UniProtKB - Q80UV9 (TAF1_MOUSE)

>sp|Q80UV9|TAF1_MOUSE Transcription initiation factor TFIID subunit 1 OS=Mus musculus OX=10090 GN=Taf1 PE=1 SV=2
MGPGWAGLLQDKGGGSPSVVMSDTDSDEESAGGGPFSLTGFLFGNINGAGQLEGESVLDD
ECKKHLAGLGALGLGSLITELTANEELSGSDGALVNDEGWIRSREDAVDYSDINEVAEDE
SRRYQQTMGSLQPLCHTDYDEDDYDADCEDIDCKLMPPPPPPPGPLKKEKDQDDITGVSE
DGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQDAAQSESKDGQLTLPLAGIMQHDA
TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEGQVQEEE
CSVELEVNQKSLWNYDYAPPPLPDQCLSDDEITMMAPVESKFSQSTGDTDKVMDTKPRVA
EWRYGPARLWYDMLGVPEDGSGFDYGFKMKKTEHESTIKCNIMKKLRKLEENSGVDLLAD
ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFTATLD
DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQNMPRILEPPVLTLDPNDENLILEIPDEKEE
ATSNSPSKENKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
SDFLIIRTRQGYFIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR
EREEQERKELQRMLLAAGSAAAGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY
VRCETVRKATVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE
KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG
TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK
IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
YYKVIVSPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
CHQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDNNTSLSVS
RDASVYQDESNLSVLDIPSATSEKQLTQEGGDGDGDLADEEEGTVQQPQASVLYEDLLMS
EGEDDEEDAGSDEEGDNPFFAIQLSESGSDSDVESGSLRPKQPRVLQENTRMGMENEESM
MSYEGDGGDASRGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEQRSGP
SVLSQVHLSEDEEDSEDFHSIAGDTDLDSDE

Entry version 129 (12 Aug 2020)
Sequence version 2 (06 Mar 2007)
Previous versions | rss

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Protein

Transcription initiation factor TFIID subunit 1

Gene

Taf1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:10438527). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4.By similarity1 Publication

Catalytic activityⁱ

Cofactorⁱ

Mg²⁺By similarity

Activity regulationⁱ

Autophosphorylates on Ser residues. Inhibited by retinoblastoma tumor suppressor protein, RB1. Binding to TAF1 or CIITA inhibits the histone acetyltransferase activity.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	1216 – 1294	HMG boxBy similarityAdd BLAST		79

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cellular response to ATP Source: MGI
cellular response to DNA damage stimulus Source: MGI
cellular response to UV Source: MGI
DNA-templated transcription, initiation Source: InterPro
histone acetylation
Source: UniProtKB
Inferred from direct assayⁱ
- "TAFII55 binding to TAFII250 inhibits its acetyltransferase activity."
  Gegonne A., Weissman J.D., Singer D.S.
  Proc. Natl. Acad. Sci. U.S.A. 98:12432-12437(2001) [PubMed] [Europe PMC] [Abstract]
midbrain development Source: MGI
negative regulation of gene expression Source: MGI
negative regulation of protein autoubiquitination Source: MGI
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage Source: MGI
negative regulation of ubiquitin-dependent protein catabolic process Source: MGI
peptidyl-serine phosphorylation Source: MGI
peptidyl-threonine phosphorylation Source: MGI
positive regulation of androgen receptor activity Source: MGI
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
positive regulation of protein binding Source: MGI
positive regulation of transcription by RNA polymerase I Source: MGI
positive regulation of transcription by RNA polymerase II Source: MGI
protein autophosphorylation Source: MGI
protein phosphorylation Source: MGI
protein polyubiquitination Source: MGI
protein stabilization Source: MGI
transcription factor catabolic process Source: MGI
ubiquitin-dependent protein catabolic process Source: MGI

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Cell cycle, Transcription, Transcription regulation
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-674695, RNA Polymerase II Pre-transcription Events R-MMU-6804756, Regulation of TP53 Activity through Phosphorylation R-MMU-73776, RNA Polymerase II Promoter Escape R-MMU-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-MMU-75953, RNA Polymerase II Transcription Initiation R-MMU-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance

