UniProtKB - Q80UG2 (PLXA4_MOUSE)
Plexin-A4
Plxna4
Functioni
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
2 PublicationsGO - Molecular functioni
- semaphorin receptor activity Source: MGI
GO - Biological processi
- anterior commissure morphogenesis Source: MGI
- axon guidance Source: MGI
- branchiomotor neuron axon guidance Source: ParkinsonsUK-UCL
- chemorepulsion of branchiomotor axon Source: MGI
- cranial nerve morphogenesis Source: MGI
- embryonic heart tube development Source: MGI
- facial nerve morphogenesis Source: MGI
- facial nerve structural organization Source: ParkinsonsUK-UCL
- glossopharyngeal nerve morphogenesis Source: MGI
- motor neuron axon guidance Source: ParkinsonsUK-UCL
- negative regulation of cell adhesion Source: GO_Central
- nervous system development Source: MGI
- neuron projection morphogenesis Source: MGI
- positive regulation of axonogenesis Source: GO_Central
- postganglionic parasympathetic fiber development Source: MGI
- regulation of axon extension involved in axon guidance Source: MGI
- regulation of cell migration Source: GO_Central
- regulation of cell shape Source: GO_Central
- regulation of GTPase activity Source: GO_Central
- regulation of negative chemotaxis Source: MGI
- semaphorin-plexin signaling pathway Source: MGI
- semaphorin-plexin signaling pathway involved in axon guidance Source: ParkinsonsUK-UCL
- sympathetic nervous system development Source: MGI
- sympathetic neuron axon guidance Source: MGI
- trigeminal nerve morphogenesis Source: MGI
- trigeminal nerve structural organization Source: ParkinsonsUK-UCL
- vagus nerve morphogenesis Source: MGI
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
Reactomei | R-MMU-399954, Sema3A PAK dependent Axon repulsion R-MMU-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-MMU-399956, CRMPs in Sema3A signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Plexin-A4 |
Gene namesi | Name:Plxna4 Synonyms:Kiaa1550 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2179061, Plxna4 |
VEuPathDBi | HostDB:ENSMUSG00000029765 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Other locations
- semaphorin receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 1236 | ExtracellularSequence analysisAdd BLAST | 1213 | |
Transmembranei | 1237 – 1257 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1258 – 1893 | CytoplasmicSequence analysisAdd BLAST | 636 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000240284 | 24 – 1893 | Plexin-A4Add BLAST | 1870 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 94 ↔ 103 | PROSITE-ProRule annotation | ||
Disulfide bondi | 129 ↔ 137 | PROSITE-ProRule annotation | ||
Disulfide bondi | 283 ↔ 404 | PROSITE-ProRule annotation | ||
Disulfide bondi | 299 ↔ 355 | PROSITE-ProRule annotation | ||
Disulfide bondi | 373 ↔ 392 | PROSITE-ProRule annotation | ||
Disulfide bondi | 509 ↔ 526 | PROSITE-ProRule annotation | ||
Disulfide bondi | 515 ↔ 557 | PROSITE-ProRule annotation | ||
Disulfide bondi | 518 ↔ 535 | PROSITE-ProRule annotation | ||
Disulfide bondi | 529 ↔ 541 | PROSITE-ProRule annotation | ||
Disulfide bondi | 592 ↔ 611 | PROSITE-ProRule annotation | ||
Glycosylationi | 654 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1006 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1131 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1179 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1349 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Disulfide bond, GlycoproteinProteomic databases
MaxQBi | Q80UG2 |
PaxDbi | Q80UG2 |
PRIDEi | Q80UG2 |
ProteomicsDBi | 289632 |
PTM databases
GlyConnecti | 2592, 12 N-Linked glycans (5 sites) |
GlyGeni | Q80UG2, 6 sites, 12 N-linked glycans (5 sites) |
iPTMneti | Q80UG2 |
PhosphoSitePlusi | Q80UG2 |
SwissPalmi | Q80UG2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000029765, Expressed in oocyte and 252 other tissues |
Genevisiblei | Q80UG2, MM |
Interactioni
Subunit structurei
Interacts with NRP1 and NRP2.
