UniProtKB - Q80VQ1 (LRRC1_MOUSE)
Protein
Leucine-rich repeat-containing protein 1
Gene
Lrrc1
Organism
Mus musculus (Mouse)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeat-containing protein 1 |
Gene namesi | Name:Lrrc1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2442313, Lrrc1 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- Membrane By similarity; Peripheral membrane protein By similarity
Note: Localized at the basolateral side of epithelial cells.By similarity
Keywords - Cellular componenti
Cytoplasm, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084490 | 1 – 524 | Leucine-rich repeat-containing protein 1Add BLAST | 524 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 480 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q80VQ1 |
jPOSTi | Q80VQ1 |
PaxDbi | Q80VQ1 |
PeptideAtlasi | Q80VQ1 |
PRIDEi | Q80VQ1 |
ProteomicsDBi | 292365 [Q80VQ1-1] 292366 [Q80VQ1-2] 292367 [Q80VQ1-3] |
PTM databases
iPTMneti | Q80VQ1 |
PhosphoSitePlusi | Q80VQ1 |
SwissPalmi | Q80VQ1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032352, Expressed in spermatid and 249 other tissues |
ExpressionAtlasi | Q80VQ1, baseline and differential |
Genevisiblei | Q80VQ1, MM |
Interactioni
Subunit structurei
Interacts with DLG1. May form a complex with DLG1 and ERBIN, where interaction between LRRC1 and ERBIN is indirect (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 229517, 1 interactor |
IntActi | Q80VQ1, 1 interactor |
STRINGi | 10090.ENSMUSP00000109048 |
Miscellaneous databases
RNActi | Q80VQ1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 11 – 34 | LRR 1Add BLAST | 24 | |
Repeati | 35 – 58 | LRR 2Add BLAST | 24 | |
Repeati | 60 – 81 | LRR 3Add BLAST | 22 | |
Repeati | 83 – 105 | LRR 4Add BLAST | 23 | |
Repeati | 107 – 126 | LRR 5Add BLAST | 20 | |
Repeati | 127 – 149 | LRR 6Add BLAST | 23 | |
Repeati | 150 – 172 | LRR 7Add BLAST | 23 | |
Repeati | 173 – 196 | LRR 8Add BLAST | 24 | |
Repeati | 198 – 218 | LRR 9Add BLAST | 21 | |
Repeati | 219 – 242 | LRR 10Add BLAST | 24 | |
Repeati | 244 – 264 | LRR 11Add BLAST | 21 | |
Repeati | 265 – 288 | LRR 12Add BLAST | 24 | |
Repeati | 290 – 310 | LRR 13Add BLAST | 21 | |
Repeati | 311 – 334 | LRR 14Add BLAST | 24 | |
Repeati | 336 – 356 | LRR 15Add BLAST | 21 | |
Repeati | 357 – 380 | LRR 16Add BLAST | 24 | |
Repeati | 382 – 405 | LRR 17Add BLAST | 24 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 456 – 512 | Sequence analysisAdd BLAST | 57 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 127 – 396 | Leu-richAdd BLAST | 270 |
Keywords - Domaini
Coiled coil, Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000154025 |
HOGENOMi | CLU_000288_18_23_1 |
InParanoidi | Q80VQ1 |
OMAi | GLIMPEY |
PhylomeDBi | Q80VQ1 |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 3 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 12 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 15 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q80VQ1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFHCIPLWRC NRHVEAIDKR HCSLVYVPEE IYRYARSLEE LLLDANQLRE
60 70 80 90 100
LPEQFFQLVK LRKLGLSDNE IQRLPPEIAN FMQLVELDVS RNDIPEIPES
110 120 130 140 150
IAFCKALQVA DFSGNPLTRL PESFPELQNL TCLSVNDISL QSLPENIGNL
160 170 180 190 200
YNLASLELRE NLLTYLPDSL TQLRRLEELD LGNNEIYNLP ESIGALLHLK
210 220 230 240 250
DLWLDGNQLS ELPQEIGNLK NLLCLDVSEN RLERLPEEIS GLTSLTYLVI
260 270 280 290 300
SQNLLETIPE GIGKLKKLSI LKLDQNRLTQ LPEAIGDCEN LTELVLTENR
310 320 330 340 350
LLTLPKSIGK LKKLSNLNAD RNKLVSLPKE IGGCCSLTMF CIRDNRLTRL
360 370 380 390 400
PAEVSQAVEL HVLDVAGNRL HHLPLSLTTL KLKALWLSDN QSQPLLTFQT
410 420 430 440 450
DIDRATGEKI LTCVLLPQMP SEPICQESLP RCGALESLVT DMSEEAWNDR
460 470 480 490 500
