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Protein

Centrosomal protein of 104 kDa

Gene

Cep104

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for ciliogenesis and for structural integrity at the ciliary tip.By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 104 kDa
Short name:
Cep104
Gene namesi
Name:Cep104
Synonyms:Kiaa0562
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2687282 Cep104

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507641 – 926Centrosomal protein of 104 kDaAdd BLAST926

Proteomic databases

MaxQBiQ80V31
PaxDbiQ80V31
PRIDEiQ80V31

PTM databases

iPTMnetiQ80V31
PhosphoSitePlusiQ80V31

Expressioni

Gene expression databases

BgeeiENSMUSG00000039523 Expressed in 248 organ(s), highest expression level in islet of Langerhans
CleanExiMM_BC046331
ExpressionAtlasiQ80V31 baseline and differential
GenevisibleiQ80V31 MM

Interactioni

Subunit structurei

Interacts with CCP110 and CEP97.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SF1Q156373EBI-11073001,EBI-744603From Homo sapiens.

Protein-protein interaction databases

BioGridi231061, 7 interactors
IntActiQ80V31, 7 interactors
STRINGi10090.ENSMUSP00000040762

Structurei

3D structure databases

ProteinModelPortaliQ80V31
SMRiQ80V31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati522 – 558HEAT 1Add BLAST37
Repeati603 – 639HEAT 2Add BLAST37

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili212 – 279Sequence analysisAdd BLAST68
Coiled coili678 – 730Sequence analysisAdd BLAST53

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG4825 Eukaryota
ENOG410XPYD LUCA
GeneTreeiENSGT00390000013405
HOVERGENiHBG080375
InParanoidiQ80V31
KOiK16458
OMAiQECQGNA
OrthoDBiEOG091G06XY
PhylomeDBiQ80V31
TreeFamiTF323766

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR008979 Galactose-bd-like_sf
IPR034085 TOG
SMARTiView protein in SMART
SM01349 TOG, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49785 SSF49785, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q80V31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPHKIGFVVV SSSGHEDGFS ARELMIHAPT VSGWRSPKFC QFPQEIVLQM
60 70 80 90 100
VERCRVRKLQ LLAHQYMISS KVEFYISESL PEYLVPYQAE RFRRLGYVSL
110 120 130 140 150
CDNEKTGCKA RELKSVYVDA VGQFLKLIFH QNHANKYNIY NQVALVAINI
160 170 180 190 200
IGDPADLGDE SNITSREKLI DHYLGHSPHN PEDPALDGTF SGRSDYISPL
210 220 230 240 250
DDLAFDMYQD PEVAQIIRRL DERKREAVKK ERYDHAKKLK QAIADLQKVG
260 270 280 290 300
ERLGRYEVEK RCAVEKEDYD LAKEKKQQMA RYRAQVYEQL ELHGLLQGEP
310 320 330 340 350
EMQRPFALPL QPLASPSSPQ HWKAVSSLPR TEKLVAEDSF AGPVLQEKPS
360 370 380 390 400
ASSPQHSAVD PSPPAAGHAP RSHTEVLPYD ERPLPVTRKQ LGEASAEAEV
410 420 430 440 450
KEADSDVRRR GVAGEPEPLT EKALREASAA IDTLGEALVA GAYSKMWSCR
460 470 480 490 500
EDALLALYKK LMEMPVGTQK EDLKNMLRAS VFLIRRAIKD IVASVFQASL
510 520 530 540 550
KLLKMIITQY IPKHKLGKLD TTHCVERAFP LLLARAGDSS ARLRVMALNF
560 570 580 590 600
IQEMALFKEV KSLQLIPSYL VQPLKANASV HLAMSQVDLL ARLLRDLGTE
610 620 630 640 650
SSGFTVDNVM KFAVSALEHR VYEVRETAVR IILDMYRQHP ALTLEHLPPD
660 670 680 690 700
DSATRRNLLY KAIFEGFAKI DGSVLPTEAE VRAQKRVATK EAEKQKKEEM
710 720 730 740 750
KALQGQSGEL RETQAGVQEK ESEAVKLRNQ DPQGRKAVLP DTPEIPANHF
760 770 780 790 800
LDNLCIFCGE RNESFTEEGL DLHYWKHCLM LTRCDHCRQV VEISSLTEHL
810 820 830 840 850
LTECDRRDGF GKCPRCSEAI PKEELPGHIK TKECSPAKPE KVANHCPLCH
860 870 880 890 900
ENFAPGEEAW KVHLMGPAGC TMNLRKTHVL YKATAPQQGK GPAAAKSSTS
910 920
APKVGSKIPT PKGGLSKSSS RTYMRR
Length:926
Mass (Da):103,946
Last modified:June 1, 2003 - v1
Checksum:i7B7822A0284F3C3F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GXW2V9GXW2_MOUSE
Centrosomal protein of 104 kDa
Cep104
524Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL806525 Genomic DNA No translation available.
BC046331 mRNA Translation: AAH46331.1
AK129163 mRNA Translation: BAC97973.1
CCDSiCCDS19005.1
RefSeqiNP_808341.1, NM_177673.2
UniGeneiMm.297905

Genome annotation databases

EnsembliENSMUST00000047497; ENSMUSP00000040762; ENSMUSG00000039523
GeneIDi230967
KEGGimmu:230967
UCSCiuc008wax.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL806525 Genomic DNA No translation available.
BC046331 mRNA Translation: AAH46331.1
AK129163 mRNA Translation: BAC97973.1
CCDSiCCDS19005.1
RefSeqiNP_808341.1, NM_177673.2
UniGeneiMm.297905

3D structure databases

ProteinModelPortaliQ80V31
SMRiQ80V31
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231061, 7 interactors
IntActiQ80V31, 7 interactors
STRINGi10090.ENSMUSP00000040762

PTM databases

iPTMnetiQ80V31
PhosphoSitePlusiQ80V31

Proteomic databases

MaxQBiQ80V31
PaxDbiQ80V31
PRIDEiQ80V31

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047497; ENSMUSP00000040762; ENSMUSG00000039523
GeneIDi230967
KEGGimmu:230967
UCSCiuc008wax.1 mouse

Organism-specific databases

CTDi9731
MGIiMGI:2687282 Cep104
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4825 Eukaryota
ENOG410XPYD LUCA
GeneTreeiENSGT00390000013405
HOVERGENiHBG080375
InParanoidiQ80V31
KOiK16458
OMAiQECQGNA
OrthoDBiEOG091G06XY
PhylomeDBiQ80V31
TreeFamiTF323766

Miscellaneous databases

ChiTaRSiCep104 mouse
PROiPR:Q80V31
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039523 Expressed in 248 organ(s), highest expression level in islet of Langerhans
CleanExiMM_BC046331
ExpressionAtlasiQ80V31 baseline and differential
GenevisibleiQ80V31 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR008979 Galactose-bd-like_sf
IPR034085 TOG
SMARTiView protein in SMART
SM01349 TOG, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49785 SSF49785, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCE104_MOUSE
AccessioniPrimary (citable) accession number: Q80V31
Secondary accession number(s): B1AX97, Q6ZQ95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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