Ticam1

Functionⁱ

Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines (PubMed:21703541).3 Publications

GO - Molecular functionⁱ

protein kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 12872135
cellular response to lipopolysaccharide
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 17658277
cellular response to oxidised low-density lipoprotein particle stimulus
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 20037584
defense response to virus
Source: MGI
Inferred from mutant phenotypeⁱ
- 12872135
inflammatory response Source: UniProtKB-KW
innate immune response Source: UniProtKB-KW
lipopolysaccharide-mediated signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 12855817
- 12872135
macrophage activation involved in immune response
Source: MGI
Inferred from mutant phenotypeⁱ
- 12872135
MyD88-independent toll-like receptor signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 12855817
- 12872135
positive regulation of autophagy
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 17658277
positive regulation of B cell activation
Source: MGI
Inferred from mutant phenotypeⁱ
- 12855817
positive regulation of B cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 12855817
positive regulation of chemokine biosynthetic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 12855817
positive regulation of cytokine production involved in inflammatory response
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 20037584
positive regulation of gene expression
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 20037584
positive regulation of I-kappaB kinase/NF-kappaB signaling
Source: MGI
Inferred from mutant phenotypeⁱ
- 12855817
positive regulation of interferon-beta biosynthetic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 12855817
- 12872135
positive regulation of interleukin-6 production
Source: MGI
Inferred from mutant phenotypeⁱ
- 12855817
positive regulation of natural killer cell activation
Source: MGI
Inferred from mutant phenotypeⁱ
- 21059856
positive regulation of NF-kappaB transcription factor activity
Source: MGI
Inferred from mutant phenotypeⁱ
- 12855817
positive regulation of nitric oxide biosynthetic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 12872135
positive regulation of protein binding
Source: MGI
Inferred from direct assayⁱ
- 19734906
positive regulation of protein ubiquitination
Source: MGI
Inferred from direct assayⁱ
- 19734906
positive regulation of tumor necrosis factor production
Source: MGI
Inferred from direct assayⁱ
- 12872135
positive regulation of type I interferon production
Source: MGI
Inferred from mutant phenotypeⁱ
- 12872135
regulation of protein homodimerization activity
Source: MGI
Inferred from mutant phenotypeⁱ
- 12872135
response to exogenous dsRNA
Source: MGI
Inferred from direct assayⁱ
- 12872135
response to lipopolysaccharide
Source: MGI
Inferred from mutant phenotypeⁱ
- 12855817
- 12872135
TRIF-dependent toll-like receptor signaling pathway
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 17658277

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Antiviral defense, Apoptosis, Immunity, Inflammatory response, Innate immunity

Biological process

Antiviral defense, Apoptosis, Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactomeⁱ	R-MMU-140534 via Death Receptors in the presence of ligand R-MMU-166166 MyD88-independent TLR4 cascade R-MMU-2562578 TRIF-mediated programmed cell death R-MMU-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-MMU-937041 IKK complex recruitment mediated by RIP1 R-MMU-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex

Reactomeⁱ

R-MMU-140534 via Death Receptors in the presence of ligand
R-MMU-166166 MyD88-independent TLR4 cascade
R-MMU-2562578 TRIF-mediated programmed cell death
R-MMU-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-MMU-937041 IKK complex recruitment mediated by RIP1
R-MMU-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: TIR domain-containing adapter molecule 1 Short name: TICAM-1 Alternative name(s): Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta Short name: TIR domain-containing adapter protein inducing IFN-beta
Gene namesⁱ	Name:Ticam1 Synonyms:Trif
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 17

Organism-specific databases

MGIⁱ	MGI:2147032 Ticam1

Keywords - Cellular componentⁱ

Cytoplasm, Cytoplasmic vesicle, Mitochondrion

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice are viable but exhibit abnormalities of the innate immune system.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000317664	1 – 732	TIR domain-containing adapter molecule 1Add BLAST		732

Post-translational modificationⁱ

Phosphorylated by TBK1.By similarity

Polyubiquitinated by TRIM38 with 'Lys-48'-linked chains, leading to proteasomal degradation.By similarity

