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Protein

Serologically defined colon cancer antigen 8 homolog

Gene

Sdccag8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the establishment of cell polarity and epithelial lumen formation. May play a role in ciliogenesis.1 Publication

GO - Biological processi

  • centrosome cycle Source: InterPro
  • establishment of cell polarity Source: UniProtKB
  • microtubule organizing center organization Source: MGI
  • neuron migration Source: MGI
  • tube formation Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Serologically defined colon cancer antigen 8 homolog
Alternative name(s):
Centrosomal colon cancer autoantigen protein
Short name:
mCCCAP
Gene namesi
Name:Sdccag8
Synonyms:Cccap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1924066 Sdccag8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

In renal epithelial cells gene knockdown results in the formation of spheroids with architectural defects characterized by disturbed localization of beta-catenin (CTNNB1) at the basolateral membrane, fewer tight junctions and an irregular lumen.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000763111 – 717Serologically defined colon cancer antigen 8 homologAdd BLAST717

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei28PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80UF4
PaxDbiQ80UF4
PRIDEiQ80UF4

PTM databases

iPTMnetiQ80UF4
PhosphoSitePlusiQ80UF4

Expressioni

Tissue specificityi

Expressed in liver, kidney, spleen, brain, heart and muscle. Expressed in photoreceptor cells of the retina.2 Publications

Gene expression databases

BgeeiENSMUSG00000026504 Expressed in 241 organ(s), highest expression level in midbrain
CleanExiMM_SDCCAG8
ExpressionAtlasiQ80UF4 baseline and differential
GenevisibleiQ80UF4 MM

Interactioni

Subunit structurei

Homodimer. Interacts with OFD1; the interaction is direct (By similarity). Interacts with FAM161A (By similarity).By similarity

Protein-protein interaction databases

BioGridi218334, 24 interactors
IntActiQ80UF4, 24 interactors
STRINGi10090.ENSMUSP00000027785

Structurei

3D structure databases

ProteinModelPortaliQ80UF4
SMRiQ80UF4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni216 – 717Sufficient for homodimerizationAdd BLAST502

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili129 – 168Sequence analysisAdd BLAST40
Coiled coili221 – 278Sequence analysisAdd BLAST58
Coiled coili352 – 590Sequence analysisAdd BLAST239
Coiled coili622 – 712Sequence analysisAdd BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi352 – 536Glu-richAdd BLAST185
Compositional biasi509 – 581Gln-richAdd BLAST73

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGC5 Eukaryota
ENOG410XQMR LUCA
GeneTreeiENSGT00730000111198
HOGENOMiHOG000133059
HOVERGENiHBG056806
InParanoidiQ80UF4
KOiK16488
OMAiQHGRLHE
OrthoDBiEOG091G069J
PhylomeDBiQ80UF4
TreeFamiTF325472

