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Entry version 121 (08 May 2019)
Sequence version 2 (06 Mar 2007)
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Protein

Transcription initiation factor TFIID subunit 1

Gene

Taf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:10438527). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4.By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Autophosphorylates on Ser residues. Inhibited by retinoblastoma tumor suppressor protein, RB1. Binding to TAF1 or CIITA inhibits the histone acetyltransferase activity.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1216 – 1294HMG boxBy similarityAdd BLAST79

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 1 (EC:2.3.1.48By similarity, EC:2.7.11.1)
Alternative name(s):
Cell cycle gene 1 protein
TBP-associated factor 250 kDa
Short name:
p250
Transcription initiation factor TFIID 250 kDa subunit
Short name:
TAF(II)250
Short name:
TAFII-250
Short name:
TAFII250
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Taf1
Synonyms:Ccg1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1336878 Taf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002785241 – 1891Transcription initiation factor TFIID subunit 1Add BLAST1891

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei328Phosphoserine; by autocatalysisBy similarity1
Modified residuei565N6-acetyllysineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki570Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki583Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1690PhosphoserineCombined sources1
Modified residuei1693PhosphoserineCombined sources1
Modified residuei1799PhosphoserineCombined sources1
Modified residuei1802PhosphoserineCombined sources1
Modified residuei1820PhosphoserineCombined sources1
Modified residuei1847PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by casein kinase II in vitro.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80UV9

PeptideAtlas

More...
PeptideAtlasi
Q80UV9

PRoteomics IDEntifications database

More...
PRIDEi
Q80UV9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80UV9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80UV9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031314 Expressed in 253 organ(s), highest expression level in manus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q80UV9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80UV9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

TAF1 is the largest component of transcription factor TFIID that is composed of TBP and a variety of TBP-associated factors (PubMed:10438527). TAF1, when part of the TFIID complex, interacts with C-terminus of TP53.

Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13.

Interacts with TAF7; the interaction is direct.

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. RB1 interacts with the N-terminal domain of TAF1.

Interacts with ASF1A and ASF1B.

Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro) (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TAF7Q155452EBI-15563115,EBI-1560194From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
234808, 2 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-932 General transcription factor complex TFIID
CPX-959 General transcription factor complex TFIID, Taf4b variant

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q80UV9

Database of interacting proteins

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DIPi
DIP-61093N

Protein interaction database and analysis system

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IntActi
Q80UV9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000098895

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q80UV9

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 435Protein kinase 1Add BLAST435
Domaini1418 – 1488Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini1446 – 1891Protein kinase 2Add BLAST446
Domaini1541 – 1611Bromo 2PROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni538 – 997Histone acetyltransferase (HAT)By similarityAdd BLAST460
Regioni1363 – 1650Interaction with ASF1A and ASF1BBy similarityAdd BLAST288

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1372 – 1379Nuclear localization signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi157 – 165Poly-Pro9
Compositional biasi204 – 211Poly-Ser8
Compositional biasi1848 – 1855Poly-Glu8

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Bromo domain mediates interaction with histones that have acetylated lysine residues at specific positions. The second domain also recognizes and binds histones that are butyrylated and crotonylated.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TAF1 family.Curated

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0008 Eukaryota
COG5076 LUCA
COG5179 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155242

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q80UV9

KEGG Orthology (KO)

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KOi
K03125

Identification of Orthologs from Complete Genome Data

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OMAi
RSFHRPP

Database of Orthologous Groups

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OrthoDBi
103411at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1100.10, 1 hit
1.20.920.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR040240 TAF1
IPR011177 TAF1_animal
IPR009067 TAF_II_230-bd
IPR036741 TAFII-230_TBP-bd_sf
IPR022591 TFIID_sub1_DUF3591
IPR041670 Znf-CCHC_6

