Ntf4

Functionⁱ

Could serve as a target-derived trophic factor for sensory and sympathetic neurons.By similarity

GO - Molecular functionⁱ

growth factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neurotrophin p75 receptor binding
Source: MGI
Traceable author statementⁱ
- 8873083

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adult locomotory behavior
Source: MGI
Inferred from mutant phenotypeⁱ
- 10681461
epidermis development
Source: MGI
Inferred from mutant phenotypeⁱ
- 9973328
ganglion mother cell fate determination
Source: MGI
Inferred from mutant phenotypeⁱ
- 10681461
innervation
Source: MGI
Inferred from direct assayⁱ
- 24378336
long-term memory
Source: MGI
Inferred from mutant phenotypeⁱ
- 10869436
mechanoreceptor differentiation
Source: MGI
Inferred from genetic interactionⁱ
- 15376326
memory
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
modulation of chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of cell death
Source: MGI
Inferred from direct assayⁱ
- 24378336
negative regulation of neuron apoptotic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nerve development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nerve growth factor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neuron projection morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peripheral nervous system development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of neuron differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sensory organ boundary specification
Source: MGI
Inferred from mutant phenotypeⁱ
- 10479455
taste bud development
Source: MGI
Inferred from direct assayⁱ
- 24378336
transmembrane receptor protein tyrosine kinase signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor

Molecular function

Growth factor

Enzyme and pathway databases

Reactomeⁱ	R-MMU-9026527 Activated NTRK2 signals through PLCG1 R-MMU-9028731 Activated NTRK2 signals through FRS2 and FRS3

Reactomeⁱ

R-MMU-9026527 Activated NTRK2 signals through PLCG1
R-MMU-9028731 Activated NTRK2 signals through FRS2 and FRS3

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neurotrophin-4 Short name: NT-4 Alternative name(s): Neurotrophin-5 Short name: NT-5 Neutrophic factor 4
Gene namesⁱ	Name:Ntf4 Synonyms:Ntf5
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:97381 Ntf5

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST	21
PropeptideⁱPRO_0000019671	22 – 79	Add BLAST	58
ChainⁱPRO_0000019672	80 – 209	Neurotrophin-4Add BLAST	130

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	75	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	96 ↔ 169	By similarity
Disulfide bondⁱ	140 ↔ 198	By similarity
Disulfide bondⁱ	157 ↔ 200	By similarity

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q80VU4
PRIDEⁱ	Q80VU4

PTM databases

PhosphoSitePlusⁱ	Q80VU4

PhosphoSitePlusⁱ

Q80VU4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000074121 Expressed in 124 organ(s), highest expression level in dorsal pancreas
CleanExⁱ	MM_NTF5
ExpressionAtlasⁱ	Q80VU4 baseline and differential
Genevisibleⁱ	Q80VU4 MM

Interactionⁱ

GO - Molecular functionⁱ

growth factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neurotrophin p75 receptor binding
Source: MGI
Traceable author statementⁱ
- 8873083

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000057916

STRINGⁱ

10090.ENSMUSP00000057916

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q80VU4
SMRⁱ	Q80VU4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the NGF-beta family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IIFY Eukaryota ENOG4111839 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007725
HOGENOMⁱ	HOG000231516
HOVERGENⁱ	HBG006494
InParanoidⁱ	Q80VU4
KEGG Orthology (KO) More...KOⁱ	K12457
OMAⁱ	WLSECKA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GHL
PhylomeDBⁱ	Q80VU4
TreeFamⁱ	TF106463

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR020408 Nerve_growth_factor-like IPR002072 Nerve_growth_factor-rel IPR019846 Nerve_growth_factor_CS IPR020432 Neurotrophin-4
PANTHERⁱ	PTHR11589 PTHR11589, 1 hit PTHR11589:SF8 PTHR11589:SF8, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00243 NGF, 1 hit
PIRSFⁱ	PIRSF001789 NGF, 1 hit
PRINTSⁱ	PR01915 NEUROTROPHN4 PR00268 NGF
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD002052 Nerve_growth_factor-rel, 1 hit
SMARTⁱ	View protein in SMART SM00140 NGF, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00248 NGF_1, 1 hit PS50270 NGF_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q80VU4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLPRHSCSLL LFLFLLPSVP MEPHPPSSTL PPFLAPEWDL LSPRVALSRG 
        60         70         80         90        100
APAGPPLLFL LEAGAYGEPA GAPANRSRRG VSETAPASRR GELAVCDAVS 
       110        120        130        140        150
GWVTDRRTAV DLRGREVEVL GEVPAAGGSP LRQYFFETRC KAESAGEGGP 
       160        170        180        190        200
GVGGGGCRGV DRRHWLSECK AKQSYVRALT ADSQGRVGWR WIRIDTACVC 

