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Protein

Whirlin

Gene

Whrn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in hearing and vision as member of the USH2 complex (PubMed:20502675). Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear (PubMed:15590699). Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear (PubMed:20502675, PubMed:24334608). In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport (PubMed:20502675).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHearing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Whirlin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WhrnImported
Synonyms:Dfnb31, Kiaa1526
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2682003 Whrn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Whrn are the cause of the phenotype whirler (wi). Mutants are characterized by deafness due to malformation of the cochlear inner and outer hair cells and by circling behavior. Stereocilia are shorter and wider than in wild-type animals and there is a decrease in the number of actin filaments in inner and outer hair cells. The number of outer hair cell stereocilia is reduced with increased spacing between them.3 Publications

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant mice for isoform 1 appear viable and comparable to their wild-type littermates in growth characteristics, reproductive performance and general health (PubMed:20502675). At 2 and 9 month of age, knockouts show a profound hearing loss across all cochlear frequencies (PubMed:20502675). At 28 to 33 months, they show signs for retinal degenration such as a thinner phtoreceptor nuclear layer and outer segments sortened (PubMed:20502675).1 Publication

Keywords - Diseasei

Deafness

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000659691 – 918WhirlinAdd BLAST918

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei696PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80VW5

PRoteomics IDEntifications database

More...
PRIDEi
Q80VW5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80VW5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80VW5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the retina. Colocalizes with RPGR in the photoreceptor connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment (at protein level). Detected in the inner ear throughout development from embryonic day 12 to 20 days after birth. Displays a dynamic pattern of expression after birth, demonstrating an ordered appearance and fade-out across stereocilia rows. Isoforms 5, 6, 7 and 8 are not detected in the retina (PubMed:20502675).5 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At E10.5, expressed in the basal plate of the spinal cord, in the ventralneural epithelium of the developing brain and in the region of the lung bud. At E12.5, expressed in the complete neuroepithelium except for the neocortex. In the developing eye, expressed in the inner neuroblastic layer. At E14.5, detected in the intervertebral cartilage, the cortex of the developing kidney, the tongue, the region of the urethra and strongly in specific regions of the brain, e.g. striatum, optic recess, ventral tegmental area, roof of the midbrain, choroid plexus of the lateral ventricles and the fourth ventricle. The developing neocortex is devoid of expression. At this timepoint, expression is first notable in the inner ear in the developing maculae of the saccule and the utricle, in the cristae of the semicircular canals and in the vestibulocochlear ganglion. In the developing neural retina, a strong signal is present in the inner neuroblastic layer. At E16.5, expression is very similar to that at E14.5. At E18.5, expression is mainly as in E16.5. Expression in the ganglion layers of the retina decreases and is no longer detected in the innermost region of these layers. From postnatal day 7 (P7) onwards, also the developing photoreceptor cells express whirlin (PubMed:16434480). Expression decreases by 11 days after birth in inner ear hair cells and by 14 days after birth in outer ear hair cells. Expressed in vestibular hair cells at high levels through to adulthood.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000039137 Expressed in 125 organ(s), highest expression level in brain

CleanEx database of gene expression profiles

More...
CleanExi
MM_WHRN

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q80VW5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80VW5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homooligomers (PubMed:15590698, PubMed:25406310). Interacts (via C-terminal PDZ domain) with MYO15A; this interaction is necessary for localization of WHRN to stereocilia tips (PubMed:15654330, PubMed:15590698). Interacts (via C-terminal PDZ domain) with MPP1/p55 (PubMed:16829577, PubMed:17584769). Interacts with LRRC4C/NGL1 (PubMed:15590698). Interacts with MYO7A (PubMed:15590698). Interacts with RPGR (PubMed:22323458). Interacts with EPS8 (PubMed:21236676). Interacts with CASK. Interacts with CIB2 (By similarity). Component of USH2 complex, composed of ADGRV1, PDZD7, USH2A and WHRN (PubMed:20502675, PubMed:25406310). Interacts (via PDZ domains) with PDZD7; the interaction is direct (PubMed:25406310). Interacts (via N-terminal PDZ domain) with USH2A (via cytoplasmic region) (PubMed:16301217, PubMed:20502675, PubMed:23055499). Interacts with ADGRV1/MASS1 (via cytoplasmic region) (PubMed:20502675, PubMed:23055499).By similarity10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q80VW5

