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Entry version 148 (16 Oct 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Calmodulin-regulated spectrin-associated protein 3

Gene

Camsap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24706919, PubMed:26715742). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24706919). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (By similarity). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (PubMed:28860385). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (By similarity). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (By similarity). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (By similarity). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (By similarity). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (By similarity).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calmodulin-regulated spectrin-associated protein 3Curated
Alternative name(s):
Marshalin1 Publication
Protein Nezha1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Camsap3Imported
Synonyms:Kiaa15431 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1916947 Camsap3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable but show growth defects (PubMed:26715742). Disorganization of epithelial architecture, characterized by impaired apical-to-basal polarity of microtubules in epithelial cells (PubMed:26715742). Defects in the stereotypic positioning of the nucleus and Golgi apparatus (PubMed:26715742).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi608 – 612LEEKR → AAAAA: Retains the ability to interact with microtubules but abolishes the apical localization in epithelial cells. 1 Publication5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000508001 – 1252Calmodulin-regulated spectrin-associated protein 3Add BLAST1252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei184PhosphothreonineBy similarity1
Modified residuei193PhosphoserineCombined sources1
Modified residuei334PhosphoserineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei351PhosphoserineCombined sources1
Modified residuei368PhosphoserineBy similarity1
Modified residuei373PhosphoserineBy similarity1
Modified residuei382PhosphoserineBy similarity1
Modified residuei548PhosphoserineBy similarity1
Modified residuei555PhosphoserineBy similarity1
Modified residuei561PhosphoserineBy similarity1
Modified residuei683PhosphoserineBy similarity1
Modified residuei767PhosphoserineBy similarity1
Modified residuei797PhosphothreonineCombined sources1
Modified residuei812PhosphoserineCombined sources1
Modified residuei881PhosphoserineCombined sources1
Modified residuei1077PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80VC9

PeptideAtlas

More...
PeptideAtlasi
Q80VC9

PRoteomics IDEntifications database

More...
PRIDEi
Q80VC9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80VC9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80VC9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q80VC9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In cochlea, restricted to the organ of Corti and increases during development (at protein level) (PubMed:24244856). Highly expressed in both sensory hair cells and supporting cells (PubMed:24244856).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000044433 Expressed in 201 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q80VC9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80VC9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PLEKHA7 (By similarity).

Interacts with CAMSAP2 (PubMed:23169647).

Interacts with KATNA1 and KATNB1; leading to regulate the length of CAMSAP3-decorated microtubule stretches (By similarity).

Interacts with AKAP9; regulating Golgi assembly in epithelial cells (By similarity).

Interacts with MACF1 (By similarity).

Interacts with isoform C of CDH23; leading to inhibit CAMSAP3 ability to induce microtubule bundle formation (PubMed:27349180).

Interacts with AKNA (PubMed:30787442).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Camsap2Q8C1B12EBI-2125556,EBI-8839434

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
213622, 4 interactors

Database of interacting proteins

More...
DIPi
DIP-52404N

Protein interaction database and analysis system

More...
IntActi
Q80VC9, 5 interactors

Molecular INTeraction database

More...
MINTi
Q80VC9

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000125993

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11252
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80VC9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q80VC9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini203 – 312Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST110
Domaini1112 – 1246CKKPROSITE-ProRule annotationAdd BLAST135

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili595 – 629Sequence analysisAdd BLAST35
Coiled coili696 – 727Sequence analysisAdd BLAST32
Coiled coili896 – 943Sequence analysisAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi496 – 549Pro-richAdd BLAST54
Compositional biasi728 – 839Pro-richAdd BLAST112

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CKK domain binds microtubules and specifically recognizes the minus-end of microtubules.PROSITE-ProRule annotationBy similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAMSAP1 family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3654 Eukaryota
ENOG4111D0B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182975

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059671

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80VC9

KEGG Orthology (KO)

