Proprotein convertase subtilisin/kexin type 9

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• apolipoprotein binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.9

    "Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor."
    Sun H., Samarghandi A., Zhang N., Yao Z., Xiong M., Teng B.B.
    Arterioscler. Thromb. Vasc. Biol. 32:1585-1595(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• apolipoprotein receptor binding Source: MGI
• low-density lipoprotein particle binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.9

    "Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor."
    Sun H., Samarghandi A., Zhang N., Yao Z., Xiong M., Teng B.B.
    Arterioscler. Thromb. Vasc. Biol. 32:1585-1595(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• low-density lipoprotein particle receptor binding Source: HGNC-UCLInferred from direct assayⁱ
  • "Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice."
    Lagace T.A., Curtis D.E., Garuti R., McNutt M.C., Park S.W., Prather H.B., Anderson N.N., Ho Y.K., Hammer R.E., Horton J.D.
    J Clin Invest 116:2995-3005(2006) [PubMed] [Europe PMC] [Abstract]
• protein self-association Source: UniProtKB
• serine-type endopeptidase activity Source: HGNC-UCL <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • Ref.6

    "The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation."
    Seidah N.G., Benjannet S., Wickham L., Marcinkiewicz J., Jasmin S.B., Stifani S., Basak A., Prat A., Chretien M.
    Proc. Natl. Acad. Sci. U.S.A. 100:928-933(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: IDENTIFICATION OF PROPEPTIDE CLEAVAGE SITE, CHARACTERIZATION.
• signaling receptor inhibitor activity Source: MGI
• sodium channel inhibitor activity Source: MGI
• very-low-density lipoprotein particle binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.9

    "Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor."
    Sun H., Samarghandi A., Zhang N., Yao Z., Xiong M., Teng B.B.
    Arterioscler. Thromb. Vasc. Biol. 32:1585-1595(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• very-low-density lipoprotein particle receptor binding Source: MGI

GO - Biological processⁱ

• apoptotic process Source: UniProtKB-KW
• cellular response to insulin stimulus Source: HGNC-UCLInferred from direct assayⁱ
  • "Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c."
    Costet P., Cariou B., Lambert G., Lalanne F., Lardeux B., Jarnoux A.L., Grefhorst A., Staels B., Krempf M.
    J Biol Chem 281:6211-6218(2006) [PubMed] [Europe PMC] [Abstract]
• cellular response to starvation Source: HGNC-UCLInferred from direct assayⁱ
  • "Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c."
    Costet P., Cariou B., Lambert G., Lalanne F., Lardeux B., Jarnoux A.L., Grefhorst A., Staels B., Krempf M.
    J Biol Chem 281:6211-6218(2006) [PubMed] [Europe PMC] [Abstract]
• cholesterol homeostasis Source: HGNC-UCLInferred from sequence or structural similarityⁱ
  • Ref.6

    "The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation."
    Seidah N.G., Benjannet S., Wickham L., Marcinkiewicz J., Jasmin S.B., Stifani S., Basak A., Prat A., Chretien M.
    Proc. Natl. Acad. Sci. U.S.A. 100:928-933(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: IDENTIFICATION OF PROPEPTIDE CLEAVAGE SITE, CHARACTERIZATION.
• cholesterol metabolic process Source: MGIInferred from direct assayⁱ
  • "Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice."
    Graham M.J., Lemonidis K.M., Whipple C.P., Subramaniam A., Monia B.P., Crooke S.T., Crooke R.M.
    J Lipid Res 48:763-767(2007) [PubMed] [Europe PMC] [Abstract]
• kidney development Source: HGNC-UCL <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • Ref.6

    "The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation."
    Seidah N.G., Benjannet S., Wickham L., Marcinkiewicz J., Jasmin S.B., Stifani S., Basak A., Prat A., Chretien M.
    Proc. Natl. Acad. Sci. U.S.A. 100:928-933(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: IDENTIFICATION OF PROPEPTIDE CLEAVAGE SITE, CHARACTERIZATION.
• lipoprotein metabolic process Source: MGIInferred from direct assayⁱ
  • "Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice."
    Graham M.J., Lemonidis K.M., Whipple C.P., Subramaniam A., Monia B.P., Crooke S.T., Crooke R.M.
    J Lipid Res 48:763-767(2007) [PubMed] [Europe PMC] [Abstract]
• liver development Source: HGNC-UCLInferred from expression patternⁱ
  • Ref.6

