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Protein

Integrator complex subunit 8

Gene

Ints8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 8
Short name:
Int8
Gene namesi
Name:Ints8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1919906 Ints8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595541 – 995Integrator complex subunit 8Add BLAST995

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80V86
MaxQBiQ80V86
PaxDbiQ80V86
PeptideAtlasiQ80V86
PRIDEiQ80V86

PTM databases

iPTMnetiQ80V86
PhosphoSitePlusiQ80V86

Expressioni

Gene expression databases

BgeeiENSMUSG00000040738 Expressed in 280 organ(s), highest expression level in cochlea
CleanExiMM_INTS8
ExpressionAtlasiQ80V86 baseline and differential
GenevisibleiQ80V86 MM

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.By similarity

Protein-protein interaction databases

BioGridi215494, 1 interactor
STRINGi10090.ENSMUSP00000038418

Structurei

3D structure databases

SMRiQ80V86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati250 – 288TPR 1Add BLAST39
Repeati320 – 356TPR 2Add BLAST37
Repeati570 – 603TPR 3Add BLAST34
Repeati833 – 866TPR 4Add BLAST34

Sequence similaritiesi

Belongs to the Integrator subunit 8 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IFPZ Eukaryota
ENOG410XRVQ LUCA
GeneTreeiENSGT00390000007597
HOVERGENiHBG080418
InParanoidiQ80V86
KOiK13145
OMAiYYSCIWD
OrthoDBiEOG091G068M
PhylomeDBiQ80V86
TreeFamiTF324241

Family and domain databases

InterProiView protein in InterPro
IPR038751 Int8
PANTHERiPTHR13350 PTHR13350, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q80V86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAEAADREA ATSSRPCTPP QTCWFEFLLE ESLLEKHLRK ACPDPAPVQL
60 70 80 90 100
IVQFLEQASK PSVNEQNQVQ PPPDNKRNRV LKLLALKVAA HLKWDLDILE
110 120 130 140 150
KSLSVPVLNM LLNELLCISK VPPGTKHVDM DLSALPPTTA MAILLYNRWA
160 170 180 190 200
IRTIVQSSFP VKQAKPGPPQ LNVMNQMQQE KELTENILKV LKEQAADCIL
210 220 230 240 250
VLEAALRLNK DLYVHTMRTL DLLAVEPGTV NGETENSTAG LKIRTEEMQC
260 270 280 290 300
QVCYDLGAAY FQQGSTDSAI YENAREKFFR TKELLAEIGS LSLHCTIDEK
310 320 330 340 350
RLAGYCQACD VLVPSSDNNS QQLTPYSQVH ICLRSGSYQE VVQIFIEDNL
360 370 380 390 400
TFTLPVQFRQ SVLRELFQKA QQGNEALDEI CFKICVCNTV RDVLEGRTIS
410 420 430 440 450
VQFNQLFLRP NKEKIDFLLE VCSRSINVEK ASDSLKGNMA AFLKNVCLGL
460 470 480 490 500
EDLQYVFMIS SHELFITLLK DEERKLLVDQ MRKRSPRVNL CIKPVTSFYD
510 520 530 540 550
IPASASVNIG QLEHQLILSV DPWRIRQILI ELHGMTSERQ FWTVSNKWEV
560 570 580 590 600
PSVYSSVILG IKDNLTRDLV YILMAKGLHC STVKDFPHSK QLFTACLELV
610 620 630 640 650
TEFSPKLRQV MLNEMLLLDI RTHEAGVGQS GERPPSDLIS RVRGYLEMRL
660 670 680 690 700
PDIPLRQVVA EECVAFMLNW RENEYLTLQV PAFLFQNNPY VKLGQLLAAT
710 720 730 740 750
CKELPGPKES RRTAKDLWEV VVQICSVSNQ HKRGNDGRVS LIKQRESTLG
760 770 780 790 800
IMYRSELLSF IKKLREPLVL TIILSLFVKL HNVREDIVND ITAEHISIWP
810 820 830 840 850
SSIPNLQSVD FEAVAITVKE LVRYTLSINP NNHAWLIIQA DIYFATNQHS
860 870 880 890 900
AALHYYLQAG AVCSDFFNKA VPPDVYTDQV IKRMIKCCSL LNCHTQVAIL
910 920 930 940 950
CQFLREIDYK TAFKSLQEQN SHDAMDSYYD YIWDVTILEY LTYLHHKRGE
960 970 980 990
TDKRQIAIKA IGQTELNASN PEEVLQLAAQ RRKKKFLQAM AKLYF
Length:995
Mass (Da):113,353
Last modified:June 1, 2003 - v1
Checksum:i021BB8C81316899A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2API3A2API3_MOUSE
Integrator complex subunit 8
Ints8
978Annotation score:

