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UniProtKB - Q80VU4 (NTF4_MOUSE)
Protein
Neurotrophin-4
Gene
Ntf4
Organism
Mus musculus (Mouse)
Status
Functioni
Could serve as a target-derived trophic factor for sensory and sympathetic neurons.
By similarityGO - Molecular functioni
- growth factor activity Source: GO_Central
- nerve growth factor receptor binding Source: GO_Central
- neurotrophin p75 receptor binding Source: MGI
GO - Biological processi
- adult locomotory behavior Source: MGI
- epidermis development Source: MGI
- ganglion mother cell fate determination Source: MGI
- innervation Source: MGI
- long-term memory Source: MGI
- mechanoreceptor differentiation Source: MGI
- memory Source: GO_Central
- modulation of chemical synaptic transmission Source: GO_Central
- negative regulation of cell death Source: MGI
- negative regulation of neuron apoptotic process Source: GO_Central
- nerve development Source: GO_Central
- nerve growth factor signaling pathway Source: GO_Central
- neuron projection morphogenesis Source: GO_Central
- peripheral nervous system development Source: GO_Central
- positive regulation of peptidyl-serine phosphorylation Source: GO_Central
- regulation of neuron differentiation Source: GO_Central
- sensory organ boundary specification Source: MGI
- taste bud development Source: MGI
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Growth factor |
Enzyme and pathway databases
Reactomei | R-MMU-9026527, Activated NTRK2 signals through PLCG1 R-MMU-9028731, Activated NTRK2 signals through FRS2 and FRS3 |
Names & Taxonomyi
Protein namesi | Recommended name: Neurotrophin-4Short name: NT-4 Alternative name(s): Neurotrophin-5 Short name: NT-5 Neutrophic factor 4 |
Gene namesi | Name:Ntf4 Synonyms:Ntf5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97381, Ntf5 |
VEuPathDBi | HostDB:ENSMUSG00000074121 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Other locations
- axon Source: GO_Central
- dendrite Source: GO_Central
- synaptic vesicle Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
PropeptideiPRO_0000019671 | 22 – 79 | Add BLAST | 58 | |
ChainiPRO_0000019672 | 80 – 209 | Neurotrophin-4Add BLAST | 130 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 75 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 96 ↔ 169 | By similarity | ||
Disulfide bondi | 140 ↔ 198 | By similarity | ||
Disulfide bondi | 157 ↔ 200 | By similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q80VU4 |
PRIDEi | Q80VU4 |
PTM databases
GlyGeni | Q80VU4, 1 site |
PhosphoSitePlusi | Q80VU4 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000074121, Expressed in dorsal pancreas and 156 other tissues |
Genevisiblei | Q80VU4, MM |
Interactioni
GO - Molecular functioni
- growth factor activity Source: GO_Central
- nerve growth factor receptor binding Source: GO_Central
- neurotrophin p75 receptor binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000057916 |
Miscellaneous databases
RNActi | Q80VU4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the NGF-beta family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502R4FK, Eukaryota |
GeneTreei | ENSGT00390000007725 |
HOGENOMi | CLU_059942_2_1_1 |
InParanoidi | Q80VU4 |
OMAi | TRCKAES |
OrthoDBi | 1156054at2759 |
PhylomeDBi | Q80VU4 |
TreeFami | TF106463 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR020408, Nerve_growth_factor-like IPR002072, Nerve_growth_factor-rel IPR019846, Nerve_growth_factor_CS IPR020432, Neurotrophin-4 |