Reactomeⁱ

R-MMU-674695, RNA Polymerase II Pre-transcription Events
R-MMU-6804756, Regulation of TP53 Activity through Phosphorylation
R-MMU-73776, RNA Polymerase II Promoter Escape
R-MMU-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953, RNA Polymerase II Transcription Initiation
R-MMU-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription initiation factor TFIID subunit 1 (EC:2.3.1.48By similarity, EC:2.7.11.1) Alternative name(s): Cell cycle gene 1 protein TBP-associated factor 250 kDa Short name: p250 Transcription initiation factor TFIID 250 kDa subunit Short name: TAF(II)250 Short name: TAFII-250 Short name: TAFII250
Gene namesⁱ	Name:Taf1 Synonyms:Ccg1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome X

Organism-specific databases

MGIⁱ	MGI:1336878, Taf1

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000278524	1 – 1891	Transcription initiation factor TFIID subunit 1Add BLAST		1891

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	328	Phosphoserine; by autocatalysisBy similarity	1
Modified residueⁱ	565	N6-acetyllysineCombined sources	1
Cross-linkⁱ	570	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	583	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	1690	PhosphoserineCombined sources	1
Modified residueⁱ	1693	PhosphoserineCombined sources	1
Modified residueⁱ	1799	PhosphoserineCombined sources	1
Modified residueⁱ	1802	PhosphoserineCombined sources	1
Modified residueⁱ	1820	PhosphoserineCombined sources	1
Modified residueⁱ	1847	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated by casein kinase II in vitro.By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q80UV9
PeptideAtlas More...PeptideAtlasⁱ	Q80UV9
PRIDEⁱ	Q80UV9

PTM databases

iPTMnetⁱ	Q80UV9
PhosphoSitePlusⁱ	Q80UV9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000031314, Expressed in manus and 266 other tissues
ExpressionAtlasⁱ	Q80UV9, baseline and differential
Genevisibleⁱ	Q80UV9, MM

Interactionⁱ

Subunit structureⁱ

TAF1 is the largest component of transcription factor TFIID that is composed of TBP and a variety of TBP-associated factors (PubMed:10438527). TAF1, when part of the TFIID complex, interacts with C-terminus of TP53.

Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13.

Interacts with TAF7; the interaction is direct.

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. RB1 interacts with the N-terminal domain of TAF1.

Interacts with ASF1A and ASF1B.

Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro) (By similarity).

By similarity

Binary interactionsⁱ

Isoform 1 [Q80UV9-1]

With	#Exp.	IntAct
TAF7 [Q15545] from Homo sapiens.	2	EBI-15563115,EBI-1560194

GO - Molecular functionⁱ

lysine-acetylated histone binding Source: MGI
nuclear hormone receptor binding Source: MGI
p53 binding Source: MGI
protein heterodimerization activity Source: MGI
RNA polymerase II-specific DNA-binding transcription factor binding Source: MGI
TBP-class protein binding Source: MGI
transcription factor binding Source: MGI

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	234808, 13 interactors
ComplexPortalⁱ	CPX-932, General transcription factor complex TFIID CPX-959, General transcription factor complex TFIID, Taf4b variant
CORUMⁱ	Q80UV9
Database of interacting proteins More...DIPⁱ	DIP-61093N
IntActⁱ	Q80UV9, 1 interactor
STRINGⁱ	10090.ENSMUSP00000098895

Miscellaneous databases

RNActⁱ	Q80UV9, protein

RNActⁱ

Q80UV9, protein

Structureⁱ

3D structure databases

SMRⁱ	Q80UV9
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 435	Protein kinase 1Add BLAST	435
Domainⁱ	1418 – 1488	Bromo 1PROSITE-ProRule annotationAdd BLAST	71
Domainⁱ	1446 – 1891	Protein kinase 2Add BLAST	446
Domainⁱ	1541 – 1611	Bromo 2PROSITE-ProRule annotationAdd BLAST	71

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	538 – 997	Histone acetyltransferase (HAT)By similarityAdd BLAST		460
Regionⁱ	1363 – 1650	Interaction with ASF1A and ASF1BBy similarityAdd BLAST		288

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	1372 – 1379	Nuclear localization signalSequence analysis		8

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	157 – 165	Poly-Pro	9
Compositional biasⁱ	204 – 211	Poly-Ser	8
Compositional biasⁱ	1848 – 1855	Poly-Glu	8

Domainⁱ

The Bromo domain mediates interaction with histones that have acetylated lysine residues at specific positions. The second domain also recognizes and binds histones that are butyrylated and crotonylated.By similarity