Database of interacting proteins

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DIPi
DIP-42047N

Protein interaction database and analysis system

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IntActi
Q80VW5, 5 interactors

Molecular INTeraction database

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MINTi
Q80VW5

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000081557

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1918
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q80VW5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q80VW5

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini141 – 224PDZ 1PROSITE-ProRule annotationAdd BLAST84
Domaini280 – 362PDZ 2PROSITE-ProRule annotationAdd BLAST83
Domaini827 – 910PDZ 3PROSITE-ProRule annotationAdd BLAST84

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 32Ala/Gly/Ser-richAdd BLAST24
Compositional biasi584 – 723Pro-richAdd BLAST140

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410ITAG Eukaryota
ENOG410XTF7 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153656

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG056634

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q80VW5

KEGG Orthology (KO)

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KOi
K21879

Identification of Orthologs from Complete Genome Data

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OMAi
GINKPGF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01FL

Database for complete collections of gene phylogenies

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PhylomeDBi
Q80VW5

TreeFam database of animal gene trees

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TreeFami
TF325033

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR033028 Whirlin

The PANTHER Classification System

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PANTHERi
PTHR23116:SF37 PTHR23116:SF37, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00595 PDZ, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50156 SSF50156, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (12+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 12 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 12 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80VW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNAQLDGLSV SSSSTGSLGS AAAAAGGGGG AGLRLLSANV RQLHQALTAL
60 70 80 90 100
LSEPEREQFT HCLNAYHARR NVFDLVRTLR VLLDSPVKRR LLPMLRLVIP
110 120 130 140 150
RSDQLLFDQY TAEGLYLPAT TPYRQPAWAA PDGAGPGEVR LVSLRRAKAH
160 170 180 190 200
EGLGFSIRGG SEHGVGIYVS LVEPGSLAEK EGLRVGDQIL RVNDKSLARV
210 220 230 240 250
THAEAVKALK GSKKLVLSVY SAGRIPGGYV TNHIYTWVDP QGRSTSPPSS
260 270 280 290 300
LPQPHGSTLR QREDDRRSTL HLLQSGDEKK VNLVLGDGRS LGLTIRGGAE
310 320 330 340 350
YGLGIYITGV DPGSEAESSG LKVGDQILEV NGRSFLNILH DEAVKLLKSS
360 370 380 390 400
RHLILTVKDV GRLPHARTTV DQTKWIASSR IGESVANSAG FPGDHTEEGT
410 420 430 440 450
SKPGFYKGPA GSQVTLSSLG NQTRALLDDQ ARHLLTEQER ATMMYYLAQY
460 470 480 490 500
RGGTISVEAM VMALFELLNT HAKFSLLSEV RSIISPQDLD RFDHLVLRRE
510 520 530 540 550
IESMKARQPP GPGVGDTYSM VSYSDTGSST GSHGTSTTVS SARERLLWLI
560 570 580 590 600
DLMENTLDLE GTGETTQGST NALPDVSVDD VKSPSEDLPG IKPPPPPPPL
610 620 630 640 650
AQGHDRLLGQ PRKPGREDPA PLSSAAHSGI VFSAPRNRSP PPGTAPTPGP
660 670 680 690 700
SSAQDSPSSP IYASISHANP SSRKPLDTHL ALVNQHPIGP FPRVQSPPHL
710 720 730 740 750
KSPPAETPGA GACLPPPSPS EHPDAVGANQ HFVLVEVHRP DSEPDVNEVR
760 770 780 790 800
ALPQTRTAST LSQLSDSGQT LSEDSGVDAG ETEASTSGRG RQTASAKNKN
810 820 830 840 850
GKEQPRTERT AEGANKPPGL LEPTSTLVRV RKSAATLGIA IEGGANTRQP
860 870 880 890 900
LPRIVTIQRG GSAHNCGQLK VGHVILEVNG QTLRGKEHKE AARIIAEAFK
910
TKERDYIDFL VTEFNVML
Length:918
Mass (Da):98,012
Last modified:December 4, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D5EA44DE0645AA4
GO
Isoform 2 (identifier: Q80VW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-390: G → GSGLR
     544-554: Missing.