More...
KOi
K17493

Identification of Orthologs from Complete Genome Data

More...
OMAi
KSAANHF

Database of Orthologous Groups

More...
OrthoDBi
741937at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80VC9

TreeFam database of animal gene trees

More...
TreeFami
TF315529

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.20.360, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032940 CAMSAP
IPR031372 CAMSAP_CC1
IPR022613 CAMSAP_CH
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR038209 CKK_dom_sf
IPR014797 CKK_domain
IPR011033 PRC_barrel-like_sf

The PANTHER Classification System

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PANTHERi
PTHR21595 PTHR21595, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17095 CAMSAP_CC1, 1 hit
PF11971 CAMSAP_CH, 1 hit
PF08683 CAMSAP_CKK, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01051 CAMSAP_CKK, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF50346 SSF50346, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit
PS51508 CKK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (17+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 17 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 17 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80VC9-1) [UniParc]FASTAAdd to basket
Also known as: Ld1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVEAAPAGSG PLRRTFLVPE IKSLDQYDFS RAKAAASLAW VLRAAFGGAE
60 70 80 90 100
HVPPELWEPF YTDQYAQEHV KPPVTRLLLS AELYCRAWRQ ALPQLEPSPS
110 120 130 140 150
PSALLALLAR RGTVPSLPEH PVREADLKHQ PILMGAHLAV IDALMVAFSF
160 170 180 190 200
EWTKTLPGPL ALSSLEHKLL FWVDTTVRRL QEKTEQEAAQ RASPAAPLDG
210 220 230 240 250
ASPAQPSIRY RKDRAIARRA PCFPNVTTLQ DLASGAALAA TIHCYCPQLL
260 270 280 290 300
RLEEVCLKDP MSVADSLYNL QLVQDFCASH LPRGCPLSLE DLLYVPPPLK
310 320 330 340 350
VNLVVLLAEM YMCFEVLKPD FVQAKDLPDG HAVSPRNTET VPSQNNSGSS
360 370 380 390 400
SPVFNFRHPL LSPGGPQSPL RGSTGSLKSS PSMSHMEALG KAWNRQLSRP
410 420 430 440 450
LSQAVSFSTP FGLDSDVDVV MGDPVLLRSV SSDSLGPPRP VSTSSRNSAQ
460 470 480 490 500
PAPESGDLPT IEEALQIIHS AEPRLLPDGA ADGSFYLHSP EGLSKPPLSP
510 520 530 540 550
YPPEGASKPL SDRLNKAPIY ISHPENPSKS SPCSTGEILK PPPPSEGSPK
560 570 580 590 600
AVASSPAANN SEVKMTSFAE RKKQLVKAEA ESGLGSPTST PVAPEALSSE
610 620 630 640 650
MSELGARLEE KRRAIEAQKR RIEAIFAKHR QRLGKSAFLQ VQPREAAGEA
660 670 680 690 700
EEEAELGSVP GGERPAGEGQ GEPSLRHKSV TFSPDLGPVP PEGLGDYNRA
710 720 730 740 750
VSKLSAALSS LQRDMQRLTD QQQRLLAPPE APGPAPPPAA WVIPGPATGP
760 770 780 790 800
KAASPSPARR APAARRSPGP GPSPTPRSPK HARPAELKLA PLTRVLTPPH
810 820 830 840 850
DVDSLPHLRK FSPSQVPVQT RSSILLSEGT PPEEPTTKPA LIEIPLASLG
860 870 880 890 900
EPAADEEGDG SPPGAEDSLE EEASSEGEPR SGLGFFYKDE DKPEDEMAQK
910 920 930 940 950
RASLLERQQR RVEEARRRKQ WQEAEKEQKR EEAARLAQEA PGLAFTTPVV
960 970 980 990 1000
ASAAPVATLA PTTRAMAPAE EEVGPRRGDF TRLEYERRAQ LKLMDDLDKV
1010 1020 1030 1040 1050
LRPRASGTGG PGRGGRRATR PRSGCCDDSA LARSPARGLL GSRLSKVYSQ
1060 1070 1080 1090 1100
STLSLSTVAN EAPNNLGVKR PTSRAPSPSG LMSPSRLPGS RERDWENGSN
1110 1120 1130 1140 1150
ASSPASVPEY TGPRLYKEPS AKSNKFIIHN ALSHCCLAGK VNEPQKNRIL
1160 1170 1180 1190 1200
EEIEKSKANH FLILFRDSSC QFRALYTLSG ETEELSRLAG YGPRTVTPAM
1210 1220 1230 1240 1250
VEGIYKYNSD RKRFTQIPAK TMSMSVDAFT IQGHLWQSKK PTTPKKGGGT

PK
Length:1,252
Mass (Da):135,175
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E14AA8640108CF4
GO
Isoform 2 (identifier: Q80VC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1042-1111: Missing.

Note: No experimental confirmation available.
Show »
Length:1,182
Mass (Da):127,774
Checksum:i0B344DA6F21D8D2F
GO
Isoform 3 (identifier: Q80VC9-3) [UniParc]FASTAAdd to basket
Also known as: Lc variant 21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SCPTRWYWKLVP

Show »
Length:1,263
Mass (Da):136,606
Checksum:i79077CD26F4C298F
GO
Isoform 4 (identifier: Q80VC9-4) [UniParc]FASTAAdd to basket
Also known as: Lb variant 21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SHAIAFCLKESGNKPPM

Show »
Length:1,268
Mass (Da):136,900
Checksum:i26BA3AAEEA18C6F6
GO
Isoform 5 (identifier: Q80VC9-5) [UniParc]FASTAAdd to basket
Also known as: La variant 21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SCPTRWYWKLVPHAIAFCLKESGNKPPM

Show »
Length:1,279
Mass (Da):138,331
Checksum:i2A8645E0CA0164E3
GO
Isoform 6 (identifier: Q80VC9-6) [UniParc]FASTAAdd to basket
Also known as: Sc variant 21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SCPTRWYWKLVP
     398-813: Missing.

Show »
Length:847
Mass (Da):92,893
Checksum:i13BEF58139993A3E
GO
Isoform 7 (identifier: Q80VC9-7) [UniParc]FASTAAdd to basket
Also known as: Sb variant 21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SHAIAFCLKESGNKPPM
     398-813: Missing.

Show »
Length:852
Mass (Da):93,187
Checksum:iD381D5023C40C828
GO
Isoform 8 (identifier: Q80VC9-8) [UniParc]FASTAAdd to basket
Also known as: Sa variant 21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SCPTRWYWKLVPHAIAFCLKESGNKPPM
     398-813: Missing.

Show »
Length:863
Mass (Da):94,618
Checksum:i95C49E4A44A97518
GO
Isoform 9 (identifier: Q80VC9-9) [UniParc]FASTAAdd to basket
Also known as: Sd variant 21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     398-813: Missing.

Show »
Length:836
Mass (Da):91,462
Checksum:iBE33607687BF91FB
GO
Isoform 10 (identifier: Q80VC9-10) [UniParc]FASTAAdd to basket
Also known as: Ld variant 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     331-331: H → HV

Show »
Length:1,253
Mass (Da):135,274
Checksum:i4B51EB0D2090CB95
GO
Isoform 11 (identifier: Q80VC9-11) [UniParc]FASTAAdd to basket
Also known as: Lb variant 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SHAIAFCLKESGNKPPM
     331-331: H → HV

Show »
Length:1,269
Mass (Da):136,999
Checksum:i4809459D083AC3DF
GO
Isoform 12 (identifier: Q80VC9-12) [UniParc]FASTAAdd to basket
Also known as: Lc variant 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SCPTRWYWKLVP
     331-331: H → HV

Show »
Length:1,264
Mass (Da):136,705
Checksum:i0566F8DB74BF9730
GO
Isoform 13 (identifier: Q80VC9-13) [UniParc]FASTAAdd to basket
Also known as: Sd variant 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     331-331: H → HV
     398-813: Missing.