The PANTHER Classification System

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PANTHERi
PTHR13900 PTHR13900, 2 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF00439 Bromodomain, 2 hits
PF12157 DUF3591, 1 hit
PF09247 TBP-binding, 1 hit
PF15288 zf-CCHC_6, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF003047 TAF1_animal, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00297 BROMO, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47055 SSF47055, 1 hit
SSF47370 SSF47370, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 2 hits
PS50014 BROMODOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80UV9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPGWAGLLQ DKGGGSPSVV MSDTDSDEES AGGGPFSLTG FLFGNINGAG
60 70 80 90 100
QLEGESVLDD ECKKHLAGLG ALGLGSLITE LTANEELSGS DGALVNDEGW
110 120 130 140 150
IRSREDAVDY SDINEVAEDE SRRYQQTMGS LQPLCHTDYD EDDYDADCED
160 170 180 190 200
IDCKLMPPPP PPPGPLKKEK DQDDITGVSE DGEGIILPSI IAPSSLASEK
210 220 230 240 250
VDFSSSSDSE SEMGPQDAAQ SESKDGQLTL PLAGIMQHDA TKLLPSVTEL
260 270 280 290 300
FPEFRPGKVL RFLRLFGPGK NVPSVWRSAR RKRKKKHREL IQEGQVQEEE
310 320 330 340 350
CSVELEVNQK SLWNYDYAPP PLPDQCLSDD EITMMAPVES KFSQSTGDTD
360 370 380 390 400
KVMDTKPRVA EWRYGPARLW YDMLGVPEDG SGFDYGFKMK KTEHESTIKC
410 420 430 440 450
NIMKKLRKLE ENSGVDLLAD ENFLMVTQLH WEDDIIWDGE DVKHKGTKPQ
460 470 480 490 500
RASLAGWLPS SMTRNAMAYN VQQGFTATLD DDKPWYSIFP IDNEDLVYGR
510 520 530 540 550
WEDNIIWDAQ NMPRILEPPV LTLDPNDENL ILEIPDEKEE ATSNSPSKEN
560 570 580 590 600
KKESSLKKSR ILLGKTGVIK EEPQQNMSQP EVKDPWNLSN DEYYYPKQQG
610 620 630 640 650
LRGTFGGNII QHSIPAVELR QPFFPTHMGP IKLRQFHRPP LKKYSFGALS
660 670 680 690 700
QPGPHSVQPL LKHIKKKAKM REQERQASGG GEMFFMRTPQ DLTGKDGDLI
710 720 730 740 750
LAEYSEENGP LMMQVGMATK IKNYYKRKPG KDPGAPDCKY GETVYCHTSP
760 770 780 790 800
FLGSLHPGQL LQAFENNLFR APIYLHKMPE SDFLIIRTRQ GYFIRELVDI
810 820 830 840 850
FVVGQQCPLF EVPGPNSKRA NTHIRDFLQV FIYRLFWKSK DRPRRIRMED
860 870 880 890 900
IKKAFPSHSE SSIRKRLKLC ADFKRTGMDS NWWVLKSDFR LPTEEEIRAM
910 920 930 940 950
VSPEQCCAYY SMIAAEQRLK DAGYGEKSFF APEEENEEDF QMKIDDEVRT
960 970 980 990 1000
APWNTTRAFI AAMKGKCLLE VTGVADPTGC GEGFSYVKIP NKPTQQKDDK
1010 1020 1030 1040 1050
EPQPVKKTVT GTDADLRRLS LKNAKQLLRK FGVPEEEIKK LSRWEVIDVV
1060 1070 1080 1090 1100
RTMSTEQARS GEGPMSKFAR GSRFSVAEHQ ERYKEECQRI FDLQNKVLSS
1110 1120 1130 1140 1150
TEVLSTDTDS SSAEDSDFEE MGKNIENMLQ NKKTSSQLSR EREEQERKEL
1160 1170 1180 1190 1200
QRMLLAAGSA AAGNNHRDDD TASVTSLNSS ATGRCLKIYR TFRDEEGKEY
1210 1220 1230 1240 1250
VRCETVRKAT VIDAYVRIRT TKDEEFIRKF ALFDEQHREE MRKERRRIQE
1260 1270 1280 1290 1300
QLRRLKRNQE KEKLKGPPEK KPKKMKERPD LKLKCGACGA IGHMRTNKFC
1310 1320 1330 1340 1350
PLYYQTNAPP SNPVAMTEEQ EEELEKTVIH NDNEELIKVE GTKIVLGKQL
1360 1370 1380 1390 1400
IESADEVRRK SLVLKFPKQQ LPPKKKRRVG TTVHCDYLNR PHKSIHRRRT
1410 1420 1430 1440 1450
DPMVTLSSIL ESIINDMRDL PNTYPFHTPV NAKVVKDYYK IITRPMDLQT
1460 1470 1480 1490 1500
LRENVRKRLY PSREEFREHL ELIVKNSATY NGPKHSLTQI SQSMLDLCDE
1510 1520 1530 1540 1550
KLKEKEDKLA RLEKAINPLL DDDDQVAFSF ILDNIVTQKM MAVPDSWPFH
1560 1570 1580 1590 1600
HPVNKKFVPD YYKVIVSPMD LETIRKNISK HKYQSRESFL DDVNLILANS
1610 1620 1630 1640 1650
VKYNGPESQY TKTAQEIVNV CHQTLTEYDE HLTQLEKDIC TAKEAALEEA
1660 1670 1680 1690 1700
ELESLDPMTP GPYTPQPPDL YDNNTSLSVS RDASVYQDES NLSVLDIPSA
1710 1720 1730 1740 1750
TSEKQLTQEG GDGDGDLADE EEGTVQQPQA SVLYEDLLMS EGEDDEEDAG
1760 1770 1780 1790 1800
SDEEGDNPFF AIQLSESGSD SDVESGSLRP KQPRVLQENT RMGMENEESM
1810 1820 1830 1840 1850
MSYEGDGGDA SRGLEDSNIS YGSYEEPDPK SNTQDTSFSS IGGYEVSEEE
1860 1870 1880 1890
EDEEEQRSGP SVLSQVHLSE DEEDSEDFHS IAGDTDLDSD E
Length:1,891
Mass (Da):214,419
Last modified:March 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A4EA0475BB3E885
GO
Isoform 2 (identifier: Q80UV9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-962: Missing.

