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1 to 25 of 109  Show
  1. 1
    "Narc-1, novel subtilase-like homologs."
    Chiang L.W.
    Patent number WO0157081, 09-AUG-2001
    Cited for: NUCLEOTIDE SEQUENCE.
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 other entry.

  2. 2
    "Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice."
    Maxwell K.N., Soccio R.E., Duncan E.M., Sehayek E., Breslow J.L.
    J. Lipid Res. 44:2109-2119(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    Category: Expression, Sequences.
    Strain: C57BL/6J.
    Tissue: Liver.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 and mapped to 3 other entries.

  3. 3
    "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Category: Sequences.
    Strain: C57BL/6J.
    Tissue: Liver.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 10610 and mapped to 42946 other entries.

  4. 4
    Category: Sequences.
    Strain: C57BL/6J.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 42070 other entries.

  5. 5
    "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Category: Sequences.
    Strain: C57BL/6J.
    Tissue: Eye.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 50469 other entries.

  6. 6
    "The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation."
    Seidah N.G., Benjannet S., Wickham L., Marcinkiewicz J., Jasmin S.B., Stifani S., Basak A., Prat A., Chretien M.
    Proc. Natl. Acad. Sci. U.S.A. 100:928-933(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROPEPTIDE CLEAVAGE SITE, CHARACTERIZATION.
    Category: Function, PTM / Processing.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2 other entries.

  7. 7
    Cited for: AUTOCATALYTIC CLEAVAGE SITE.
    Category: Function, PTM / Processing.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2 other entries.

  8. 8
    "PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans."
    Dewpura T., Raymond A., Hamelin J., Seidah N.G., Mbikay M., Chretien M., Mayne J.
    FEBS J. 275:3480-3493(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-50, IDENTIFICATION BY MASS SPECTROMETRY.
    Category: PTM / Processing, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 and mapped to 1 other entries.

  9. 9
    "Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor."
    Sun H., Samarghandi A., Zhang N., Yao Z., Xiong M., Teng B.B.
    Arterioscler. Thromb. Vasc. Biol. 32:1585-1595(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Category: Function.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 3 and mapped to 20 other entries.

  10. 10
    "PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling."
    Kysenius K., Muggalla P., Maetlik K., Arumaee U., Huttunen H.J.
    Cell. Mol. Life Sci. 69:1903-1916(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Category: Function.
    Source: UniProtKB/Swiss-Prot (reviewed).
  11. 11
    "Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia."
    Dubuc G., Chamberland A., Wassef H., Davignon J., Seidah N.G., Bernier L., Prat A.
    Arterioscler. Thromb. Vasc. Biol. 24:1454-1459(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Expression, Sequences.
    Annotation: Human mouse and rat PCSK9 promoters contain 2 typical conserved motifs for cholesterol regulation: a sterol regulatory element (SRE) and an Sp1 site.Imported.
    Source: GeneRIF:100102.

    This publication is mapped to 4 other entries.

  12. 12
    "NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol."
    Benjannet S., Rhainds D., Essalmani R., Mayne J., Wickham L., Jin W., Asselin M.C., Hamelin J., Varret M., Allard D., Trillard M., Abifadel M., Tebon A., Attie A.D., Rader D.J., Boileau C., Brissette L., Chretien M., Prat A., Seidah N.G.
    J. Biol. Chem. 279:48865-48875(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location, Pathology & Biotech.
    Annotation: NARC-1 has a role in regulating both the level of LDLR and that of circulating apoB-containing lipoproteins in an LDLR-dependent and -independent fashionImported.
    Source: GeneRIF:100102.

    This publication is mapped to 4 other entries.

  13. 13
    "Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver."
    Park S.W., Moon Y.A., Horton J.D.
    J. Biol. Chem. 279:50630-50638(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Affects plasma LDL cholesterol levels by altering LDL receptor protein levels via a post-transcriptional mechanism.Imported.
    Source: GeneRIF:100102.

    This publication is mapped to 1 other entry.

  14. 14
    "Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment."
    Maxwell K.N., Fisher E.A., Breslow J.L.
    Proc. Natl. Acad. Sci. U.S.A. 102:2069-2074(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Results indicate that overexpression of proprotein convertase subtilisin kexin 9 induces the degradation of the low-density lipoprotein receptor by a nonproteasomal mechanism in a post-endoplasmic reticulum compartment.Imported.
    Source: GeneRIF:100102.

    This publication is mapped to 1 other entry.

  15. 15
    "Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells."
    Lalanne F., Lambert G., Amar M.J., Chetiveaux M., Zair Y., Jarnoux A.L., Ouguerram K., Friburg J., Seidah N.G., Brewer H.B. Jr., Krempf M., Costet P.
    J. Lipid Res. 46:1312-1319(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: PCSK9 has a role in LDL clearance but not in apoB-containing lipoprotein productionImported.
    Source: GeneRIF:100102, MGI:2140260.