Sequence similaritiesⁱ

Belongs to the TAF1 family.Curated

Keywords - Domainⁱ

Bromodomain, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0008, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155242
InParanoidⁱ	Q80UV9
KEGG Orthology (KO) More...KOⁱ	K03125
OMAⁱ	KACPLYT
Database of Orthologous Groups More...OrthoDBⁱ	103411at2759

Family and domain databases

Gene3Dⁱ	1.10.1100.10, 1 hit 1.20.920.10, 2 hits
InterProⁱ	View protein in InterPro IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR040240, TAF1 IPR011177, TAF1_animal IPR009067, TAF_II_230-bd IPR036741, TAFII-230_TBP-bd_sf IPR022591, TFIID_sub1_DUF3591 IPR041670, Znf-CCHC_6
PANTHERⁱ	PTHR13900, PTHR13900, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00439, Bromodomain, 2 hits PF12157, DUF3591, 1 hit PF09247, TBP-binding, 1 hit PF15288, zf-CCHC_6, 1 hit
PIRSFⁱ	PIRSF003047, TAF1_animal, 1 hit
PRINTSⁱ	PR00503, BROMODOMAIN
SMARTⁱ	View protein in SMART SM00297, BROMO, 2 hits
SUPFAMⁱ	SSF47055, SSF47055, 1 hit SSF47370, SSF47370, 2 hits
PROSITEⁱ	View protein in PROSITE PS00633, BROMODOMAIN_1, 2 hits PS50014, BROMODOMAIN_2, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q80UV9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MGPGWAGLLQ DKGGGSPSVV MSDTDSDEES AGGGPFSLTG FLFGNINGAG 
        60         70         80         90        100
QLEGESVLDD ECKKHLAGLG ALGLGSLITE LTANEELSGS DGALVNDEGW 
       110        120        130        140        150
IRSREDAVDY SDINEVAEDE SRRYQQTMGS LQPLCHTDYD EDDYDADCED 
       160        170        180        190        200
IDCKLMPPPP PPPGPLKKEK DQDDITGVSE DGEGIILPSI IAPSSLASEK 
       210        220        230        240        250
VDFSSSSDSE SEMGPQDAAQ SESKDGQLTL PLAGIMQHDA TKLLPSVTEL 
       260        270        280        290        300
FPEFRPGKVL RFLRLFGPGK NVPSVWRSAR RKRKKKHREL IQEGQVQEEE 
       310        320        330        340        350
CSVELEVNQK SLWNYDYAPP PLPDQCLSDD EITMMAPVES KFSQSTGDTD 
       360        370        380        390        400
KVMDTKPRVA EWRYGPARLW YDMLGVPEDG SGFDYGFKMK KTEHESTIKC 
       410        420        430        440        450
NIMKKLRKLE ENSGVDLLAD ENFLMVTQLH WEDDIIWDGE DVKHKGTKPQ 
       460        470        480        490        500
RASLAGWLPS SMTRNAMAYN VQQGFTATLD DDKPWYSIFP IDNEDLVYGR 
       510        520        530        540        550
WEDNIIWDAQ NMPRILEPPV LTLDPNDENL ILEIPDEKEE ATSNSPSKEN 
       560        570        580        590        600
KKESSLKKSR ILLGKTGVIK EEPQQNMSQP EVKDPWNLSN DEYYYPKQQG 
       610        620        630        640        650
LRGTFGGNII QHSIPAVELR QPFFPTHMGP IKLRQFHRPP LKKYSFGALS 
       660        670        680        690        700
