UniProtKB - Q80W85 (NPM2_MOUSE)
Protein
Nucleoplasmin-2
Gene
Npm2
Organism
Mus musculus (Mouse)
Status
Functioni
Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.
GO - Molecular functioni
- chromatin binding Source: MGI
- enzyme binding Source: MGI
- histone binding Source: GO_Central
- identical protein binding Source: MGI
- RNA binding Source: GO_Central
GO - Biological processi
- blastocyst development Source: UniProtKB
- chromatin remodeling Source: MGI
- oocyte differentiation Source: UniProtKB
- positive regulation of catalytic activity Source: MGI
- positive regulation of DNA metabolic process Source: MGI
- positive regulation of DNA replication Source: MGI
- positive regulation of meiotic nuclear division Source: UniProtKB
- regulation of exit from mitosis Source: UniProtKB
- single fertilization Source: UniProtKB
Keywordsi
Molecular function | Chaperone, Chromatin regulator, Developmental protein |
Biological process | Fertilization |
Names & Taxonomyi
Protein namesi | Recommended name: Nucleoplasmin-2 |
Gene namesi | Name:Npm2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1890811, Npm2 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Note: Found in the oocyte nucleus before nuclear membrane breakdown, after which it is redistributed to the cytoplasm.
Nucleus
- nuclear chromatin Source: UniProtKB
- nucleolus Source: GO_Central
- nucleoplasm Source: GO_Central
- nucleus Source: MGI
Other locations
- cytoplasm Source: GO_Central
- cytoplasmic chromatin Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219488 | 1 – 207 | Nucleoplasmin-2Add BLAST | 207 |
Proteomic databases
PaxDbi | Q80W85 |
PRIDEi | Q80W85 |
2D gel databases
REPRODUCTION-2DPAGEi | Q80W85 |
PTM databases
iPTMneti | Q80W85 |
PhosphoSitePlusi | Q80W85 |
Expressioni
Tissue specificityi
Ovary specific.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000047911, Expressed in primary oocyte and 56 other tissues |
ExpressionAtlasi | Q80W85, baseline and differential |
Interactioni
Subunit structurei
Homopentamer, when bound to H2A-H2B dimers only. Homodecamer of two stacked pentamers, when bound to H2A-H2B dimers and H3-H4 tetramers simultaneously (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 57 | Interaction between pentamersBy similarity | 1 | |
Sitei | 84 | Interaction between pentamersBy similarity | 1 |
GO - Molecular functioni
- enzyme binding Source: MGI
- histone binding Source: GO_Central
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 236605, 1 interactor |
STRINGi | 10090.ENSMUSP00000057365 |
Miscellaneous databases
RNActi | Q80W85, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 129 – 152 | Acidic tract A2By similarityAdd BLAST | 24 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 165 – 180 | Bipartite nuclear localization signalBy similarityAdd BLAST | 16 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 128 – 141 | Poly-GluAdd BLAST | 14 | |
Compositional biasi | 168 – 171 | Poly-Lys | 4 |
Domaini
The acidic tract A2 mediates histone binding.By similarity
Sequence similaritiesi
Belongs to the nucleoplasmin family.Curated
Phylogenomic databases
eggNOGi | ENOG502S0N8, Eukaryota |
GeneTreei | ENSGT00940000161418 |
HOGENOMi | CLU_058838_2_0_1 |
InParanoidi | Q80W85 |
OMAi | CLGENAK |
OrthoDBi | 1485080at2759 |
PhylomeDBi | Q80W85 |
TreeFami | TF327704 |
Family and domain databases