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q80UF7
PRIDEⁱ	Q80UF7

PTM databases

PhosphoSitePlusⁱ	Q80UF7

PhosphoSitePlusⁱ

Q80UF7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000047123 Expressed in 153 organ(s), highest expression level in intestine
CleanExⁱ	MM_TICAM1
Genevisibleⁱ	Q80UF7 MM

Interactionⁱ

Subunit structureⁱ

Homodimer (By similarity). Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1; this complex exists in resting cells with or without poly(I:C) RNA ligand stimulation (PubMed:21703541). Interacts (via TIR domain) with DDX21 (via C-terminus) (PubMed:21703541). Interacts (via TIR domain) with DHX36 (via C-terminus) (PubMed:21703541). Interacts with AZI2, IRF3 and IRF7 (By similarity). Interacts with TICAM2 in TLR4 recruitment (By similarity). Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation (By similarity). Interacts with IKBKB and IKBKE (By similarity). Interaction with SARM1 blocks TICAM1-dependent transcription factor activation (By similarity). Interacts with TRAF3. Interacts with TRAFD1. Interacts with UBQLN1 (via UBA domain). Interacts with TBK1, TRAF6 and RIPK1 and these interactions are enhanced in the presence of WDFY1 (By similarity). Interacts (via the TIR domain) with TLR3 in response to poly(I:C) and this interaction is enhanced in the presence of WDFY1 (PubMed:25736436). Interacts with TLR4 in response to poly(I:C) in a WDFY1-dependent manner (PubMed:25736436). Interacts with WDFY1 in response to poly(I:C) (PubMed:25736436). Interacts with TRIM56 (By similarity).By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
Btk	P35991	2	EBI-3649271,EBI-625119
Cblb	Q3TTA7	2	EBI-3649271,EBI-3649276
Tbk1	Q9WUN2	2	EBI-3649271,EBI-764193
Traf3	Q60803	2	EBI-3649271,EBI-520135

GO - Molecular functionⁱ

protein kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	223122, 9 interactors
Database of interacting proteins More...DIPⁱ	DIP-60033N
IntActⁱ	Q80UF7, 6 interactors
STRINGⁱ	10090.ENSMUSP00000055104

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q80UF7
SMRⁱ	Q80UF7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	392 – 465	TIRAdd BLAST		74

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 153	TRIF-NTDBy similarityAdd BLAST		153
Regionⁱ	514 – 713	Sufficient to induce apoptosisBy similarityAdd BLAST		200

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	84 – 91	TRAF6-bindingBy similarity	8
Motifⁱ	247 – 254	TRAF6-bindingBy similarity	8
Motifⁱ	296 – 306	TRAF6-bindingBy similarityAdd BLAST	11

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	348 – 384	Pro-richAdd BLAST		37
Compositional biasⁱ	602 – 679	Pro-richAdd BLAST		78

Domainⁱ

The N-terminal region is essential for activation of the IFNB promoter activity.By similarity

The N-terminal domain (TRIF-NTD) is globular and consists of two alpha-helical subdomains connected by a 14-residue linker. It shares structural similarity with IFIT family members N-terminal regions.By similarity

Phylogenomic databases

eggNOGⁱ	ENOG410IJUV Eukaryota ENOG410Y8DE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000141066
HOGENOMⁱ	HOG000068973
HOVERGENⁱ	HBG108551
InParanoidⁱ	Q80UF7
KEGG Orthology (KO) More...KOⁱ	K05842
OMAⁱ	EEKLCPA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07G7
PhylomeDBⁱ	Q80UF7
TreeFamⁱ	TF336953