Show »
Length:837
Mass (Da):91,561
Checksum:i32C2E0B9A927A919
GO
Isoform 14 (identifier: Q80VC9-14) [UniParc]FASTAAdd to basket
Also known as: La variant 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SCPTRWYWKLVPHAIAFCLKESGNKPPM
     331-331: H → HV

Show »
Length:1,280
Mass (Da):138,430
Checksum:i547579E2461ADA7D
GO
Isoform 15 (identifier: Q80VC9-15) [UniParc]FASTAAdd to basket
Also known as: Sc variant 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SCPTRWYWKLVP
     331-331: H → HV
     398-813: Missing.

Show »
Length:848
Mass (Da):92,992
Checksum:i811F6D2C5E998FB2
GO
Isoform 16 (identifier: Q80VC9-16) [UniParc]FASTAAdd to basket
Also known as: Sb variant 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SHAIAFCLKESGNKPPM
     331-331: H → HV
     398-813: Missing.

Show »
Length:853
Mass (Da):93,286
Checksum:i9F7F520CDD9C5640
GO
Isoform 17 (identifier: Q80VC9-17) [UniParc]FASTAAdd to basket
Also known as: Sa variant 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SCPTRWYWKLVPHAIAFCLKESGNKPPM
     331-331: H → HV
     398-813: Missing.

Show »
Length:864
Mass (Da):94,717
Checksum:iB239174795E4BFFD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LJI9A0A140LJI9_MOUSE
Calmodulin-regulated spectrin-assoc...
Camsap3
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LJ93A0A140LJ93_MOUSE
Calmodulin-regulated spectrin-assoc...
Camsap3
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti199 – 207DGASPAQPS → LTSLSSCPQ in BAD90256 (Ref. 6) Curated9
Sequence conflicti892K → E in BAC38313 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059237207S → SCPTRWYWKLVP in isoform 3, isoform 6, isoform 12 and isoform 15. 1
Alternative sequenceiVSP_059238207S → SHAIAFCLKESGNKPPM in isoform 4, isoform 7, isoform 11 and isoform 16. 1
Alternative sequenceiVSP_059239207S → SCPTRWYWKLVPHAIAFCLK ESGNKPPM in isoform 5, isoform 8, isoform 14 and isoform 17. 1
Alternative sequenceiVSP_059240331H → HV in isoform 10, isoform 11, isoform 12, isoform 13, isoform 14, isoform 15, isoform 16 and isoform 17. 1
Alternative sequenceiVSP_059241398 – 813Missing in isoform 6, isoform 7, isoform 8, isoform 9, isoform 13, isoform 15, isoform 16 and isoform 17. Add BLAST416
Alternative sequenceiVSP_0137051042 – 1111Missing in isoform 2. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KC426930 mRNA Translation: AGX24909.1
KC426931 mRNA Translation: AGX24910.1
KC426932 mRNA Translation: AGX24911.1
KC426933 mRNA Translation: AGX24912.1
KC426934 mRNA Translation: AGX24913.1
KC426935 mRNA Translation: AGX24914.1
KC426936 mRNA Translation: AGX24915.1
KC426937 mRNA Translation: AGX24916.1
KC426938 mRNA Translation: AGX24917.1
KC426939 mRNA Translation: AGX24918.1
KC426940 mRNA Translation: AGX24919.1
KC426941 mRNA Translation: AGX24920.1
KC426942 mRNA Translation: AGX24921.1
KC426943 mRNA Translation: AGX24922.1
KC426944 mRNA Translation: AGX24923.1
KC426945 mRNA Translation: AGX24924.1
AK081728 mRNA Translation: BAC38313.1
AC170806 Genomic DNA No translation available.
CH466566 Genomic DNA Translation: EDL21921.1
BC048787 mRNA Translation: AAH48787.1
AK220401 Transcribed RNA Translation: BAD90256.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS22064.1 [Q80VC9-1]
CCDS52469.1 [Q80VC9-10]
CCDS85488.1 [Q80VC9-5]
CCDS85489.1 [Q80VC9-3]
CCDS85490.1 [Q80VC9-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001157221.1, NM_001163749.1 [Q80VC9-10]
NP_001334040.1, NM_001347111.1 [Q80VC9-5]
NP_001334041.1, NM_001347112.1 [Q80VC9-4]
NP_001334042.1, NM_001347113.1 [Q80VC9-3]
NP_081447.2, NM_027171.3 [Q80VC9-1]
XP_006508937.1, XM_006508874.1
XP_006508939.1, XM_006508876.1
XP_006508941.1, XM_006508878.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000057028; ENSMUSP00000058958; ENSMUSG00000044433 [Q80VC9-1]
ENSMUST00000171962; ENSMUSP00000125993; ENSMUSG00000044433 [Q80VC9-10]
ENSMUST00000207077; ENSMUSP00000146852; ENSMUSG00000044433 [Q80VC9-4]
ENSMUST00000207432; ENSMUSP00000146896; ENSMUSG00000044433 [Q80VC9-5]
ENSMUST00000207533; ENSMUSP00000147209; ENSMUSG00000044433 [Q80VC9-7]
ENSMUST00000207712; ENSMUSP00000146565; ENSMUSG00000044433 [Q80VC9-13]
ENSMUST00000207970; ENSMUSP00000146772; ENSMUSG00000044433 [Q80VC9-3]
ENSMUST00000208240; ENSMUSP00000146359; ENSMUSG00000044433 [Q80VC9-15]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
69697

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:69697

UCSC genome browser

More...
UCSCi
uc009krw.2 mouse [Q80VC9-1]
uc012fym.1 mouse
uc033jds.1 mouse
uc033jdu.1 mouse
uc033jdv.1 mouse
uc033jdy.1 mouse
uc033jec.1 mouse
uc033jed.1 mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC426930 mRNA Translation: AGX24909.1
KC426931 mRNA Translation: AGX24910.1
KC426932 mRNA Translation: AGX24911.1
KC426933 mRNA Translation: AGX24912.1
KC426934 mRNA Translation: AGX24913.1
KC426935 mRNA Translation: AGX24914.1
KC426936 mRNA Translation: AGX24915.1
KC426937 mRNA Translation: AGX24916.1
KC426938 mRNA Translation: AGX24917.1
KC426939 mRNA Translation: AGX24918.1
KC426940 mRNA Translation: AGX24919.1
KC426941 mRNA Translation: AGX24920.1
KC426942 mRNA Translation: AGX24921.1
KC426943 mRNA Translation: AGX24922.1
KC426944 mRNA Translation: AGX24923.1
KC426945 mRNA Translation: AGX24924.1
AK081728 mRNA Translation: BAC38313.1
AC170806 Genomic DNA No translation available.
CH466566 Genomic DNA Translation: EDL21921.1
BC048787 mRNA Translation: AAH48787.1
AK220401 Transcribed RNA Translation: BAD90256.1
CCDSiCCDS22064.1 [Q80VC9-1]
CCDS52469.1 [Q80VC9-10]
CCDS85488.1 [Q80VC9-5]
CCDS85489.1 [Q80VC9-3]
CCDS85490.1 [Q80VC9-4]
RefSeqiNP_001157221.1, NM_001163749.1 [Q80VC9-10]
NP_001334040.1, NM_001347111.1 [Q80VC9-5]
NP_001334041.1, NM_001347112.1 [Q80VC9-4]
NP_001334042.1, NM_001347113.1 [Q80VC9-3]
NP_081447.2, NM_027171.3 [Q80VC9-1]
XP_006508937.1, XM_006508874.1
XP_006508939.1, XM_006508876.1
XP_006508941.1, XM_006508878.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UGJNMR-A1113-1240[»]
5LZNX-ray1.40A1121-1239[»]
5M50electron microscopy5.30C1121-1238[»]
5OW5X-ray1.70E/F461-470[»]
SMRiQ80VC9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi213622, 4 interactors
DIPiDIP-52404N
IntActiQ80VC9, 5 interactors
MINTiQ80VC9
STRINGi10090.ENSMUSP00000125993

PTM databases

iPTMnetiQ80VC9
PhosphoSitePlusiQ80VC9
SwissPalmiQ80VC9

Proteomic databases

PaxDbiQ80VC9
PeptideAtlasiQ80VC9
PRIDEiQ80VC9

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
69697

Genome annotation databases

EnsembliENSMUST00000057028; ENSMUSP00000058958; ENSMUSG00000044433 [Q80VC9-1]
ENSMUST00000171962; ENSMUSP00000125993; ENSMUSG00000044433 [Q80VC9-10]
ENSMUST00000207077; ENSMUSP00000146852; ENSMUSG00000044433 [Q80VC9-4]
ENSMUST00000207432; ENSMUSP00000146896; ENSMUSG00000044433 [Q80VC9-5]
ENSMUST00000207533; ENSMUSP00000147209; ENSMUSG00000044433 [Q80VC9-7]
ENSMUST00000207712; ENSMUSP00000146565; ENSMUSG00000044433 [Q80VC9-13]
ENSMUST00000207970; ENSMUSP00000146772; ENSMUSG00000044433 [Q80VC9-3]
ENSMUST00000208240; ENSMUSP00000146359; ENSMUSG00000044433 [Q80VC9-15]
GeneIDi69697
KEGGimmu:69697
UCSCiuc009krw.2 mouse [Q80VC9-1]
uc012fym.1 mouse
uc033jds.1 mouse
uc033jdu.1 mouse
uc033jdv.1 mouse
uc033jdy.1 mouse
uc033jec.1 mouse
uc033jed.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57662
MGIiMGI:1916947 Camsap3

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG3654 Eukaryota
ENOG4111D0B LUCA
GeneTreeiENSGT00950000182975
HOGENOMiHOG000059671
InParanoidiQ80VC9
KOiK17493
OMAiKSAANHF
OrthoDBi741937at2759
PhylomeDBiQ80VC9
TreeFamiTF315529

Miscellaneous databases

EvolutionaryTraceiQ80VC9

Protein Ontology

More...
PROi
PR:Q80VC9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000044433 Expressed in 201 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ80VC9 baseline and differential
GenevisibleiQ80VC9 MM

Family and domain databases

Gene3Di3.10.20.360, 1 hit
InterProiView protein in InterPro
IPR032940 CAMSAP
IPR031372 CAMSAP_CC1
IPR022613 CAMSAP_CH
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR038209 CKK_dom_sf
IPR014797 CKK_domain
IPR011033 PRC_barrel-like_sf
PANTHERiPTHR21595 PTHR21595, 2 hits
PfamiView protein in Pfam
PF17095 CAMSAP_CC1, 1 hit
PF11971 CAMSAP_CH, 1 hit
PF08683 CAMSAP_CKK, 1 hit
SMARTiView protein in SMART
SM01051 CAMSAP_CKK, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF50346 SSF50346, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS51508 CKK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAMP3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80VC9
Secondary accession number(s): E9Q5B0
, Q5DTW9, Q8BUZ0, U5LGR7, U5LGS1, U5LGS5, U5LGT0, U5LHT8, U5LHU4, U5LHW1, U5LHW4, U5LHW9, U5LK15, U5LK19, U5LK24, U5LK70, U5LK74, U5LK79
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2003
Last modified: October 16, 2019
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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