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Entry version 111 (31 Jul 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Microtubule organization protein AKNA

Gene

Akna

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (PubMed:30787442). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (PubMed:30787442). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (PubMed:30787442). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (PubMed:30787442). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (By similarity). Binds to A/T-rich promoters (By similarity). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable).By similarityCurated1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1088 – 1096A.T hook9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processNeurogenesis, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule organization protein AKNACurated
Alternative name(s):
AT-hook-containing transcription factorCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AknaImported
Synonyms:Kiaa19681 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2140340 Akna

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Neonatal lethality: mice fail to thrive and most of them die by postnatal day 10 (PubMed:21606955). Mice display systemic inflammation, predominantly in the lungs, accompanied by enhanced leukocyte infiltration and alveolar destruction (PubMed:21606955).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002891601 – 1404Microtubule organization protein AKNAAdd BLAST1404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei51PhosphoserineCombined sources1
Modified residuei302PhosphoserineBy similarity1
Modified residuei485PhosphoserineBy similarity1
Modified residuei520PhosphoserineBy similarity1
Modified residuei617PhosphoserineCombined sources1
Modified residuei750PhosphoserineBy similarity1
Modified residuei753PhosphoserineBy similarity1
Modified residuei831PhosphoserineBy similarity1
Modified residuei860PhosphoserineBy similarity1
Modified residuei971PhosphoserineBy similarity1
Modified residuei1144PhosphoserineCombined sources1
Modified residuei1145PhosphoserineCombined sources1
Modified residuei1200PhosphoserineBy similarity1
Modified residuei1339PhosphoserineBy similarity1
Modified residuei1352PhosphoserineBy similarity1
Modified residuei1389PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated; phosphorylation regulates dissociation from and reassembly at the centrosome.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q80VW7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80VW7

PeptideAtlas

More...
PeptideAtlasi
Q80VW7

PRoteomics IDEntifications database

More...
PRIDEi
Q80VW7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80VW7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80VW7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neural stem cells isolated at the peak of subventricular zone (SVZ): localizes at the subdistal appendages of the mother centriole in specific subtypes of neural stem cells and in almost all basal progenitors.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During development, expressed when the subventricular zone (SVZ) is generated (low at 11 dpc, high at 14 dpc and low at 18 dpc).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039158 Expressed in 226 organ(s), highest expression level in lymph node

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q80VW7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DCTN1 (PubMed:30787442).

Interacts with MAPRE1/EB1 (PubMed:30787442).

Interacts with ODF2 (PubMed:30787442).

Interacts with CAMSAP3 (PubMed:30787442).

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000041614

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q80VW7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni754 – 787PESTAdd BLAST34
Regioni885 – 906PESTAdd BLAST22

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AKNA family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IDZE Eukaryota
ENOG4111ICK LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154254

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q80VW7

KEGG Orthology (KO)

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KOi
K21404

Identification of Orthologs from Complete Genome Data

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OMAi
GHKRISE

Database of Orthologous Groups

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OrthoDBi
112521at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80VW7

