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Protein

Multiple epidermal growth factor-like domains protein 6

Gene

Megf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multiple epidermal growth factor-like domains protein 6
Short name:
Multiple EGF-like domains protein 6
Alternative name(s):
Epidermal growth factor-like protein 3
Short name:
EGF-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Megf6
Synonyms:Egfl3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1919351 Megf6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000005562827 – 1572Multiple epidermal growth factor-like domains protein 6Add BLAST1546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 107Sequence analysis
Disulfide bondi73 ↔ 79Sequence analysis
Disulfide bondi106 ↔ 119Sequence analysis
Disulfide bondi126 ↔ 137By similarity
Disulfide bondi133 ↔ 146By similarity
Disulfide bondi148 ↔ 161By similarity
Disulfide bondi167 ↔ 178By similarity
Disulfide bondi174 ↔ 187By similarity
Disulfide bondi189 ↔ 202By similarity
Disulfide bondi291 ↔ 302By similarity
Disulfide bondi298 ↔ 311By similarity
Disulfide bondi313 ↔ 326By similarity
Disulfide bondi418 ↔ 429By similarity
Disulfide bondi425 ↔ 438By similarity
Disulfide bondi440 ↔ 453By similarity
Disulfide bondi522 ↔ 535By similarity
Disulfide bondi529 ↔ 542By similarity
Disulfide bondi544 ↔ 553By similarity
Disulfide bondi566 ↔ 578By similarity
Disulfide bondi572 ↔ 585By similarity
Disulfide bondi587 ↔ 596By similarity
Disulfide bondi609 ↔ 621By similarity
Disulfide bondi615 ↔ 628By similarity
Disulfide bondi630 ↔ 639By similarity
Disulfide bondi788 ↔ 797By similarity
Disulfide bondi791 ↔ 804By similarity
Disulfide bondi806 ↔ 815By similarity
Disulfide bondi832 ↔ 840By similarity
Disulfide bondi834 ↔ 847By similarity
Disulfide bondi849 ↔ 858By similarity
Disulfide bondi871 ↔ 884By similarity
Disulfide bondi875 ↔ 891By similarity
Disulfide bondi893 ↔ 902By similarity
Disulfide bondi915 ↔ 927By similarity
Disulfide bondi921 ↔ 934By similarity
Disulfide bondi936 ↔ 945By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1000N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1001 ↔ 1013By similarity
Disulfide bondi1007 ↔ 1020By similarity
Disulfide bondi1022 ↔ 1031By similarity
Disulfide bondi1044 ↔ 1056By similarity
Disulfide bondi1050 ↔ 1063By similarity
Disulfide bondi1065 ↔ 1074By similarity
Disulfide bondi1087 ↔ 1099By similarity
Disulfide bondi1093 ↔ 1106By similarity
Disulfide bondi1108 ↔ 1117By similarity
Disulfide bondi1134 ↔ 1142By similarity
Disulfide bondi1136 ↔ 1149By similarity
Disulfide bondi1151 ↔ 1160By similarity
Disulfide bondi1173 ↔ 1185By similarity
Disulfide bondi1177 ↔ 1192By similarity
Disulfide bondi1194 ↔ 1203By similarity
Disulfide bondi1260 ↔ 1272By similarity
Disulfide bondi1266 ↔ 1279By similarity
Disulfide bondi1281 ↔ 1290By similarity
Disulfide bondi1303 ↔ 1315By similarity
Disulfide bondi1309 ↔ 1322By similarity
Disulfide bondi1324 ↔ 1333By similarity
Disulfide bondi1346 ↔ 1358By similarity
Disulfide bondi1352 ↔ 1365By similarity
Disulfide bondi1367 ↔ 1376By similarity
Disulfide bondi1393 ↔ 1401By similarity
Disulfide bondi1395 ↔ 1408By similarity
Disulfide bondi1410 ↔ 1419By similarity
Disulfide bondi1432 ↔ 1444By similarity
Disulfide bondi1438 ↔ 1451By similarity
Disulfide bondi1453 ↔ 1462By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q80V70

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80V70

PRoteomics IDEntifications database

More...
PRIDEi
Q80V70

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80V70

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

CleanEx database of gene expression profiles

More...
CleanExi
MM_MEGF6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000030897

