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Protein

Plexin-A4

Gene

Plxna4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.2 Publications

GO - Molecular functioni

  • semaphorin receptor activity Source: MGI

GO - Biological processi

  • anterior commissure morphogenesis Source: MGI
  • axon guidance Source: MGI
  • branchiomotor neuron axon guidance Source: ParkinsonsUK-UCL
  • chemorepulsion of branchiomotor axon Source: MGI
  • cranial nerve morphogenesis Source: MGI
  • facial nerve morphogenesis Source: MGI
  • facial nerve structural organization Source: ParkinsonsUK-UCL
  • glossopharyngeal nerve morphogenesis Source: MGI
  • motor neuron axon guidance Source: ParkinsonsUK-UCL
  • nervous system development Source: MGI
  • neuron projection morphogenesis Source: MGI
  • postganglionic parasympathetic fiber development Source: MGI
  • regulation of axon extension involved in axon guidance Source: MGI
  • regulation of negative chemotaxis Source: MGI
  • semaphorin-plexin signaling pathway Source: MGI
  • semaphorin-plexin signaling pathway involved in axon guidance Source: ParkinsonsUK-UCL
  • sympathetic nervous system development Source: MGI
  • trigeminal nerve morphogenesis Source: MGI
  • trigeminal nerve structural organization Source: ParkinsonsUK-UCL
  • vagus nerve morphogenesis Source: MGI

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-399954 Sema3A PAK dependent Axon repulsion
R-MMU-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-MMU-399956 CRMPs in Sema3A signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-A4
Gene namesi
Name:Plxna4
Synonyms:Kiaa1550
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2179061 Plxna4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 1236ExtracellularSequence analysisAdd BLAST1213
Transmembranei1237 – 1257HelicalSequence analysisAdd BLAST21
Topological domaini1258 – 1893CytoplasmicSequence analysisAdd BLAST636

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Mice exhibit defasciculation of the facial branchiomotor nerve and of the ophthalmic branch of the trigeminus, with variable severity. In mice lacking both Plxna3 and Plxna4, migrating neurons do not show the normal response to Sema3A and Sema3F and do not migrate away from these semaphorins (in vitro).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000024028424 – 1893Plexin-A4Add BLAST1870

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 103PROSITE-ProRule annotation
Disulfide bondi129 ↔ 137PROSITE-ProRule annotation
Disulfide bondi283 ↔ 404PROSITE-ProRule annotation
Disulfide bondi299 ↔ 355PROSITE-ProRule annotation
Disulfide bondi373 ↔ 392PROSITE-ProRule annotation
Disulfide bondi509 ↔ 526PROSITE-ProRule annotation
Disulfide bondi515 ↔ 557PROSITE-ProRule annotation
Disulfide bondi518 ↔ 535PROSITE-ProRule annotation
Disulfide bondi529 ↔ 541PROSITE-ProRule annotation
Disulfide bondi592 ↔ 611PROSITE-ProRule annotation
Glycosylationi654N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1006N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1131N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1179N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1349N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ80UG2
PaxDbiQ80UG2
PRIDEiQ80UG2

PTM databases

iPTMnetiQ80UG2
PhosphoSitePlusiQ80UG2
SwissPalmiQ80UG2

Expressioni

Tissue specificityi

Expressed in the developing nervous system. Widely expressed in both the central and peripheral nervous systems. Expressed in the peripheral ganglia, somatosensory, olfactory, visual, auditory and equilibrium systems.1 Publication

Gene expression databases

BgeeiENSMUSG00000029765
CleanExiMM_PLXNA4
GenevisibleiQ80UG2 MM

Interactioni

Subunit structurei

Interacts with NRP1 and NRP2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Sema6aO354643EBI-8057809,EBI-8057848