InterProi | View protein in InterPro IPR004301, Nucleoplasmin IPR024057, Nucleoplasmin_core_dom IPR036824, Nucleoplasmin_core_dom_sf |
PANTHERi | PTHR22747, PTHR22747, 1 hit |
Pfami | View protein in Pfam PF03066, Nucleoplasmin, 1 hit |
SUPFAMi | SSF69203, SSF69203, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q80W85-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRHSTSSVT ETTAKNMLWG SELNQEKQTC TFRGQGEKKD SCKLLLSTIC
60 70 80 90 100
LGEKAKEEVN RVEVLSQEGR KPPITIATLK ASVLPMVTVS GIELSPPVTF
110 120 130 140 150
RLRTGSGPVF LSGLECYETS DLTWEDDEEE EEEEEEEDED EDADISLEEI
160 170 180 190 200
PVKQVKRVAP QKQMSIAKKK KVEKEEDETV VRPSPQDKSP WKKEKSTPRA
KKPVTKK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2I3BR42 | A0A2I3BR42_MOUSE | Nucleoplasmin-2 | Npm2 | 168 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 196 | S → F in BAC35815 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY262112 mRNA Translation: AAP33133.1 AK054533 mRNA Translation: BAC35815.1 |
CCDSi | CCDS27261.1 |
RefSeqi | NP_851990.2, NM_181345.3 XP_006519206.1, XM_006519143.2 XP_006519208.1, XM_006519145.3 XP_006519209.1, XM_006519146.3 XP_006519210.1, XM_006519147.2 XP_011243393.1, XM_011245091.2 XP_017171550.1, XM_017316061.1 |
Genome annotation databases
Ensembli | ENSMUST00000062629; ENSMUSP00000057365; ENSMUSG00000047911 |
GeneIDi | 328440 |
KEGGi | mmu:328440 |
UCSCi | uc007uot.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY262112 mRNA Translation: AAP33133.1 AK054533 mRNA Translation: BAC35815.1 |
CCDSi | CCDS27261.1 |
RefSeqi | NP_851990.2, NM_181345.3 XP_006519206.1, XM_006519143.2 XP_006519208.1, XM_006519145.3 XP_006519209.1, XM_006519146.3 XP_006519210.1, XM_006519147.2 XP_011243393.1, XM_011245091.2 XP_017171550.1, XM_017316061.1 |
3D structure databases
SMRi | Q80W85 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 236605, 1 interactor |
STRINGi | 10090.ENSMUSP00000057365 |
PTM databases
iPTMneti | Q80W85 |
PhosphoSitePlusi | Q80W85 |
2D gel databases
REPRODUCTION-2DPAGEi | Q80W85 |
Proteomic databases
PaxDbi | Q80W85 |
PRIDEi | Q80W85 |
Protocols and materials databases
Antibodypediai | 22452, 91 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000062629; ENSMUSP00000057365; ENSMUSG00000047911 |
GeneIDi | 328440 |
KEGGi | mmu:328440 |
UCSCi | uc007uot.2, mouse |
Organism-specific databases
CTDi | 10361 |
MGIi | MGI:1890811, Npm2 |
Phylogenomic databases
eggNOGi | ENOG502S0N8, Eukaryota |
GeneTreei | ENSGT00940000161418 |
HOGENOMi | CLU_058838_2_0_1 |
InParanoidi | Q80W85 |
OMAi | CLGENAK |
OrthoDBi | 1485080at2759 |
PhylomeDBi | Q80W85 |
TreeFami | TF327704 |
Miscellaneous databases
BioGRID-ORCSi | 328440, 1 hit in 17 CRISPR screens |
ChiTaRSi | Npm2, mouse |
PROi | PR:Q80W85 |
RNActi | Q80W85, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000047911, Expressed in primary oocyte and 56 other tissues |
ExpressionAtlasi | Q80W85, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR004301, Nucleoplasmin IPR024057, Nucleoplasmin_core_dom IPR036824, Nucleoplasmin_core_dom_sf |
PANTHERi | PTHR22747, PTHR22747, 1 hit |
Pfami | View protein in Pfam PF03066, Nucleoplasmin, 1 hit |
SUPFAMi | SSF69203, SSF69203, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NPM2_MOUSE | |
Accessioni | Q80W85Primary (citable) accession number: Q80W85 Secondary accession number(s): Q8BW23 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2003 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families