Show »
Length:911
Mass (Da):97,013
Checksum:i3195E2DB7907E92F
GO
Isoform 3 (identifier: Q80VW5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     544-554: Missing.

Note: Major isoform.
Show »
Length:907
Mass (Da):96,600
Checksum:iC23C5823AE9BD457
GO
Isoform 4 (identifier: Q80VW5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     544-554: Missing.
     758-758: Missing.

Show »
Length:906
Mass (Da):96,528
Checksum:iF96EFC6C1DF9D029
GO
Isoform 5 (identifier: Q80VW5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-357: Missing.
     358-402: KDVGRLPHAR...GDHTEEGTSK → MTTWCHRPRV...SSGLCPSVFQ
     544-554: Missing.

Show »
Length:550
Mass (Da):58,669
Checksum:iFB4D9E8BDD6DD09B
GO
Isoform 6 (identifier: Q80VW5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-442: Missing.

Show »
Length:476
Mass (Da):50,709
Checksum:iBDA13DA400C3E0F4
GO
Isoform 7 (identifier: Q80VW5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-442: Missing.
     544-554: Missing.

Show »
Length:465
Mass (Da):49,296
Checksum:i5EE7EB675198EBE2
GO
Isoform 8 (identifier: Q80VW5-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-503: Missing.
     544-554: Missing.

Show »
Length:404
Mass (Da):42,208
Checksum:i47E37E2D1D9647EE
GO
Isoform 9 (identifier: Q80VW5-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-552: Missing.

Show »
Length:366
Mass (Da):38,480
Checksum:i4EECE4260B616897
GO
Isoform 10 (identifier: Q80VW5-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     544-571: ERLLWLIDLMENTLDLEGTGETTQGSTN → VSHPCPILGEKVRARIRCFPPKPRVPHL
     572-918: Missing.

Note: No experimental confirmation available.
Show »
Length:571
Mass (Da):61,584
Checksum:iB1B7F2811EF53A9D
GO
Isoform 11 (identifier: Q80VW5-11) [UniParc]FASTAAdd to basket
Also known as: WhirlinNT2

The sequence of this isoform differs from the canonical sequence as follows:
     555-566: NTLDLEGTGETT → VPSFCRGRLGVP
     567-918: Missing.

Note: May be due to intron retention.
Show »
Length:566
Mass (Da):61,080
Checksum:i4EEDB18EC7979658
GO
Isoform 12 (identifier: Q80VW5-12) [UniParc]FASTAAdd to basket
Also known as: WhirlinNT1

The sequence of this isoform differs from the canonical sequence as follows:
     323-918: Missing.