Protein-protein interaction databases

IntActiQ80UG2, 1 interactor
MINTiQ80UG2
STRINGi10090.ENSMUSP00000110748

Structurei

3D structure databases

ProteinModelPortaliQ80UG2
SMRiQ80UG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 506SemaPROSITE-ProRule annotationAdd BLAST483
Domaini508 – 558PSI 1Add BLAST51
Domaini654 – 701PSI 2Add BLAST48
Domaini802 – 855PSI 3Add BLAST54
Domaini857 – 951IPT/TIG 1Add BLAST95
Domaini953 – 1036IPT/TIG 2Add BLAST84
Domaini1039 – 1138IPT/TIG 3Add BLAST100
Domaini1141 – 1229IPT/TIG 4Add BLAST89

Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
GeneTreeiENSGT00760000119048
HOGENOMiHOG000231377
HOVERGENiHBG105711
InParanoidiQ80UG2
KOiK06820
OMAiHQSDLTE
OrthoDBiEOG091G00EK
TreeFamiTF312962

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 2 hits
PF01403 Sema, 1 hit
PF01833 TIG, 4 hits
SMARTiView protein in SMART
SM00429 IPT, 4 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 2 hits
SSF81296 SSF81296, 4 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80UG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAMPWNWTC LLSHLLVVGM GSSTLLPRQP PQLSQKPSFV TFRGEPAEGF
60 70 80 90 100
NHLVVDERTG HIYLGAVNRI YKLSSDLKVL VTHQTGPDED NPKCYPPRIV
110 120 130 140 150
QTCNEPLAST NNVNKMLLID YKENRLIACG SLYQGICKLL RLEDLFKLGE
160 170 180 190 200
PFHKKEHYLS GVNESGSVFG VIVSYSNFDD KLFIATAVDG KPEYFPTISS
210 220 230 240 250
RKLTKNSEAD GMFAYVFHDE FVASMIKIPS DTFTVIPDFD IYYVYGFSSG
260 270 280 290 300
NFVYFLTLQP EMVSPPGSTT KEQVYTSKLV RLCKEDTAFN SYVEVPIGCE
310 320 330 340 350
RNGVEYRLLQ AAYLSKAGAV LGRTLGVRPD DDLLFTVFSK GQKRKMKSLD
360 370 380 390 400
ESALCIFILK QINDRIKDRL QSCYRGEGTL DLAWLKVKDI PCSSALLTID
410 420 430 440 450
DNFCGLDMNA PLGVSEMVRG IPVFTEDRDR MTSVIAYVYK NHSLAFVGTK
460 470 480 490 500
SGKLKKIRVD GPKGNALQYE TVQVVDSGPV LRDMAFSKDH EQLYIMSERQ
510 520 530 540 550
LTRVPVESCG QYRSCGECLG SGDPHCGWCV LHNTCTRKER CERSREPRRF
560 570 580 590 600
ASEMKQCVRL TVHPNNISVS QYNVLLVLET YNVPELSAGV NCTFEDLSEM
610 620 630 640 650
DGLVIGNQIQ CYSPAAKEVP RIITENGDHH VVQLQLKSKE TGMTFASTSF
660 670 680 690 700
VFYNCSVHNS CLSCVESPYR CHWCKYRHVC THDPNTCSFQ EGRVKLPEDC
710 720 730 740 750
PQLLRVDKIL VPVEVIKPIT LKAKNLPQPQ SGQRGYECIL NIQGIEQRVP
760 770 780 790 800
ALRFNSSSVQ CQNTSYSYEG MEINNLPVEL TVVWNGHFNI DNPAQNKVYL
810 820 830 840 850
YKCGAMRESC GLCLKADPDF ECGWCQSPGQ CTLRQHCPAH ESRWLELSGA
860 870 880 890 900
NSKCTNPRIT EIIPVTGPRE GGTKVTIRGE NLGLEFRDIA SHVKVAGVEC
910 920 930 940 950
SPLVDGYIPA EQIVCEMGEA KPSQHAGFVE ICVAVCRPEF MARSSQLYYF
960 970 980 990 1000
MTLTLADLKP NRGPMSGGTQ VTITGTNLNA GSNVVVMFGS QPCLFHRRSP