Family and domain databases

InterProiView protein in InterPro
IPR031887 SDCCAG8
PANTHERiPTHR34343 PTHR34343, 1 hit
PfamiView protein in Pfam
PF15964 CCCAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q80UF4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKSPGNSTL EDSLGQYQRS LRERANRSIH QLKCALREVD VTVEEDALDP
60 70 80 90 100
STSINVENED TGVAWHELQH SHAVNQLKAL LRQQTNKENE TSPPRRRKLS
110 120 130 140 150
PSRPSECDDG SMPTMHNLVP IINDQSQYIH HLEAEVKFCK DELSGMKNRV
160 170 180 190 200
QVVVLENERL QQELKSQRPE ETLREQTFLD ASGNMQNSWI MTREDSRVDE
210 220 230 240 250
AAKRPFSHGD AETGKTASTG DANKWKLELE RLKLTYEAKT DLLESQLMLL
260 270 280 290 300
RKDLAEYQKT CEDLKERLKH KESLLAASAS SRVGGLCLKC AQHEAVLSQT
310 320 330 340 350
HSNVHIQTIE RLTKERDDLM SVLVSVRSSL AEAQKRETSA YEQVKHAVQM
360 370 380 390 400
TEEANFEKTK ALIQCEQLKS ELERQTERLE KELASQQEKR AVEKEMIKKE
410 420 430 440 450
VAREREDAES KMLILSQNIA KLEAQVEKVT REKTAAVSHL EEIQNHVASQ
460 470 480 490 500
EMDVTKVCGE MRFQLNKTKM EKDEVEKEHR EYKAKSHKDL EMKVQEIEKL
510 520 530 540 550
RLELSESEQH VEQEQQKAAR ARQECLRVTE LLGEAERQLH LTRLEKDSIQ
560 570 580 590 600
QSFSNEAKAQ ALQAQQREQE LTQKIQQMET QHDKTESEQY LLLTSQNTFL
610 620 630 640 650
TKLKEECCLL AKKLEKVSLK SRSQIVRLSQ EKRYLCDKLE KLQKRNDELE
660 670 680 690 700
EQCIQHGRVH ETMKERLRQL DKHGQATAQQ LVQLLNKQNQ LLLERQNLSE
710
EVARLRAQLP SMPQSDC
Length:717
Mass (Da):82,979
Last modified:June 1, 2003 - v1
Checksum:iC9F69DBFB3DCD59D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q2E2E9Q2E2_MOUSE
Serologically defined colon cancer ...
Sdccag8
379Annotation score:
Q05DD9Q05DD9_MOUSE
Sdccag8 protein
Sdccag8
367Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250729 mRNA Translation: AAO27828.1
AK132316 mRNA Translation: BAE21100.1
AK133622 mRNA Translation: BAE21753.1
CCDSiCCDS35798.1
RefSeqiNP_084032.1, NM_029756.3
UniGeneiMm.171399

Genome annotation databases

EnsembliENSMUST00000027785; ENSMUSP00000027785; ENSMUSG00000026504
GeneIDi76816
KEGGimmu:76816
UCSCiuc007duj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250729 mRNA Translation: AAO27828.1
AK132316 mRNA Translation: BAE21100.1
AK133622 mRNA Translation: BAE21753.1
CCDSiCCDS35798.1
RefSeqiNP_084032.1, NM_029756.3
UniGeneiMm.171399

3D structure databases

ProteinModelPortaliQ80UF4
SMRiQ80UF4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218334, 24 interactors
IntActiQ80UF4, 24 interactors
STRINGi10090.ENSMUSP00000027785

PTM databases

iPTMnetiQ80UF4
PhosphoSitePlusiQ80UF4

Proteomic databases

MaxQBiQ80UF4
PaxDbiQ80UF4
PRIDEiQ80UF4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027785; ENSMUSP00000027785; ENSMUSG00000026504
GeneIDi76816
KEGGimmu:76816
UCSCiuc007duj.2 mouse

Organism-specific databases

CTDi10806
MGIiMGI:1924066 Sdccag8

Phylogenomic databases

eggNOGiENOG410IGC5 Eukaryota
ENOG410XQMR LUCA
GeneTreeiENSGT00730000111198
HOGENOMiHOG000133059
HOVERGENiHBG056806
InParanoidiQ80UF4
KOiK16488
OMAiQHGRLHE
OrthoDBiEOG091G069J
PhylomeDBiQ80UF4
TreeFamiTF325472

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRSiSdccag8 mouse
PROiPR:Q80UF4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026504 Expressed in 241 organ(s), highest expression level in midbrain
CleanExiMM_SDCCAG8
ExpressionAtlasiQ80UF4 baseline and differential
GenevisibleiQ80UF4 MM

Family and domain databases

InterProiView protein in InterPro
IPR031887 SDCCAG8
PANTHERiPTHR34343 PTHR34343, 1 hit
PfamiView protein in Pfam
PF15964 CCCAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSDCG8_MOUSE
AccessioniPrimary (citable) accession number: Q80UF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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