Note: May be due to intron retention.
Show »
Length:322
Mass (Da):34,324
Checksum:i7DC71EAD135F55ED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I7HNW6I7HNW6_MOUSE
Whirlin
Whrn
164Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RBK9F6RBK9_MOUSE
Whirlin
Whrn
74Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7BB17F7BB17_MOUSE
Whirlin
Whrn
28Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti504M → V in BAE34281 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0299341 – 552Missing in isoform 9. 1 PublicationAdd BLAST552
Alternative sequenceiVSP_0299351 – 503Missing in isoform 8. 1 PublicationAdd BLAST503
Alternative sequenceiVSP_0299361 – 442Missing in isoform 6 and isoform 7. 1 PublicationAdd BLAST442
Alternative sequenceiVSP_0299371 – 357Missing in isoform 5. 1 PublicationAdd BLAST357
Alternative sequenceiVSP_045293323 – 918Missing in isoform 12. 1 PublicationAdd BLAST596
Alternative sequenceiVSP_029938358 – 402KDVGR…EGTSK → MTTWCHRPRVRWSGSCVCGD HQHNARSHSLPRSLDSSGLC PSVFQ in isoform 5. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_029939390G → GSGLR in isoform 2. 1 Publication1
Alternative sequenceiVSP_029940544 – 571ERLLW…QGSTN → VSHPCPILGEKVRARIRCFP PKPRVPHL in isoform 10. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_029941544 – 554Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 7 and isoform 8. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_045294555 – 566NTLDL…TGETT → VPSFCRGRLGVP in isoform 11. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_045295567 – 918Missing in isoform 11. 1 PublicationAdd BLAST352
Alternative sequenceiVSP_029942572 – 918Missing in isoform 10. 1 PublicationAdd BLAST347
Alternative sequenceiVSP_029943758Missing in isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY739114 mRNA Translation: AAV87519.1
AY739115 mRNA Translation: AAV87520.1
AY739116 mRNA Translation: AAV87521.1
AY739117 mRNA Translation: AAV87522.1
AY739118 mRNA Translation: AAV87523.1
AY739119 mRNA Translation: AAV87524.1
AY739120 mRNA Translation: AAV87525.1
AY739121 mRNA Translation: AAV87526.1
AY739122 mRNA Translation: AAV87527.1
HQ148552 mRNA Translation: AEL23234.1
HQ148553 mRNA Translation: AEL23235.1
AK157955 mRNA Translation: BAE34281.1
AL683828 Genomic DNA No translation available.
AK122523 mRNA Translation: BAC65805.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS18255.1 [Q80VW5-1]
CCDS18256.1 [Q80VW5-4]
CCDS18257.1 [Q80VW5-3]
CCDS38778.1 [Q80VW5-2]

NCBI Reference Sequences

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RefSeqi
NP_001008791.1, NM_001008791.2 [Q80VW5-1]
NP_001008792.1, NM_001008792.2 [Q80VW5-2]
NP_001008793.1, NM_001008793.2 [Q80VW5-4]
NP_001263300.1, NM_001276371.1 [Q80VW5-12]
NP_082916.1, NM_028640.2 [Q80VW5-3]
XP_017175899.1, XM_017320410.1 [Q80VW5-5]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.300397

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000063650; ENSMUSP00000069664; ENSMUSG00000039137 [Q80VW5-3]
ENSMUST00000063672; ENSMUSP00000065838; ENSMUSG00000039137 [Q80VW5-10]
ENSMUST00000084510; ENSMUSP00000081557; ENSMUSG00000039137 [Q80VW5-1]
ENSMUST00000095037; ENSMUSP00000092647; ENSMUSG00000039137 [Q80VW5-8]
ENSMUST00000095038; ENSMUSP00000092648; ENSMUSG00000039137 [Q80VW5-6]
ENSMUST00000102867; ENSMUSP00000099931; ENSMUSG00000039137 [Q80VW5-4]
ENSMUST00000107393; ENSMUSP00000103016; ENSMUSG00000039137 [Q80VW5-2]
ENSMUST00000119294; ENSMUSP00000114030; ENSMUSG00000039137 [Q80VW5-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
73750

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:73750

UCSC genome browser

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UCSCi
uc008tgf.1 mouse [Q80VW5-9]
uc008tgg.1 mouse [Q80VW5-5]
uc008tgh.2 mouse [Q80VW5-1]
uc008tgi.2 mouse [Q80VW5-4]
uc008tgj.2 mouse [Q80VW5-2]
uc008tgk.2 mouse [Q80VW5-3]
uc008tgm.1 mouse [Q80VW5-8]
uc008tgn.1 mouse [Q80VW5-7]
uc008tgp.2 mouse [Q80VW5-10]
uc033icr.1 mouse [Q80VW5-12]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY739114 mRNA Translation: AAV87519.1
AY739115 mRNA Translation: AAV87520.1
AY739116 mRNA Translation: AAV87521.1
AY739117 mRNA Translation: AAV87522.1
AY739118 mRNA Translation: AAV87523.1
AY739119 mRNA Translation: AAV87524.1
AY739120 mRNA Translation: AAV87525.1
AY739121 mRNA Translation: AAV87526.1
AY739122 mRNA Translation: AAV87527.1
HQ148552 mRNA Translation: AEL23234.1
HQ148553 mRNA Translation: AEL23235.1
AK157955 mRNA Translation: BAE34281.1
AL683828 Genomic DNA No translation available.
AK122523 mRNA Translation: BAC65805.1
CCDSiCCDS18255.1 [Q80VW5-1]
CCDS18256.1 [Q80VW5-4]
CCDS18257.1 [Q80VW5-3]
CCDS38778.1 [Q80VW5-2]
RefSeqiNP_001008791.1, NM_001008791.2 [Q80VW5-1]
NP_001008792.1, NM_001008792.2 [Q80VW5-2]
NP_001008793.1, NM_001008793.2 [Q80VW5-4]
NP_001263300.1, NM_001276371.1 [Q80VW5-12]
NP_082916.1, NM_028640.2 [Q80VW5-3]
XP_017175899.1, XM_017320410.1 [Q80VW5-5]
UniGeneiMm.300397

