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Protein

TOX high mobility group box family member 3

Gene

Tox3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi254 – 322HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processApoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TOX high mobility group box family member 3
Alternative name(s):
Trinucleotide repeat-containing gene 9 protein
Gene namesi
Name:Tox3
Synonyms:Tnrc9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:3039593 Tox3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002863541 – 575TOX high mobility group box family member 3Add BLAST575

Proteomic databases

MaxQBiQ80W03
PaxDbiQ80W03
PRIDEiQ80W03

PTM databases

iPTMnetiQ80W03
PhosphoSitePlusiQ80W03

Expressioni

Gene expression databases

BgeeiENSMUSG00000043668
CleanExiMM_TOX3
ExpressionAtlasiQ80W03 baseline and differential
GenevisibleiQ80W03 MM

Interactioni

Subunit structurei

Homodimer. Interacts (via HGM box) with CITED1 (via C-terminus); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with CREB1 (phosphorylated form). Interacts with CREB1; the interaction is not depolarization dependent. Interacts with CREBBP (via C-terminus) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi232663, 8 interactors
STRINGi10090.ENSMUSP00000105250

Structurei

3D structure databases

ProteinModelPortaliQ80W03
SMRiQ80W03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi244 – 249Poly-Lys6
Compositional biasi430 – 571Gln-richAdd BLAST142

Domaini

the C-terminus is required for calcium responsiveness but not for transactivation activity.By similarity
The N-terminus is absolutely necessary for transactivation activity.By similarity

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
GeneTreeiENSGT00560000076898
HOGENOMiHOG000230949
HOVERGENiHBG051183
InParanoidiQ80W03
OMAiTMRLPMN
OrthoDBiEOG091G12A3
PhylomeDBiQ80W03
TreeFamiTF106481

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q80W03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVRFYPAAA GDPAGLDFAQ CLGYYGYSKL GNNNYMNMAE ANNAFFAASE
60 70 80 90 100
QTFHTPSLGD EEFEIPPITP PPESDPTLGM PDALLPFQTL SDPLPSQGTE
110 120 130 140 150
FTPQFPPQSL DLPSITISRN LVEQDGVLHS NGLHMDQSHT QVSQYRQDPS
160 170 180 190 200
LVMRSIVHMT DGARSGIMPP AQLTTINQSQ LSAQLGLNLG GANVSHTSPS
210 220 230 240 250
PPASKSATPS PSSSINEEDA DDANRAIGEK RTAPDSGKKP KTPKKKKKKD
260 270 280 290 300
PNEPQKPVSA YALFFRDTQA AIKGQNPNAT FGEVSKIVAS MWDSLGEEQK
310 320 330 340 350
QVYKRKTEAA KKEYLKALAA YRASLVSKAA AESAEAQTIR SVQQTLASTN
360 370 380 390 400
LTSSLLLNTS LSQHGTVPAS PQTLPQSLPR SIAPKPLTMR LPMSQIVTSV
410 420 430 440 450
TIAANMPSNI GAPLISSMGT TMVGSATSTQ VSPSVQTQQH QMQLQQQQQQ
460 470 480 490 500
QQQMQQMQQQ QLQQHQMHQQ IQQQMQQQHF QHHMQQHLQQ QQQQHLQQQL
510 520 530 540 550
SQQQLQQQLQ QHLQLQQLQH MQHQSQPSPR QHSPVTSQIT SPIPAIGSPQ
560 570
PASQQHQPQI QSQTQTQVLP QVSIF
Length:575
Mass (Da):63,174
Last modified:June 1, 2003 - v1
Checksum:iE1B95AD9F3BCFC91
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10A → G in BAC38545 (PubMed:16141072).Curated1
Sequence conflicti14A → S in BAC38545 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082602 mRNA Translation: BAC38545.1
BC052044 mRNA Translation: AAH52044.1
CCDSiCCDS22516.1
RefSeqiNP_766501.2, NM_172913.3
UniGeneiMm.302755

Genome annotation databases

EnsembliENSMUST00000109621; ENSMUSP00000105250; ENSMUSG00000043668
GeneIDi244579
KEGGimmu:244579
UCSCiuc009msb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTOX3_MOUSE
AccessioniPrimary (citable) accession number: Q80W03
Secondary accession number(s): Q8BIV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: June 1, 2003
Last modified: June 20, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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