Plexin-A4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• semaphorin receptor activity Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • Ref.1

    "Identification and characterization of a novel mouse plexin, plexin-A4."
    Suto F., Murakami Y., Nakamura F., Goshima Y., Fujisawa H.
    Mech. Dev. 120:385-396(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.

GO - Biological processⁱ

• anterior commissure morphogenesis Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance."
    Suto F., Ito K., Uemura M., Shimizu M., Shinkawa Y., Sanbo M., Shinoda T., Tsuboi M., Takashima S., Yagi T., Fujisawa H.
    J Neurosci 25:3628-3637(2005) [PubMed] [Europe PMC] [Abstract]
• axon guidance Source: MGIInferred from mutant phenotypeⁱ
  • "Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance."
    Suto F., Ito K., Uemura M., Shimizu M., Shinkawa Y., Sanbo M., Shinoda T., Tsuboi M., Takashima S., Yagi T., Fujisawa H.
    J Neurosci 25:3628-3637(2005) [PubMed] [Europe PMC] [Abstract]
• branchiomotor neuron axon guidance Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • Ref.6

    "Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development."
    Schwarz Q., Waimey K.E., Golding M., Takamatsu H., Kumanogoh A., Fujisawa H., Cheng H.J., Ruhrberg C.
    Dev. Biol. 324:1-9(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: DISRUPTION PHENOTYPE.
• chemorepulsion of branchiomotor axon Source: MGIInferred from mutant phenotypeⁱ
  • "Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance."
    Suto F., Ito K., Uemura M., Shimizu M., Shinkawa Y., Sanbo M., Shinoda T., Tsuboi M., Takashima S., Yagi T., Fujisawa H.
    J Neurosci 25:3628-3637(2005) [PubMed] [Europe PMC] [Abstract]
• cranial nerve morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance."
    Suto F., Ito K., Uemura M., Shimizu M., Shinkawa Y., Sanbo M., Shinoda T., Tsuboi M., Takashima S., Yagi T., Fujisawa H.
    J Neurosci 25:3628-3637(2005) [PubMed] [Europe PMC] [Abstract]
• embryonic heart tube development Source: MGIInferred from mutant phenotypeⁱ
  • "Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin."
    Poltavski D.M., Colombier P., Hu J., Duron A., Black B.L., Makita T.
    Elife 8:e42528-e42528(2019) [PubMed] [Europe PMC] [Abstract]
• facial nerve morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance."
    Suto F., Ito K., Uemura M., Shimizu M., Shinkawa Y., Sanbo M., Shinoda T., Tsuboi M., Takashima S., Yagi T., Fujisawa H.
    J Neurosci 25:3628-3637(2005) [PubMed] [Europe PMC] [Abstract]
• facial nerve structural organization Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • Ref.6

    "Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development."
    Schwarz Q., Waimey K.E., Golding M., Takamatsu H., Kumanogoh A., Fujisawa H., Cheng H.J., Ruhrberg C.
    Dev. Biol. 324:1-9(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: DISRUPTION PHENOTYPE.
• glossopharyngeal nerve morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance."
    Suto F., Ito K., Uemura M., Shimizu M., Shinkawa Y., Sanbo M., Shinoda T., Tsuboi M., Takashima S., Yagi T., Fujisawa H.
    J Neurosci 25:3628-3637(2005) [PubMed] [Europe PMC] [Abstract]
• motor neuron axon guidance Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • Ref.6

    "Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development."
    Schwarz Q., Waimey K.E., Golding M., Takamatsu H., Kumanogoh A., Fujisawa H., Cheng H.J., Ruhrberg C.
    Dev. Biol. 324:1-9(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: DISRUPTION PHENOTYPE.
• negative regulation of cell adhesion Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• nervous system development Source: MGIInferred from genetic interactionⁱ
  • Ref.1