1 PublicationBinary interactionsi
Q80UG2
With | #Exp. | IntAct |
---|---|---|
Sema6a [O35464] | 3 | EBI-8057809,EBI-8057848 |
Protein-protein interaction databases
BioGRIDi | 232552, 7 interactors |
IntActi | Q80UG2, 4 interactors |
MINTi | Q80UG2 |
STRINGi | 10090.ENSMUSP00000110748 |
Miscellaneous databases
RNActi | Q80UG2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 506 | SemaPROSITE-ProRule annotationAdd BLAST | 483 | |
Domaini | 508 – 558 | PSI 1Add BLAST | 51 | |
Domaini | 654 – 701 | PSI 2Add BLAST | 48 | |
Domaini | 802 – 855 | PSI 3Add BLAST | 54 | |
Domaini | 857 – 951 | IPT/TIG 1Add BLAST | 95 | |
Domaini | 953 – 1036 | IPT/TIG 2Add BLAST | 84 | |
Domaini | 1039 – 1138 | IPT/TIG 3Add BLAST | 100 | |
Domaini | 1141 – 1229 | IPT/TIG 4Add BLAST | 89 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3610, Eukaryota |
GeneTreei | ENSGT01020000230473 |
HOGENOMi | CLU_001436_2_0_1 |
InParanoidi | Q80UG2 |
OMAi | KVYLYKC |
OrthoDBi | 90434at2759 |
PhylomeDBi | Q80UG2 |
TreeFami | TF312962 |
Family and domain databases
DisProti | DP02528 |
Gene3Di | 1.10.506.10, 1 hit 2.130.10.10, 1 hit 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR031148, Plexin IPR013548, Plexin_cytoplasmic_RasGAP_dom IPR002165, Plexin_repeat IPR016201, PSI IPR008936, Rho_GTPase_activation_prot IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR041019, TIG1_plexin IPR041362, TIG2_plexin IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR22625, PTHR22625, 1 hit |
Pfami | View protein in Pfam PF08337, Plexin_cytopl, 1 hit PF01437, PSI, 3 hits PF01403, Sema, 1 hit PF01833, TIG, 4 hits PF18020, TIG_2, 1 hit PF17960, TIG_plexin, 1 hit |
SMARTi | View protein in SMART SM00429, IPT, 4 hits SM00423, PSI, 3 hits SM00630, Sema, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF48350, SSF48350, 1 hit SSF81296, SSF81296, 4 hits |
PROSITEi | View protein in PROSITE PS51004, SEMA, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MKAMPWNWTC LLSHLLVVGM GSSTLLPRQP PQLSQKPSFV TFRGEPAEGF
60 70 80 90 100
NHLVVDERTG HIYLGAVNRI YKLSSDLKVL VTHQTGPDED NPKCYPPRIV
110 120 130 140 150
QTCNEPLAST NNVNKMLLID YKENRLIACG SLYQGICKLL RLEDLFKLGE
160 170 180 190 200
PFHKKEHYLS GVNESGSVFG VIVSYSNFDD KLFIATAVDG KPEYFPTISS
210 220 230 240 250
RKLTKNSEAD GMFAYVFHDE FVASMIKIPS DTFTVIPDFD IYYVYGFSSG
260 270 280 290 300
NFVYFLTLQP EMVSPPGSTT KEQVYTSKLV RLCKEDTAFN SYVEVPIGCE
310 320 330 340 350
RNGVEYRLLQ AAYLSKAGAV LGRTLGVRPD DDLLFTVFSK GQKRKMKSLD
360 370 380 390 400
ESALCIFILK QINDRIKDRL QSCYRGEGTL DLAWLKVKDI PCSSALLTID
410 420 430 440 450
DNFCGLDMNA PLGVSEMVRG IPVFTEDRDR MTSVIAYVYK NHSLAFVGTK
460 470 480 490 500
SGKLKKIRVD GPKGNALQYE TVQVVDSGPV LRDMAFSKDH EQLYIMSERQ
510 520 530 540 550
LTRVPVESCG QYRSCGECLG SGDPHCGWCV LHNTCTRKER CERSREPRRF
560 570 580 590 600
ASEMKQCVRL TVHPNNISVS QYNVLLVLET YNVPELSAGV NCTFEDLSEM
610 620 630 640 650
DGLVIGNQIQ CYSPAAKEVP RIITENGDHH VVQLQLKSKE TGMTFASTSF
660 670 680 690 700
VFYNCSVHNS CLSCVESPYR CHWCKYRHVC THDPNTCSFQ EGRVKLPEDC
710 720 730 740 750
PQLLRVDKIL VPVEVIKPIT LKAKNLPQPQ SGQRGYECIL NIQGIEQRVP