Family and domain databases

Gene3Dⁱ	3.40.50.10140, 1 hit
InterProⁱ	View protein in InterPro IPR025735 RHIM_dom IPR017278 TICAM1 IPR035897 Toll_tir_struct_dom_sf
PANTHERⁱ	PTHR23213:SF331 PTHR23213:SF331, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12721 RHIM, 1 hit
PIRSFⁱ	PIRSF037744 TIR_Ticam, 1 hit
SUPFAMⁱ	SSF52200 SSF52200, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q80UF7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDNPGPSLRG AFGILGALER DRLTHLKHKL GSLCSGSQES KLLHAMVLLA 
        60         70         80         90        100
LGQDTEARVS LESLKMNTVA QLVAHQWADM ETTEGPEEPP DLSWTVARLY 
       110        120        130        140        150
HLLAEENLCP ASTRDMAYQV ALRDFASQGD HQLGQLQNEA WDRCSSDIKG 
       160        170        180        190        200
DPSGFQPLHS HQGSLQPPSA SPAVTRSQPR PIDTPDWSWG HTLHSTNSTA 
       210        220        230        240        250
SLASHLEISQ SPTLAFLSSH HGTHGPSKLC NTPLDTQEPQ LVPEGCQEPE 
       260        270        280        290        300
EISWPPSVET SVSLGLPHEI SVPEVSPEEA SPILPDALAA PDTSVHCPIE 
       310        320        330        340        350
CTELSTNSRS PLTSTTESVG KQWPITSQRS PQVPVGDDSL QNTTSSSPPA 
       360        370        380        390        400
QPPSLQASPK LPPSPLSSAS SPSSYPAPPT STSPVLDHSE TSDQKFYNFV 
       410        420        430        440        450
VIHARADEQV ALRIREKLET LGVPDGATFC EEFQVPGRGE LHCLQDAIDH 
       460        470        480        490        500
SGFTILLLTA SFDCSLSLHQ INHALMNSLT QSGRQDCVIP LLPLECSQAQ 
       510        520        530        540        550
LSPDTTRLLH SIVWLDEHSP IFARKVANTF KTQKLQAQRV RWKKAQEART 
       560        570        580        590        600
LKEQSIQLEA ERQNVAAISA AYTAYVHSYR AWQAEMNKLG VAFGKNLSLG 
       610        620        630        640        650
TPTPSWPGCP QPIPSHPQGG TPVFPYSPQP PSFPQPPCFP QPPSFPQPPS 
       660        670        680        690        700
FPLPPVSSPQ SQSFPSASSP APQTPGPQPL IIHHAQMVQL GVNNHMWGHT 
       710        720        730 
GAQSSDDKTE CSENPCMGPL TDQGEPLLET PE

Length:732

Mass (Da):79,230

Last modified:June 1, 2003 - v1

Checksum:ⁱ2EAC87F1936B7C83

GO

Sequence cautionⁱ

The sequence AAH33406 differs from that shown.Curated

The sequence AAH37048 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAH62191 differs from that shown. Reason: Frameshift at position 350.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	227	S → G in BAE29344 (PubMed:16141072).Curated	1
Sequence conflictⁱ	351 – 435	Missing in AAH62191 (PubMed:15489334).CuratedAdd BLAST	85
Sequence conflictⁱ	435	V → A in BAE25531 (PubMed:16141072).Curated	1
Sequence conflictⁱ	513	V → A in BAE29344 (PubMed:16141072).Curated	1
Sequence conflictⁱ	628 – 639	Missing in AAH33406 (PubMed:15489334).CuratedAdd BLAST	12

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB091053 mRNA Translation: BAC55581.1 AK143766 mRNA Translation: BAE25531.1 AK150150 mRNA Translation: BAE29344.1 AK155245 mRNA Translation: BAE33144.1 BC033406 mRNA Translation: AAH33406.1 Sequence problems. BC037048 mRNA Translation: AAH37048.1 Different initiation. BC062191 mRNA Translation: AAH62191.1 Frameshift. BC094338 mRNA Translation: AAH94338.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS28900.1
NCBI Reference Sequences More...RefSeqⁱ	NP_778154.1, NM_174989.4
UniGeneⁱ	Mm.203952

Genome annotation databases

Ensemblⁱ	ENSMUST00000058136; ENSMUSP00000055104; ENSMUSG00000047123
GeneIDⁱ	106759
KEGGⁱ	mmu:106759
UCSC genome browser More...UCSCⁱ	uc008dbm.2 mouse