Sequence cautioni

The sequence AAH50192 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH57618 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC25374 differs from that shown. Reason: Frameshift at position 5.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40K → R in BAC33786 (PubMed:16141072).Curated1
Sequence conflicti60K → Q in BAC25374 (PubMed:16141072).Curated1
Sequence conflicti442F → L in AAH50192 (PubMed:15489334).Curated1
Sequence conflicti600V → M in BAE41225 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049513 mRNA Translation: BAC33786.1
AK012736 mRNA Translation: BAC25374.2 Frameshift.
AK140829 mRNA Translation: BAE24491.1
AK164951 mRNA Translation: BAE37977.1
AK169552 mRNA Translation: BAE41225.1
AL840625 Genomic DNA No translation available.
BC049092 mRNA Translation: AAH49092.1
BC050192 mRNA Translation: AAH50192.1 Different initiation.
BC057618 mRNA Translation: AAH57618.1 Different initiation.
CCDSiCCDS17967.1
RefSeqiNP_001153067.1, NM_001159595.1
NP_835213.3, NM_178112.5
UniGeneiMm.246713

Genome annotation databases

EnsembliENSMUST00000044616; ENSMUSP00000038418; ENSMUSG00000040738
ENSMUST00000108319; ENSMUSP00000103955; ENSMUSG00000040738
GeneIDi72656
KEGGimmu:72656
UCSCiuc008rzg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049513 mRNA Translation: BAC33786.1
AK012736 mRNA Translation: BAC25374.2 Frameshift.
AK140829 mRNA Translation: BAE24491.1
AK164951 mRNA Translation: BAE37977.1
AK169552 mRNA Translation: BAE41225.1
AL840625 Genomic DNA No translation available.
BC049092 mRNA Translation: AAH49092.1
BC050192 mRNA Translation: AAH50192.1 Different initiation.
BC057618 mRNA Translation: AAH57618.1 Different initiation.
CCDSiCCDS17967.1
RefSeqiNP_001153067.1, NM_001159595.1
NP_835213.3, NM_178112.5
UniGeneiMm.246713

3D structure databases

SMRiQ80V86
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215494, 1 interactor
STRINGi10090.ENSMUSP00000038418

PTM databases

iPTMnetiQ80V86
PhosphoSitePlusiQ80V86

Proteomic databases

EPDiQ80V86
MaxQBiQ80V86
PaxDbiQ80V86
PeptideAtlasiQ80V86
PRIDEiQ80V86

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044616; ENSMUSP00000038418; ENSMUSG00000040738
ENSMUST00000108319; ENSMUSP00000103955; ENSMUSG00000040738
GeneIDi72656
KEGGimmu:72656
UCSCiuc008rzg.2 mouse

Organism-specific databases

CTDi55656
MGIiMGI:1919906 Ints8

Phylogenomic databases

eggNOGiENOG410IFPZ Eukaryota
ENOG410XRVQ LUCA
GeneTreeiENSGT00390000007597
HOVERGENiHBG080418
InParanoidiQ80V86
KOiK13145
OMAiYYSCIWD
OrthoDBiEOG091G068M
PhylomeDBiQ80V86
TreeFamiTF324241

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes

Miscellaneous databases

PROiPR:Q80V86
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040738 Expressed in 280 organ(s), highest expression level in cochlea
CleanExiMM_INTS8
ExpressionAtlasiQ80V86 baseline and differential
GenevisibleiQ80V86 MM

Family and domain databases

InterProiView protein in InterPro
IPR038751 Int8
PANTHERiPTHR13350 PTHR13350, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINT8_MOUSE
AccessioniPrimary (citable) accession number: Q80V86
Secondary accession number(s): A2API4
, Q3TEM3, Q3TNW0, Q6PFD3, Q810I3, Q8BQJ8, Q8BT91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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