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UniProtKB - Q80VW7 (AKNA_MOUSE)

Entry version 125 (25 May 2022)
Sequence version 1 (01 Jun 2003)
Previous versions | rss
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Protein

Microtubule organization protein AKNA

Gene

Akna

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (PubMed:30787442).

Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (PubMed:30787442).

Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (PubMed:30787442).

Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (PubMed:30787442).

In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (By similarity).

Binds to A/T-rich promoters (By similarity).

It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable).

By similarityCurated1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1088 – 1096A.T hook9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processNeurogenesis, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule organization protein AKNACurated
Alternative name(s):
AT-hook-containing transcription factorCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AknaImported
Synonyms:Kiaa19681 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2140340, Akna

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000039158

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Neonatal lethality: mice fail to thrive and most of them die by postnatal day 10 (PubMed:21606955). Mice display systemic inflammation, predominantly in the lungs, accompanied by enhanced leukocyte infiltration and alveolar destruction (PubMed:21606955).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002891601 – 1404Microtubule organization protein AKNAAdd BLAST1404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei51PhosphoserineCombined sources1
Modified residuei302PhosphoserineBy similarity1
Modified residuei485PhosphoserineBy similarity1
Modified residuei520PhosphoserineBy similarity1
Modified residuei617PhosphoserineCombined sources1
Modified residuei750PhosphoserineBy similarity1
Modified residuei753PhosphoserineBy similarity1
Modified residuei831PhosphoserineBy similarity1
Modified residuei860PhosphoserineBy similarity1
Modified residuei971PhosphoserineBy similarity1
Modified residuei1144PhosphoserineCombined sources1
Modified residuei1145PhosphoserineCombined sources1
Modified residuei1200PhosphoserineBy similarity1
Modified residuei1339PhosphoserineBy similarity1
Modified residuei1352PhosphoserineBy similarity1
Modified residuei1389PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated; phosphorylation regulates dissociation from and reassembly at the centrosome.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q80VW7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q80VW7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q80VW7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q80VW7

PeptideAtlas

More...PeptideAtlasi		Q80VW7

PRoteomics IDEntifications database

More...PRIDEi		Q80VW7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		296154 [Q80VW7-1]
296155 [Q80VW7-2]
296156 [Q80VW7-3]
296157 [Q80VW7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q80VW7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q80VW7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neural stem cells isolated at the peak of subventricular zone (SVZ): localizes at the subdistal appendages of the mother centriole in specific subtypes of neural stem cells and in almost all basal progenitors.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During development, expressed when the subventricular zone (SVZ) is generated (low at 11 dpc, high at 14 dpc and low at 18 dpc).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000039158, Expressed in granulocyte and 256 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q80VW7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DCTN1 (PubMed:30787442).

Interacts with MAPRE1/EB1 (PubMed:30787442).

Interacts with ODF2 (PubMed:30787442).

Interacts with CAMSAP3 (PubMed:30787442).

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000041614

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q80VW7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q80VW7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q80VW7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 304DisorderedSequence analysisAdd BLAST304
Regioni317 – 382DisorderedSequence analysisAdd BLAST66
Regioni494 – 549DisorderedSequence analysisAdd BLAST56
Regioni645 – 708DisorderedSequence analysisAdd BLAST64
Regioni754 – 787PESTAdd BLAST34
Regioni755 – 1038DisorderedSequence analysisAdd BLAST284
Regioni885 – 906PESTAdd BLAST22
Regioni1085 – 1185DisorderedSequence analysisAdd BLAST101
Regioni1208 – 1235DisorderedSequence analysisAdd BLAST28
Regioni1253 – 1286DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 36Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi53 – 71Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi72 – 90Acidic residuesSequence analysisAdd BLAST19
Compositional biasi180 – 210Polar residuesSequence analysisAdd BLAST31
Compositional biasi263 – 279Polar residuesSequence analysisAdd BLAST17
Compositional biasi287 – 304Polar residuesSequence analysisAdd BLAST18
Compositional biasi353 – 368Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi516 – 549Polar residuesSequence analysisAdd BLAST34
Compositional biasi658 – 708Polar residuesSequence analysisAdd BLAST51
Compositional biasi760 – 776Acidic residuesSequence analysisAdd BLAST17
Compositional biasi802 – 823Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi852 – 867Polar residuesSequence analysisAdd BLAST16
Compositional biasi898 – 937Polar residuesSequence analysisAdd BLAST40
Compositional biasi959 – 981Polar residuesSequence analysisAdd BLAST23
Compositional biasi1004 – 1038Polar residuesSequence analysisAdd BLAST35
Compositional biasi1085 – 1105Polar residuesSequence analysisAdd BLAST21
Compositional biasi1107 – 1134Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi1215 – 1235Polar residuesSequence analysisAdd BLAST21
Compositional biasi1254 – 1271Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AKNA family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRSN, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154254

