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Protein

Leucine-rich repeat-containing protein 1

Gene

Lrrc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 1
Gene namesi
Name:Lrrc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2442313 Lrrc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844901 – 524Leucine-rich repeat-containing protein 1Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei480PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80VQ1
PaxDbiQ80VQ1
PeptideAtlasiQ80VQ1
PRIDEiQ80VQ1

PTM databases

iPTMnetiQ80VQ1
PhosphoSitePlusiQ80VQ1
SwissPalmiQ80VQ1

Expressioni

Gene expression databases

BgeeiENSMUSG00000032352
CleanExiMM_LRRC1
ExpressionAtlasiQ80VQ1 baseline and differential
GenevisibleiQ80VQ1 MM

Interactioni

Subunit structurei

Interacts with DLG1. May form a complex with DLG1 and ERBIN, where interaction between LRRC1 and ERBIN is indirect (By similarity).By similarity

Protein-protein interaction databases

BioGridi229517, 1 interactor
IntActiQ80VQ1, 1 interactor
STRINGi10090.ENSMUSP00000109048

Structurei

3D structure databases

ProteinModelPortaliQ80VQ1
SMRiQ80VQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 34LRR 1Add BLAST24
Repeati35 – 58LRR 2Add BLAST24
Repeati60 – 81LRR 3Add BLAST22
Repeati83 – 105LRR 4Add BLAST23
Repeati107 – 126LRR 5Add BLAST20
Repeati127 – 149LRR 6Add BLAST23
Repeati150 – 172LRR 7Add BLAST23
Repeati173 – 196LRR 8Add BLAST24
Repeati198 – 218LRR 9Add BLAST21
Repeati219 – 242LRR 10Add BLAST24
Repeati244 – 264LRR 11Add BLAST21
Repeati265 – 288LRR 12Add BLAST24
Repeati290 – 310LRR 13Add BLAST21
Repeati311 – 334LRR 14Add BLAST24
Repeati336 – 356LRR 15Add BLAST21
Repeati357 – 380LRR 16Add BLAST24
Repeati382 – 405LRR 17Add BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili456 – 512Sequence analysisAdd BLAST57

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi127 – 396Leu-richAdd BLAST270

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KCZ0 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00840000129686
HOGENOMiHOG000116557
HOVERGENiHBG052357
InParanoidiQ80VQ1
OMAiFQTDTDH
OrthoDBiEOG091G01EF
PhylomeDBiQ80VQ1

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 12 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 15 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80VQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFHCIPLWRC NRHVEAIDKR HCSLVYVPEE IYRYARSLEE LLLDANQLRE
60 70 80 90 100
LPEQFFQLVK LRKLGLSDNE IQRLPPEIAN FMQLVELDVS RNDIPEIPES
110 120 130 140 150
IAFCKALQVA DFSGNPLTRL PESFPELQNL TCLSVNDISL QSLPENIGNL
160 170 180 190 200
YNLASLELRE NLLTYLPDSL TQLRRLEELD LGNNEIYNLP ESIGALLHLK
210 220 230 240 250
DLWLDGNQLS ELPQEIGNLK NLLCLDVSEN RLERLPEEIS GLTSLTYLVI
260 270 280 290 300
SQNLLETIPE GIGKLKKLSI LKLDQNRLTQ LPEAIGDCEN LTELVLTENR
310 320 330 340 350
LLTLPKSIGK LKKLSNLNAD RNKLVSLPKE IGGCCSLTMF CIRDNRLTRL
360 370 380 390 400
PAEVSQAVEL HVLDVAGNRL HHLPLSLTTL KLKALWLSDN QSQPLLTFQT
410 420 430 440 450
DIDRATGEKI LTCVLLPQMP SEPICQESLP RCGALESLVT DMSEEAWNDR
460 470 480 490 500
SVHRVSAIRF LEDEKDEDEN ETRTLQRRAT PHPGELKNMK KTVENLRNDM
510 520
NAAKGLDSNK NEVNHAAERV TTSV
Length:524
Mass (Da):59,412
Last modified:July 19, 2004 - v2
Checksum:i546AA6726A1109D8
GO
Isoform 2 (identifier: Q80VQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Show »
Length:443
Mass (Da):49,664
Checksum:iAB413EB34B04EF01
GO
Isoform 3 (identifier: Q80VQ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-349: IGGCCSLTMFCIRDNRLTR → EHISGKVCRLFYHKAATAI
     350-524: Missing.

Show »
Length:349
Mass (Da):39,788
Checksum:iE2C0177B26A57554
GO

Sequence cautioni

The sequence AAH46591 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115N → D in BAC38586 (PubMed:16141072).Curated1
Sequence conflicti369R → K in BAC34508 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0109141 – 81Missing in isoform 2. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_010915331 – 349IGGCC…NRLTR → EHISGKVCRLFYHKAATAI in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_010916350 – 524Missing in isoform 3. 1 PublicationAdd BLAST175

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK051043 mRNA Translation: BAC34508.1
AK082721 mRNA Translation: BAC38586.1
AK147075 mRNA Translation: BAE27656.1
BC046591 mRNA Translation: AAH46591.1 Different initiation.
BC087542 mRNA Translation: AAH87542.1
CCDSiCCDS72282.1 [Q80VQ1-1]
RefSeqiNP_001139520.1, NM_001146048.1 [Q80VQ1-1]
NP_766116.3, NM_172528.3
UniGeneiMm.28534
Mm.482664

Genome annotation databases

EnsembliENSMUST00000183734; ENSMUSP00000138912; ENSMUSG00000032352 [Q80VQ1-3]
ENSMUST00000183873; ENSMUSP00000139226; ENSMUSG00000032352 [Q80VQ1-1]
GeneIDi214345
KEGGimmu:214345
UCSCiuc009qtk.2 mouse [Q80VQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLRRC1_MOUSE
AccessioniPrimary (citable) accession number: Q80VQ1
Secondary accession number(s): Q3UI50, Q8BKR1, Q8BUS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: February 28, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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