    "The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation."
    Seidah N.G., Benjannet S., Wickham L., Marcinkiewicz J., Jasmin S.B., Stifani S., Basak A., Prat A., Chretien M.
    Proc. Natl. Acad. Sci. U.S.A. 100:928-933(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: IDENTIFICATION OF PROPEPTIDE CLEAVAGE SITE, CHARACTERIZATION.
• low-density lipoprotein particle receptor catabolic process Source: UniProtKB
• low-density lipoprotein receptor particle metabolic process Source: MGIInferred from direct assayⁱ
  • "Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice."
    Graham M.J., Lemonidis K.M., Whipple C.P., Subramaniam A., Monia B.P., Crooke S.T., Crooke R.M.
    J Lipid Res 48:763-767(2007) [PubMed] [Europe PMC] [Abstract]
• lysosomal transport Source: MGI
• negative regulation of low-density lipoprotein particle clearance Source: MGI
• negative regulation of low-density lipoprotein particle receptor binding Source: MGI
• negative regulation of low-density lipoprotein receptor activity Source: MGI
• negative regulation of receptor internalization Source: MGI
• negative regulation of receptor-mediated endocytosis involved in cholesterol transport Source: MGI
• negative regulation of receptor recycling Source: MGI
• negative regulation of sodium ion transmembrane transporter activity Source: MGI
• neurogenesis Source: HGNC-UCLInferred from expression patternⁱ
  • Ref.6

    "The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation."
    Seidah N.G., Benjannet S., Wickham L., Marcinkiewicz J., Jasmin S.B., Stifani S., Basak A., Prat A., Chretien M.
    Proc. Natl. Acad. Sci. U.S.A. 100:928-933(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: IDENTIFICATION OF PROPEPTIDE CLEAVAGE SITE, CHARACTERIZATION.
• neuron differentiation Source: HGNC-UCLInferred from direct assayⁱ
  • "Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system."
    Poirier S., Prat A., Marcinkiewicz E., Paquin J., Chitramuthu B.P., Baranowski D., Cadieux B., Bennett H.P., Seidah N.G.
    J Neurochem 98:838-850(2006) [PubMed] [Europe PMC] [Abstract]
• phospholipid metabolic process Source: MGIInferred from direct assayⁱ
  • "Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice."
    Graham M.J., Lemonidis K.M., Whipple C.P., Subramaniam A., Monia B.P., Crooke S.T., Crooke R.M.
    J Lipid Res 48:763-767(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of low-density lipoprotein particle receptor catabolic process Source: MGI
• positive regulation of neuron apoptotic process Source: HGNC-UCLInferred from sequence or structural similarityⁱ
  • Ref.6

    "The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation."
    Seidah N.G., Benjannet S., Wickham L., Marcinkiewicz J., Jasmin S.B., Stifani S., Basak A., Prat A., Chretien M.
    Proc. Natl. Acad. Sci. U.S.A. 100:928-933(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: IDENTIFICATION OF PROPEPTIDE CLEAVAGE SITE, CHARACTERIZATION.
• positive regulation of receptor internalization Source: MGI
• protein autoprocessing Source: HGNC-UCLInferred from sequence or structural similarityⁱ
  • Ref.6

    "The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation."
    Seidah N.G., Benjannet S., Wickham L., Marcinkiewicz J., Jasmin S.B., Stifani S., Basak A., Prat A., Chretien M.
    Proc. Natl. Acad. Sci. U.S.A. 100:928-933(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: IDENTIFICATION OF PROPEPTIDE CLEAVAGE SITE, CHARACTERIZATION.
• protein processing Source: MGI
• regulation of low-density lipoprotein particle receptor catabolic process Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells."
    Lalanne F., Lambert G., Amar M.J., Chetiveaux M., Zair Y., Jarnoux A.L., Ouguerram K., Friburg J., Seidah N.G., Brewer H.B. Jr., Krempf M., Costet P.
    J Lipid Res 46:1312-1319(2005) [PubMed] [Europe PMC] [Abstract]
  • "Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9."
    Rashid S., Curtis D.E., Garuti R., Anderson N.N., Bashmakov Y., Ho Y.K., Hammer R.E., Moon Y.A., Horton J.D.
    Proc Natl Acad Sci U S A 102:5374-5379(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of neuron apoptotic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.10

