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Protein

Spermatogenesis-associated protein 7 homolog

Gene

Spata7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in photoreceptor cells maintenance (PubMed:25398945). It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as protein trafficking across the CC to the outer segments (PubMed:25398945).1 Publication

GO - Biological processi

Keywordsi

Biological processSensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 7 homolog
Gene namesi
Name:Spata7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2144877 Spata7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

STATA7 knockdown results in photoreceptor cells degeneration and severe early-onset retinal defects. At molecular level, a substantial reduction of RPGRIP1 levels at the CC and its mislocalization to the inner segment are observed in mutant mice, as well as impaired RHO trafficking from the inner to the outer segment of photoreceptors.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000721051 – 582Spermatogenesis-associated protein 7 homologAdd BLAST582

Proteomic databases

PaxDbiQ80VP2
PRIDEiQ80VP2

PTM databases

iPTMnetiQ80VP2
PhosphoSitePlusiQ80VP2

Expressioni

Tissue specificityi

Expressed in the retina (PubMed:19268277). Found in the photoreceptor cell layer, where localizes at the region between the inner segment and outer segment (PubMed:25398945).2 Publications

Gene expression databases

BgeeiENSMUSG00000021007 Expressed in 191 organ(s), highest expression level in testis
CleanExiMM_SPATA7
ExpressionAtlasiQ80VP2 baseline and differential
GenevisibleiQ80VP2 MM

Interactioni

Subunit structurei

Interacts with RPGRIP1 (PubMed:25398945). Found in a complex with CFAP410, NEK1 and SPATA7 (By similarity). Interacts with NEK1 (By similarity).By similarity1 Publication

Protein-protein interaction databases

IntActiQ80VP2, 2 interactors
STRINGi10090.ENSMUSP00000045827

Structurei

3D structure databases

ProteinModelPortaliQ80VP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IKU4 Eukaryota
ENOG4111WP7 LUCA
GeneTreeiENSGT00390000014113
HOGENOMiHOG000132972
HOVERGENiHBG055067
InParanoidiQ80VP2
KOiK19655
OMAiNRHLPFT
OrthoDBiEOG091G06RB
PhylomeDBiQ80VP2
TreeFamiTF330591

Family and domain databases

InterProiView protein in InterPro
IPR029357 SPATA7
PANTHERiPTHR14917 PTHR14917, 1 hit
PfamiView protein in Pfam
PF15244 HSD3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q80VP2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGSRRVRAT SVLPRYSPPC LFTGHLSTKS NAFCTDSSSL RLSTLQLVKN
60 70 80 90 100
HMAIHYNKIL SAKAAVDCSI PVSVNTSIKY ADQQRREKLR KELARCEKEF
110 120 130 140 150
KLSKSAMQTN SKMNSKFFVN SLQKPSGEPQ DQDVFIEEMT RYPSFSKSLI
160 170 180 190 200
PSSEGLHLSL PESSKMLMSG TQKHASTSPS RHSGCGHGCD RRPRSAHQFQ
210 220 230 240 250
VALAKTPSGD LLEKHSDLFS NKQSPFTPRT LKTEAKSFLS QYRYYTPAKR
260 270 280 290 300
RKDFSDQRME AETQTELSSF NSELGTAEKT SSKDSEVNIN QVPNYTRNGA
310 320 330 340 350
EDKIAPLPSQ GQNLAWDSIQ DGILQQSSER ASCKLSTEFS PDSKIYSDEE
360 370 380 390 400
ELLYLSFMEN VTDEILKLGL FSNRFLERLF ERHIKKNKHH LEEGKMRYLL
410 420 430 440 450
HGLKVDLGCI SEEDPAKQKH FRMLNQLHFQ KALISRENEF VSDEETVSHH
460 470 480 490 500
ERQQYQEALD MLSAVPKDEN KMFSLPGEFL IPAHKVKHSE GVIIQQVNDE
510 520 530 540 550
TDNEASPWNE NNPSVSDSVI DQETSVDVIE GDSDFERAET SRELCCLSTS
560 570 580
LSPSGPFPSI NGGSNHGKEL STLRIMGMSI ED
Length:582
Mass (Da):65,655
Last modified:June 1, 2003 - v1
Checksum:i414A6A684A421DF5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U5D0Q3U5D0_MOUSE
Spermatogenesis-associated protein ...
Spata7
415Annotation score:
Q3TTL3Q3TTL3_MOUSE
SPATA7 isoform
Spata7
550Annotation score:

Sequence cautioni

The sequence BAC36832 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077500 mRNA Translation: BAC36832.1 Different initiation.
BC046960 mRNA Translation: AAH46960.1
CCDSiCCDS26097.1
RefSeqiNP_849245.2, NM_178914.4
XP_011242281.1, XM_011243979.2
UniGeneiMm.210053

Genome annotation databases

EnsembliENSMUST00000048402; ENSMUSP00000045827; ENSMUSG00000021007
GeneIDi104871
KEGGimmu:104871
UCSCiuc007ora.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077500 mRNA Translation: BAC36832.1 Different initiation.
BC046960 mRNA Translation: AAH46960.1
CCDSiCCDS26097.1
RefSeqiNP_849245.2, NM_178914.4
XP_011242281.1, XM_011243979.2
UniGeneiMm.210053

3D structure databases

ProteinModelPortaliQ80VP2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80VP2, 2 interactors
STRINGi10090.ENSMUSP00000045827

PTM databases

iPTMnetiQ80VP2
PhosphoSitePlusiQ80VP2

Proteomic databases

PaxDbiQ80VP2
PRIDEiQ80VP2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048402; ENSMUSP00000045827; ENSMUSG00000021007
GeneIDi104871
KEGGimmu:104871
UCSCiuc007ora.2 mouse

Organism-specific databases

CTDi55812
MGIiMGI:2144877 Spata7

Phylogenomic databases

eggNOGiENOG410IKU4 Eukaryota
ENOG4111WP7 LUCA
GeneTreeiENSGT00390000014113
HOGENOMiHOG000132972
HOVERGENiHBG055067
InParanoidiQ80VP2
KOiK19655
OMAiNRHLPFT
OrthoDBiEOG091G06RB
PhylomeDBiQ80VP2
TreeFamiTF330591

Miscellaneous databases

PROiPR:Q80VP2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021007 Expressed in 191 organ(s), highest expression level in testis
CleanExiMM_SPATA7
ExpressionAtlasiQ80VP2 baseline and differential
GenevisibleiQ80VP2 MM

Family and domain databases

InterProiView protein in InterPro
IPR029357 SPATA7
PANTHERiPTHR14917 PTHR14917, 1 hit
PfamiView protein in Pfam
PF15244 HSD3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPAT7_MOUSE
AccessioniPrimary (citable) accession number: Q80VP2
Secondary accession number(s): Q8BK23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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