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q80UF7	TIR domain-containing adapter molecule 1	)	HUMAN		712	UniRef50_Q8IUC6
TIR domain-containing adapter molecule 1		MACFA		719
TIR domain-containing adapter molecule 1 (Fragment)		MACMU		68
TICAM1 isoform 1		PANTR		713
TIR domain-containing adaptor molecule 1		western gorilla		712
+75

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB091053 mRNA Translation: BAC55581.1 AK143766 mRNA Translation: BAE25531.1 AK150150 mRNA Translation: BAE29344.1 AK155245 mRNA Translation: BAE33144.1 BC033406 mRNA Translation: AAH33406.1 Sequence problems. BC037048 mRNA Translation: AAH37048.1 Different initiation. BC062191 mRNA Translation: AAH62191.1 Frameshift. BC094338 mRNA Translation: AAH94338.1
CCDSⁱ	CCDS28900.1
RefSeqⁱ	NP_778154.1, NM_174989.4
UniGeneⁱ	Mm.203952

3D structure databases

ProteinModelPortalⁱ	Q80UF7
SMRⁱ	Q80UF7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	223122, 9 interactors
DIPⁱ	DIP-60033N
IntActⁱ	Q80UF7, 6 interactors
STRINGⁱ	10090.ENSMUSP00000055104

PTM databases

PhosphoSitePlusⁱ	Q80UF7

PhosphoSitePlusⁱ

Q80UF7

Proteomic databases

PaxDbⁱ	Q80UF7
PRIDEⁱ	Q80UF7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000058136; ENSMUSP00000055104; ENSMUSG00000047123
GeneIDⁱ	106759
KEGGⁱ	mmu:106759
UCSCⁱ	uc008dbm.2 mouse

Organism-specific databases

CTDⁱ	148022
MGIⁱ	MGI:2147032 Ticam1

Phylogenomic databases

eggNOGⁱ	ENOG410IJUV Eukaryota ENOG410Y8DE LUCA
GeneTreeⁱ	ENSGT00900000141066
HOGENOMⁱ	HOG000068973
HOVERGENⁱ	HBG108551
InParanoidⁱ	Q80UF7
KOⁱ	K05842
OMAⁱ	EEKLCPA
OrthoDBⁱ	EOG091G07G7
PhylomeDBⁱ	Q80UF7
TreeFamⁱ	TF336953

Enzyme and pathway databases

Reactomeⁱ	R-MMU-140534 via Death Receptors in the presence of ligand R-MMU-166166 MyD88-independent TLR4 cascade R-MMU-2562578 TRIF-mediated programmed cell death R-MMU-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-MMU-937041 IKK complex recruitment mediated by RIP1 R-MMU-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex

Reactomeⁱ

R-MMU-140534 via Death Receptors in the presence of ligand
R-MMU-166166 MyD88-independent TLR4 cascade
R-MMU-2562578 TRIF-mediated programmed cell death
R-MMU-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-MMU-937041 IKK complex recruitment mediated by RIP1
R-MMU-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q80UF7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000047123 Expressed in 153 organ(s), highest expression level in intestine
CleanExⁱ	MM_TICAM1
Genevisibleⁱ	Q80UF7 MM

Family and domain databases

Gene3Dⁱ	3.40.50.10140, 1 hit
InterProⁱ	View protein in InterPro IPR025735 RHIM_dom IPR017278 TICAM1 IPR035897 Toll_tir_struct_dom_sf
PANTHERⁱ	PTHR23213:SF331 PTHR23213:SF331, 1 hit
Pfamⁱ	View protein in Pfam PF12721 RHIM, 1 hit
PIRSFⁱ	PIRSF037744 TIR_Ticam, 1 hit
SUPFAMⁱ	SSF52200 SSF52200, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TCAM1_MOUSE
Accessionⁱ	Q80UF7Primary (citable) accession number: Q80UF7 Secondary accession number(s): Q3UDB7 , Q3UP66, Q6P6J2, Q8CIB7, Q8JZV0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
	Last sequence update:	June 1, 2003
	Last modified:	October 10, 2018
	This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniRef

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Supporting data

UniProtKB - Q80UF7 (TCAM1_MOUSE)

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TIR domain-containing adapter molecule 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Cytosol

Other locations

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