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q80V70

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80V70

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 121EMIPROSITE-ProRule annotationAdd BLAST82
Domaini122 – 162EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini163 – 203EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini287 – 327EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini414 – 454EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini518 – 554EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini562 – 597EGF-like 6PROSITE-ProRule annotationAdd BLAST36
Domaini605 – 640EGF-like 7PROSITE-ProRule annotationAdd BLAST36
Domaini785 – 816EGF-like 8PROSITE-ProRule annotationAdd BLAST32
Domaini829 – 859EGF-like 9PROSITE-ProRule annotationAdd BLAST31
Domaini867 – 903EGF-like 10PROSITE-ProRule annotationAdd BLAST37
Domaini911 – 946EGF-like 11PROSITE-ProRule annotationAdd BLAST36
Domaini997 – 1032EGF-like 12PROSITE-ProRule annotationAdd BLAST36
Domaini1040 – 1075EGF-like 13PROSITE-ProRule annotationAdd BLAST36
Domaini1083 – 1118EGF-like 14PROSITE-ProRule annotationAdd BLAST36
Domaini1131 – 1161EGF-like 15PROSITE-ProRule annotationAdd BLAST31
Domaini1169 – 1204EGF-like 16PROSITE-ProRule annotationAdd BLAST36
Domaini1256 – 1291EGF-like 17PROSITE-ProRule annotationAdd BLAST36
Domaini1299 – 1334EGF-like 18PROSITE-ProRule annotationAdd BLAST36
Domaini1342 – 1377EGF-like 19PROSITE-ProRule annotationAdd BLAST36
Domaini1390 – 1420EGF-like 20PROSITE-ProRule annotationAdd BLAST31
Domaini1428 – 1463EGF-like 21PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1218 Eukaryota
ENOG410XQWV LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000097840

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079790

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80V70

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80V70

TreeFam database of animal gene trees

More...
TreeFami
TF332598

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR013111 EGF_extracell
IPR011489 EMI_domain
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662 cEGF, 2 hits
PF07974 EGF_2, 1 hit
PF07645 EGF_CA, 2 hits
PF12661 hEGF, 4 hits
PF00053 Laminin_EGF, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 32 hits
SM00179 EGF_CA, 8 hits
SM00180 EGF_Lam, 23 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 5 hits
PS00022 EGF_1, 23 hits
PS01186 EGF_2, 23 hits
PS50026 EGF_3, 22 hits
PS01187 EGF_CA, 5 hits
PS51041 EMI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q80V70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVGVEARAS WRVVALTLLL LPAVPAASQP LPPRPLQPSM PHVCAEQKLT
60 70 80 90 100
LVGHRQPCVQ AFSRVVPVWR SGCGQQAWCV GQERRTVYYM SYRQVYATEA
110 120 130 140 150
RTVFRCCPGW SQKPGQEGCL SDVDECANAN GGCEGPCCNT VGGFYCRCPP
160 170 180 190 200
GYQLQGDGKT CQDVDECRSH NGGCQHRCVN TPGSYLCECK PGFRLHTDGR
210 220 230 240 250
TCLAISSCTL GNGGCQHQCV QLTVTQHRCQ CRPQYQLQED GRRCVRRSPC
260 270 280 290 300
ADGNGGCMHT CQELRGLAHC GCHPGYQLAA DRKACEDVDE CALGLAQCAH
310 320 330 340 350
GCLNTQGSFK CVCHAGYELG ADGRQCYRIE MEIVNSCEAG NGGCSHGCSH
360 370 380 390 400
TSTGPLCTCP RGYELDEDQK TCIDIDDCAN SPCCQQVCAN TPGGYECSCF
410 420 430 440 450
AGYRLNTDGC GCEDVDECAS GHSGCEHHCS NLAGSFQCFC EAGYRLDEDR
460 470 480 490 500
RGCTPLEESV VDLDGQLPFV RPLPHIAVLG DELPQLFQDD YGAEEEAVAE
510 520 530 540 550
LRGEHTLTEK FVCLDHSFGH DCSLTCDDCR NGGTCFPGLD GCDCPEGWTG
560 570 580 590 600
IICNETCPPD TFGKNCSSPC ICQNGGTCDP VSGACRCPPG VSGAHCEDGC
610 620 630 640 650
PKGFYGKHCR KKCHCANRGR CHRLYGACLC DPGLYGRFCH LACPPWAFGP
660 670 680 690 700
GCSEDCLCEQ SHTRSCNSKD GSCSCKAGFQ GERCEAECEP GSFGPGCRNR
710 720 730 740 750
CTCRPGVACD PVSGECRTQC PPGYQGEDCG QECPVGTFGV NCSGSCSCVG
760 770 780 790 800
APCHRVTGEC LCPPGKTGED CGADCPEGRW GLGCQEICPA CEHGASCDPE
810 820 830 840 850
TGTCLCLPGF VGSRCQDACP AGWFGTGCQM RCACANDGHC HPATGRCSCA
860 870 880 890 900
PGWTGLSCQR ACDSGHWGPD CIHPCNCSAG HGNCDAVSGL CLCEAGYEGP
910 920 930 940 950
QCEQWCRQGY FGPGCEQKCR CEHGATCDHV SGACTCPAGW RGSFCEHACP
960 970 980 990 1000
AGFFGLDCGS ACNCSAGAPC DAVTGSCICP AGRWGPHCAQ TCPPLTFGLN
1010 1020 1030 1040 1050
CSQICTCFNG ASCDPVLGQC HCAPGWMGPT CLQACPAGLY GKNCQHSCLC
1060 1070 1080 1090 1100
RNGGSCDPIL GQCTCPEGWT GLACENECLP GHHGAGCRLN CSCLNGGTCD
1110 1120 1130 1140 1150
RLTGHCRCPA GWTGDKCQSP CVSGMFGVHC EEHCACRKGA TCHHVTGACL
1160 1170 1180 1190 1200
CPPGWRGSHC EQACPRGWFG EACAQRCHCP PGASCHHVSG ECHCPPGFTG
1210 1220 1230 1240 1250
PGCEQACQPG TFGKDCEHPC QCPGETWACH PASGACVCAA GYHGTDCQQR
1260 1270 1280 1290 1300
CPSGRYGPGC EQICKCLNGG TCDPATGACY CPAGFLGADC SLACPQGRFG
1310 1320 1330 1340 1350
PSCAHVCTCG QGAACDPVSG TCICPPGKTG GHCERGCPQD RFGKGCEHKC
1360 1370 1380 1390 1400
ACRNGGLCHA TNGSCSCPLG WMGPHCEHAC PAGRYGAACL LECSCQNNGS
1410 1420 1430 1440 1450
CEPTSGACLC GPGFYGQACE DTCPAGFHGS GCQRVCECQQ GAPCDPVSGR
1460 1470 1480 1490 1500
CLCPAGFRGQ FCERGCKPGF FGDGCLQQCN SPTGVPCDPI SGLCLCPPGR
1510 1520 1530 1540 1550
AGTTCDLDCR RGRFGPGCAL RCDCGGGADC DPISGQCHCV DSYTGPTCRE
1560 1570
VPTQLSSIRP APQHSSSKAM KH
Length:1,572
Mass (Da):164,723
Last modified:January 9, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i210DD9589B0FD85A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQ83A0A0A0MQ83_MOUSE
Multiple epidermal growth factor-li...
Megf6
1,572Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ASH4B1ASH4_MOUSE
Multiple epidermal growth factor-li...
Megf6
1,192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YCL7F6YCL7_MOUSE
Multiple epidermal growth factor-li...
Megf6
332Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1055S → N in CAM21839 (PubMed:19468303).Curated1
Sequence conflicti1110A → T in CAM21839 (PubMed:19468303).Curated1
Sequence conflicti1458R → H in CAM21839 (PubMed:19468303).Curated1
Sequence conflicti1481S → C in AAH58571 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL627123 Genomic DNA Translation: CAM21839.1
BC031402 mRNA Translation: AAH31402.1
BC039980 mRNA Translation: AAH39980.1
BC058571 mRNA Translation: AAH58571.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51398.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.275216