PANTHERi | PTHR11589, PTHR11589, 1 hit PTHR11589:SF8, PTHR11589:SF8, 1 hit |
Pfami | View protein in Pfam PF00243, NGF, 1 hit |
PIRSFi | PIRSF001789, NGF, 1 hit |
PRINTSi | PR01915, NEUROTROPHN4 PR00268, NGF |
SMARTi | View protein in SMART SM00140, NGF, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00248, NGF_1, 1 hit PS50270, NGF_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q80VU4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPRHSCSLL LFLFLLPSVP MEPHPPSSTL PPFLAPEWDL LSPRVALSRG
60 70 80 90 100
APAGPPLLFL LEAGAYGEPA GAPANRSRRG VSETAPASRR GELAVCDAVS
110 120 130 140 150
GWVTDRRTAV DLRGREVEVL GEVPAAGGSP LRQYFFETRC KAESAGEGGP
160 170 180 190 200
GVGGGGCRGV DRRHWLSECK AKQSYVRALT ADSQGRVGWR WIRIDTACVC
TLLSRTGRA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GT57 | A0A1B0GT57_MOUSE | Neurotrophin 5 | Ntf5 | 54 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC052191 mRNA Translation: AAH52191.1 |
CCDSi | CCDS21241.1 |
RefSeqi | NP_937833.1, NM_198190.1 XP_006541375.1, XM_006541312.3 XP_006541376.1, XM_006541313.2 XP_011249221.1, XM_011250919.2 |
Genome annotation databases
Ensembli | ENSMUST00000058879; ENSMUSP00000057916; ENSMUSG00000074121 |
GeneIDi | 78405 |
KEGGi | mmu:78405 |
UCSCi | uc009gva.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC052191 mRNA Translation: AAH52191.1 |
CCDSi | CCDS21241.1 |
RefSeqi | NP_937833.1, NM_198190.1 XP_006541375.1, XM_006541312.3 XP_006541376.1, XM_006541313.2 XP_011249221.1, XM_011250919.2 |
3D structure databases
SMRi | Q80VU4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000057916 |
PTM databases
GlyGeni | Q80VU4, 1 site |
PhosphoSitePlusi | Q80VU4 |
Proteomic databases
PaxDbi | Q80VU4 |
PRIDEi | Q80VU4 |
Protocols and materials databases
Antibodypediai | 65111, 630 antibodies from 42 providers |
DNASUi | 78405 |
Genome annotation databases
Ensembli | ENSMUST00000058879; ENSMUSP00000057916; ENSMUSG00000074121 |
GeneIDi | 78405 |
KEGGi | mmu:78405 |
UCSCi | uc009gva.1, mouse |
Organism-specific databases
CTDi | 78405 |
MGIi | MGI:97381, Ntf5 |
VEuPathDBi | HostDB:ENSMUSG00000074121 |
Phylogenomic databases
eggNOGi | ENOG502R4FK, Eukaryota |
GeneTreei | ENSGT00390000007725 |
HOGENOMi | CLU_059942_2_1_1 |
InParanoidi | Q80VU4 |
OMAi | TRCKAES |
OrthoDBi | 1156054at2759 |
PhylomeDBi | Q80VU4 |
TreeFami | TF106463 |
Enzyme and pathway databases
Reactomei | R-MMU-9026527, Activated NTRK2 signals through PLCG1 R-MMU-9028731, Activated NTRK2 signals through FRS2 and FRS3 |
Miscellaneous databases
BioGRID-ORCSi | 78405, 0 hits in 64 CRISPR screens |
ChiTaRSi | Ntf5, mouse |
PROi | PR:Q80VU4 |
RNActi | Q80VU4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000074121, Expressed in dorsal pancreas and 156 other tissues |
Genevisiblei | Q80VU4, MM |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR020408, Nerve_growth_factor-like IPR002072, Nerve_growth_factor-rel IPR019846, Nerve_growth_factor_CS IPR020432, Neurotrophin-4 |
PANTHERi | PTHR11589, PTHR11589, 1 hit PTHR11589:SF8, PTHR11589:SF8, 1 hit |
Pfami | View protein in Pfam PF00243, NGF, 1 hit |
PIRSFi | PIRSF001789, NGF, 1 hit |
PRINTSi | PR01915, NEUROTROPHN4 PR00268, NGF |
SMARTi | View protein in SMART SM00140, NGF, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00248, NGF_1, 1 hit PS50270, NGF_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NTF4_MOUSE | |
Accessioni | Q80VU4Primary (citable) accession number: Q80VU4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families