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UniProtKB - Q80UF7 (TCAM1_MOUSE)

Entry version 135 (07 Apr 2021)
Sequence version 1 (01 Jun 2003)
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Protein

TIR domain-containing adapter molecule 1

Gene

Ticam1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12855817, PubMed:16002681, PubMed:21703541). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12855817, PubMed:16002681, PubMed:21703541). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12855817, PubMed:16002681, PubMed:21703541). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines (PubMed:21703541).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiviral defense, Apoptosis, Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-140534, Caspase activation via Death Receptors in the presence of ligand
R-MMU-166166, MyD88-independent TLR4 cascade
R-MMU-2562578, TRIF-mediated programmed cell death
R-MMU-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-MMU-937041, IKK complex recruitment mediated by RIP1
R-MMU-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-MMU-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TIR domain-containing adapter molecule 1
Short name:
TICAM-1
Alternative name(s):
Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
Short name:
TIR domain-containing adapter protein inducing IFN-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ticam1
Synonyms:Trif
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2147032, Ticam1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable but exhibit abnormalities of the innate immune system.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003176641 – 732TIR domain-containing adapter molecule 1Add BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei209PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by TBK1. Following activation, phosphorylated by TBK1 at Ser-209 in the pLxIS motif. The phosphorylated pLxIS motif constitutes an IRF3-binding motif, leading to recruitment of the transcription factor IRF3 to induce type-I interferons and other cytokines.By similarity
Polyubiquitinated by TRIM38 with 'Lys-48'-linked chains, leading to proteasomal degradation. Polyubiquitinated with 'Lys-6'- and 'Lys-33'-linked chains in a TRIM8-dependent manner; ubiquitination disrupts the interaction with TBK1 and subsequent interferon production.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q80UF7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q80UF7

PRoteomics IDEntifications database

More...PRIDEi		Q80UF7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		263143

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q80UF7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000047123, Expressed in intestine and 176 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q80UF7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1; this complex exists in resting cells with or without poly(I:C) RNA ligand stimulation (PubMed:21703541).

Interacts (via TIR domain) with DDX21 (via C-terminus) (PubMed:21703541).

Interacts (via TIR domain) with DHX36 (via C-terminus) (PubMed:21703541).

Interacts with AZI2 and IRF7 (By similarity).

Interacts (when phosphorylated) with IRF3; following activation and phosphorylation on the pLxIS motif by TBK1, recruits IRF3 (By similarity).

Interacts with TICAM2 in TLR4 recruitment (By similarity). Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation (By similarity).

Interacts with IKBKB and IKBKE (By similarity). Interaction with SARM1 blocks TICAM1-dependent transcription factor activation (By similarity).

Interacts with TRAF3.

Interacts with TRAFD1.

Interacts with UBQLN1 (via UBA domain).

Interacts with TBK1, TRAF6 and RIPK1 and these interactions are enhanced in the presence of WDFY1 (By similarity).

Interacts (via the TIR domain) with TLR3 in response to poly(I:C) and this interaction is enhanced in the presence of WDFY1 (PubMed:25736436).

Interacts with TLR4 in response to poly(I:C) in a WDFY1-dependent manner (PubMed:25736436).

Interacts with WDFY1 in response to poly(I:C) (PubMed:25736436).

Interacts with TRIM56 (By similarity).

Interacts (via the TIR domain) with TLR5 (By similarity).

Interacts with TRIM8 (By similarity).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		223122, 9 interactors

Database of interacting proteins

More...DIPi		DIP-60033N

Protein interaction database and analysis system

More...IntActi		Q80UF7, 6 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000055104

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q80UF7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q80UF7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini395 – 534TIRPROSITE-ProRule annotationAdd BLAST140

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 153TRIF-NTDBy similarityAdd BLAST153
Regioni514 – 713Sufficient to induce apoptosisBy similarityAdd BLAST200