QPGPHSVQPL LKHIKKKAKM REQERQASGG GEMFFMRTPQ DLTGKDGDLI 
       710        720        730        740        750
LAEYSEENGP LMMQVGMATK IKNYYKRKPG KDPGAPDCKY GETVYCHTSP 
       760        770        780        790        800
FLGSLHPGQL LQAFENNLFR APIYLHKMPE SDFLIIRTRQ GYFIRELVDI 
       810        820        830        840        850
FVVGQQCPLF EVPGPNSKRA NTHIRDFLQV FIYRLFWKSK DRPRRIRMED 
       860        870        880        890        900
IKKAFPSHSE SSIRKRLKLC ADFKRTGMDS NWWVLKSDFR LPTEEEIRAM 
       910        920        930        940        950
VSPEQCCAYY SMIAAEQRLK DAGYGEKSFF APEEENEEDF QMKIDDEVRT 
       960        970        980        990       1000
APWNTTRAFI AAMKGKCLLE VTGVADPTGC GEGFSYVKIP NKPTQQKDDK 
      1010       1020       1030       1040       1050
EPQPVKKTVT GTDADLRRLS LKNAKQLLRK FGVPEEEIKK LSRWEVIDVV 
      1060       1070       1080       1090       1100
RTMSTEQARS GEGPMSKFAR GSRFSVAEHQ ERYKEECQRI FDLQNKVLSS 
      1110       1120       1130       1140       1150
TEVLSTDTDS SSAEDSDFEE MGKNIENMLQ NKKTSSQLSR EREEQERKEL 
      1160       1170       1180       1190       1200
QRMLLAAGSA AAGNNHRDDD TASVTSLNSS ATGRCLKIYR TFRDEEGKEY 
      1210       1220       1230       1240       1250
VRCETVRKAT VIDAYVRIRT TKDEEFIRKF ALFDEQHREE MRKERRRIQE 
      1260       1270       1280       1290       1300
QLRRLKRNQE KEKLKGPPEK KPKKMKERPD LKLKCGACGA IGHMRTNKFC 
      1310       1320       1330       1340       1350
PLYYQTNAPP SNPVAMTEEQ EEELEKTVIH NDNEELIKVE GTKIVLGKQL 
      1360       1370       1380       1390       1400
IESADEVRRK SLVLKFPKQQ LPPKKKRRVG TTVHCDYLNR PHKSIHRRRT 
      1410       1420       1430       1440       1450
DPMVTLSSIL ESIINDMRDL PNTYPFHTPV NAKVVKDYYK IITRPMDLQT 
      1460       1470       1480       1490       1500
LRENVRKRLY PSREEFREHL ELIVKNSATY NGPKHSLTQI SQSMLDLCDE 
      1510       1520       1530       1540       1550
KLKEKEDKLA RLEKAINPLL DDDDQVAFSF ILDNIVTQKM MAVPDSWPFH 
      1560       1570       1580       1590       1600
HPVNKKFVPD YYKVIVSPMD LETIRKNISK HKYQSRESFL DDVNLILANS 
      1610       1620       1630       1640       1650
VKYNGPESQY TKTAQEIVNV CHQTLTEYDE HLTQLEKDIC TAKEAALEEA 
      1660       1670       1680       1690       1700
ELESLDPMTP GPYTPQPPDL YDNNTSLSVS RDASVYQDES NLSVLDIPSA 
      1710       1720       1730       1740       1750
TSEKQLTQEG GDGDGDLADE EEGTVQQPQA SVLYEDLLMS EGEDDEEDAG 
      1760       1770       1780       1790       1800
SDEEGDNPFF AIQLSESGSD SDVESGSLRP KQPRVLQENT RMGMENEESM 
      1810       1820       1830       1840       1850
MSYEGDGGDA SRGLEDSNIS YGSYEEPDPK SNTQDTSFSS IGGYEVSEEE 
      1860       1870       1880       1890 
EDEEEQRSGP SVLSQVHLSE DEEDSEDFHS IAGDTDLDSD E