    "Identification and characterization of a novel mouse plexin, plexin-A4."
    Suto F., Murakami Y., Nakamura F., Goshima Y., Fujisawa H.
    Mech. Dev. 120:385-396(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
• neuron projection morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance."
    Suto F., Ito K., Uemura M., Shimizu M., Shinkawa Y., Sanbo M., Shinoda T., Tsuboi M., Takashima S., Yagi T., Fujisawa H.
    J Neurosci 25:3628-3637(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of axonogenesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• postganglionic parasympathetic fiber development Source: MGIInferred from mutant phenotypeⁱ
  • "Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance."
    Suto F., Ito K., Uemura M., Shimizu M., Shinkawa Y., Sanbo M., Shinoda T., Tsuboi M., Takashima S., Yagi T., Fujisawa H.
    J Neurosci 25:3628-3637(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of axon extension involved in axon guidance Source: MGIInferred from mutant phenotypeⁱ
  • "Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance."
    Suto F., Ito K., Uemura M., Shimizu M., Shinkawa Y., Sanbo M., Shinoda T., Tsuboi M., Takashima S., Yagi T., Fujisawa H.
    J Neurosci 25:3628-3637(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of cell migration Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of cell shape Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of GTPase activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of negative chemotaxis Source: MGIInferred from mutant phenotypeⁱ
  • "Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance."
    Suto F., Ito K., Uemura M., Shimizu M., Shinkawa Y., Sanbo M., Shinoda T., Tsuboi M., Takashima S., Yagi T., Fujisawa H.
    J Neurosci 25:3628-3637(2005) [PubMed] [Europe PMC] [Abstract]
• semaphorin-plexin signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance."
    Suto F., Ito K., Uemura M., Shimizu M., Shinkawa Y., Sanbo M., Shinoda T., Tsuboi M., Takashima S., Yagi T., Fujisawa H.
    J Neurosci 25:3628-3637(2005) [PubMed] [Europe PMC] [Abstract]
• semaphorin-plexin signaling pathway involved in axon guidance Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • Ref.6

    "Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development."
    Schwarz Q., Waimey K.E., Golding M., Takamatsu H., Kumanogoh A., Fujisawa H., Cheng H.J., Ruhrberg C.
    Dev. Biol. 324:1-9(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: DISRUPTION PHENOTYPE.
• sympathetic nervous system development Source: MGIInferred from mutant phenotypeⁱ
  • "Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance."
    Suto F., Ito K., Uemura M., Shimizu M., Shinkawa Y., Sanbo M., Shinoda T., Tsuboi M., Takashima S., Yagi T., Fujisawa H.
    J Neurosci 25:3628-3637(2005) [PubMed] [Europe PMC] [Abstract]
• sympathetic neuron axon guidance Source: MGIInferred from genetic interactionⁱ
  • "Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin."
    Poltavski D.M., Colombier P., Hu J., Duron A., Black B.L., Makita T.
    Elife 8:e42528-e42528(2019) [PubMed] [Europe PMC] [Abstract]
• trigeminal nerve morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance."
    Suto F., Ito K., Uemura M., Shimizu M., Shinkawa Y., Sanbo M., Shinoda T., Tsuboi M., Takashima S., Yagi T., Fujisawa H.
    J Neurosci 25:3628-3637(2005) [PubMed] [Europe PMC] [Abstract]
• trigeminal nerve structural organization Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • Ref.6