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005641_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q80VW7

Identification of Orthologs from Complete Genome Data

More...OMAi		GTEVHWA

Database of Orthologous Groups

More...OrthoDBi		112521at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q80VW7

TreeFam database of animal gene trees

More...TreeFami		TF336885

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR022150, AKNA_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12443, AKNA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q80VW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSGAKAQW VGPSLGQGPR RRRWAWAEEQ DTDGRRDQGW GNSQSLPEAP 
        60         70         80         90        100
SPELLEDFRR AQEHLPPLEW DPDMQDSEES SGEETEADDA SSPEGSTVPL 
       110        120        130        140        150
PWLSRSNQQL DMSEEELDEA SGRPEVDLAG ESCTELECED QGDSSPPPPG 
       160        170        180        190        200
QGPAKGWVTF IKQGSNYRPS EHLEAQPSVE HSRTKSWSSG TVSLRQPSDS 
       210        220        230        240        250
LGSTWEGDTE VPQPSILPKA LPQSPCHNFP HPGDRNGGDV APATPTEFRD 
       260        270        280        290        300
SLAAPAQNAE CSAGTWGEET TSLPSSRPED QTWKRTKTSP KPLPSRFTGS 
       310        320        330        340        350
VSPLSTRLGA IKKVVPQHKQ GATLAGHSSS QAPKYGRGRR LNYPLPDFSK 
       360        370        380        390        400
VGPRVRFPKD ENYRPPKSRG HNRQQGSTRP LIFKSPAEIV RDVLLSSGEA 
       410        420        430        440        450
SLAKESSLAH TITRVPQEFQ TPEQATELVH QLQEDYHKLL TKYAEAENTI 
       460        470        480        490        500
DQLRLGAKVH LYSDPPQPSQ SFCSGSMPQG SKVLSFSIPQ PRVAEWWPDP 
       510        520        530        540        550
AQDPQASEAT GWPFPRTDLS PSSSPGVATP GRLPQSQGIA TDQPSTGQTQ 
       560        570        580        590        600
ALTSQASRLL AKVQSFEELV LAGHLPPQDQ IKSLEQLRAA HMALEAEYLQ 
       610        620        630        640        650
ACREELLDPQ LDASQGSPRT LNLCRELEAE IYHLGQRLEE LQDHMDQTQR 
       660        670        680        690        700
ETEPCRPDLQ DSTPTMSFLP QSAHLSMPSG PVSLPDGQTY QEPATTTTTS 
       710        720        730        740        750
PGSSCTLPIN KKLSLSIKTE ESPRGLPVPL RDRTLQVEQD FHGLLERYLS 
       760        770        780        790        800
VKSLPEALRD EDEDDLEEEE EEQDHQGPLE VDSPATAPGK TEAVRVPPGE 
       810        820        830        840        850
RPTQAEESHR DATQEDEEQM GPMKSPDFRP SMARDTYTPV LDTAEVAQRG 
       860        870        880        890        900
TKAMVSHQSS LTSLEESRPS ELLPRKALLR AGGPHTEEPW MVSPETDSGF 
       910        920        930        940        950
VGSETSIVSP FTQTPEHRLS HVSTSGPSAQ HLTASVPGDR TSHPKARGLM 
       960        970        980        990       1000
VPRRATETGI PRSRTQQHFS SLSSPGRGAQ SCHLEETSVA KIAVPRSEFK 
      1010       1020       1030       1040       1050
RQKQISKQLL PSGRTSPDSA PAPTAASTPH GSAESTANLL LNRTERDQAI 
      1060       1070       1080       1090       1100
KDLQAEVSRL RLQLEDSLHR PHPDGPACVA SAFNHSTQTQ EKLGSSPSWG 
      1110       1120       1130       1140       1150
PHYGSKSTER LSREPNGVEP AEPMGRRRAR SSSVPRDVPR LYLSSESESP 
      1160       1170       1180       1190       1200
APRLSSEKSR TFEEHPEAAQ WGTRPQSSSK RRERVSFRGQ YTGQEYHILS 
      1210       1220       1230       1240       1250
PKAILKDSGT PSCPHCHPIR TQDTGSAVSR DTTRGSSAAD TLRCALCGEV 
      1260       1270       1280       1290       1300
KSSAEADGSS SGPSEKNTPK KPSTPILKRK NRQTGSPVRM APGLWYLAAA 
      1310       1320       1330       1340       1350
PPAPAPPALA YISSAPIMPY LPPTVYYAAP APTSAQTASP QPARGPRRTR 
      1360       1370       1380       1390       1400
HSVQLGLNDL EELQAALREA AQAAENVRST TRQLSRSLSA DLRHARSLRG 

