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Protein

Protein SDA1 homolog

Gene

Sdad1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for 60S pre-ribosomal subunits export to the cytoplasm.By similarity

GO - Biological processi

  • actin cytoskeleton organization Source: GO_Central
  • cellular response to leukemia inhibitory factor Source: MGI
  • ribosomal large subunit biogenesis Source: InterPro
  • ribosomal large subunit export from nucleus Source: InterPro

Keywordsi

Biological processProtein transport, Ribosome biogenesis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SDA1 homolog
Alternative name(s):
SDA1 domain-containing protein 1
Gene namesi
Name:Sdad1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2140779 Sdad1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002874831 – 687Protein SDA1 homologAdd BLAST687

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei232PhosphoserineBy similarity1
Modified residuei234PhosphoserineBy similarity1
Modified residuei236PhosphoserineBy similarity1
Modified residuei552PhosphothreonineBy similarity1
Modified residuei585PhosphoserineCombined sources1
Modified residuei589PhosphoserineCombined sources1
Modified residuei595PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80UZ2
PeptideAtlasiQ80UZ2
PRIDEiQ80UZ2

PTM databases

iPTMnetiQ80UZ2
PhosphoSitePlusiQ80UZ2

Expressioni

Gene expression databases

CleanExiMM_SDAD1

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031364

Structurei

3D structure databases

ProteinModelPortaliQ80UZ2
SMRiQ80UZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili254 – 315Sequence analysisAdd BLAST62

Sequence similaritiesi

Belongs to the SDA1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2229 Eukaryota
ENOG410XPHI LUCA
HOGENOMiHOG000204601
HOVERGENiHBG059552
InParanoidiQ80UZ2
KOiK14856
PhylomeDBiQ80UZ2
TreeFamiTF105727

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR027312 Sda1
IPR007949 SDA1_dom
IPR012977 Uncharacterised_NUC130/133_N
PANTHERiPTHR12730 PTHR12730, 1 hit
PfamiView protein in Pfam
PF08158 NUC130_3NT, 1 hit
PF05285 SDA1, 2 hits
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80UZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGRNNNKLP SNLPQLQNLI KRDPPAYVEE FLQQYNHYKS NMEIFKLQPN
60 70 80 90 100
KPSKELAELV MFMAQIGQCY PEHLSNFPQE LKDLLSYNHT VLDPDLRMTF
110 120 130 140 150
CKALILLRNK NLINPSSLLE LFFELLRCHD KLLRKTLYTH IVTDIKNINA
160 170 180 190 200
KHKNNKVNVV LQNFMYTMLR DSNATAAKMS LDVMIELYRR NIWNDAKTVN
210 220 230 240 250
VITTACFSKI TKILVAALTF FLGKDEEEKQ DSDSESEDDG PTARDLLVQY
260 270 280 290 300
ATGKKGSKNK KKLEKAMKVL KKQKKKKKPE VFNFSAIHLI HDPQDFAEKL
310 320 330 340 350
LKQLESCKER FEVKMMLMNL ISRLVGIHEL FLFNFYPFVQ RFLQPHQREV
360 370 380 390 400
TKILLFAAQA SHHLVPPEII QSLLVTVANN FVTDKNSGEV MTVGINAIKE
410 420 430 440 450
ITARCPLAMT EELLQDLAQY KTHKDKNVMM SARTLIHLFR TLNPQMLQKK
460 470 480 490 500
FRGKPTEASI EARIQEYGEL DAKDYIPGAE VLELEKGENT EDDEDGWESA
510 520 530 540 550
SLSEEEEEDG EWVDVHHSSD EEQQAIATKL DSMPMEERKA KAAAISTSRV
560 570 580 590 600
LTQDDFQKIR MAQMKKEMDA APGKAQKRKY LEIDSDEESR GELLSLRDIE
610 620 630 640 650
RLHKKPKSDK ETRLATAMAG RTDRKEFVRK KTKINPFSSS TNKEKKKQKN
660 670 680
FMMMRYSQNV RSKSARSFRD KQLALRDALL KKRKRMK
Length:687
Mass (Da):79,559
Last modified:June 1, 2003 - v1
Checksum:iBC2B308F178DAFF7
GO
Isoform 2 (identifier: Q80UZ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-271: Missing.

