UniProtKB - Q80UC8 (GP139_MOUSE)
Protein
Probable G-protein coupled receptor 139
Gene
Gpr139
Organism
Mus musculus (Mouse)
Status
Functioni
Orphan receptor. Seems to act through a G(q/11)-mediated pathway.
GO - Molecular functioni
- G protein-coupled receptor activity Source: MGI
- identical protein binding Source: MGI
- neuropeptide receptor activity Source: MGI
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: MGI
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 139Alternative name(s): G(q)-coupled orphan receptor GPRg1 G-protein-coupled receptor PGR3 |
Gene namesi | Name:Gpr139 Synonyms:Gm495, Gprg1, Pgr3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2685341, Gpr139 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 21 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 22 – 42 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 43 – 57 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 58 – 78 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 79 – 94 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 95 – 115 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 116 – 140 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 141 – 161 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 162 – 173 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 174 – 194 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 195 – 220 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 221 – 241 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 242 – 260 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 261 – 281 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 282 – 345 | CytoplasmicSequence analysisAdd BLAST | 64 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069616 | 1 – 345 | Probable G-protein coupled receptor 139Add BLAST | 345 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q80UC8 |
PRIDEi | Q80UC8 |
PTM databases
GlyGeni | Q80UC8, 1 site |
PhosphoSitePlusi | Q80UC8 |
Expressioni
Tissue specificityi
Expressed almost exclusively in the brain. Abundantly expressed in the ventrolateral region of caudate putamen, the habenular nucleus, the zona incerta, and the medial mammillary nucleus.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000066197, Expressed in brain and 66 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000081700 |
Miscellaneous databases
RNActi | Q80UC8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000159473 |
HOGENOMi | CLU_009579_24_1_1 |
InParanoidi | Q80UC8 |
OMAi | MQMPPVP |
OrthoDBi | 790152at2759 |
PhylomeDBi | Q80UC8 |
TreeFami | TF334275 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q80UC8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEHTHAHLAA NSSACGLGFV PVVYYSFLLC LGLPANILTV IILSQLVARR
60 70 80 90 100
QKSSYNYLLA LAAADILVLF FIVFVDFLLE DFILTMQMPL IPDKIIEVLE
110 120 130 140 150
FSSIHTSIWI TVPLTVDRYI AVCHPLKYHT VSYPARTRKV ILSVYITCFL
160 170 180 190 200
TSIPYYWWPN IWTEDYISTS MHHVLVWIHC FTVYLVPCSI FFILNSIIVY
210 220 230 240 250
KLRRKSNFRL RGYSTGKTTA ILFTITSIFA TLWAPRIIMI LYHLYGAPIQ
260 270 280 290 300
NPWLVHIMLD VANMLALLNT AINFFLYCFI SKRFRTMAAA TLKALFKCQK
310 320 330 340
QPVQFYTNHN FSITSSPWIS PANSHCIKML VYQYDKHGKP IKVSP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB196532 mRNA Translation: BAD97443.1 BC125496 mRNA Translation: AAI25497.1 BC125498 mRNA Translation: AAI25499.1 AY255548 mRNA Translation: AAO85060.1 |
CCDSi | CCDS21778.1 |
RefSeqi | NP_001019309.1, NM_001024138.1 |
Genome annotation databases
Ensembli | ENSMUST00000084650; ENSMUSP00000081700; ENSMUSG00000066197 |
GeneIDi | 209776 |
KEGGi | mmu:209776 |
UCSCi | uc009jky.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB196532 mRNA Translation: BAD97443.1 BC125496 mRNA Translation: AAI25497.1 BC125498 mRNA Translation: AAI25499.1 AY255548 mRNA Translation: AAO85060.1 |
CCDSi | CCDS21778.1 |
RefSeqi | NP_001019309.1, NM_001024138.1 |
3D structure databases
SMRi | Q80UC8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000081700 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q80UC8, 1 site |
PhosphoSitePlusi | Q80UC8 |
Proteomic databases
PaxDbi | Q80UC8 |
PRIDEi | Q80UC8 |
Protocols and materials databases
Antibodypediai | 12144, 141 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000084650; ENSMUSP00000081700; ENSMUSG00000066197 |
GeneIDi | 209776 |
KEGGi | mmu:209776 |
UCSCi | uc009jky.1, mouse |
Organism-specific databases
CTDi | 124274 |
MGIi | MGI:2685341, Gpr139 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000159473 |
HOGENOMi | CLU_009579_24_1_1 |
InParanoidi | Q80UC8 |
OMAi | MQMPPVP |
OrthoDBi | 790152at2759 |
PhylomeDBi | Q80UC8 |
TreeFami | TF334275 |
Miscellaneous databases
BioGRID-ORCSi | 209776, 0 hits in 17 CRISPR screens |
PROi | PR:Q80UC8 |
RNActi | Q80UC8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000066197, Expressed in brain and 66 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP139_MOUSE | |
Accessioni | Q80UC8Primary (citable) accession number: Q80UC8 Secondary accession number(s): Q059X1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | January 10, 2006 | |
Last modified: | December 2, 2020 | |
This is version 105 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries