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Protein

SH3 domain and tetratricopeptide repeat-containing protein 2

Gene

Sh3tc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain and tetratricopeptide repeat-containing protein 2
Gene namesi
Name:Sh3tc2
Synonyms:Kiaa1985
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2444417 Sh3tc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063571 – 1289SH3 domain and tetratricopeptide repeat-containing protein 2Add BLAST1289

Proteomic databases

PaxDbiQ80VA5
PRIDEiQ80VA5

PTM databases

iPTMnetiQ80VA5
PhosphoSitePlusiQ80VA5

Expressioni

Gene expression databases

BgeeiENSMUSG00000045629 Expressed in 93 organ(s), highest expression level in placenta labyrinth
CleanExiMM_SH3TC2
GenevisibleiQ80VA5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055094

Structurei

3D structure databases

ProteinModelPortaliQ80VA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 239SH3 1PROSITE-ProRule annotationAdd BLAST64
Domaini267 – 330SH3 2PROSITE-ProRule annotationAdd BLAST64
Repeati529 – 562TPR 1Add BLAST34
Repeati758 – 791TPR 2Add BLAST34
Repeati837 – 870TPR 3Add BLAST34
Repeati1002 – 1038TPR 4Add BLAST37
Repeati1085 – 1119TPR 5Add BLAST35
Repeati1120 – 1153TPR 6Add BLAST34
Repeati1167 – 1200TPR 7Add BLAST34
Repeati1211 – 1245TPR 8Add BLAST35

Keywords - Domaini

Repeat, SH3 domain, TPR repeat

Phylogenomic databases

eggNOGiENOG410IFSQ Eukaryota
ENOG410Y8HX LUCA
GeneTreeiENSGT00530000063812
HOGENOMiHOG000121783
HOVERGENiHBG054553
InParanoidiQ80VA5
OMAiEDTEIQV
OrthoDBiEOG091G00MK
PhylomeDBiQ80VA5
TreeFamiTF333167

Family and domain databases

Gene3Di1.25.40.10, 4 hits
InterProiView protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00018 SH3_1, 1 hit
PF07653 SH3_2, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 2 hits
SM00028 TPR, 6 hits
SUPFAMiSSF48452 SSF48452, 4 hits
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS50002 SH3, 2 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q80VA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGGCFCIPGE RSLPWGPGKE GSSKDPPGLA EDTSSLENKR KCFLPQNMTQ
60 70 80 90 100
DLVLSFCVKS RSRRCVNAAL QEAARRRLWA LENEAQEVHA LFKDLSARLV
110 120 130 140 150
SVQSQKDQFL ITFKTLEEIW KFSTYLNLGY VSICLEHLFF DHTYWLNSRL
160 170 180 190 200
VDDTEIQVSV DDNHLENIYL GLLLQEGHFF CRAVCSVAQP ADKEGEYLTL
210 220 230 240 250
CKNELISVLS GGESECEAMS LVTGQRGLVP MSALEPLPVP FHQWFLKNHP
260 270 280 290 300
GICGLPRKRD WTGSGQIGRG RCKALMDYEQ EERDELCFLQ GESIDVIGFV
310 320 330 340 350
IPGLQWFIGK SVSSGEVGFV PTRSIDLDSC SPMSKNSAFF SDEERSSLWS
360 370 380 390 400
PGSERKAECS GFLCSLAHTD ITSIYRLSEF EAIQNLQNDL SASQPEGFRE
410 420 430 440 450
ARSGGTWMER QTIGSRRSSG SGDSSPEEDE LISASSDSYH LPEPEDLDDP
460 470 480 490 500
ELFMDLSTSL EEDDVEHFAP ILAFLDHEGY TDHFKSLYDF SFSFLTSSFY
510 520 530 540 550
SFSEEDELVA YLETSRKWAK MSHMTWAHAR LCFLLGRLSI RKTKLSQARV
560 570 580 590 600
YFEEAIRVLD GAFEDLSLVA ALYINLAAIY LRQRLRHKGP TLLEKAGALL
610 620 630 640 650
ACLPDHEFST KNELDVVTYV LRQGIVVGSG LLEARSCFLA IRLLLSLGRH
660 670 680 690 700
EEVVPFAERL QLLSGHPPAS EATATMLSSL YDKKYLPHLA VASVQKRGPQ
710 720 730 740 750
SARGMSLSIW QAYLVLQNAT KILGVPSSNW CEVSALACPT LRQALAACEE
760 770 780 790 800
LSDQDIQRTL CLILSKMYLQ HQSPDGSVHY LSQAHVLGKL LGEEEAFESS
810 820 830 840 850
LCLAWAYLLG RQTEKALEIL EPLLCSLRET ECVTQRGVVH NLLGLAFEDE
860 870 880 890 900
GRTSRAAKSY LRALIRAREM GNIRNQAVSM ANLGHLTLKS CMQQSARGYL
910 920 930 940 950
LQAVRLYSEL QASKETDMEL VQVLLWLGQA SVSGHQLVHS RLCYEMALLF
960 970 980 990 1000
GLRHQHLSSQ LQVTKSLCHF YSSVSPNPDA CITYHEHWLA LAQQLRDREM
1010 1020 1030 1040 1050
EGQLLESLGQ LYRNLNTSRS LRRSLACIKE SLRIFVDLGE RDKAAEAWLG
1060 1070 1080 1090 1100
AGRLHYLMQE DELVELYLQE AIQTALRSEE PSLALKLYEE AGDVFFNGTR
1110 1120 1130 1140 1150
HRHRAVEYYR AGAVPLARRM KALRTELRIF NKLTELQISL EGYEKALEFA
1160 1170 1180 1190 1200
TLAARLSVLT GDQKQELVAF HRLATVYFSL NMYEMAEDCY LKTLSLCPPW
1210 1220 1230 1240 1250
LQSPKEALYY AKVYCRLGRL TFYQLKDAHD ATEYFLLALA AAVLMGDEEL
1260 1270 1280
QNTIKNRLDS ICQSPLWHSN PFGCSSERAR WLSGGSLAL
Length:1,289
Mass (Da):145,144
Last modified:April 13, 2004 - v2
Checksum:iE96C52181ADD9936
GO
Isoform 2 (identifier: Q80VA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-407: Missing.
     1020-1289: Missing.

