet, implicating a role in diet-induced obesity (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000052396
CleanExiMM_MOGAT2
GenevisibleiQ80W94 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064041

Chemistry databases

BindingDBiQ80W94

Structurei

3D structure databases

ProteinModelPortaliQ80W94
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0831 Eukaryota
ENOG410XTG3 LUCA
GeneTreeiENSGT00750000117391
HOGENOMiHOG000179738
HOVERGENiHBG065791
InParanoidiQ80W94
KOiK14457
OMAiRLGFIKI
OrthoDBiEOG091G0BGQ
PhylomeDBiQ80W94
TreeFamiTF314707

Family and domain databases

InterProiView protein in InterPro
IPR007130 DAGAT
PfamiView protein in Pfam
PF03982 DAGAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q80W94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEFAPLLVP WERRLQTFAV LQWVFSFLAL AQLCIVIFVG LLFTRFWLFS
60 70 80 90 100
VLYATWWYLD WDKPRQGGRP IQFFRRLAIW KYMKDYFPVS LVKTAELDPS
110 120 130 140 150
RNYIAGFHPH GVLAAGAFLN LCTESTGFTS LFPGIRSYLM MLTVWFRAPF
160 170 180 190 200
FRDYIMSGGL VSSEKVSADH ILSRKGGGNL LAIIVGGAQE ALDARPGAYR
210 220 230 240 250
LLLKNRKGFI RLALMHGAAL VPIFSFGENN LFNQVENTPG TWLRWIQNRL
260 270 280 290 300
QKIMGISLPL FHGRGVFQYS FGLMPFRQPI TTIVGKPIEV QMTPQPSREE
310 320 330
VDRLHQRYIK ELCKLFEEHK LKFNVPEDQH LEFC
Length:334
Mass (Da):38,591
Last modified:June 1, 2003 - v1
Checksum:iBFC7C84A22B607BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157609 mRNA Translation: AAO23673.1
AK133854 mRNA Translation: BAE21888.1
BC052831 mRNA Translation: AAH52831.1
CCDSiCCDS21478.1
RefSeqiNP_803231.1, NM_177448.4
UniGeneiMm.208030

Genome annotation databases

EnsembliENSMUST00000064231; ENSMUSP00000064041; ENSMUSG00000052396
GeneIDi233549
KEGGimmu:233549
UCSCiuc009ilf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMOGT2_MOUSE
AccessioniPrimary (citable) accession number: Q80W94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2003
Last modified: June 7, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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