    "PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling."
    Kysenius K., Muggalla P., Maetlik K., Arumaee U., Huttunen H.J.
    Cell. Mol. Life Sci. 69:1903-1916(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• regulation of signaling receptor activity Source: MGI
• triglyceride metabolic process Source: MGIInferred from direct assayⁱ
  • "Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice."
    Graham M.J., Lemonidis K.M., Whipple C.P., Subramaniam A., Monia B.P., Crooke S.T., Crooke R.M.
    J Lipid Res 48:763-767(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Sites

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• apolipoprotein binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.9

    "Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor."
    Sun H., Samarghandi A., Zhang N., Yao Z., Xiong M., Teng B.B.
    Arterioscler. Thromb. Vasc. Biol. 32:1585-1595(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• apolipoprotein receptor binding Source: MGI
• low-density lipoprotein particle receptor binding Source: HGNC-UCLInferred from direct assayⁱ
  • "Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice."
    Lagace T.A., Curtis D.E., Garuti R., McNutt M.C., Park S.W., Prather H.B., Anderson N.N., Ho Y.K., Hammer R.E., Horton J.D.
    J Clin Invest 116:2995-3005(2006) [PubMed] [Europe PMC] [Abstract]
• protein self-association Source: UniProtKB
• very-low-density lipoprotein particle binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.9

    "Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor."
    Sun H., Samarghandi A., Zhang N., Yao Z., Xiong M., Teng B.B.
    Arterioscler. Thromb. Vasc. Biol. 32:1585-1595(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• very-low-density lipoprotein particle receptor binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MGTHCSAWLR WPLLPLLPPL LLLLLLLCPT GAGAQDEDGD YEELMLALPS 
        60         70         80         90        100
QEDGLADEAA HVATATFRRC SKEAWRLPGT YIVVLMEETQ RLQIEQTAHR 
       110        120        130        140        150
LQTRAARRGY VIKVLHIFYD LFPGFLVKMS SDLLGLALKL PHVEYIEEDS 
       160        170        180        190        200
FVFAQSIPWN LERIIPAWHQ TEEDRSPDGS SQVEVYLLDT SIQGAHREIE 
       210        220        230        240        250
GRVTITDFNS VPEEDGTRFH RQASKCDSHG THLAGVVSGR DAGVAKGTSL 
       260        270        280        290        300
HSLRVLNCQG KGTVSGTLIG LEFIRKSQLI QPSGPLVVLL PLAGGYSRIL 
       310        320        330        340        350
NAACRHLART GVVLVAAAGN FRDDACLYSP ASAPEVITVG ATNAQDQPVT 
       360        370        380        390        400
LGTLGTNFGR CVDLFAPGKD IIGASSDCST CFMSQSGTSQ AAAHVAGIVA 
       410        420        430        440        450
RMLSREPTLT LAELRQRLIH FSTKDVINMA WFPEDQQVLT PNLVATLPPS 
       460        470        480        490        500
THETGGQLLC RTVWSAHSGP TRTATATARC APEEELLSCS SFSRSGRRRG 
       510        520        530        540        550
DWIEAIGGQQ VCKALNAFGG EGVYAVARCC LVPRANCSIH NTPAARAGLE 
       560        570        580        590        600
THVHCHQKDH VLTGCSFHWE VEDLSVRRQP ALRSRRQPGQ CVGHQAASVY 
       610        620        630        640        650
ASCCHAPGLE CKIKEHGISG PSEQVTVACE AGWTLTGCNV LPGASLTLGA 
       660        670        680        690 
YSVDNLCVAR VHDTARADRT SGEATVAAAI CCRSRPSAKA SWVQ       

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Peptidase families
   Classification of peptidase families and list of entries
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
3. SIMILARITY comments
   Index of protein domains and families