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6FDDX-ray1.75A/B/C/D/E/F420-499[»]
6FDEX-ray1.85A420-499[»]
ProteinModelPortaliQ80VW5
SMRiQ80VW5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ80VW5
DIPiDIP-42047N
IntActiQ80VW5, 5 interactors
MINTiQ80VW5
STRINGi10090.ENSMUSP00000081557

PTM databases

iPTMnetiQ80VW5
PhosphoSitePlusiQ80VW5

Proteomic databases

PaxDbiQ80VW5
PRIDEiQ80VW5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063650; ENSMUSP00000069664; ENSMUSG00000039137 [Q80VW5-3]
ENSMUST00000063672; ENSMUSP00000065838; ENSMUSG00000039137 [Q80VW5-10]
ENSMUST00000084510; ENSMUSP00000081557; ENSMUSG00000039137 [Q80VW5-1]
ENSMUST00000095037; ENSMUSP00000092647; ENSMUSG00000039137 [Q80VW5-8]
ENSMUST00000095038; ENSMUSP00000092648; ENSMUSG00000039137 [Q80VW5-6]
ENSMUST00000102867; ENSMUSP00000099931; ENSMUSG00000039137 [Q80VW5-4]
ENSMUST00000107393; ENSMUSP00000103016; ENSMUSG00000039137 [Q80VW5-2]
ENSMUST00000119294; ENSMUSP00000114030; ENSMUSG00000039137 [Q80VW5-7]
GeneIDi73750
KEGGimmu:73750
UCSCiuc008tgf.1 mouse [Q80VW5-9]
uc008tgg.1 mouse [Q80VW5-5]
uc008tgh.2 mouse [Q80VW5-1]
uc008tgi.2 mouse [Q80VW5-4]
uc008tgj.2 mouse [Q80VW5-2]
uc008tgk.2 mouse [Q80VW5-3]
uc008tgm.1 mouse [Q80VW5-8]
uc008tgn.1 mouse [Q80VW5-7]
uc008tgp.2 mouse [Q80VW5-10]
uc033icr.1 mouse [Q80VW5-12]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
25861
MGIiMGI:2682003 Whrn

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiENOG410ITAG Eukaryota
ENOG410XTF7 LUCA
GeneTreeiENSGT00940000153656
HOVERGENiHBG056634
InParanoidiQ80VW5
KOiK21879
OMAiGINKPGF
OrthoDBiEOG091G01FL
PhylomeDBiQ80VW5
TreeFamiTF325033

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Whrn mouse

Protein Ontology

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PROi
PR:Q80VW5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039137 Expressed in 125 organ(s), highest expression level in brain
CleanExiMM_WHRN
ExpressionAtlasiQ80VW5 baseline and differential
GenevisibleiQ80VW5 MM

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR033028 Whirlin
PANTHERiPTHR23116:SF37 PTHR23116:SF37, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 3 hits
SMARTiView protein in SMART
SM00228 PDZ, 3 hits
SUPFAMiSSF50156 SSF50156, 3 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWHRN_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80VW5
Secondary accession number(s): A2AGD2
, I6MML6, I6MML7, Q3TZC8, Q5MLF1, Q5MLF2, Q5MLF3, Q5MLF4, Q5MLF5, Q5MLF6, Q5MLF7, Q5MLF8, Q5MLF9, Q80TC2, Q80VW4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 4, 2007
Last modified: December 5, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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