760 770 780 790 800
ALRFNSSSVQ CQNTSYSYEG MEINNLPVEL TVVWNGHFNI DNPAQNKVYL
810 820 830 840 850
YKCGAMRESC GLCLKADPDF ECGWCQSPGQ CTLRQHCPAH ESRWLELSGA
860 870 880 890 900
NSKCTNPRIT EIIPVTGPRE GGTKVTIRGE NLGLEFRDIA SHVKVAGVEC
910 920 930 940 950
SPLVDGYIPA EQIVCEMGEA KPSQHAGFVE ICVAVCRPEF MARSSQLYYF
960 970 980 990 1000
MTLTLADLKP NRGPMSGGTQ VTITGTNLNA GSNVVVMFGS QPCLFHRRSP
1010 1020 1030 1040 1050
SYIICNTTSS EEVLDMKVTV QVDRARIRQD LVFQYVEDPT IVRIEPEWSI
1060 1070 1080 1090 1100
VSGNTPIAVW GTHLDLIQNP QIRAKHGGKE HINICEVLNA TEMTCQAPAL
1110 1120 1130 1140 1150
ALGPDHQSDL TERPEEFGFI LDNVQSLLIL NKTNFTYYPN PVFEAFSPSG
1160 1170 1180 1190 1200
ILELKPGTPI ILKGKNLIPP VAGGNVKLNY TVLVGEKPCT VTVSDVQLLC
1210 1220 1230 1240 1250
ESPNLIGRHK VMARVGGMEY SPGMVYIAPD SPLSLPAIVS IAVAGGLLII
1260 1270 1280 1290 1300
FIVAVLIAYK RKSRESDLTL KRLQMQMDNL ESRVALECKE AFAELQTDIH
1310 1320 1330 1340 1350
ELTSDLDGAG IPFLDYRTYT MRVLFPGIED HPVLRDLEVP GYRQERVEKG
1360 1370 1380 1390 1400
LKLFAQLINN KVFLLSFIRT LESQRSFSMR DRGNVASLIM TVLQSKLEYA
1410 1420 1430 1440 1450
TDVLKQLLAD LIDKNLESKN HPKLLLRRTE SVAEKMLTNW FTFLLYKFLK
1460 1470 1480 1490 1500
ECAGEPLFSL FCAIKQQMEK GPIDAITGEA RYSLSEDKLI RQQIEYKTLV
1510 1520 1530 1540 1550
LSCVSPDNVN SPEVPVKILN CDTITQVKEK ILDAIFKNVP CSHRPKAADM
1560 1570 1580 1590 1600
DLEWRQGSGA RMILQDEDIT TKIENDWKRL NTVAHYQVPD GSVVALVSKQ
1610 1620 1630 1640 1650
VTAYNAVNNS TVSRTSASKY ENMIRYTGSP DSLRSRTPMI TPDLESGVKL
1660 1670 1680 1690 1700
WHLVKNHEHG DQKEGDRGSK MVSEIYLTRL LATKGTLQKF VDDLFETIFS
1710 1720 1730 1740 1750
TAHRGSALPL AIKYMFDFLD EQADKHGIHD PHVRHTWKSN CLPLRFWVNM
1760 1770 1780 1790 1800
IKNPQFVFDI HKNSITDACL SVVAQTFMDS CSTSEHRLGK DSPSNKLLYA
1810 1820 1830 1840 1850
KDIPSYKNWV ERYYSDIGKM PAISDQDMNA YLAEQSRMHM NEFNTMSALS
1860 1870 1880 1890
EIFSYVGKYS EEILGPLDHD DQCGKQKLAY KLEQVITLMS LDS
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 683 – 684 | DP → GR in BAC56599 (PubMed:12591607).Curated | 2 | |
Sequence conflicti | 1607 | V → E in BAC34692 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB073228 mRNA Translation: BAC56599.1 Different initiation. AC153629 Genomic DNA No translation available. AC153867 Genomic DNA No translation available. AC158678 Genomic DNA No translation available. AK051614 mRNA Translation: BAC34692.1 AK220402 mRNA Translation: BAD90257.1 |
CCDSi | CCDS19985.2 |
RefSeqi | NP_786926.2, NM_175750.3 |
Genome annotation databases
Ensembli | ENSMUST00000115096; ENSMUSP00000110748; ENSMUSG00000029765 |
GeneIDi | 243743 |
KEGGi | mmu:243743 |
UCSCi | uc009bgm.3, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB073228 mRNA Translation: BAC56599.1 Different initiation. AC153629 Genomic DNA No translation available. AC153867 Genomic DNA No translation available. AC158678 Genomic DNA No translation available. AK051614 mRNA Translation: BAC34692.1 AK220402 mRNA Translation: BAD90257.1 |
CCDSi | CCDS19985.2 |
RefSeqi | NP_786926.2, NM_175750.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5L5K | X-ray | 7.50 | A | 36-1229 | [»] | |