Note: No experimental confirmation available.
Show »
Length:929
Mass (Da):105,780
Checksum:iA92987089CF8811D
GO
Isoform 3 (identifier: Q80UV9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-198: Missing.

Note: No experimental confirmation available.
Show »
Length:1,870
Mass (Da):212,382
Checksum:iC7C3C29E868C630F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1Q2W7B1Q2W7_MOUSE
Transcription initiation factor TFI...
Taf1 N-TAF1
1,893Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YZK4D3YZK4_MOUSE
Transcription initiation factor TFI...
Taf1
1,902Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1B9S4R1B9_MOUSE
Transcription initiation factor TFI...
Taf1
1,733Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC34383 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti217D → E in AAD23348 (PubMed:10070062).Curated1
Sequence conflicti221S → A in AAD23348 (PubMed:10070062).Curated1
Sequence conflicti261R → H in AAD23348 (PubMed:10070062).Curated1
Sequence conflicti289E → K in AAD23348 (PubMed:10070062).Curated1
Sequence conflicti867 – 868LK → EG in AAC62118 (PubMed:9751712).Curated2
Sequence conflicti876T → Q in AAD23349 (PubMed:10070062).Curated1
Sequence conflicti1302 – 1306LYYQT → AFVAS in AAC62118 (PubMed:9751712).Curated5
Sequence conflicti1358R → P in AAD23350 (PubMed:10070062).Curated1
Sequence conflicti1388L → F in AAD23350 (PubMed:10070062).Curated1
Sequence conflicti1450T → E in AAD23350 (PubMed:10070062).Curated1
Sequence conflicti1469 – 1470HL → QM in AAD23350 (PubMed:10070062).Curated2
Sequence conflicti1736D → N in AAH94568 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0233201 – 962Missing in isoform 2. 1 PublicationAdd BLAST962
Alternative sequenceiVSP_023321178 – 198Missing in isoform 3. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL806534 Genomic DNA No translation available.
AL831722 Genomic DNA No translation available.
BC047418 mRNA Translation: AAH47418.1
BC094568 mRNA Translation: AAH94568.1
AK045586 mRNA Translation: BAC32425.1
AK046668 mRNA Translation: BAC32828.1
AK049826 mRNA Translation: BAC33938.1
AK050691 mRNA Translation: BAC34383.1 Different initiation.
AK132088 mRNA Translation: BAE20976.1
AK143571 mRNA Translation: BAE25442.1
AF081115 mRNA Translation: AAD23349.1
AF081116 mRNA Translation: AAD23348.1
AF081117 mRNA Translation: AAD23350.1
AF022178 mRNA Translation: AAC62118.1