    This publication is mapped to 12 other entries.

  16. 16
    "Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9."
    Rashid S., Curtis D.E., Garuti R., Anderson N.N., Bashmakov Y., Ho Y.K., Hammer R.E., Moon Y.A., Horton J.D.
    Proc. Natl. Acad. Sci. U.S.A. 102:5374-5379(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: livers of knockout mice lacking PCSK9 manifest increased LDLR protein but not mRNA; increased LDLR protein led to increased clearance of circulating lipoproteins and decreased plasma cholesterol levelsImported.
    Source: GeneRIF:100102, MGI:2140260.

    This publication is mapped to 9 other entries.

  17. 17
    "Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c."
    Costet P., Cariou B., Lambert G., Lalanne F., Lardeux B., Jarnoux A.L., Grefhorst A., Staels B., Krempf M.
    J. Biol. Chem. 281:6211-6218(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Source: MGI:2140260.

    This publication is mapped to 16 other entries.

  18. 18
    "Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects."
    Desai J., Shannon M.E., Johnson M.D., Ruff D.W., Hughes L.A., Kerley M.K., Carpenter D.A., Johnson D.K., Rinchik E.M., Culiat C.T.
    Hum. Mol. Genet. 15:1329-1341(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Source: MGI:2140260.

    This publication is mapped to 925 other entries.

  19. 19
    "BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system."
    Magdaleno S., Jensen P., Brumwell C.L., Seal A., Lehman K., Asbury A., Cheung T., Cornelius T., Batten D.M., Eden C., Norland S.M., Rice D.S., Dosooye N., Shakya S., Mehta P., Curran T.
    PLoS Biol. 4:e86-e86(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Source: MGI:2140260.

    This publication is mapped to 20159 other entries.

  20. 20
    "Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor."
    Lambert G., Jarnoux A.L., Pineau T., Pape O., Chetiveaux M., Laboisse C., Krempf M., Costet P.
    Endocrinology 147:4985-4995(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: the negative modulation of low-density lipoprotein receptor expression by PCSK9 also promotes an overproduction of nascent very-low-density lipoprotein in vivo upon fastingImported.
    Source: GeneRIF:100102, MGI:2140260.

    This publication is mapped to 11 other entries.

  21. 21
    "Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system."
    Poirier S., Prat A., Marcinkiewicz E., Paquin J., Chitramuthu B.P., Baranowski D., Cadieux B., Bennett H.P., Seidah N.G.
    J. Neurochem. 98:838-850(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: A novel role is supported for NARC-1/PCSK9 at the onset of the neuronal/neuroectodermal differentiation process in central nervous system development distinct from that in cholesterogenic organs such as liver.Imported.
    Source: GeneRIF:100102, MGI:2140260.

    This publication is mapped to 8 other entries.

  22. 22
    "Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice."
    Lagace T.A., Curtis D.E., Garuti R., McNutt M.C., Park S.W., Prather H.B., Anderson N.N., Ho Y.K., Hammer R.E., Horton J.D.
    J. Clin. Invest. 116:2995-3005(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Source: MGI:2140260.

    This publication is mapped to 22 other entries.

  23. 23
    "Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice."
    Graham M.J., Lemonidis K.M., Whipple C.P., Subramaniam A., Monia B.P., Crooke S.T., Crooke R.M.
    J. Lipid Res. 48:763-767(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: a critical role for LDLR in mediating the lipid-lowering effects of PCSK9 inhibitionImported.
    Source: GeneRIF:100102, MGI:2140260.

    This publication is mapped to 9 other entries.

  24. 24
    "The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates."
    Mayer G., Hamelin J., Asselin M.C., Pasquato A., Marcinkiewicz E., Tang M., Tabibzadeh S., Seidah N.G.
    J. Biol. Chem. 283:2373-2384(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Function, PTM / Processing.
    Annotation: after stimulation the protease activity of PC5A is enhanced as evidenced by the cleavage of the PC5A substrates Lefty ADAMTS-4 endothelial lipase and PCSK9.Imported.
    Source: GeneRIF:100102.

    This publication is mapped to 32 other entries.

  25. 25
    "The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2."
    Poirier S., Mayer G., Benjannet S., Bergeron E., Marcinkiewicz J., Nassoury N., Mayer H., Nimpf J., Prat A., Seidah N.G.
    J. Biol. Chem. 283:2363-2372(2008) [PubMed] [Europe PMC] [Abstract]
    Annotation: the activity of PCSK9 and its binding affinity on VLDLR and ApoER2 does not depend on the presence of LDLR.Imported.
    Source: GeneRIF:100102.

    This publication is cited by 2 and mapped to 28 other entries.

1 to 25 of 109  Show
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