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Protein

Steroid receptor RNA activator 1

Gene

Sra1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis (By similarity).By similarity

Miscellaneous

Appears to be the first example of a new class of functional RNAs also able to encode a protein.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Receptor, Ribonucleoprotein
Biological processApoptosis, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Steroid receptor RNA activator 1
Alternative name(s):
Steroid receptor RNA activator protein
Short name:
SRAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sra1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1344414 Sra1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002341061 – 232Steroid receptor RNA activator 1Add BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei60PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q80VJ2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q80VJ2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80VJ2

PeptideAtlas

More...
PeptideAtlasi
Q80VJ2

PRoteomics IDEntifications database

More...
PRIDEi
Q80VJ2

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00317966

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80VJ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80VJ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000006050 Expressed in 297 organ(s), highest expression level in colon

CleanEx database of gene expression profiles

More...
CleanExi
MM_SRA1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q80VJ2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80VJ2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

SRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1 and RARG in the nucleus. Interacts with AR.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
204880, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q80VJ2, 2 interactors

Molecular INTeraction database

More...
MINTi
Q80VJ2

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000133360

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1232
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q80VJ2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80VJ2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q80VJ2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi56 – 101Pro-richAdd BLAST46

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SRA1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK8X Eukaryota
ENOG4112996 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156824

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000127508

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG061820

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80VJ2

TreeFam database of animal gene trees

More...
TreeFami
TF314789

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009917 SRA1-protein/COPII_Sec31
IPR040243 Steroid_recept_RNA_1

The PANTHER Classification System

More...
PANTHERi
PTHR18834 PTHR18834, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07304 SRA1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q80VJ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMRCPAGGAE VEMAELYVKP GNKERGWNDP PQFSYGLQTQ TGGPKRTPLT
60 70 80 90 100
KRVAAPQDGS PRAPETSGPP PVDHPPPSSK ASRPPPMGSC PATGVEPPSS
110 120 130 140 150
PVIESETLIE DVLRPLEQAL EDCHGHTKKQ VCDDISRRLA LLREQWAGGK
160 170 180 190 200
LSIPVKKRMA LLVQELLHHQ WDAADDIHRS LMVDHVTEVS QWMVGVKRLI
210 220 230
AEKKSLSSEE TKEEKFTVEP ENQTIPGFQQ PS
Length:232
Mass (Da):25,557
Last modified:June 28, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0838CA544C75A678
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH26480 differs from that shown. Contaminating sequence.Curated
The sequence AAH26480 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH48362 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB24943 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB26893 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE32451 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5P → A in BAB24943 (PubMed:16141072).Curated1
Sequence conflicti10E → G in BAB24943 (PubMed:16141072).Curated1
Sequence conflicti27W → G in BAB24943 (PubMed:16141072).Curated1
Sequence conflicti140A → V in AAH48362 (PubMed:15489334).Curated1
Sequence conflicti185H → Y in AAH48362 (PubMed:15489334).Curated1
Sequence conflicti204K → R in AAH48362 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC115631 Genomic DNA No translation available.
AK007302 mRNA Translation: BAB24943.1 Different initiation.
AK010375 mRNA Translation: BAB26893.1 Different initiation.
AK154232 mRNA Translation: BAE32451.1 Different initiation.
BC026480 mRNA Translation: AAH26480.1 Sequence problems.
BC048362 mRNA Translation: AAH48362.1 Different initiation.
CN836515 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29156.2

NCBI Reference Sequences

More...
RefSeqi
NP_001157878.1, NM_001164406.1
NP_079567.2, NM_025291.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.29058

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000173875; ENSMUSP00000133360; ENSMUSG00000006050

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
24068

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:24068

UCSC genome browser

More...
UCSCi
uc008eny.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115631 Genomic DNA No translation available.
AK007302 mRNA Translation: BAB24943.1 Different initiation.
AK010375 mRNA Translation: BAB26893.1 Different initiation.
AK154232 mRNA Translation: BAE32451.1 Different initiation.
BC026480 mRNA Translation: AAH26480.1 Sequence problems.
BC048362 mRNA Translation: AAH48362.1 Different initiation.
CN836515 mRNA No translation available.
CCDSiCCDS29156.2
RefSeqiNP_001157878.1, NM_001164406.1
NP_079567.2, NM_025291.3
UniGeneiMm.29058

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YRUNMR-A102-206[»]
ProteinModelPortaliQ80VJ2
SMRiQ80VJ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204880, 2 interactors
IntActiQ80VJ2, 2 interactors
MINTiQ80VJ2
STRINGi10090.ENSMUSP00000133360

PTM databases

iPTMnetiQ80VJ2
PhosphoSitePlusiQ80VJ2

2D gel databases

REPRODUCTION-2DPAGEiIPI00317966

Proteomic databases

EPDiQ80VJ2
MaxQBiQ80VJ2
PaxDbiQ80VJ2
PeptideAtlasiQ80VJ2
PRIDEiQ80VJ2

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
24068
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000173875; ENSMUSP00000133360; ENSMUSG00000006050
GeneIDi24068
KEGGimmu:24068
UCSCiuc008eny.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10011
MGIiMGI:1344414 Sra1

Phylogenomic databases

eggNOGiENOG410IK8X Eukaryota
ENOG4112996 LUCA
GeneTreeiENSGT00940000156824
HOGENOMiHOG000127508
HOVERGENiHBG061820
InParanoidiQ80VJ2
TreeFamiTF314789

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sra1 mouse
EvolutionaryTraceiQ80VJ2

Protein Ontology

More...
PROi
PR:Q80VJ2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000006050 Expressed in 297 organ(s), highest expression level in colon
CleanExiMM_SRA1
ExpressionAtlasiQ80VJ2 baseline and differential
GenevisibleiQ80VJ2 MM

Family and domain databases

InterProiView protein in InterPro
IPR009917 SRA1-protein/COPII_Sec31
IPR040243 Steroid_recept_RNA_1
PANTHERiPTHR18834 PTHR18834, 1 hit
PfamiView protein in Pfam
PF07304 SRA1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRA1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80VJ2
Secondary accession number(s): E9QM44
, Q8R0S3, Q9CWU7, Q9D973
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 28, 2011
Last modified: December 5, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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