Length:1,891

Mass (Da):214,419

Last modified:March 6, 2007 - v2

Checksum:ⁱ9A4EA0475BB3E885

Isoform 2 (identifier: Q80UV9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-962: Missing.

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        10         20         30         40         50
MKGKCLLEVT GVADPTGCGE GFSYVKIPNK PTQQKDDKEP QPVKKTVTGT 
        60         70         80         90        100
DADLRRLSLK NAKQLLRKFG VPEEEIKKLS RWEVIDVVRT MSTEQARSGE 
       110        120        130        140        150
GPMSKFARGS RFSVAEHQER YKEECQRIFD LQNKVLSSTE VLSTDTDSSS 
       160        170        180        190        200
AEDSDFEEMG KNIENMLQNK KTSSQLSRER EEQERKELQR MLLAAGSAAA 
       210        220        230        240        250
GNNHRDDDTA SVTSLNSSAT GRCLKIYRTF RDEEGKEYVR CETVRKATVI 
       260        270        280        290        300
DAYVRIRTTK DEEFIRKFAL FDEQHREEMR KERRRIQEQL RRLKRNQEKE 
       310        320        330        340        350
KLKGPPEKKP KKMKERPDLK LKCGACGAIG HMRTNKFCPL YYQTNAPPSN 
       360        370        380        390        400
PVAMTEEQEE ELEKTVIHND NEELIKVEGT KIVLGKQLIE SADEVRRKSL 
       410        420        430        440        450
VLKFPKQQLP PKKKRRVGTT VHCDYLNRPH KSIHRRRTDP MVTLSSILES 
       460        470        480        490        500
IINDMRDLPN TYPFHTPVNA KVVKDYYKII TRPMDLQTLR ENVRKRLYPS 
       510        520        530        540        550
REEFREHLEL IVKNSATYNG PKHSLTQISQ SMLDLCDEKL KEKEDKLARL 
       560        570        580        590        600
EKAINPLLDD DDQVAFSFIL DNIVTQKMMA VPDSWPFHHP VNKKFVPDYY 
       610        620        630        640        650
KVIVSPMDLE TIRKNISKHK YQSRESFLDD VNLILANSVK YNGPESQYTK 
       660        670        680        690        700
TAQEIVNVCH QTLTEYDEHL TQLEKDICTA KEAALEEAEL ESLDPMTPGP 
       710        720        730        740        750
YTPQPPDLYD NNTSLSVSRD ASVYQDESNL SVLDIPSATS EKQLTQEGGD 
       760        770        780        790        800
GDGDLADEEE GTVQQPQASV LYEDLLMSEG EDDEEDAGSD EEGDNPFFAI 
       810        820        830        840        850
QLSESGSDSD VESGSLRPKQ PRVLQENTRM GMENEESMMS YEGDGGDASR 
       860        870        880        890        900
GLEDSNISYG SYEEPDPKSN TQDTSFSSIG GYEVSEEEED EEEQRSGPSV 
       910        920 
LSQVHLSEDE EDSEDFHSIA GDTDLDSDE

Show »

Length:929

Mass (Da):105,780

Checksum:ⁱA92987089CF8811D

Isoform 3 (identifier: Q80UV9-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
178-198: Missing.