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi84 – 91TRAF6-bindingBy similarity8
Motifi206 – 209pLxIS motifBy similarity4
Motifi247 – 254TRAF6-bindingBy similarity8
Motifi296 – 306TRAF6-bindingBy similarityAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi348 – 384Pro-richAdd BLAST37
Compositional biasi602 – 679Pro-richAdd BLAST78

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The pLxIS motif constitutes an IRF3-binding motif: following phosphorylation by TBK1, the phosphorylated pLxIS motif of TICAM1 recruits IRF3. IRF3 is then phosphorylated and activated by TBK1 to induce type-I interferons and other cytokines.By similarity
The N-terminal region is essential for activation of the IFNB promoter activity.By similarity
The N-terminal domain (TRIF-NTD) is globular and consists of two alpha-helical subdomains connected by a 14-residue linker. It shares structural similarity with IFIT family members N-terminal regions.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RXF3, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162411

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022539_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q80UF7

Identification of Orthologs from Complete Genome Data

More...OMAi		YNFVVLH

Database of Orthologous Groups

More...OrthoDBi		435629at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q80UF7

TreeFam database of animal gene trees

More...TreeFami		TF336953

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.10140, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025735, RHIM_dom
IPR017278, TICAM1
IPR035897, Toll_tir_struct_dom_sf
IPR040886, TRIF_N

The PANTHER Classification System

More...PANTHERi		PTHR47230, PTHR47230, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12721, RHIM, 1 hit
PF17798, TRIF-NTD, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037744, TIR_Ticam, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52200, SSF52200, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50104, TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q80UF7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNPGPSLRG AFGILGALER DRLTHLKHKL GSLCSGSQES KLLHAMVLLA 
        60         70         80         90        100
LGQDTEARVS LESLKMNTVA QLVAHQWADM ETTEGPEEPP DLSWTVARLY 
       110        120        130        140        150
HLLAEENLCP ASTRDMAYQV ALRDFASQGD HQLGQLQNEA WDRCSSDIKG 
       160        170        180        190        200
DPSGFQPLHS HQGSLQPPSA SPAVTRSQPR PIDTPDWSWG HTLHSTNSTA 
       210        220        230        240        250
SLASHLEISQ SPTLAFLSSH HGTHGPSKLC NTPLDTQEPQ LVPEGCQEPE 
       260        270        280        290        300
EISWPPSVET SVSLGLPHEI SVPEVSPEEA SPILPDALAA PDTSVHCPIE 
       310        320        330        340        350
CTELSTNSRS PLTSTTESVG KQWPITSQRS PQVPVGDDSL QNTTSSSPPA 
       360        370        380        390        400
QPPSLQASPK LPPSPLSSAS SPSSYPAPPT STSPVLDHSE TSDQKFYNFV 
       410        420        430        440        450
VIHARADEQV ALRIREKLET LGVPDGATFC EEFQVPGRGE LHCLQDAIDH 
       460        470        480        490        500
SGFTILLLTA SFDCSLSLHQ INHALMNSLT QSGRQDCVIP LLPLECSQAQ 
       510        520        530        540        550
LSPDTTRLLH SIVWLDEHSP IFARKVANTF KTQKLQAQRV RWKKAQEART 
       560        570        580        590        600
LKEQSIQLEA ERQNVAAISA AYTAYVHSYR AWQAEMNKLG VAFGKNLSLG 
       610        620        630        640        650
TPTPSWPGCP QPIPSHPQGG TPVFPYSPQP PSFPQPPCFP QPPSFPQPPS 
       660        670        680        690        700
FPLPPVSSPQ SQSFPSASSP APQTPGPQPL IIHHAQMVQL GVNNHMWGHT 
       710        720        730 
GAQSSDDKTE CSENPCMGPL TDQGEPLLET PE
Length:732
Mass (Da):79,230
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2EAC87F1936B7C83
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH33406 differs from that shown.Curated
The sequence AAH37048 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH62191 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti227S → G in BAE29344 (PubMed:16141072).Curated1
Sequence conflicti351 – 435Missing in AAH62191 (PubMed:15489334).CuratedAdd BLAST85
Sequence conflicti435V → A in BAE25531 (PubMed:16141072).Curated1
Sequence conflicti513V → A in BAE29344 (PubMed:16141072).Curated1
Sequence conflicti628 – 639Missing in AAH33406 (PubMed:15489334).CuratedAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB091053 mRNA Translation: BAC55581.1
AK143766 mRNA Translation: BAE25531.1
AK150150 mRNA Translation: BAE29344.1
AK155245 mRNA Translation: BAE33144.1
BC033406 mRNA Translation: AAH33406.1 Sequence problems.
BC037048 mRNA Translation: AAH37048.1 Different initiation.
BC062191 mRNA Translation: AAH62191.1 Frameshift.
BC094338 mRNA Translation: AAH94338.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS28900.1