TreeFam database of animal gene trees

More...
TreeFami
TF336885

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022150 AKNA

The PANTHER Classification System

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PANTHERi
PTHR21510 PTHR21510, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12443 AKNA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q80VW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSGAKAQW VGPSLGQGPR RRRWAWAEEQ DTDGRRDQGW GNSQSLPEAP
60 70 80 90 100
SPELLEDFRR AQEHLPPLEW DPDMQDSEES SGEETEADDA SSPEGSTVPL
110 120 130 140 150
PWLSRSNQQL DMSEEELDEA SGRPEVDLAG ESCTELECED QGDSSPPPPG
160 170 180 190 200
QGPAKGWVTF IKQGSNYRPS EHLEAQPSVE HSRTKSWSSG TVSLRQPSDS
210 220 230 240 250
LGSTWEGDTE VPQPSILPKA LPQSPCHNFP HPGDRNGGDV APATPTEFRD
260 270 280 290 300
SLAAPAQNAE CSAGTWGEET TSLPSSRPED QTWKRTKTSP KPLPSRFTGS
310 320 330 340 350
VSPLSTRLGA IKKVVPQHKQ GATLAGHSSS QAPKYGRGRR LNYPLPDFSK
360 370 380 390 400
VGPRVRFPKD ENYRPPKSRG HNRQQGSTRP LIFKSPAEIV RDVLLSSGEA
410 420 430 440 450
SLAKESSLAH TITRVPQEFQ TPEQATELVH QLQEDYHKLL TKYAEAENTI
460 470 480 490 500
DQLRLGAKVH LYSDPPQPSQ SFCSGSMPQG SKVLSFSIPQ PRVAEWWPDP
510 520 530 540 550
AQDPQASEAT GWPFPRTDLS PSSSPGVATP GRLPQSQGIA TDQPSTGQTQ
560 570 580 590 600
ALTSQASRLL AKVQSFEELV LAGHLPPQDQ IKSLEQLRAA HMALEAEYLQ
610 620 630 640 650
ACREELLDPQ LDASQGSPRT LNLCRELEAE IYHLGQRLEE LQDHMDQTQR
660 670 680 690 700
ETEPCRPDLQ DSTPTMSFLP QSAHLSMPSG PVSLPDGQTY QEPATTTTTS
710 720 730 740 750
PGSSCTLPIN KKLSLSIKTE ESPRGLPVPL RDRTLQVEQD FHGLLERYLS
760 770 780 790 800
VKSLPEALRD EDEDDLEEEE EEQDHQGPLE VDSPATAPGK TEAVRVPPGE
810 820 830 840 850
RPTQAEESHR DATQEDEEQM GPMKSPDFRP SMARDTYTPV LDTAEVAQRG
860 870 880 890 900
TKAMVSHQSS LTSLEESRPS ELLPRKALLR AGGPHTEEPW MVSPETDSGF
910 920 930 940 950
VGSETSIVSP FTQTPEHRLS HVSTSGPSAQ HLTASVPGDR TSHPKARGLM
960 970 980 990 1000
VPRRATETGI PRSRTQQHFS SLSSPGRGAQ SCHLEETSVA KIAVPRSEFK
1010 1020 1030 1040 1050
RQKQISKQLL PSGRTSPDSA PAPTAASTPH GSAESTANLL LNRTERDQAI
1060 1070 1080 1090 1100
KDLQAEVSRL RLQLEDSLHR PHPDGPACVA SAFNHSTQTQ EKLGSSPSWG
1110 1120 1130 1140 1150
PHYGSKSTER LSREPNGVEP AEPMGRRRAR SSSVPRDVPR LYLSSESESP
1160 1170 1180 1190 1200
APRLSSEKSR TFEEHPEAAQ WGTRPQSSSK RRERVSFRGQ YTGQEYHILS
1210 1220 1230 1240 1250
PKAILKDSGT PSCPHCHPIR TQDTGSAVSR DTTRGSSAAD TLRCALCGEV
1260 1270 1280 1290 1300
KSSAEADGSS SGPSEKNTPK KPSTPILKRK NRQTGSPVRM APGLWYLAAA
1310 1320 1330 1340 1350
PPAPAPPALA YISSAPIMPY LPPTVYYAAP APTSAQTASP QPARGPRRTR
1360 1370 1380 1390 1400
HSVQLGLNDL EELQAALREA AQAAENVRST TRQLSRSLSA DLRHARSLRG

SCLF
Length:1,404
Mass (Da):153,123
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD24B6545BFA01372
GO
Isoform 2 (identifier: Q80VW7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     512-530: WPFPRTDLSPSSSPGVATP → ELGKEPGLLSTPLLMEGEP
     531-1404: Missing.

Note: No experimental confirmation available.
Show »
Length:530
Mass (Da):57,936
Checksum:iD108F6831B01B259
GO
Isoform 3 (identifier: Q80VW7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1226-1244: SAVSRDTTRGSSAADTLRC → KRQHFVQWRLKPLPTEKFY
     1245-1404: Missing.

Note: No experimental confirmation available.
Show »
Length:1,244
Mass (Da):136,764
Checksum:i59BE199AA5A4FEFA
GO
Isoform 4 (identifier: Q80VW7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-353: Missing.
     1226-1244: SAVSRDTTRGSSAADTLRC → KRQHFVQWRLKPLPTEKFY
     1245-1404: Missing.

Note: No experimental confirmation available.
Show »
Length:1,095
Mass (Da):120,835
Checksum:i265B731CD1668EE3
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC98278 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti396S → R in BAE32751 (PubMed:16141072).Curated1
Sequence conflicti527V → M in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti534P → S in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti558R → Q in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti712K → E in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti928 – 929Missing in BAC98278 (PubMed:14621295).Curated2
Sequence conflicti928 – 929Missing in AAH25835 (PubMed:15489334).Curated2
Sequence conflicti944P → S in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti944P → S in AAH25835 (PubMed:15489334).Curated1
Sequence conflicti956 – 958TET → IEA in BAC98278 (PubMed:14621295).Curated3
Sequence conflicti956 – 958TET → IEA in AAH25835 (PubMed:15489334).Curated3
Sequence conflicti963S → T in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti963S → T in AAH25835 (PubMed:15489334).Curated1
Sequence conflicti967 – 969QHF → RHL in BAC98278 (PubMed:14621295).Curated3
Sequence conflicti967 – 969QHF → RHL in AAH25835 (PubMed:15489334).Curated3
Sequence conflicti1113R → G in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti1113R → G in AAH25835 (PubMed:15489334).Curated1
Sequence conflicti1166P → S in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti1166P → S in AAH25835 (PubMed:15489334).Curated1
Sequence conflicti1211P → L in BAC98278 (PubMed:14621295).Curated1
Sequence conflicti1211P → L in AAH25835 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_025941205 – 353Missing in isoform 4. 1 PublicationAdd BLAST149
Alternative sequenceiVSP_025942512 – 530WPFPR…GVATP → ELGKEPGLLSTPLLMEGEP in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_025943531 – 1404Missing in isoform 2. 1 PublicationAdd BLAST874
Alternative sequenceiVSP_0259441226 – 1244SAVSR…DTLRC → KRQHFVQWRLKPLPTEKFY in isoform 3 and isoform 4. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_0259451245 – 1404Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST160

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK129468 mRNA Translation: BAC98278.1 Different initiation.
AK154663 mRNA Translation: BAE32751.1
AK170121 mRNA Translation: BAE41578.1
AK170885 mRNA Translation: BAE42093.1
AL683828 Genomic DNA No translation available.
BC025835 mRNA Translation: AAH25835.1
BC036324 mRNA Translation: AAH36324.1
BC092227 mRNA Translation: AAH92227.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS38777.1 [Q80VW7-1]

NCBI Reference Sequences

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RefSeqi
NP_001038979.1, NM_001045514.3 [Q80VW7-1]
NP_001292361.1, NM_001305432.1 [Q80VW7-1]
XP_006537583.1, XM_006537520.3 [Q80VW7-1]
XP_006537584.1, XM_006537521.2 [Q80VW7-1]
XP_006537585.1, XM_006537522.3 [Q80VW7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000035724; ENSMUSP00000041614; ENSMUSG00000039158 [Q80VW7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
100182

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:100182

UCSC genome browser

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UCSCi
uc008tgb.3 mouse [Q80VW7-1]
uc008tge.2 mouse [Q80VW7-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129468 mRNA Translation: BAC98278.1 Different initiation.
AK154663 mRNA Translation: BAE32751.1
AK170121 mRNA Translation: BAE41578.1
AK170885 mRNA Translation: BAE42093.1
AL683828 Genomic DNA No translation available.
BC025835 mRNA Translation: AAH25835.1
BC036324 mRNA Translation: AAH36324.1
BC092227 mRNA Translation: AAH92227.1
CCDSiCCDS38777.1 [Q80VW7-1]
RefSeqiNP_001038979.1, NM_001045514.3 [Q80VW7-1]
NP_001292361.1, NM_001305432.1 [Q80VW7-1]
XP_006537583.1, XM_006537520.3 [Q80VW7-1]
XP_006537584.1, XM_006537521.2 [Q80VW7-1]
XP_006537585.1, XM_006537522.3 [Q80VW7-1]

3D structure databases

SMRiQ80VW7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041614

PTM databases

iPTMnetiQ80VW7
PhosphoSitePlusiQ80VW7

Proteomic databases

EPDiQ80VW7
PaxDbiQ80VW7
PeptideAtlasiQ80VW7
PRIDEiQ80VW7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035724; ENSMUSP00000041614; ENSMUSG00000039158 [Q80VW7-1]
GeneIDi100182
KEGGimmu:100182
UCSCiuc008tgb.3 mouse [Q80VW7-1]
uc008tge.2 mouse [Q80VW7-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80709
MGIiMGI:2140340 Akna

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IDZE Eukaryota
ENOG4111ICK LUCA
GeneTreeiENSGT00940000154254
InParanoidiQ80VW7
KOiK21404
OMAiGHKRISE
OrthoDBi112521at2759
PhylomeDBiQ80VW7
TreeFamiTF336885

Miscellaneous databases

Protein Ontology

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PROi
PR:Q80VW7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039158 Expressed in 226 organ(s), highest expression level in lymph node
GenevisibleiQ80VW7 MM

Family and domain databases

InterProiView protein in InterPro
IPR022150 AKNA
PANTHERiPTHR21510 PTHR21510, 1 hit
PfamiView protein in Pfam
PF12443 AKNA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKNA_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80VW7
Secondary accession number(s): Q3TC64
, Q3TDM3, Q3U3N4, Q6ZPF9, Q8CFV0, Q8R114
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2003
Last modified: July 31, 2019
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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