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Protein

Pre-mRNA-processing factor 40 homolog B

Gene

Prpf40b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in pre-mRNA splicing.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-processing factor 40 homolog B
Alternative name(s):
Huntingtin yeast partner C
Huntingtin-interacting protein C
Gene namesi
Name:Prpf40b
Synonyms:Hypc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1925583 Prpf40b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003092831 – 870Pre-mRNA-processing factor 40 homolog BAdd BLAST870

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei148N6-acetyllysineBy similarity1
Cross-linki175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei764PhosphoserineBy similarity1
Modified residuei831PhosphoserineBy similarity1
Cross-linki837Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei851PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ80W14
PRIDEiQ80W14

PTM databases

iPTMnetiQ80W14
PhosphoSitePlusiQ80W14

Interactioni

Subunit structurei

Interacts with the N-terminus of HD.By similarity

Protein-protein interaction databases

IntActiQ80W14, 1 interactor
MINTiQ80W14
STRINGi10090.ENSMUSP00000115869

Structurei

3D structure databases

ProteinModelPortaliQ80W14
SMRiQ80W14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 125WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini133 – 166WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini276 – 330FF 1Add BLAST55
Domaini340 – 397FF 2Add BLAST58
Domaini410 – 470FF 3Add BLAST61
Domaini490 – 550FF 4Add BLAST61
Domaini554 – 610FF 5Add BLAST57
Domaini625 – 682FF 6Add BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili604 – 640Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 72Pro-richAdd BLAST70

Sequence similaritiesi

Belongs to the PRPF40 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0152 Eukaryota
COG5104 LUCA
HOGENOMiHOG000231802
HOVERGENiHBG059634
InParanoidiQ80W14
KOiK12821
TreeFamiTF318732

Family and domain databases

CDDicd00201 WW, 2 hits
Gene3Di1.10.10.440, 5 hits
InterProiView protein in InterPro
IPR002713 FF_domain
IPR036517 FF_domain_sf
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF01846 FF, 2 hits
PF00397 WW, 2 hits
SMARTiView protein in SMART
SM00441 FF, 4 hits
SM00456 WW, 2 hits
SUPFAMiSSF51045 SSF51045, 2 hits
SSF81698 SSF81698, 5 hits
PROSITEiView protein in PROSITE
PS51676 FF, 6 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 2 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80W14-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMPPPFMPPP GLPPPFPPMG LPPMSQRPPA IPPMPPGILP PMLPPMGAPP
60 70 80 90 100
PLTQIPGMVP PMMPGMLMPA VPVTAATAPG ADTASSAVAG TGPPRALWSE
110 120 130 140 150
HVAPDGRIYY YNADDKQSVW EKPSVLKSKA ELLLSQCPWK EYKSDTGKPY
160 170 180 190 200
YYNNQSQESR WTRPKDLDDL EALVKQESAG KQQTQQLQTL QPQPPQPQPD
210 220 230 240 250
PPPIPPGPIP VPMALLEPEP GRSEDCDVLE AAQPLEQGFL QREEGPSSST
260 270 280 290 300
GQHRQPQEEE EAKPEPERSG LSWSNREKAK QAFKELLRDK AVPSNASWEQ
310 320 330 340 350
AMKMVVTDPR YSALPKLSEK KQAFNAYKAQ REKEEKEEAR LRAKEAKQTL
360 370 380 390 400
QHFLEQHERM TSTTRYRRAE QTFGDLEVWA VVPERERKEV YDDVLFFLAK
410 420 430 440 450
KEKEQAKQLR RRNIQALKSI LDGMSSVNFQ TTWSQAQQYL MDNPSFAQDQ
460 470 480 490 500
QLQNMDKEDA LICFEEHIRA LEREEEEERE RARLRERRQQ RKNREAFQSF
510 520 530 540 550
LDELHETGQL HSMSTWMELY PAVSTDVRFA NMLGQPGSTP LDLFKFYVEE
560 570 580 590 600
LKARFHDEKK IIKDILKDRG FCVEVNTAFE DFAHVISFDK RAAALDAGNI
610 620 630 640 650
KLTFNSLLEK AEARETEREK EEARRMRRRE AAFRSMLRQA VPALELGTAW
660 670 680 690 700
EEVRERFVCD SAFEQITLES ERIRLFREFL QVLEQTECQH LHTKGRKHGR
710 720 730 740 750
KGKKHHRKRS HSPSGSESDE EELPPPSLRP PKRRRRNPSE SGSEPSSSLD
760 770 780 790 800
SVESGGAALG GPGSPSSHLL LGSDHGLRKT KKPKKKTKKR RHKSTSPDSE
810 820 830 840 850
TDPEDKAGKE SEDREQEQDR EPRQAELPNR SPGFGIKKEK TGWDTSESEL
860 870
SEGELERRRR TLLQQLDDHQ
Length:870
Mass (Da):99,300
Last modified:November 13, 2007 - v2
Checksum:i4D0C2429AF35EAD7
GO
Isoform 2 (identifier: Q80W14-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     538-557: STPLDLFKFYVEELKARFHD → KAARLPLVCSAFLPCQPLWT
     558-870: Missing.

Show »
Length:557
Mass (Da):63,277
Checksum:i74DB650883C35523
GO
Isoform 3 (identifier: Q80W14-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     685-685: Missing.
     714-714: S → SVSRQ

Show »
Length:873
Mass (Da):99,642
Checksum:iE3FD869C37279BFF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti616T → R in AAD39464 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029122538 – 557STPLD…ARFHD → KAARLPLVCSAFLPCQPLWT in isoform 2. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_029123558 – 870Missing in isoform 2. 2 PublicationsAdd BLAST313
Alternative sequenceiVSP_029124685Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_029125714S → SVSRQ in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135440 mRNA Translation: AAD39464.1
AK019183 mRNA Translation: BAB31591.1
AK140075 mRNA Translation: BAE24230.1
BC051961 mRNA Translation: AAH51961.1
BC082994 mRNA Translation: AAH82994.1
CCDSiCCDS27818.1 [Q80W14-3]
RefSeqiNP_001335185.1, NM_001348256.1
NP_061256.1, NM_018786.3
UniGeneiMm.358668

Genome annotation databases

GeneIDi54614
KEGGimmu:54614
UCSCiuc007xph.1 mouse [Q80W14-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPR40B_MOUSE
AccessioniPrimary (citable) accession number: Q80W14
Secondary accession number(s): Q5XKB4, Q9CS39, Q9WVC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: February 28, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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