Note: No experimental confirmation available.
Show »
Length:686
Mass (Da):79,431
Checksum:i4E80F98D75358640
GO
Isoform 3 (identifier: Q80UZ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-239: DD → VG
     240-687: Missing.

Note: No experimental confirmation available.
Show »
Length:239
Mass (Da):27,745
Checksum:i84B6A0F4DAAFBF8F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0B7A0A0R4J0B7_MOUSE
Protein SDA1
Sdad1
687Annotation score:
A0A0J9YU58A0A0J9YU58_MOUSE
Protein SDA1
Sdad1
64Annotation score:
A0A0J9YV20A0A0J9YV20_MOUSE
Protein SDA1
Sdad1
686Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238D → E in BAC26657 (PubMed:16141072).Curated1
Sequence conflicti238D → E in BAE35938 (PubMed:16141072).Curated1
Sequence conflicti488E → D in BAC26657 (PubMed:16141072).Curated1
Sequence conflicti488E → D in BAE35938 (PubMed:16141072).Curated1
Sequence conflicti664S → T in BAC26657 (PubMed:16141072).Curated1
Sequence conflicti670D → E in BAC26657 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025506238 – 239DD → VG in isoform 3. 1 Publication2
Alternative sequenceiVSP_025507240 – 687Missing in isoform 3. 1 PublicationAdd BLAST448
Alternative sequenceiVSP_025508271Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029881 mRNA Translation: BAC26657.1
AK160646 mRNA Translation: BAE35938.1
AK164608 mRNA Translation: BAE37846.1
BC005751 mRNA Translation: AAH05751.1
BC042708 mRNA Translation: AAH42708.1
CCDSiCCDS19429.1 [Q80UZ2-1]
RefSeqiNP_766301.1, NM_172713.2
UniGeneiMm.86564

Genome annotation databases

GeneIDi231452
KEGGimmu:231452
UCSCiuc008yct.1 mouse [Q80UZ2-1]
uc008ycu.1 mouse [Q80UZ2-3]
uc012dyp.1 mouse [Q80UZ2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029881 mRNA Translation: BAC26657.1
AK160646 mRNA Translation: BAE35938.1
AK164608 mRNA Translation: BAE37846.1
BC005751 mRNA Translation: AAH05751.1
BC042708 mRNA Translation: AAH42708.1
CCDSiCCDS19429.1 [Q80UZ2-1]
RefSeqiNP_766301.1, NM_172713.2
UniGeneiMm.86564

3D structure databases

ProteinModelPortaliQ80UZ2
SMRiQ80UZ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031364

PTM databases

iPTMnetiQ80UZ2
PhosphoSitePlusiQ80UZ2

Proteomic databases

PaxDbiQ80UZ2
PeptideAtlasiQ80UZ2
PRIDEiQ80UZ2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi231452
KEGGimmu:231452
UCSCiuc008yct.1 mouse [Q80UZ2-1]
uc008ycu.1 mouse [Q80UZ2-3]
uc012dyp.1 mouse [Q80UZ2-2]

Organism-specific databases

CTDi55153
MGIiMGI:2140779 Sdad1

Phylogenomic databases

eggNOGiKOG2229 Eukaryota
ENOG410XPHI LUCA
HOGENOMiHOG000204601
HOVERGENiHBG059552
InParanoidiQ80UZ2
KOiK14856
PhylomeDBiQ80UZ2
TreeFamiTF105727

Miscellaneous databases

PROiPR:Q80UZ2
SOURCEiSearch...

Gene expression databases

CleanExiMM_SDAD1

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR027312 Sda1
IPR007949 SDA1_dom
IPR012977 Uncharacterised_NUC130/133_N
PANTHERiPTHR12730 PTHR12730, 1 hit
PfamiView protein in Pfam
PF08158 NUC130_3NT, 1 hit
PF05285 SDA1, 2 hits
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSDA1_MOUSE
AccessioniPrimary (citable) accession number: Q80UZ2
Secondary accession number(s): Q3TP91
, Q3TUN3, Q8CDL7, Q99JQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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