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Protein

Membrane-associated progesterone receptor component 2

Gene

Pgrmc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for steroids.Curated

GO - Molecular functioni

  • heme binding Source: GO_Central
  • steroid binding Source: UniProtKB-KW

Keywordsi

Molecular functionReceptor
LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated progesterone receptor component 2
Gene namesi
Name:Pgrmc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1918054 Pgrmc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 62HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001217441 – 217Membrane-associated progesterone receptor component 2Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84PhosphoserineBy similarity1
Modified residuei98PhosphoserineBy similarity1
Modified residuei202PhosphoserineCombined sources1
Modified residuei204PhosphotyrosineBy similarity1
Modified residuei205PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80UU9
MaxQBiQ80UU9
PaxDbiQ80UU9
PeptideAtlasiQ80UU9
PRIDEiQ80UU9

PTM databases

iPTMnetiQ80UU9
PhosphoSitePlusiQ80UU9
SwissPalmiQ80UU9

Expressioni

Gene expression databases

BgeeiENSMUSG00000049940 Expressed in 296 organ(s), highest expression level in ear
CleanExiMM_PGRMC2
GenevisibleiQ80UU9 MM

Interactioni

Protein-protein interaction databases

BioGridi214264, 3 interactors
IntActiQ80UU9, 6 interactors
MINTiQ80UU9
STRINGi10090.ENSMUSP00000056643

Structurei

3D structure databases

ProteinModelPortaliQ80UU9
SMRiQ80UU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 195Cytochrome b5 heme-bindingAdd BLAST100

Domaini

The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 131 and 155.By similarity

Sequence similaritiesi

Belongs to the cytochrome b5 family. MAPR subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1110 Eukaryota
ENOG4111UG0 LUCA
GeneTreeiENSGT00730000110959
HOGENOMiHOG000187840
HOVERGENiHBG059971
InParanoidiQ80UU9
KOiK17278
OMAiYTDEEDI
OrthoDBiEOG091G0PXT
PhylomeDBiQ80UU9
TreeFamiTF314562

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit

Sequencei

Sequence statusi: Complete.

Q80UU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGDGDVKL STLGSGGESG GDGSPGGAGA TAARSSWVAA LLATGGEMLL
60 70 80 90 100
NVALVALVLL GAYRLWVRWG RRGLCSGPGA GEESPAATLP RMKKRDFSLE
110 120 130 140 150
QLRQYDGART PRILLAVNGK VFDVTKGSKF YGPAGPYGIF AGRDASRGLA
160 170 180 190 200
TFCLDKDALR DEYDDLSDLN AVQMESVREW EMQFKEKYDY VGRLLKPGEE
210
PSEYTDEEDT KDHSKQD
Length:217
Mass (Da):23,334
Last modified:January 9, 2007 - v2
Checksum:i0291B0EFE8AD3403
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC100511 Genomic DNA No translation available.
BC044759 mRNA Translation: AAH44759.1
CCDSiCCDS50899.1
RefSeqiNP_081834.1, NM_027558.1
UniGeneiMm.40321

Genome annotation databases

EnsembliENSMUST00000058578; ENSMUSP00000056643; ENSMUSG00000049940
GeneIDi70804
KEGGimmu:70804
UCSCiuc008pce.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC100511 Genomic DNA No translation available.
BC044759 mRNA Translation: AAH44759.1
CCDSiCCDS50899.1
RefSeqiNP_081834.1, NM_027558.1
UniGeneiMm.40321

3D structure databases

ProteinModelPortaliQ80UU9
SMRiQ80UU9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214264, 3 interactors
IntActiQ80UU9, 6 interactors
MINTiQ80UU9
STRINGi10090.ENSMUSP00000056643

PTM databases

iPTMnetiQ80UU9
PhosphoSitePlusiQ80UU9
SwissPalmiQ80UU9

Proteomic databases

EPDiQ80UU9
MaxQBiQ80UU9
PaxDbiQ80UU9
PeptideAtlasiQ80UU9
PRIDEiQ80UU9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058578; ENSMUSP00000056643; ENSMUSG00000049940
GeneIDi70804
KEGGimmu:70804
UCSCiuc008pce.2 mouse

Organism-specific databases

CTDi10424
MGIiMGI:1918054 Pgrmc2

Phylogenomic databases

eggNOGiKOG1110 Eukaryota
ENOG4111UG0 LUCA
GeneTreeiENSGT00730000110959
HOGENOMiHOG000187840
HOVERGENiHBG059971
InParanoidiQ80UU9
KOiK17278
OMAiYTDEEDI
OrthoDBiEOG091G0PXT
PhylomeDBiQ80UU9
TreeFamiTF314562

Miscellaneous databases

ChiTaRSiPgrmc2 mouse
PROiPR:Q80UU9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049940 Expressed in 296 organ(s), highest expression level in ear
CleanExiMM_PGRMC2
GenevisibleiQ80UU9 MM

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPGRC2_MOUSE
AccessioniPrimary (citable) accession number: Q80UU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 9, 2007
Last modified: November 7, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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