SCLF
Length:1,404
Mass (Da):153,123
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD24B6545BFA01372
GO
Isoform 2 (identifier: Q80VW7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     512-530: WPFPRTDLSPSSSPGVATP → ELGKEPGLLSTPLLMEGEP
     531-1404: Missing.

Show »
Length:530
Mass (Da):57,936
Checksum:iD108F6831B01B259
GO
Isoform 3 (identifier: Q80VW7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1226-1244: SAVSRDTTRGSSAADTLRC → KRQHFVQWRLKPLPTEKFY
     1245-1404: Missing.

Show »
Length:1,244
Mass (Da):136,764
Checksum:i59BE199AA5A4FEFA
GO
Isoform 4 (identifier: Q80VW7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-353: Missing.
     1226-1244: SAVSRDTTRGSSAADTLRC → KRQHFVQWRLKPLPTEKFY
     1245-1404: Missing.

Show »
Length:1,095
Mass (Da):120,835
Checksum:i265B731CD1668EE3
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC98278 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti396S → R in BAE32751 (PubMed:16141072).Curated1
Sequence conflicti527V → M in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti534P → S in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti558R → Q in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti712K → E in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti928 – 929Missing in BAC98278 (PubMed:14621295).Curated2
Sequence conflicti928 – 929Missing in AAH25835 (PubMed:15489334).Curated2
Sequence conflicti944P → S in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti944P → S in AAH25835 (PubMed:15489334).Curated1
Sequence conflicti956 – 958TET → IEA in BAC98278 (PubMed:14621295).Curated3
Sequence conflicti956 – 958TET → IEA in AAH25835 (PubMed:15489334).Curated3
Sequence conflicti963S → T in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti963S → T in AAH25835 (PubMed:15489334).Curated1
Sequence conflicti967 – 969QHF → RHL in BAC98278 (PubMed:14621295).Curated3
Sequence conflicti967 – 969QHF → RHL in AAH25835 (PubMed:15489334).Curated3
Sequence conflicti1113R → G in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti1113R → G in AAH25835 (PubMed:15489334).Curated1
Sequence conflicti1166P → S in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti1166P → S in AAH25835 (PubMed:15489334).Curated1
Sequence conflicti1211P → L in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti1211P → L in AAH25835 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_025941205 – 353Missing in isoform 4. 1 PublicationAdd BLAST149
Alternative sequenceiVSP_025942512 – 530WPFPR…GVATP → ELGKEPGLLSTPLLMEGEP in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_025943531 – 1404Missing in isoform 2. 1 PublicationAdd BLAST874
Alternative sequenceiVSP_0259441226 – 1244SAVSR…DTLRC → KRQHFVQWRLKPLPTEKFY in isoform 3 and isoform 4. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_0259451245 – 1404Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST160