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627123 Genomic DNA Translation: CAM21839.1
BC031402 mRNA Translation: AAH31402.1
BC039980 mRNA Translation: AAH39980.1
BC058571 mRNA Translation: AAH58571.1
CCDSiCCDS51398.1
UniGeneiMm.275216

3D structure databases

ProteinModelPortaliQ80V70
SMRiQ80V70
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030897

PTM databases

PhosphoSitePlusiQ80V70

Proteomic databases

MaxQBiQ80V70
PaxDbiQ80V70
PRIDEiQ80V70

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1919351 Megf6

Phylogenomic databases

eggNOGiKOG1218 Eukaryota
ENOG410XQWV LUCA
HOGENOMiHOG000097840
HOVERGENiHBG079790
InParanoidiQ80V70
PhylomeDBiQ80V70
TreeFamiTF332598

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Megf6 mouse

Protein Ontology

More...
PROi
PR:Q80V70

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

CleanExiMM_MEGF6

Family and domain databases

InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR013111 EGF_extracell
IPR011489 EMI_domain
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
PfamiView protein in Pfam
PF12662 cEGF, 2 hits
PF07974 EGF_2, 1 hit
PF07645 EGF_CA, 2 hits
PF12661 hEGF, 4 hits
PF00053 Laminin_EGF, 7 hits
SMARTiView protein in SMART
SM00181 EGF, 32 hits
SM00179 EGF_CA, 8 hits
SM00180 EGF_Lam, 23 hits
SUPFAMiSSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 5 hits
PS00022 EGF_1, 23 hits
PS01186 EGF_2, 23 hits
PS50026 EGF_3, 22 hits
PS01187 EGF_CA, 5 hits
PS51041 EMI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEGF6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80V70
Secondary accession number(s): A2A913
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: January 9, 2007
Last modified: November 7, 2018
This is version 114 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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