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Protein

Snurportin-1

Gene

Snupn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-191859 snRNP Assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Snurportin-1
Alternative name(s):
RNA U transporter 1
Gene namesi
Name:Snupn
Synonyms:Rnut1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1913319 Snupn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910721 – 358Snurportin-1Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei351PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ80W37
MaxQBiQ80W37
PaxDbiQ80W37
PeptideAtlasiQ80W37
PRIDEiQ80W37

PTM databases

iPTMnetiQ80W37
PhosphoSitePlusiQ80W37

Expressioni

Gene expression databases

BgeeiENSMUSG00000055334 Expressed in 237 organ(s), highest expression level in oocyte
CleanExiMM_SNUPN
GenevisibleiQ80W37 MM

Interactioni

Subunit structurei

Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts (via IBB domain) with KPNB1; the interaction is direct. Interacts with DDX20, IPO7, SMN1, SNRPB and XPO1. Interacts directly with XPO1. Its interaction with XPO1 and binding to m3G-cap U snRNPs appears to be mutually exclusive.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei106Interaction with m3G-cap structureBy similarity1
Sitei145Interaction with m3G-cap structureBy similarity1
Sitei278Interaction with m3G-cap structureBy similarity1

Protein-protein interaction databases

BioGridi211191, 2 interactors
ComplexPortaliCPX-1111 Importin complex, Snurportin variant
STRINGi10090.ENSMUSP00000067200

Structurei

3D structure databases

ProteinModelPortaliQ80W37
SMRiQ80W37
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 73IBBPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 160Necessary for interaction with XPO1By similarityAdd BLAST160
Regioni1 – 65Necessary for interaction with KPNB1 and m3G-cap U1 and U5 snRNP import receptor activityBy similarityAdd BLAST65
Regioni128 – 130Interaction with m3G-cap structureBy similarity3
Regioni210 – 329Necessary for binding to the m3G-cap structureBy similarityAdd BLAST120

Sequence similaritiesi

Belongs to the snurportin family.Curated

Phylogenomic databases

eggNOGiKOG3132 Eukaryota
ENOG410XQNJ LUCA
GeneTreeiENSGT00510000047494
HOGENOMiHOG000012990
HOVERGENiHBG053257
InParanoidiQ80W37
KOiK13151
OMAiYHRQTHY
OrthoDBiEOG091G0PL0
PhylomeDBiQ80W37
TreeFamiTF313108

Family and domain databases

InterProiView protein in InterPro
IPR002652 Importin-a_IBB
IPR017336 Snurportin-1
IPR024721 Snurportin-1_N
PANTHERiPTHR13403 PTHR13403, 1 hit
PfamiView protein in Pfam
PF11538 Snurportin1, 1 hit
PIRSFiPIRSF037955 Snurportin-1, 1 hit
PROSITEiView protein in PROSITE
PS51214 IBB, 1 hit

Sequencei

Sequence statusi: Complete.

Q80W37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEELSQALAS SFSVSQELNS TAAPHPRLCQ YKSKYSSLEQ SERRRQLLEL
60 70 80 90 100
QKSKRLDYVN HARRLAEDDW TGMESGEEEN KKDEEEMDID PSKKLPKRYA
110 120 130 140 150
NQLMLSEWLI DVPSDLGQEW IVVVCPVGKR ALIVASRGST SAYTKSGYCV
160 170 180 190 200
NRFSSLLPGG NRRNSTTAKD YTILDCIYSE VNQTYYVLDV MCWRGHPFYD
210 220 230 240 250
CQTDFRFYWM HSKLPEEEGL GEKTKINPFK FVGLKNFPCT PESLCEVLSM
260 270 280 290 300
DFPFEVDGLL FYHKQTHYSP GSTPLVGWLR PYMVSDILGV AVPAGPLTTK
310 320 330 340 350
PEYAGHQLQQ IIEHKRSQED TKEKLTHKAS ENGHYELEHL STPKLRNPPH

SSESLMDN
Length:358
Mass (Da):41,032
Last modified:June 1, 2003 - v1
Checksum:i6750602E83C69155
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155315 mRNA Translation: BAE33185.1
BC049638 mRNA Translation: AAH49638.1
BC061258 mRNA Translation: AAH61258.1
CCDSiCCDS23214.1
RefSeqiNP_848461.1, NM_178374.3
XP_011241086.1, XM_011242784.2
UniGeneiMm.220984

Genome annotation databases

EnsembliENSMUST00000068856; ENSMUSP00000067200; ENSMUSG00000055334
GeneIDi66069
KEGGimmu:66069
UCSCiuc009ptr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155315 mRNA Translation: BAE33185.1
BC049638 mRNA Translation: AAH49638.1
BC061258 mRNA Translation: AAH61258.1
CCDSiCCDS23214.1
RefSeqiNP_848461.1, NM_178374.3
XP_011241086.1, XM_011242784.2
UniGeneiMm.220984

3D structure databases

ProteinModelPortaliQ80W37
SMRiQ80W37
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211191, 2 interactors
ComplexPortaliCPX-1111 Importin complex, Snurportin variant
STRINGi10090.ENSMUSP00000067200

PTM databases

iPTMnetiQ80W37
PhosphoSitePlusiQ80W37

Proteomic databases

EPDiQ80W37
MaxQBiQ80W37
PaxDbiQ80W37
PeptideAtlasiQ80W37
PRIDEiQ80W37

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068856; ENSMUSP00000067200; ENSMUSG00000055334
GeneIDi66069
KEGGimmu:66069
UCSCiuc009ptr.1 mouse

Organism-specific databases

CTDi10073
MGIiMGI:1913319 Snupn

Phylogenomic databases

eggNOGiKOG3132 Eukaryota
ENOG410XQNJ LUCA
GeneTreeiENSGT00510000047494
HOGENOMiHOG000012990
HOVERGENiHBG053257
InParanoidiQ80W37
KOiK13151
OMAiYHRQTHY
OrthoDBiEOG091G0PL0
PhylomeDBiQ80W37
TreeFamiTF313108

Enzyme and pathway databases

ReactomeiR-MMU-191859 snRNP Assembly

Miscellaneous databases

PROiPR:Q80W37
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055334 Expressed in 237 organ(s), highest expression level in oocyte
CleanExiMM_SNUPN
GenevisibleiQ80W37 MM

Family and domain databases

InterProiView protein in InterPro
IPR002652 Importin-a_IBB
IPR017336 Snurportin-1
IPR024721 Snurportin-1_N
PANTHERiPTHR13403 PTHR13403, 1 hit
PfamiView protein in Pfam
PF11538 Snurportin1, 1 hit
PIRSFiPIRSF037955 Snurportin-1, 1 hit
PROSITEiView protein in PROSITE
PS51214 IBB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPN1_MOUSE
AccessioniPrimary (citable) accession number: Q80W37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: October 10, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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