Note: No experimental confirmation available.
Show »
Length:612
Mass (Da):68,751
Checksum:iAE7EC8945EDAA20E
GO
Isoform 3 (identifier: Q80VA5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-156: YVSICLEHLFFDHTYWLNSRLVDDTEI → MPWVGGGEHLSPSSRLVEPDTGELVCL
     157-1289: Missing.

Note: No experimental confirmation available.
Show »
Length:156
Mass (Da):17,401
Checksum:i08A9BA72A7A8B9BE
GO
Isoform 4 (identifier: Q80VA5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     959-1001: SQLQVTKSLC...AQQLRDREME → TRCPRTPMRA...WSPLGSFIGT
     1002-1289: Missing.

Note: No experimental confirmation available.
Show »
Length:1,001
Mass (Da):112,135
Checksum:i0A35D21557144991
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0098871 – 407Missing in isoform 2. 1 PublicationAdd BLAST407
Alternative sequenceiVSP_009888130 – 156YVSIC…DDTEI → MPWVGGGEHLSPSSRLVEPD TGELVCL in isoform 3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_009889157 – 1289Missing in isoform 3. 1 PublicationAdd BLAST1133
Alternative sequenceiVSP_009890959 – 1001SQLQV…DREME → TRCPRTPMRALPIMNTGWPW LSNSGIGRWRDSYWSPLGSF IGT in isoform 4. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_0098911002 – 1289Missing in isoform 4. 1 PublicationAdd BLAST288
Alternative sequenceiVSP_0098921020 – 1289Missing in isoform 2. 1 PublicationAdd BLAST270

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031388 mRNA Translation: BAC27379.1
AK048066 mRNA Translation: BAC33233.1
AK052534 mRNA Translation: BAC35030.1
BC037000 mRNA No translation available.
BC049856 mRNA Translation: AAH49856.1
CCDSiCCDS37840.1 [Q80VA5-1]
RefSeqiNP_766216.2, NM_172628.2 [Q80VA5-1]
UniGeneiMm.262320

Genome annotation databases

EnsembliENSMUST00000051720; ENSMUSP00000055094; ENSMUSG00000045629 [Q80VA5-1]
GeneIDi225608
KEGGimmu:225608
UCSCiuc008fcu.1 mouse [Q80VA5-3]
uc008fcv.1 mouse [Q80VA5-1]
uc008fcw.1 mouse [Q80VA5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031388 mRNA Translation: BAC27379.1
AK048066 mRNA Translation: BAC33233.1
AK052534 mRNA Translation: BAC35030.1
BC037000 mRNA No translation available.
BC049856 mRNA Translation: AAH49856.1
CCDSiCCDS37840.1 [Q80VA5-1]
RefSeqiNP_766216.2, NM_172628.2 [Q80VA5-1]
UniGeneiMm.262320

3D structure databases

ProteinModelPortaliQ80VA5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055094

PTM databases

iPTMnetiQ80VA5
PhosphoSitePlusiQ80VA5

Proteomic databases

PaxDbiQ80VA5
PRIDEiQ80VA5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051720; ENSMUSP00000055094; ENSMUSG00000045629 [Q80VA5-1]
GeneIDi225608
KEGGimmu:225608
UCSCiuc008fcu.1 mouse [Q80VA5-3]
uc008fcv.1 mouse [Q80VA5-1]
uc008fcw.1 mouse [Q80VA5-2]

Organism-specific databases

CTDi79628
MGIiMGI:2444417 Sh3tc2
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IFSQ Eukaryota
ENOG410Y8HX LUCA
GeneTreeiENSGT00530000063812
HOGENOMiHOG000121783
HOVERGENiHBG054553
InParanoidiQ80VA5
OMAiEDTEIQV
OrthoDBiEOG091G00MK
PhylomeDBiQ80VA5
TreeFamiTF333167

Miscellaneous databases

ChiTaRSiSh3tc2 mouse
PROiPR:Q80VA5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045629 Expressed in 93 organ(s), highest expression level in placenta labyrinth
CleanExiMM_SH3TC2
GenevisibleiQ80VA5 MM

Family and domain databases

Gene3Di1.25.40.10, 4 hits
InterProiView protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00018 SH3_1, 1 hit
PF07653 SH3_2, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 2 hits
SM00028 TPR, 6 hits
SUPFAMiSSF48452 SSF48452, 4 hits
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS50002 SH3, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiS3TC2_MOUSE
AccessioniPrimary (citable) accession number: Q80VA5
Secondary accession number(s): Q8BWH2, Q8BXB8, Q8C0G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 7, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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