    "Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development."
    Schwarz Q., Waimey K.E., Golding M., Takamatsu H., Kumanogoh A., Fujisawa H., Cheng H.J., Ruhrberg C.
    Dev. Biol. 324:1-9(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: DISRUPTION PHENOTYPE.
• vagus nerve morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance."
    Suto F., Ito K., Uemura M., Shimizu M., Shinkawa Y., Sanbo M., Shinoda T., Tsuboi M., Takashima S., Yagi T., Fujisawa H.
    J Neurosci 25:3628-3637(2005) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MKAMPWNWTC LLSHLLVVGM GSSTLLPRQP PQLSQKPSFV TFRGEPAEGF 
        60         70         80         90        100
NHLVVDERTG HIYLGAVNRI YKLSSDLKVL VTHQTGPDED NPKCYPPRIV 
       110        120        130        140        150
QTCNEPLAST NNVNKMLLID YKENRLIACG SLYQGICKLL RLEDLFKLGE 
       160        170        180        190        200
PFHKKEHYLS GVNESGSVFG VIVSYSNFDD KLFIATAVDG KPEYFPTISS 
       210        220        230        240        250
RKLTKNSEAD GMFAYVFHDE FVASMIKIPS DTFTVIPDFD IYYVYGFSSG 
       260        270        280        290        300
NFVYFLTLQP EMVSPPGSTT KEQVYTSKLV RLCKEDTAFN SYVEVPIGCE 
       310        320        330        340        350
RNGVEYRLLQ AAYLSKAGAV LGRTLGVRPD DDLLFTVFSK GQKRKMKSLD 
       360        370        380        390        400
ESALCIFILK QINDRIKDRL QSCYRGEGTL DLAWLKVKDI PCSSALLTID 
       410        420        430        440        450
DNFCGLDMNA PLGVSEMVRG IPVFTEDRDR MTSVIAYVYK NHSLAFVGTK 
       460        470        480        490        500
SGKLKKIRVD GPKGNALQYE TVQVVDSGPV LRDMAFSKDH EQLYIMSERQ 
       510        520        530        540        550
LTRVPVESCG QYRSCGECLG SGDPHCGWCV LHNTCTRKER CERSREPRRF 
       560        570        580        590        600
ASEMKQCVRL TVHPNNISVS QYNVLLVLET YNVPELSAGV NCTFEDLSEM 
       610        620        630        640        650
DGLVIGNQIQ CYSPAAKEVP RIITENGDHH VVQLQLKSKE TGMTFASTSF 
       660        670        680        690        700
VFYNCSVHNS CLSCVESPYR CHWCKYRHVC THDPNTCSFQ EGRVKLPEDC 
       710        720        730        740        750
PQLLRVDKIL VPVEVIKPIT LKAKNLPQPQ SGQRGYECIL NIQGIEQRVP 
       760        770        780        790        800
ALRFNSSSVQ CQNTSYSYEG MEINNLPVEL TVVWNGHFNI DNPAQNKVYL 
       810        820        830        840        850
YKCGAMRESC GLCLKADPDF ECGWCQSPGQ CTLRQHCPAH ESRWLELSGA 
       860        870        880        890        900
NSKCTNPRIT EIIPVTGPRE GGTKVTIRGE NLGLEFRDIA SHVKVAGVEC 
       910        920        930        940        950
SPLVDGYIPA EQIVCEMGEA KPSQHAGFVE ICVAVCRPEF MARSSQLYYF 
       960        970        980        990       1000
MTLTLADLKP NRGPMSGGTQ VTITGTNLNA GSNVVVMFGS QPCLFHRRSP 
      1010       1020       1030       1040       1050
SYIICNTTSS EEVLDMKVTV QVDRARIRQD LVFQYVEDPT IVRIEPEWSI 
      1060       1070       1080       1090       1100
VSGNTPIAVW GTHLDLIQNP QIRAKHGGKE HINICEVLNA TEMTCQAPAL 
      1110       1120       1130       1140       1150
ALGPDHQSDL TERPEEFGFI LDNVQSLLIL NKTNFTYYPN PVFEAFSPSG 
      1160       1170       1180       1190       1200
ILELKPGTPI ILKGKNLIPP VAGGNVKLNY TVLVGEKPCT VTVSDVQLLC 
      1210       1220       1230       1240       1250
ESPNLIGRHK VMARVGGMEY SPGMVYIAPD SPLSLPAIVS IAVAGGLLII 
      1260       1270       1280       1290       1300
FIVAVLIAYK RKSRESDLTL KRLQMQMDNL ESRVALECKE AFAELQTDIH 
      1310       1320       1330       1340       1350
ELTSDLDGAG IPFLDYRTYT MRVLFPGIED HPVLRDLEVP GYRQERVEKG 
      1360       1370       1380       1390       1400
LKLFAQLINN KVFLLSFIRT LESQRSFSMR DRGNVASLIM TVLQSKLEYA 
      1410       1420       1430       1440       1450
TDVLKQLLAD LIDKNLESKN HPKLLLRRTE SVAEKMLTNW FTFLLYKFLK 
      1460       1470       1480       1490       1500
ECAGEPLFSL FCAIKQQMEK GPIDAITGEA RYSLSEDKLI RQQIEYKTLV 
      1510       1520       1530       1540       1550
LSCVSPDNVN SPEVPVKILN CDTITQVKEK ILDAIFKNVP CSHRPKAADM 
      1560       1570       1580       1590       1600
DLEWRQGSGA RMILQDEDIT TKIENDWKRL NTVAHYQVPD GSVVALVSKQ 
      1610       1620       1630       1640       1650
VTAYNAVNNS TVSRTSASKY ENMIRYTGSP DSLRSRTPMI TPDLESGVKL 
      1660       1670       1680       1690       1700
WHLVKNHEHG DQKEGDRGSK MVSEIYLTRL LATKGTLQKF VDDLFETIFS 
      1710       1720       1730       1740       1750
TAHRGSALPL AIKYMFDFLD EQADKHGIHD PHVRHTWKSN CLPLRFWVNM 
      1760       1770       1780       1790       1800
IKNPQFVFDI HKNSITDACL SVVAQTFMDS CSTSEHRLGK DSPSNKLLYA 
      1810       1820       1830       1840       1850
KDIPSYKNWV ERYYSDIGKM PAISDQDMNA YLAEQSRMHM NEFNTMSALS 
      1860       1870       1880       1890 
EIFSYVGKYS EEILGPLDHD DQCGKQKLAY KLEQVITLMS LDS        

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families