« Hide

        10         20         30         40         50
MGPGWAGLLQ DKGGGSPSVV MSDTDSDEES AGGGPFSLTG FLFGNINGAG 
        60         70         80         90        100
QLEGESVLDD ECKKHLAGLG ALGLGSLITE LTANEELSGS DGALVNDEGW 
       110        120        130        140        150
IRSREDAVDY SDINEVAEDE SRRYQQTMGS LQPLCHTDYD EDDYDADCED 
       160        170        180        190        200
IDCKLMPPPP PPPGPLKKEK DQDDITGEKV DFSSSSDSES EMGPQDAAQS 
       210        220        230        240        250
ESKDGQLTLP LAGIMQHDAT KLLPSVTELF PEFRPGKVLR FLRLFGPGKN 
       260        270        280        290        300
VPSVWRSARR KRKKKHRELI QEGQVQEEEC SVELEVNQKS LWNYDYAPPP 
       310        320        330        340        350
LPDQCLSDDE ITMMAPVESK FSQSTGDTDK VMDTKPRVAE WRYGPARLWY 
       360        370        380        390        400
DMLGVPEDGS GFDYGFKMKK TEHESTIKCN IMKKLRKLEE NSGVDLLADE 
       410        420        430        440        450
NFLMVTQLHW EDDIIWDGED VKHKGTKPQR ASLAGWLPSS MTRNAMAYNV 
       460        470        480        490        500
QQGFTATLDD DKPWYSIFPI DNEDLVYGRW EDNIIWDAQN MPRILEPPVL 
       510        520        530        540        550
TLDPNDENLI LEIPDEKEEA TSNSPSKENK KESSLKKSRI LLGKTGVIKE 
       560        570        580        590        600
EPQQNMSQPE VKDPWNLSND EYYYPKQQGL RGTFGGNIIQ HSIPAVELRQ 
       610        620        630        640        650
PFFPTHMGPI KLRQFHRPPL KKYSFGALSQ PGPHSVQPLL KHIKKKAKMR 
       660        670        680        690        700
EQERQASGGG EMFFMRTPQD LTGKDGDLIL AEYSEENGPL MMQVGMATKI 
       710        720        730        740        750
KNYYKRKPGK DPGAPDCKYG ETVYCHTSPF LGSLHPGQLL QAFENNLFRA 
       760        770        780        790        800
PIYLHKMPES DFLIIRTRQG YFIRELVDIF VVGQQCPLFE VPGPNSKRAN 
       810        820        830        840        850
THIRDFLQVF IYRLFWKSKD RPRRIRMEDI KKAFPSHSES SIRKRLKLCA 
       860        870        880        890        900
DFKRTGMDSN WWVLKSDFRL PTEEEIRAMV SPEQCCAYYS MIAAEQRLKD 
       910        920        930        940        950
AGYGEKSFFA PEEENEEDFQ MKIDDEVRTA PWNTTRAFIA AMKGKCLLEV 
       960        970        980        990       1000
TGVADPTGCG EGFSYVKIPN KPTQQKDDKE PQPVKKTVTG TDADLRRLSL 
      1010       1020       1030       1040       1050
KNAKQLLRKF GVPEEEIKKL SRWEVIDVVR TMSTEQARSG EGPMSKFARG 
      1060       1070       1080       1090       1100
SRFSVAEHQE RYKEECQRIF DLQNKVLSST EVLSTDTDSS SAEDSDFEEM 
      1110       1120       1130       1140       1150
GKNIENMLQN KKTSSQLSRE REEQERKELQ RMLLAAGSAA AGNNHRDDDT 
      1160       1170       1180       1190       1200
ASVTSLNSSA TGRCLKIYRT FRDEEGKEYV RCETVRKATV IDAYVRIRTT 
      1210       1220       1230       1240       1250
KDEEFIRKFA LFDEQHREEM RKERRRIQEQ LRRLKRNQEK EKLKGPPEKK 
      1260       1270       1280       1290       1300
PKKMKERPDL KLKCGACGAI GHMRTNKFCP LYYQTNAPPS NPVAMTEEQE 
      1310       1320       1330       1340       1350
EELEKTVIHN DNEELIKVEG TKIVLGKQLI ESADEVRRKS LVLKFPKQQL 
      1360       1370       1380       1390       1400
PPKKKRRVGT TVHCDYLNRP HKSIHRRRTD PMVTLSSILE SIINDMRDLP 
      1410       1420       1430       1440       1450
NTYPFHTPVN AKVVKDYYKI ITRPMDLQTL RENVRKRLYP SREEFREHLE 
      1460       1470       1480       1490       1500
LIVKNSATYN GPKHSLTQIS QSMLDLCDEK LKEKEDKLAR LEKAINPLLD 
      1510       1520       1530       1540       1550
DDDQVAFSFI LDNIVTQKMM AVPDSWPFHH PVNKKFVPDY YKVIVSPMDL 
      1560       1570       1580       1590       1600
ETIRKNISKH KYQSRESFLD DVNLILANSV KYNGPESQYT KTAQEIVNVC 
      1610       1620       1630       1640       1650
HQTLTEYDEH LTQLEKDICT AKEAALEEAE LESLDPMTPG PYTPQPPDLY 
      1660       1670       1680       1690       1700
DNNTSLSVSR DASVYQDESN LSVLDIPSAT SEKQLTQEGG DGDGDLADEE 
      1710       1720       1730       1740       1750
EGTVQQPQAS VLYEDLLMSE GEDDEEDAGS DEEGDNPFFA IQLSESGSDS 
      1760       1770       1780       1790       1800
DVESGSLRPK QPRVLQENTR MGMENEESMM SYEGDGGDAS RGLEDSNISY 
      1810       1820       1830       1840       1850
GSYEEPDPKS NTQDTSFSSI GGYEVSEEEE DEEEQRSGPS VLSQVHLSED 
      1860       1870
EEDSEDFHSI AGDTDLDSDE

Show »

Length:1,870

Mass (Da):212,382

Checksum:ⁱC7C3C29E868C630F

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B1Q2W7	B1Q2W7_MOUSE	Transcription initiation factor TFI... Transcription initiation factor TFIID subunit	Taf1 N-TAF1	1,893	Annotation score:
D3YZK4	D3YZK4_MOUSE	Transcription initiation factor TFI... Transcription initiation factor TFIID subunit	Taf1	1,902	Annotation score:
S4R1B9	S4R1B9_MOUSE	Transcription initiation factor TFI... Transcription initiation factor TFIID subunit 1	Taf1	1,733	Annotation score:

Sequence cautionⁱ

The sequence BAC34383 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	217	D → E in AAD23348 (PubMed:10070062).Curated	1
Sequence conflictⁱ	221	S → A in AAD23348 (PubMed:10070062).Curated	1
Sequence conflictⁱ	261	R → H in AAD23348 (PubMed:10070062).Curated	1
Sequence conflictⁱ	289	E → K in AAD23348 (PubMed:10070062).Curated	1
Sequence conflictⁱ	867 – 868	LK → EG in AAC62118 (PubMed:9751712).Curated	2
Sequence conflictⁱ	876	T → Q in AAD23349 (PubMed:10070062).Curated	1
Sequence conflictⁱ	1302 – 1306	LYYQT → AFVAS in AAC62118 (PubMed:9751712).Curated	5
Sequence conflictⁱ	1358	R → P in AAD23350 (PubMed:10070062).Curated	1
Sequence conflictⁱ	1388	L → F in AAD23350 (PubMed:10070062).Curated	1
Sequence conflictⁱ	1450	T → E in AAD23350 (PubMed:10070062).Curated	1
Sequence conflictⁱ	1469 – 1470	HL → QM in AAD23350 (PubMed:10070062).Curated	2
Sequence conflictⁱ	1736	D → N in AAH94568 (PubMed:15489334).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_023320	1 – 962	Missing in isoform 2. 1 PublicationAdd BLAST		962
Alternative sequenceⁱVSP_023321	178 – 198	Missing in isoform 3. 1 PublicationAdd BLAST		21

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL806534 Genomic DNA No translation available. AL831722 Genomic DNA No translation available. BC047418 mRNA Translation: AAH47418.1 BC094568 mRNA Translation: AAH94568.1 AK045586 mRNA Translation: BAC32425.1 AK046668 mRNA Translation: BAC32828.1 AK049826 mRNA Translation: BAC33938.1 AK050691 mRNA Translation: BAC34383.1 Different initiation. AK132088 mRNA Translation: BAE20976.1 AK143571 mRNA Translation: BAE25442.1 AF081115 mRNA Translation: AAD23349.1 AF081116 mRNA Translation: AAD23348.1 AF081117 mRNA Translation: AAD23350.1 AF022178 mRNA Translation: AAC62118.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001277658.1, NM_001290729.1 XP_006528113.1, XM_006528050.3 [Q80UV9-1] XP_006528115.1, XM_006528052.3 [Q80UV9-3]

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL806534 Genomic DNA No translation available.
AL831722 Genomic DNA No translation available.
BC047418 mRNA Translation: AAH47418.1
BC094568 mRNA Translation: AAH94568.1
AK045586 mRNA Translation: BAC32425.1
AK046668 mRNA Translation: BAC32828.1
AK049826 mRNA Translation: BAC33938.1
AK050691 mRNA Translation: BAC34383.1 Different initiation.
AK132088 mRNA Translation: BAE20976.1
AK143571 mRNA Translation: BAE25442.1
AF081115 mRNA Translation: AAD23349.1
AF081116 mRNA Translation: AAD23348.1
AF081117 mRNA Translation: AAD23350.1
AF022178 mRNA Translation: AAC62118.1

RefSeqⁱ

NP_001277658.1, NM_001290729.1
XP_006528113.1, XM_006528050.3 [Q80UV9-1]
XP_006528115.1, XM_006528052.3 [Q80UV9-3]

Genome annotation databases

Ensemblⁱ	ENSMUST00000118878; ENSMUSP00000112772; ENSMUSG00000031314 [Q80UV9-3]
GeneIDⁱ	270627
KEGGⁱ	mmu:270627
UCSC genome browser More...UCSCⁱ	uc009txy.1, mouse [Q80UV9-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q80UV9	Transcription initiation factor TFIID subunit 1	)	HUMAN		1872	UniRef90_P21675
Transcription initiation factor TFIID subunit 1		MESAU		1865
Transcription initiation factor TFIID subunit		PIG		2001
Uncharacterized protein (Fragment)		BALPH		363
Transcription initiation factor TFIID subunit		CANLF		1989
+546

Protein	Similar proteins		Species	Score	Length	Source
Q80UV9	Transcription initiation factor TFIID subunit 1	)	HUMAN		1872	UniRef50_P21675
Transcription initiation factor TFIID subunit 1		MESAU		1865
Transcription initiation factor TFIID subunit		PIG		2001
Uncharacterized protein (Fragment)		BALPH		363
Transcription initiation factor TFIID subunit		CANLF		1989
+1458

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL806534 Genomic DNA No translation available. AL831722 Genomic DNA No translation available. BC047418 mRNA Translation: AAH47418.1 BC094568 mRNA Translation: AAH94568.1 AK045586 mRNA Translation: BAC32425.1 AK046668 mRNA Translation: BAC32828.1 AK049826 mRNA Translation: BAC33938.1 AK050691 mRNA Translation: BAC34383.1 Different initiation. AK132088 mRNA Translation: BAE20976.1 AK143571 mRNA Translation: BAE25442.1 AF081115 mRNA Translation: AAD23349.1 AF081116 mRNA Translation: AAD23348.1 AF081117 mRNA Translation: AAD23350.1 AF022178 mRNA Translation: AAC62118.1
RefSeqⁱ	NP_001277658.1, NM_001290729.1 XP_006528113.1, XM_006528050.3 [Q80UV9-1] XP_006528115.1, XM_006528052.3 [Q80UV9-3]