NCBI Reference Sequences

More...
RefSeqi
NP_001277658.1, NM_001290729.1
XP_006528113.1, XM_006528050.3 [Q80UV9-1]
XP_006528115.1, XM_006528052.3 [Q80UV9-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000118878; ENSMUSP00000112772; ENSMUSG00000031314 [Q80UV9-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
270627

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:270627

UCSC genome browser

More...
UCSCi
uc009txy.1 mouse [Q80UV9-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL806534 Genomic DNA No translation available.
AL831722 Genomic DNA No translation available.
BC047418 mRNA Translation: AAH47418.1
BC094568 mRNA Translation: AAH94568.1
AK045586 mRNA Translation: BAC32425.1
AK046668 mRNA Translation: BAC32828.1
AK049826 mRNA Translation: BAC33938.1
AK050691 mRNA Translation: BAC34383.1 Different initiation.
AK132088 mRNA Translation: BAE20976.1
AK143571 mRNA Translation: BAE25442.1
AF081115 mRNA Translation: AAD23349.1
AF081116 mRNA Translation: AAD23348.1
AF081117 mRNA Translation: AAD23350.1
AF022178 mRNA Translation: AAC62118.1
RefSeqiNP_001277658.1, NM_001290729.1
XP_006528113.1, XM_006528050.3 [Q80UV9-1]
XP_006528115.1, XM_006528052.3 [Q80UV9-3]

3D structure databases

SMRiQ80UV9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi234808, 2 interactors
ComplexPortaliCPX-932 General transcription factor complex TFIID
CPX-959 General transcription factor complex TFIID, Taf4b variant
CORUMiQ80UV9
DIPiDIP-61093N
IntActiQ80UV9, 1 interactor
STRINGi10090.ENSMUSP00000098895

PTM databases

iPTMnetiQ80UV9
PhosphoSitePlusiQ80UV9

Proteomic databases

PaxDbiQ80UV9
PeptideAtlasiQ80UV9
PRIDEiQ80UV9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118878; ENSMUSP00000112772; ENSMUSG00000031314 [Q80UV9-3]
GeneIDi270627
KEGGimmu:270627
UCSCiuc009txy.1 mouse [Q80UV9-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6872
MGIiMGI:1336878 Taf1

Phylogenomic databases

eggNOGiKOG0008 Eukaryota
COG5076 LUCA
COG5179 LUCA
GeneTreeiENSGT00940000155242
InParanoidiQ80UV9
KOiK03125
OMAiRSFHRPP
OrthoDBi103411at2759

Enzyme and pathway databases

ReactomeiR-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Taf1 mouse

Protein Ontology

More...
PROi
PR:Q80UV9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031314 Expressed in 253 organ(s), highest expression level in manus
ExpressionAtlasiQ80UV9 baseline and differential
GenevisibleiQ80UV9 MM

Family and domain databases

Gene3Di1.10.1100.10, 1 hit
1.20.920.10, 2 hits
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR040240 TAF1
IPR011177 TAF1_animal
IPR009067 TAF_II_230-bd
IPR036741 TAFII-230_TBP-bd_sf
IPR022591 TFIID_sub1_DUF3591
IPR041670 Znf-CCHC_6
PANTHERiPTHR13900 PTHR13900, 2 hits
PfamiView protein in Pfam
PF00439 Bromodomain, 2 hits
PF12157 DUF3591, 1 hit
PF09247 TBP-binding, 1 hit
PF15288 zf-CCHC_6, 1 hit
PIRSFiPIRSF003047 TAF1_animal, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 2 hits
SUPFAMiSSF47055 SSF47055, 1 hit
SSF47370 SSF47370, 2 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 2 hits
PS50014 BROMODOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAF1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80UV9
Secondary accession number(s): A2AM32
, A2AM33, O35361, Q3UPF3, Q3V223, Q505F9, Q8BQH8, Q8BQQ7, Q8BR59, Q8C7N8, Q9WTW9, Q9WTX0, Q9WTX1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: May 8, 2019
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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