TLLSRTGRA

Length:209

Mass (Da):22,346

Last modified:June 1, 2003 - v1

Checksum:ⁱ797AE81A2A33EAB6

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A1B0GT57	A0A1B0GT57_MOUSE		Neurotrophin 5 Neurotrophin 5	Ntf5	54	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC052191 mRNA Translation: AAH52191.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21241.1
NCBI Reference Sequences More...RefSeqⁱ	NP_937833.1, NM_198190.1 XP_006541375.1, XM_006541312.3 XP_006541376.1, XM_006541313.2 XP_011249221.1, XM_011250919.2
UniGeneⁱ	Mm.20344

Genome annotation databases

Ensemblⁱ	ENSMUST00000058879; ENSMUSP00000057916; ENSMUSG00000074121
GeneIDⁱ	78405
KEGGⁱ	mmu:78405
UCSC genome browser More...UCSCⁱ	uc009gva.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q80VU4	Neurotrophin 5 (Fragment)		MOUSE		74	UniRef100_Q80VU4
Neurotrophin 5 (Fragment)		MOUSE		54

Protein	Similar proteins		Species	Score	Length	Source
Q80VU4	Neurotrophin-4		RAT		209	UniRef90_Q80VU4
Neurotrophin 5 (Fragment)		MOUSE		74
Neurotrophin 4		CANLF		223
Uncharacterized protein		AOTNA		210
neurotrophin-4		Florida manatee		210
+11

Protein	Similar proteins		Species	Score	Length	Source
Q80VU4	Neurotrophin-4	)	HUMAN		210	UniRef50_P34130
Neurotrophin-4		RAT		209
NTF4 isoform 1		PANTR		210
Uncharacterized protein		PANPA		210
Uncharacterized protein		ICTTR		210
+41

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC052191 mRNA Translation: AAH52191.1
CCDSⁱ	CCDS21241.1
RefSeqⁱ	NP_937833.1, NM_198190.1 XP_006541375.1, XM_006541312.3 XP_006541376.1, XM_006541313.2 XP_011249221.1, XM_011250919.2
UniGeneⁱ	Mm.20344

3D structure databases

ProteinModelPortalⁱ	Q80VU4
SMRⁱ	Q80VU4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000057916

STRINGⁱ

10090.ENSMUSP00000057916

PTM databases

PhosphoSitePlusⁱ	Q80VU4

PhosphoSitePlusⁱ

Q80VU4

Proteomic databases

PaxDbⁱ	Q80VU4
PRIDEⁱ	Q80VU4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000058879; ENSMUSP00000057916; ENSMUSG00000074121
GeneIDⁱ	78405
KEGGⁱ	mmu:78405
UCSCⁱ	uc009gva.1 mouse

Organism-specific databases

CTDⁱ	78405
MGIⁱ	MGI:97381 Ntf5

Phylogenomic databases

eggNOGⁱ	ENOG410IIFY Eukaryota ENOG4111839 LUCA
GeneTreeⁱ	ENSGT00390000007725
HOGENOMⁱ	HOG000231516
HOVERGENⁱ	HBG006494
InParanoidⁱ	Q80VU4
KOⁱ	K12457
OMAⁱ	WLSECKA
OrthoDBⁱ	EOG091G0GHL
PhylomeDBⁱ	Q80VU4
TreeFamⁱ	TF106463

Enzyme and pathway databases

Reactomeⁱ	R-MMU-9026527 Activated NTRK2 signals through PLCG1 R-MMU-9028731 Activated NTRK2 signals through FRS2 and FRS3

Reactomeⁱ

R-MMU-9026527 Activated NTRK2 signals through PLCG1
R-MMU-9028731 Activated NTRK2 signals through FRS2 and FRS3

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q80VU4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000074121 Expressed in 124 organ(s), highest expression level in dorsal pancreas
CleanExⁱ	MM_NTF5
ExpressionAtlasⁱ	Q80VU4 baseline and differential
Genevisibleⁱ	Q80VU4 MM

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR020408 Nerve_growth_factor-like IPR002072 Nerve_growth_factor-rel IPR019846 Nerve_growth_factor_CS IPR020432 Neurotrophin-4
PANTHERⁱ	PTHR11589 PTHR11589, 1 hit PTHR11589:SF8 PTHR11589:SF8, 1 hit
Pfamⁱ	View protein in Pfam PF00243 NGF, 1 hit
PIRSFⁱ	PIRSF001789 NGF, 1 hit
PRINTSⁱ	PR01915 NEUROTROPHN4 PR00268 NGF
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD002052 Nerve_growth_factor-rel, 1 hit
SMARTⁱ	View protein in SMART SM00140 NGF, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00248 NGF_1, 1 hit PS50270 NGF_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NTF4_MOUSE
Accessionⁱ	Q80VU4Primary (citable) accession number: Q80VU4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
	Last sequence update:	June 1, 2003
	Last modified:	November 7, 2018
	This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q80VU4 (NTF4_MOUSE)

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Neurotrophin-4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