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

RefSeqⁱ

NP_001277658.1, NM_001290729.1
XP_006528113.1, XM_006528050.3 [Q80UV9-1]
XP_006528115.1, XM_006528052.3 [Q80UV9-3]

3D structure databases

SMRⁱ	Q80UV9
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	234808, 13 interactors
ComplexPortalⁱ	CPX-932, General transcription factor complex TFIID CPX-959, General transcription factor complex TFIID, Taf4b variant
CORUMⁱ	Q80UV9
DIPⁱ	DIP-61093N
IntActⁱ	Q80UV9, 1 interactor
STRINGⁱ	10090.ENSMUSP00000098895

PTM databases

iPTMnetⁱ	Q80UV9
PhosphoSitePlusⁱ	Q80UV9

Proteomic databases

PaxDbⁱ	Q80UV9
PeptideAtlasⁱ	Q80UV9
PRIDEⁱ	Q80UV9

Genome annotation databases

Ensemblⁱ	ENSMUST00000118878; ENSMUSP00000112772; ENSMUSG00000031314 [Q80UV9-3]
GeneIDⁱ	270627
KEGGⁱ	mmu:270627
UCSCⁱ	uc009txy.1, mouse [Q80UV9-2]

Organism-specific databases

CTDⁱ	6872
MGIⁱ	MGI:1336878, Taf1

Phylogenomic databases

eggNOGⁱ	KOG0008, Eukaryota
GeneTreeⁱ	ENSGT00940000155242
InParanoidⁱ	Q80UV9
KOⁱ	K03125
OMAⁱ	KACPLYT
OrthoDBⁱ	103411at2759

Enzyme and pathway databases

Reactomeⁱ	R-MMU-674695, RNA Polymerase II Pre-transcription Events R-MMU-6804756, Regulation of TP53 Activity through Phosphorylation R-MMU-73776, RNA Polymerase II Promoter Escape R-MMU-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-MMU-75953, RNA Polymerase II Transcription Initiation R-MMU-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance

Reactomeⁱ

Miscellaneous databases

BioGRID-ORCSⁱ	270627, 7 hits in 19 CRISPR screens
ChiTaRSⁱ	Taf1, mouse
Protein Ontology More...PROⁱ	PR:Q80UV9
RNActⁱ	Q80UV9, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000031314, Expressed in manus and 266 other tissues
ExpressionAtlasⁱ	Q80UV9, baseline and differential
Genevisibleⁱ	Q80UV9, MM

Family and domain databases

Gene3Dⁱ	1.10.1100.10, 1 hit 1.20.920.10, 2 hits
InterProⁱ	View protein in InterPro IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR040240, TAF1 IPR011177, TAF1_animal IPR009067, TAF_II_230-bd IPR036741, TAFII-230_TBP-bd_sf IPR022591, TFIID_sub1_DUF3591 IPR041670, Znf-CCHC_6
PANTHERⁱ	PTHR13900, PTHR13900, 2 hits
Pfamⁱ	View protein in Pfam PF00439, Bromodomain, 2 hits PF12157, DUF3591, 1 hit PF09247, TBP-binding, 1 hit PF15288, zf-CCHC_6, 1 hit
PIRSFⁱ	PIRSF003047, TAF1_animal, 1 hit
PRINTSⁱ	PR00503, BROMODOMAIN
SMARTⁱ	View protein in SMART SM00297, BROMO, 2 hits
SUPFAMⁱ	SSF47055, SSF47055, 1 hit SSF47370, SSF47370, 2 hits
PROSITEⁱ	View protein in PROSITE PS00633, BROMODOMAIN_1, 2 hits PS50014, BROMODOMAIN_2, 2 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TAF1_MOUSE
Accessionⁱ	Q80UV9Primary (citable) accession number: Q80UV9 Secondary accession number(s): A2AM32 Q9WTX1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
	Last sequence update:	March 6, 2007
	Last modified:	August 12, 2020
	This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q80UV9 (TAF1_MOUSE)

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Transcription initiation factor TFIID subunit 1

Taf1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Isoform 1 [Q80UV9-1]

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