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK129468 mRNA Translation: BAC98278.1 Different initiation.
AK154663 mRNA Translation: BAE32751.1
AK170121 mRNA Translation: BAE41578.1
AK170885 mRNA Translation: BAE42093.1
AL683828 Genomic DNA No translation available.
BC025835 mRNA Translation: AAH25835.1
BC036324 mRNA Translation: AAH36324.1
BC092227 mRNA Translation: AAH92227.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS38777.1 [Q80VW7-1]

NCBI Reference Sequences

More...RefSeqi		NP_001038979.1, NM_001045514.3 [Q80VW7-1]
NP_001292361.1, NM_001305432.1 [Q80VW7-1]
XP_006537583.1, XM_006537520.3 [Q80VW7-1]
XP_006537584.1, XM_006537521.2 [Q80VW7-1]
XP_006537585.1, XM_006537522.3 [Q80VW7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000035724; ENSMUSP00000041614; ENSMUSG00000039158 [Q80VW7-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100182

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:100182

UCSC genome browser

More...UCSCi		uc008tgb.3, mouse [Q80VW7-1]
uc008tge.2, mouse [Q80VW7-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129468 mRNA Translation: BAC98278.1 Different initiation.
AK154663 mRNA Translation: BAE32751.1
AK170121 mRNA Translation: BAE41578.1
AK170885 mRNA Translation: BAE42093.1
AL683828 Genomic DNA No translation available.
BC025835 mRNA Translation: AAH25835.1
BC036324 mRNA Translation: AAH36324.1
BC092227 mRNA Translation: AAH92227.1
CCDSiCCDS38777.1 [Q80VW7-1]
RefSeqiNP_001038979.1, NM_001045514.3 [Q80VW7-1]
NP_001292361.1, NM_001305432.1 [Q80VW7-1]
XP_006537583.1, XM_006537520.3 [Q80VW7-1]
XP_006537584.1, XM_006537521.2 [Q80VW7-1]
XP_006537585.1, XM_006537522.3 [Q80VW7-1]

3D structure databases

AlphaFoldDBiQ80VW7
SMRiQ80VW7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041614

PTM databases

iPTMnetiQ80VW7
PhosphoSitePlusiQ80VW7

Proteomic databases

EPDiQ80VW7
jPOSTiQ80VW7
MaxQBiQ80VW7
PaxDbiQ80VW7
PeptideAtlasiQ80VW7
PRIDEiQ80VW7
ProteomicsDBi296154 [Q80VW7-1]
296155 [Q80VW7-2]
296156 [Q80VW7-3]
296157 [Q80VW7-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		54667, 41 antibodies from 14 providers

Genome annotation databases

EnsembliENSMUST00000035724; ENSMUSP00000041614; ENSMUSG00000039158 [Q80VW7-1]
GeneIDi100182
KEGGimmu:100182
UCSCiuc008tgb.3, mouse [Q80VW7-1]
uc008tge.2, mouse [Q80VW7-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80709
MGIiMGI:2140340, Akna
VEuPathDBiHostDB:ENSMUSG00000039158

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiENOG502QRSN, Eukaryota
GeneTreeiENSGT00940000154254
HOGENOMiCLU_005641_0_0_1
InParanoidiQ80VW7
OMAiGTEVHWA
OrthoDBi112521at2759
PhylomeDBiQ80VW7
TreeFamiTF336885

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		100182, 2 hits in 57 CRISPR screens

Protein Ontology

More...PROi		PR:Q80VW7
RNActiQ80VW7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000039158, Expressed in granulocyte and 256 other tissues
GenevisibleiQ80VW7, MM

Family and domain databases

InterProiView protein in InterPro
IPR022150, AKNA_dom
PfamiView protein in Pfam
PF12443, AKNA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKNA_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80VW7
Secondary accession number(s): Q3TC64
, Q3TDM3, Q3U3N4, Q6ZPF9, Q8CFV0, Q8R114
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2003
Last modified: May 25, 2022
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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