SVHRVSAIRF LEDEKDEDEN ETRTLQRRAT PHPGELKNMK KTVENLRNDM
510 520
NAAKGLDSNK NEVNHAAERV TTSV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3X9W3 | G3X9W3_MOUSE | Leucine-rich repeat-containing prot... | Lrrc1 | 479 | Annotation score: | ||
V9GX13 | V9GX13_MOUSE | Leucine-rich repeat-containing prot... | Lrrc1 | 63 | Annotation score: |
Sequence cautioni
The sequence AAH46591 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 115 | N → D in BAC38586 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 369 | R → K in BAC34508 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010914 | 1 – 81 | Missing in isoform 2. 1 PublicationAdd BLAST | 81 | |
Alternative sequenceiVSP_010915 | 331 – 349 | IGGCC…NRLTR → EHISGKVCRLFYHKAATAI in isoform 3. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_010916 | 350 – 524 | Missing in isoform 3. 1 PublicationAdd BLAST | 175 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK051043 mRNA Translation: BAC34508.1 AK082721 mRNA Translation: BAC38586.1 AK147075 mRNA Translation: BAE27656.1 BC046591 mRNA Translation: AAH46591.1 Different initiation. BC087542 mRNA Translation: AAH87542.1 |
CCDSi | CCDS72282.1 [Q80VQ1-1] |
RefSeqi | NP_001139520.1, NM_001146048.1 [Q80VQ1-1] NP_766116.3, NM_172528.3 |
Genome annotation databases
Ensembli | ENSMUST00000183734; ENSMUSP00000138912; ENSMUSG00000032352 [Q80VQ1-3] ENSMUST00000183873; ENSMUSP00000139226; ENSMUSG00000032352 [Q80VQ1-1] |
GeneIDi | 214345 |
KEGGi | mmu:214345 |
UCSCi | uc009qtk.2, mouse [Q80VQ1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK051043 mRNA Translation: BAC34508.1 AK082721 mRNA Translation: BAC38586.1 AK147075 mRNA Translation: BAE27656.1 BC046591 mRNA Translation: AAH46591.1 Different initiation. BC087542 mRNA Translation: AAH87542.1 |
CCDSi | CCDS72282.1 [Q80VQ1-1] |
RefSeqi | NP_001139520.1, NM_001146048.1 [Q80VQ1-1] NP_766116.3, NM_172528.3 |
3D structure databases
SMRi | Q80VQ1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 229517, 1 interactor |
IntActi | Q80VQ1, 1 interactor |
STRINGi | 10090.ENSMUSP00000109048 |
PTM databases
iPTMneti | Q80VQ1 |
PhosphoSitePlusi | Q80VQ1 |
SwissPalmi | Q80VQ1 |
Proteomic databases
EPDi | Q80VQ1 |
jPOSTi | Q80VQ1 |
PaxDbi | Q80VQ1 |
PeptideAtlasi | Q80VQ1 |
PRIDEi | Q80VQ1 |
ProteomicsDBi | 292365 [Q80VQ1-1] 292366 [Q80VQ1-2] 292367 [Q80VQ1-3] |
Protocols and materials databases
Antibodypediai | 17278, 92 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000183734; ENSMUSP00000138912; ENSMUSG00000032352 [Q80VQ1-3] ENSMUST00000183873; ENSMUSP00000139226; ENSMUSG00000032352 [Q80VQ1-1] |
GeneIDi | 214345 |
KEGGi | mmu:214345 |
UCSCi | uc009qtk.2, mouse [Q80VQ1-1] |
Organism-specific databases
CTDi | 55227 |
MGIi | MGI:2442313, Lrrc1 |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000154025 |
HOGENOMi | CLU_000288_18_23_1 |
InParanoidi | Q80VQ1 |
OMAi | GLIMPEY |
PhylomeDBi | Q80VQ1 |
Miscellaneous databases
BioGRID-ORCSi | 214345, 0 hits in 52 CRISPR screens |
ChiTaRSi | Lrrc1, mouse |
PROi | PR:Q80VQ1 |
RNActi | Q80VQ1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032352, Expressed in spermatid and 249 other tissues |
ExpressionAtlasi | Q80VQ1, baseline and differential |
Genevisiblei | Q80VQ1, MM |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 3 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 12 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 15 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LRRC1_MOUSE | |
Accessioni | Q80VQ1Primary (citable) accession number: Q80VQ1 Secondary accession number(s): Q3UI50, Q8BKR1, Q8BUS9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | July 19, 2004 | |
Last modified: | April 7, 2021 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot