Mxd3

Functionⁱ

Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.1 Publication

Miscellaneous

Mice deficient for Mxd3 show increased sensitivity of neuronal and lymphoid cells to gamma-radiation induced apoptosis.

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Max dimerization protein 3 Short name: Max dimerizer 3 Alternative name(s): Max-associated protein 3
Gene namesⁱ	Name:Mxd3 Synonyms:Mad3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 13

Organism-specific databases

MGIⁱ	MGI:104987 Mxd3

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000253708	1 – 206	Max dimerization protein 3Add BLAST		206

Proteomic databases

PaxDbⁱ	Q80US8
PRIDEⁱ	Q80US8

PTM databases

PhosphoSitePlusⁱ	Q80US8

PhosphoSitePlusⁱ

Q80US8

Expressionⁱ

Tissue specificityⁱ

Expressed only in the proliferating areas of the testis and thymus.1 Publication

Developmental stageⁱ

Expressed during neural and epidermal differentiation. Expression restricted to proliferating cells prior to differentiation. Specifically expressed in the S phase of the cell cycle in neuronal progenitor cells. In the developing embryo, detected from 9.5 to 12.5 dpc especially in the ventricular zone of the neuroepithelia, in the progression zone of the limb buds and in the aortic arches and liver. In the spinal cord at embryonic days 10.5, 11.5 and 12.5 dpc, expressed in the cells at the perimeter of the ventricular zone. In the developing epidermis, expressed only in the uppermost differentiated cell layers underneath the stratum corneum.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000021485 Expressed in 243 organ(s), highest expression level in head
CleanExⁱ	MM_MXD3
Genevisibleⁱ	Q80US8 MM

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17.2 Publications

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	201271, 1 interactor
Database of interacting proteins More...DIPⁱ	DIP-948N
STRINGⁱ	10090.ENSMUSP00000021941

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q80US8
SMRⁱ	Q80US8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	57 – 109	bHLHPROSITE-ProRule annotationAdd BLAST		53

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	8 – 25	Interaction with SIN3A and SIN3B1 PublicationAdd BLAST		18

Phylogenomic databases

eggNOGⁱ	ENOG410IPD7 Eukaryota ENOG410YHJP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046360
HOGENOMⁱ	HOG000247060
HOVERGENⁱ	HBG006314
InParanoidⁱ	Q80US8
KEGG Orthology (KO) More...KOⁱ	K09114
OMAⁱ	WEQRELR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QBK
PhylomeDBⁱ	Q80US8
TreeFamⁱ	TF315654

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q80US8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEPVASNIQV LLQAAEFLER REREAEHGYA SLCPHHSPGT VCRRRKPPLQ 
        60         70         80         90        100
APGALNSGRS VHNELEKRRR AQLKRCLEQL RQQMPLGVDC TRYTTLSLLR 
       110        120        130        140        150
RARVHIQKLE EQEQQARRLK EKLRSKQQSL QQQLEQLQGL PGARERERLR 
       160        170        180        190        200
ADSLDSSGLS SERSDSDQED LEVDVESLVF GTETELLQSF SAGREHSYSH 

STCAWL

Length:206

Mass (Da):23,635

Last modified:June 1, 2003 - v1

Checksum:ⁱ17E1149064907085

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	177	S → N in AAB02794 (PubMed:8521822).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U32394 mRNA Translation: AAB02794.1 AK138742 mRNA Translation: BAE23764.1 BC051970 mRNA Translation: AAH51970.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS26543.1
PIRⁱ	S60005
NCBI Reference Sequences More...RefSeqⁱ	NP_057871.2, NM_016662.4
UniGeneⁱ	Mm.20350

Genome annotation databases

Ensemblⁱ	ENSMUST00000021941; ENSMUSP00000021941; ENSMUSG00000021485
GeneIDⁱ	17121
KEGGⁱ	mmu:17121
UCSC genome browser More...UCSCⁱ	uc007qqn.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q80US8	Max dimerization protein 3		RAT		206	UniRef90_Q80US8
Uncharacterized protein		NEOLE		206
UPI000A310D79		MUSPA		208
UPI000A318654		MUSCR		208
UPI00038BDDF9		MICOH		206
+1

Protein	Similar proteins		Species	Score	Length	Source
Q80US8	Max dimerization protein 3		RAT		206	UniRef50_Q80US8
Max dimerization protein 3		DANRE		200
Max dimerization protein 3		HUMAN		206
Max dimerization protein 3		XENTR		200
Max dimerization protein 3		XENLA		200
+217

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U32394 mRNA Translation: AAB02794.1 AK138742 mRNA Translation: BAE23764.1 BC051970 mRNA Translation: AAH51970.1
CCDSⁱ	CCDS26543.1
PIRⁱ	S60005
RefSeqⁱ	NP_057871.2, NM_016662.4
UniGeneⁱ	Mm.20350

3D structure databases

ProteinModelPortalⁱ	Q80US8
SMRⁱ	Q80US8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	201271, 1 interactor
DIPⁱ	DIP-948N
STRINGⁱ	10090.ENSMUSP00000021941

PTM databases

PhosphoSitePlusⁱ	Q80US8

PhosphoSitePlusⁱ

Q80US8

Proteomic databases

PaxDbⁱ	Q80US8
PRIDEⁱ	Q80US8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000021941; ENSMUSP00000021941; ENSMUSG00000021485
GeneIDⁱ	17121
KEGGⁱ	mmu:17121
UCSCⁱ	uc007qqn.1 mouse

Organism-specific databases

CTDⁱ	83463
MGIⁱ	MGI:104987 Mxd3

Phylogenomic databases

eggNOGⁱ	ENOG410IPD7 Eukaryota ENOG410YHJP LUCA
GeneTreeⁱ	ENSGT00510000046360
HOGENOMⁱ	HOG000247060
HOVERGENⁱ	HBG006314
InParanoidⁱ	Q80US8
KOⁱ	K09114
OMAⁱ	WEQRELR
OrthoDBⁱ	EOG091G0QBK
PhylomeDBⁱ	Q80US8
TreeFamⁱ	TF315654

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q80US8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000021485 Expressed in 243 organ(s), highest expression level in head
CleanExⁱ	MM_MXD3
Genevisibleⁱ	Q80US8 MM

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MAD3_MOUSE
Accessionⁱ	Q80US8Primary (citable) accession number: Q80US8 Secondary accession number(s): Q60947
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
	Last sequence update:	June 1, 2003
	Last modified:	November 7, 2018
	This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q80US8 (MAD3_MOUSE)

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Max dimerization protein 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