5L5L | X-ray | 8.00 | A/B | 36-1229 | [»] | |
5L5M | X-ray | 8.00 | A | 36-1229 | [»] | |
5L5N | X-ray | 8.50 | A | 36-1229 | [»] | |
7M0R | electron microscopy | 3.70 | A/B | 36-1229 | [»] | |
AlphaFoldDBi | Q80UG2 | |||||
SMRi | Q80UG2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 232552, 7 interactors |
IntActi | Q80UG2, 4 interactors |
MINTi | Q80UG2 |
STRINGi | 10090.ENSMUSP00000110748 |
PTM databases
GlyConnecti | 2592, 12 N-Linked glycans (5 sites) |
GlyGeni | Q80UG2, 6 sites, 12 N-linked glycans (5 sites) |
iPTMneti | Q80UG2 |
PhosphoSitePlusi | Q80UG2 |
SwissPalmi | Q80UG2 |
Proteomic databases
MaxQBi | Q80UG2 |
PaxDbi | Q80UG2 |
PRIDEi | Q80UG2 |
ProteomicsDBi | 289632 |
Protocols and materials databases
Antibodypediai | 32143, 203 antibodies from 25 providers |
DNASUi | 243743 |
Genome annotation databases
Ensembli | ENSMUST00000115096; ENSMUSP00000110748; ENSMUSG00000029765 |
GeneIDi | 243743 |
KEGGi | mmu:243743 |
UCSCi | uc009bgm.3, mouse |
Organism-specific databases
CTDi | 91584 |
MGIi | MGI:2179061, Plxna4 |
VEuPathDBi | HostDB:ENSMUSG00000029765 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG3610, Eukaryota |
GeneTreei | ENSGT01020000230473 |
HOGENOMi | CLU_001436_2_0_1 |
InParanoidi | Q80UG2 |
OMAi | KVYLYKC |
OrthoDBi | 90434at2759 |
PhylomeDBi | Q80UG2 |
TreeFami | TF312962 |
Enzyme and pathway databases
Reactomei | R-MMU-399954, Sema3A PAK dependent Axon repulsion R-MMU-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-MMU-399956, CRMPs in Sema3A signaling |
Miscellaneous databases
BioGRID-ORCSi | 243743, 1 hit in 72 CRISPR screens |
ChiTaRSi | Plxna4, mouse |
PROi | PR:Q80UG2 |
RNActi | Q80UG2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029765, Expressed in oocyte and 252 other tissues |
Genevisiblei | Q80UG2, MM |
Family and domain databases
DisProti | DP02528 |
Gene3Di | 1.10.506.10, 1 hit 2.130.10.10, 1 hit 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR031148, Plexin IPR013548, Plexin_cytoplasmic_RasGAP_dom IPR002165, Plexin_repeat IPR016201, PSI IPR008936, Rho_GTPase_activation_prot IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR041019, TIG1_plexin IPR041362, TIG2_plexin IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR22625, PTHR22625, 1 hit |
Pfami | View protein in Pfam PF08337, Plexin_cytopl, 1 hit PF01437, PSI, 3 hits PF01403, Sema, 1 hit PF01833, TIG, 4 hits PF18020, TIG_2, 1 hit PF17960, TIG_plexin, 1 hit |
SMARTi | View protein in SMART SM00429, IPT, 4 hits SM00423, PSI, 3 hits SM00630, Sema, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF48350, SSF48350, 1 hit SSF81296, SSF81296, 4 hits |
PROSITEi | View protein in PROSITE PS51004, SEMA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PLXA4_MOUSE | |
Accessioni | Q80UG2Primary (citable) accession number: Q80UG2 Secondary accession number(s): E9QN64, Q5DTW8, Q8BKK9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 13, 2006 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 140 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families