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Protein

Insulin-induced gene 2 protein

Gene

Insig2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR (By similarity).By similarity

GO - Molecular functioni

  • transcription factor binding Source: RGD

GO - Biological processi

Keywordsi

Biological processCholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-induced gene 2 protein
Short name:
INSIG-2
Gene namesi
Name:Insig2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi631417 Insig2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei131 – 148HelicalSequence analysisAdd BLAST18
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002868011 – 225Insulin-induced gene 2 proteinAdd BLAST225

Proteomic databases

PaxDbiQ80UA9
PRIDEiQ80UA9

PTM databases

PhosphoSitePlusiQ80UA9

Expressioni

Gene expression databases

BgeeiENSRNOG00000002478 Expressed in 9 organ(s), highest expression level in liver
GenevisibleiQ80UA9 RN

Interactioni

Subunit structurei

Binds to the SCAP-SREBF2 complex only in the presence of sterols. Interacts with RNF139 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003391

Family & Domainsi

Sequence similaritiesi

Belongs to the INSIG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4363 Eukaryota
ENOG410XQ2M LUCA
GeneTreeiENSGT00580000081600
HOGENOMiHOG000253021
HOVERGENiHBG058958
InParanoidiQ80UA9
OMAiALYEYKF
OrthoDBiEOG091G0L61
PhylomeDBiQ80UA9
TreeFamiTF331013

Family and domain databases

InterProiView protein in InterPro
IPR025929 INSIG_fam
PANTHERiPTHR15301 PTHR15301, 1 hit
PfamiView protein in Pfam
PF07281 INSIG, 1 hit

Sequencei

Sequence statusi: Complete.

Q80UA9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEGETESPR PKKRGPYISS VTSQSVNVVI RGVVLFFIGV FLALVLNLLQ
60 70 80 90 100
IQRNVTLFPP DVITSIFSSA WWVPPCCGTA SAVIGLLYPC IDRHLGEPHK
110 120 130 140 150
FKREWSSVMR CVAVFVGINH ASAKVDFDNN FQFSLTLAAL SVGLWWTFDR
160 170 180 190 200
SRSGFGLGVG IAFLATVVTQ LLVYNGVYQY TSPDFLYVRS WLPCIFFAGG
210 220
ITMGNIGRQL AMYECKVIAE KSHQE
Length:225
Mass (Da):24,968
Last modified:June 1, 2003 - v1
Checksum:i534E933526CB2195
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152392 mRNA Translation: AAN78347.1
BC085682 mRNA Translation: AAH85682.1
RefSeqiNP_835192.1, NM_178091.4
XP_006249729.1, XM_006249667.3
XP_006249730.1, XM_006249668.3
XP_006249731.1, XM_006249669.3
XP_017454176.1, XM_017598687.1
UniGeneiRn.16736
Rn.217040

Genome annotation databases

EnsembliENSRNOT00000003391; ENSRNOP00000003391; ENSRNOG00000002478
GeneIDi288985
KEGGirno:288985
UCSCiRGD:631417 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152392 mRNA Translation: AAN78347.1
BC085682 mRNA Translation: AAH85682.1
RefSeqiNP_835192.1, NM_178091.4
XP_006249729.1, XM_006249667.3
XP_006249730.1, XM_006249668.3
XP_006249731.1, XM_006249669.3
XP_017454176.1, XM_017598687.1
UniGeneiRn.16736
Rn.217040

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003391

PTM databases

PhosphoSitePlusiQ80UA9

Proteomic databases

PaxDbiQ80UA9
PRIDEiQ80UA9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003391; ENSRNOP00000003391; ENSRNOG00000002478
GeneIDi288985
KEGGirno:288985
UCSCiRGD:631417 rat

Organism-specific databases

CTDi51141
RGDi631417 Insig2

Phylogenomic databases

eggNOGiKOG4363 Eukaryota
ENOG410XQ2M LUCA
GeneTreeiENSGT00580000081600
HOGENOMiHOG000253021
HOVERGENiHBG058958
InParanoidiQ80UA9
OMAiALYEYKF
OrthoDBiEOG091G0L61
PhylomeDBiQ80UA9
TreeFamiTF331013

Miscellaneous databases

PROiPR:Q80UA9

Gene expression databases

BgeeiENSRNOG00000002478 Expressed in 9 organ(s), highest expression level in liver
GenevisibleiQ80UA9 RN

Family and domain databases

InterProiView protein in InterPro
IPR025929 INSIG_fam
PANTHERiPTHR15301 PTHR15301, 1 hit
PfamiView protein in Pfam
PF07281 INSIG, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINSI2_RAT
AccessioniPrimary (citable) accession number: Q80UA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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