1010 1020 1030 1040 1050
SYIICNTTSS EEVLDMKVTV QVDRARIRQD LVFQYVEDPT IVRIEPEWSI
1060 1070 1080 1090 1100
VSGNTPIAVW GTHLDLIQNP QIRAKHGGKE HINICEVLNA TEMTCQAPAL
1110 1120 1130 1140 1150
ALGPDHQSDL TERPEEFGFI LDNVQSLLIL NKTNFTYYPN PVFEAFSPSG
1160 1170 1180 1190 1200
ILELKPGTPI ILKGKNLIPP VAGGNVKLNY TVLVGEKPCT VTVSDVQLLC
1210 1220 1230 1240 1250
ESPNLIGRHK VMARVGGMEY SPGMVYIAPD SPLSLPAIVS IAVAGGLLII
1260 1270 1280 1290 1300
FIVAVLIAYK RKSRESDLTL KRLQMQMDNL ESRVALECKE AFAELQTDIH
1310 1320 1330 1340 1350
ELTSDLDGAG IPFLDYRTYT MRVLFPGIED HPVLRDLEVP GYRQERVEKG
1360 1370 1380 1390 1400
LKLFAQLINN KVFLLSFIRT LESQRSFSMR DRGNVASLIM TVLQSKLEYA
1410 1420 1430 1440 1450
TDVLKQLLAD LIDKNLESKN HPKLLLRRTE SVAEKMLTNW FTFLLYKFLK
1460 1470 1480 1490 1500
ECAGEPLFSL FCAIKQQMEK GPIDAITGEA RYSLSEDKLI RQQIEYKTLV
1510 1520 1530 1540 1550
LSCVSPDNVN SPEVPVKILN CDTITQVKEK ILDAIFKNVP CSHRPKAADM
1560 1570 1580 1590 1600
DLEWRQGSGA RMILQDEDIT TKIENDWKRL NTVAHYQVPD GSVVALVSKQ
1610 1620 1630 1640 1650
VTAYNAVNNS TVSRTSASKY ENMIRYTGSP DSLRSRTPMI TPDLESGVKL
1660 1670 1680 1690 1700
WHLVKNHEHG DQKEGDRGSK MVSEIYLTRL LATKGTLQKF VDDLFETIFS
1710 1720 1730 1740 1750
TAHRGSALPL AIKYMFDFLD EQADKHGIHD PHVRHTWKSN CLPLRFWVNM
1760 1770 1780 1790 1800
IKNPQFVFDI HKNSITDACL SVVAQTFMDS CSTSEHRLGK DSPSNKLLYA
1810 1820 1830 1840 1850
KDIPSYKNWV ERYYSDIGKM PAISDQDMNA YLAEQSRMHM NEFNTMSALS
1860 1870 1880 1890
EIFSYVGKYS EEILGPLDHD DQCGKQKLAY KLEQVITLMS LDS
Length:1,893
Mass (Da):212,560
Last modified:July 27, 2011 - v3
Checksum:iC785B0D895AD8DB7
GO

Sequence cautioni

The sequence BAC56599 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti683 – 684DP → GR in BAC56599 (PubMed:12591607).Curated2
Sequence conflicti1607V → E in BAC34692 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073228 mRNA Translation: BAC56599.1 Different initiation.
AC153629 Genomic DNA No translation available.
AC153867 Genomic DNA No translation available.
AC158678 Genomic DNA No translation available.
AK051614 mRNA Translation: BAC34692.1
AK220402 mRNA Translation: BAD90257.1
CCDSiCCDS19985.2
RefSeqiNP_786926.2, NM_175750.3
UniGeneiMm.444029

Genome annotation databases

EnsembliENSMUST00000115096; ENSMUSP00000110748; ENSMUSG00000029765
GeneIDi243743
KEGGimmu:243743
UCSCiuc009bgm.3 mouse

Similar proteinsi

Entry informationi

Entry nameiPLXA4_MOUSE
AccessioniPrimary (citable) accession number: Q80UG2
Secondary accession number(s): E9QN64, Q5DTW8, Q8BKK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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