UniProtKB - Q80VG1 (SCML4_MOUSE)
Protein
Sex comb on midleg-like protein 4
Gene
Scml4
Organism
Mus musculus (Mouse)
Status
Functioni
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).By similarity
GO - Molecular functioni
- chromatin binding Source: GO_Central
- histone binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Sex comb on midleg-like protein 4 |
Gene namesi | Name:Scml4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2446140, Scml4 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000337172 | 1 – 408 | Sex comb on midleg-like protein 4Add BLAST | 408 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 55 | PhosphoserineCombined sources | 1 | |
Modified residuei | 65 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q80VG1 |
PRIDEi | Q80VG1 |
PTM databases
iPTMneti | Q80VG1 |
PhosphoSitePlusi | Q80VG1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000044770, Expressed in blood and 98 other tissues |
Genevisiblei | Q80VG1, MM |
Interactioni
GO - Molecular functioni
- histone binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 234479, 1 interactor |
STRINGi | 10090.ENSMUSP00000053157 |
Miscellaneous databases
RNActi | Q80VG1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 340 – 406 | SAMAdd BLAST | 67 |
Sequence similaritiesi
Belongs to the SCM family.Curated
Phylogenomic databases
eggNOGi | KOG3766, Eukaryota |
GeneTreei | ENSGT00940000157463 |
HOGENOMi | CLU_045829_0_0_1 |
InParanoidi | Q80VG1 |
OMAi | TVCLYVN |
OrthoDBi | 229086at2759 |
PhylomeDBi | Q80VG1 |
TreeFami | TF106488 |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit 1.20.1380.20, 1 hit |
InterProi | View protein in InterPro IPR001660, SAM IPR013761, SAM/pointed_sf IPR033763, SCML2_RBR IPR021987, SLED IPR038348, SLED_sf |
Pfami | View protein in Pfam PF17208, RBR, 1 hit PF00536, SAM_1, 1 hit PF12140, SLED, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q80VG1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQTQRVPGRK RGRPPLHSTR VQMAVHNLYS ASAASVPAVT IPKKRGRKPR
60 70 80 90 100
YKIKSPVLMT PLALSPPRST PEPDLSSIPQ DAATIPSLVV PEALTVCLYI
110 120 130 140 150
NKQADVGPYL ERRKLQQLPE RLGPERPATV LQQAVQACID CAHQPRLVFS
160 170 180 190 200
LVKQGYRGEL VSVSASFDGK QHLRSLPVVN SVGYVLRFLT KLCRSLLCDN
210 220 230 240 250
LFSHLPFPGS IGASDKAQER EDGRTESAKV ATAEECLANA VGMNRYAMDF
260 270 280 290 300
SHRGSVTHSS SLYKRLTCGD SHLAGGPATT TSGSRTNPVP SGGSSSPGLR
310 320 330 340 350
LPASSPKRNG TAIEGNRCAP SPSPEVQDTR RPSSRNPSTW TVEDVVRFVK
360 370 380 390 400
DADPEALGPH VELFRKHEID GNALLLLRSD MIMKYLGLKL GPALKLCYHI
DKLKQAKF
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z554 | D3Z554_MOUSE | Sex comb on midleg-like protein 4 | Scml4 | 94 | Annotation score: | ||
D3YY47 | D3YY47_MOUSE | Sex comb on midleg-like protein 4 | Scml4 | 224 | Annotation score: | ||
D3Z791 | D3Z791_MOUSE | Sex comb on midleg-like protein 4 | Scml4 | 177 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 31 | A → T in AAH43310 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033947 | 1 – 58 | Missing in isoform 2. 1 PublicationAdd BLAST | 58 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK034171 mRNA Translation: BAC28615.1 AK047972 mRNA Translation: BAE20663.1 AK172160 mRNA Translation: BAE42854.1 BC043310 mRNA Translation: AAH43310.1 AK220309 mRNA Translation: BAD90230.1 |
CCDSi | CCDS23816.1 [Q80VG1-1] CCDS87999.1 [Q80VG1-2] |
RefSeqi | NP_766526.3, NM_172938.3 [Q80VG1-1] XP_006512816.1, XM_006512753.3 |
Genome annotation databases
Ensembli | ENSMUST00000063063; ENSMUSP00000053157; ENSMUSG00000044770 [Q80VG1-1] ENSMUST00000105494; ENSMUSP00000101133; ENSMUSG00000044770 [Q80VG1-2] |
GeneIDi | 268297 |
KEGGi | mmu:268297 |
UCSCi | uc007eza.2, mouse [Q80VG1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK034171 mRNA Translation: BAC28615.1 AK047972 mRNA Translation: BAE20663.1 AK172160 mRNA Translation: BAE42854.1 BC043310 mRNA Translation: AAH43310.1 AK220309 mRNA Translation: BAD90230.1 |
CCDSi | CCDS23816.1 [Q80VG1-1] CCDS87999.1 [Q80VG1-2] |
RefSeqi | NP_766526.3, NM_172938.3 [Q80VG1-1] XP_006512816.1, XM_006512753.3 |
3D structure databases
SMRi | Q80VG1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 234479, 1 interactor |
STRINGi | 10090.ENSMUSP00000053157 |
PTM databases
iPTMneti | Q80VG1 |
PhosphoSitePlusi | Q80VG1 |
Proteomic databases
PaxDbi | Q80VG1 |
PRIDEi | Q80VG1 |
Protocols and materials databases
Antibodypediai | 32183, 61 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000063063; ENSMUSP00000053157; ENSMUSG00000044770 [Q80VG1-1] ENSMUST00000105494; ENSMUSP00000101133; ENSMUSG00000044770 [Q80VG1-2] |
GeneIDi | 268297 |
KEGGi | mmu:268297 |
UCSCi | uc007eza.2, mouse [Q80VG1-1] |
Organism-specific databases
CTDi | 256380 |
MGIi | MGI:2446140, Scml4 |
Phylogenomic databases
eggNOGi | KOG3766, Eukaryota |
GeneTreei | ENSGT00940000157463 |
HOGENOMi | CLU_045829_0_0_1 |
InParanoidi | Q80VG1 |
OMAi | TVCLYVN |
OrthoDBi | 229086at2759 |
PhylomeDBi | Q80VG1 |
TreeFami | TF106488 |
Miscellaneous databases
BioGRID-ORCSi | 268297, 1 hit in 17 CRISPR screens |
ChiTaRSi | Scml4, mouse |
PROi | PR:Q80VG1 |
RNActi | Q80VG1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000044770, Expressed in blood and 98 other tissues |
Genevisiblei | Q80VG1, MM |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit 1.20.1380.20, 1 hit |
InterProi | View protein in InterPro IPR001660, SAM IPR013761, SAM/pointed_sf IPR033763, SCML2_RBR IPR021987, SLED IPR038348, SLED_sf |
Pfami | View protein in Pfam PF17208, RBR, 1 hit PF00536, SAM_1, 1 hit PF12140, SLED, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCML4_MOUSE | |
Accessioni | Q80VG1Primary (citable) accession number: Q80VG1 Secondary accession number(s): Q3TA16 Q8CC08 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | May 20, 2008 | |
Last modified: | February 10, 2021 | |
This is version 121 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families