Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SEC14 domain and spectrin repeat-containing protein 1

Gene

Sestd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14 domain and spectrin repeat-containing protein 1
Alternative name(s):
Huntingtin-interacting protein-like protein
Gene namesi
Name:Sestd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1916262 Sestd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003094801 – 696SEC14 domain and spectrin repeat-containing protein 1Add BLAST696

Proteomic databases

MaxQBiQ80UK0
PaxDbiQ80UK0
PeptideAtlasiQ80UK0
PRIDEiQ80UK0

PTM databases

iPTMnetiQ80UK0
PhosphoSitePlusiQ80UK0

Expressioni

Gene expression databases

BgeeiENSMUSG00000042272 Expressed in 242 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_SESTD1
GenevisibleiQ80UK0 MM

Interactioni

Subunit structurei

Interacts (via the spectrin 1 repeat) with TRPC4 and TRPC5 (via CIRB domain). Interacts with CTNNB1.By similarity

Protein-protein interaction databases

BioGridi230712, 6 interactors
IntActiQ80UK0, 7 interactors
STRINGi10090.ENSMUSP00000099720

Structurei

3D structure databases

ProteinModelPortaliQ80UK0
SMRiQ80UK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 153CRAL-TRIOPROSITE-ProRule annotationAdd BLAST153
Repeati275 – 378Spectrin 1Add BLAST104
Repeati381 – 494Spectrin 2Add BLAST114
Repeati500 – 602Spectrin 3Add BLAST103

Sequence similaritiesi

Belongs to the SOLO family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4240 Eukaryota
ENOG410XPZN LUCA
GeneTreeiENSGT00730000111148
HOGENOMiHOG000072717
HOVERGENiHBG104429
InParanoidiQ80UK0
OMAiCTTRSSG
OrthoDBiEOG091G03F6
PhylomeDBiQ80UK0
TreeFamiTF332003

Family and domain databases

CDDicd00170 SEC14, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
PfamiView protein in Pfam
PF13716 CRAL_TRIO_2, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit

Sequencei

Sequence statusi: Complete.

Q80UK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEASVILPIL KKKLAFLSGG KDRRSGLILT IPLCLEQTSM DELSVTLDYL
60 70 80 90 100
LSIPSEKCKA RGFTVIVDGR KSQWNVVKTV VLMLQNVVPA EVSLVCVVKP
110 120 130 140 150
DEFWDKKVTH FCFWKEKDRL GFEVILVSAN KLTRYIEPCQ LTEDFGGSLT
160 170 180 190 200
YDHMDWLNKR LVFEKFTKES TSLLDELALI NNGSDKGNEQ EKERSVDLNF
210 220 230 240 250
LPSVDPETVL QTGHELLSEL QQRRFNGSDG GVSWSPMDDE LLAQPQVMKL
260 270 280 290 300
LDSLREQYTR YQEVCRQRSK RTQLEEIQQK VMQVVNWLEG PGSEQLRAQW
310 320 330 340 350
GIGDSIRASQ ALQQKHEEIE SQHSEWFAVY VELNQQIAAL LNAGDEEDLV
360 370 380 390 400
ELKSLQQQLS DVCYRQASQL EFRQNLLQAA LEFHGVAQDL SQQLDGLLGM
410 420 430 440 450
LCVDVAPADG ASIQQTLKLL EEKLKSVDVG LQGLREKGQG LLDQISNQAS
460 470 480 490 500
WAYGKDVTIE NKENVDHIQG VMEDMQLRKQ RCEDMVDVRR LKMLQMVQLF
510 520 530 540 550
KCEEDASQAV EWLSELLDAL LKTHIRLGDD AQETKVLLEK HRKFVDVAQS
560 570 580 590 600
TYDYGRQLLQ ATVVLCQSLR CTSRSSGDTL PRLNRVWKQF TVASEERVHR
610 620 630 640 650
LEMAIAFHSN AEKILQDCPE EPEAMNDEEQ FEEIEAIGKS LLDRLTIPVV
660 670 680 690
YPDGTEQYFG SPSDMASTAE HIRDRMKLVS LKRQQLRHPE LVTTES
Length:696
Mass (Da):79,376
Last modified:June 1, 2003 - v1
Checksum:i8354593E717D73F4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti480 – 482QRC → HAS in AAH38005 (PubMed:19468303).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772242 Genomic DNA No translation available.
BC038005 mRNA Translation: AAH38005.1
BC044853 mRNA Translation: AAH44853.1
BC048358 mRNA Translation: AAH48358.1
AK166483 mRNA Translation: BAE38801.1
CCDSiCCDS16163.1
RefSeqiNP_780674.1, NM_175465.6
XP_006499263.1, XM_006499200.2
XP_006499264.1, XM_006499201.2
XP_006499265.1, XM_006499202.3
UniGeneiMm.27120

Genome annotation databases

EnsembliENSMUST00000102659; ENSMUSP00000099720; ENSMUSG00000042272
ENSMUST00000102660; ENSMUSP00000099721; ENSMUSG00000042272
GeneIDi228071
KEGGimmu:228071
UCSCiuc008kfx.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772242 Genomic DNA No translation available.
BC038005 mRNA Translation: AAH38005.1
BC044853 mRNA Translation: AAH44853.1
BC048358 mRNA Translation: AAH48358.1
AK166483 mRNA Translation: BAE38801.1
CCDSiCCDS16163.1
RefSeqiNP_780674.1, NM_175465.6
XP_006499263.1, XM_006499200.2
XP_006499264.1, XM_006499201.2
XP_006499265.1, XM_006499202.3
UniGeneiMm.27120

3D structure databases

ProteinModelPortaliQ80UK0
SMRiQ80UK0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230712, 6 interactors
IntActiQ80UK0, 7 interactors
STRINGi10090.ENSMUSP00000099720

PTM databases

iPTMnetiQ80UK0
PhosphoSitePlusiQ80UK0

Proteomic databases

MaxQBiQ80UK0
PaxDbiQ80UK0
PeptideAtlasiQ80UK0
PRIDEiQ80UK0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102659; ENSMUSP00000099720; ENSMUSG00000042272
ENSMUST00000102660; ENSMUSP00000099721; ENSMUSG00000042272
GeneIDi228071
KEGGimmu:228071
UCSCiuc008kfx.3 mouse

Organism-specific databases

CTDi91404
MGIiMGI:1916262 Sestd1

Phylogenomic databases

eggNOGiKOG4240 Eukaryota
ENOG410XPZN LUCA
GeneTreeiENSGT00730000111148
HOGENOMiHOG000072717
HOVERGENiHBG104429
InParanoidiQ80UK0
OMAiCTTRSSG
OrthoDBiEOG091G03F6
PhylomeDBiQ80UK0
TreeFamiTF332003

Miscellaneous databases

ChiTaRSiSestd1 mouse
PROiPR:Q80UK0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042272 Expressed in 242 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_SESTD1
GenevisibleiQ80UK0 MM

Family and domain databases

CDDicd00170 SEC14, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
PfamiView protein in Pfam
PF13716 CRAL_TRIO_2, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSESD1_MOUSE
AccessioniPrimary (citable) accession number: Q80UK0
Secondary accession number(s): Q3TLJ1, Q810W3, Q8CI09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again