NCBI Reference Sequences

More...RefSeqi		NP_778154.1, NM_174989.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000058136; ENSMUSP00000055104; ENSMUSG00000047123

Database of genes from NCBI RefSeq genomes

More...GeneIDi		106759

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:106759

UCSC genome browser

More...UCSCi		uc008dbm.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB091053 mRNA Translation: BAC55581.1
AK143766 mRNA Translation: BAE25531.1
AK150150 mRNA Translation: BAE29344.1
AK155245 mRNA Translation: BAE33144.1
BC033406 mRNA Translation: AAH33406.1 Sequence problems.
BC037048 mRNA Translation: AAH37048.1 Different initiation.
BC062191 mRNA Translation: AAH62191.1 Frameshift.
BC094338 mRNA Translation: AAH94338.1
CCDSiCCDS28900.1
RefSeqiNP_778154.1, NM_174989.4

3D structure databases

SMRiQ80UF7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi223122, 9 interactors
DIPiDIP-60033N
IntActiQ80UF7, 6 interactors
STRINGi10090.ENSMUSP00000055104

PTM databases

PhosphoSitePlusiQ80UF7

Proteomic databases

EPDiQ80UF7
PaxDbiQ80UF7
PRIDEiQ80UF7
ProteomicsDBi263143

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11536, 350 antibodies

Genome annotation databases

EnsembliENSMUST00000058136; ENSMUSP00000055104; ENSMUSG00000047123
GeneIDi106759
KEGGimmu:106759
UCSCiuc008dbm.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		148022
MGIiMGI:2147032, Ticam1

Phylogenomic databases

eggNOGiENOG502RXF3, Eukaryota
GeneTreeiENSGT00940000162411
HOGENOMiCLU_022539_0_0_1
InParanoidiQ80UF7
OMAiYNFVVLH
OrthoDBi435629at2759
PhylomeDBiQ80UF7
TreeFamiTF336953

Enzyme and pathway databases

ReactomeiR-MMU-140534, Caspase activation via Death Receptors in the presence of ligand
R-MMU-166166, MyD88-independent TLR4 cascade
R-MMU-2562578, TRIF-mediated programmed cell death
R-MMU-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-MMU-937041, IKK complex recruitment mediated by RIP1
R-MMU-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-MMU-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		106759, 3 hits in 54 CRISPR screens

Protein Ontology

More...PROi		PR:Q80UF7
RNActiQ80UF7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000047123, Expressed in intestine and 176 other tissues
GenevisibleiQ80UF7, MM

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR025735, RHIM_dom
IPR017278, TICAM1
IPR035897, Toll_tir_struct_dom_sf
IPR040886, TRIF_N
PANTHERiPTHR47230, PTHR47230, 1 hit
PfamiView protein in Pfam
PF12721, RHIM, 1 hit
PF17798, TRIF-NTD, 1 hit
PIRSFiPIRSF037744, TIR_Ticam, 1 hit
SUPFAMiSSF52200, SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50104, TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCAM1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80UF7
Secondary accession number(s): Q3UDB7
, Q3UP66, Q6P6J2, Q8CIB7, Q8JZV0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: April 7, 2021
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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