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UniProtKB - Q80U93 (NU214_MOUSE)

Entry version 137 (12 Aug 2020)
Sequence version 2 (22 Jul 2008)
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Protein

Nuclear pore complex protein Nup214

Gene

Nup214

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-159227, Transport of the SLBP independent Mature mRNA
R-MMU-159230, Transport of the SLBP Dependant Mature mRNA
R-MMU-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-MMU-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein
R-MMU-191859, snRNP Assembly
R-MMU-3108214, SUMOylation of DNA damage response and repair proteins
R-MMU-3232142, SUMOylation of ubiquitinylation proteins
R-MMU-3301854, Nuclear Pore Complex (NPC) Disassembly
R-MMU-3371453, Regulation of HSF1-mediated heat shock response
R-MMU-4085377, SUMOylation of SUMOylation proteins
R-MMU-450520, HuR (ELAVL1) binds and stabilizes mRNA
R-MMU-4551638, SUMOylation of chromatin organization proteins
R-MMU-4570464, SUMOylation of RNA binding proteins
R-MMU-4615885, SUMOylation of DNA replication proteins
R-MMU-5578749, Transcriptional regulation by small RNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex protein Nup214
Alternative name(s):
214 kDa nucleoporin
Nucleoporin Nup214
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nup214
Synonyms:Kiaa0023
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1095411, Nup214

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003450142 – 2085Nuclear pore complex protein Nup214Add BLAST2084

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylglycineBy similarity1
Modified residuei30PhosphoserineBy similarity1
Modified residuei416PhosphothreonineBy similarity1
Modified residuei421PhosphoserineBy similarity1
Modified residuei430PhosphoserineBy similarity1
Modified residuei433PhosphoserineBy similarity1
Modified residuei437PhosphothreonineBy similarity1
Modified residuei645PhosphoserineBy similarity1
Modified residuei651PhosphoserineBy similarity1
Modified residuei660PhosphoserineBy similarity1
Modified residuei672PhosphoserineBy similarity1
Modified residuei754PhosphoserineBy similarity1
Modified residuei930PhosphoserineCombined sources1
Modified residuei960PhosphoserineBy similarity1
Modified residuei964PhosphoserineBy similarity1
Modified residuei979PhosphoserineBy similarity1
Modified residuei1027PhosphothreonineBy similarity1
Modified residuei1029PhosphoserineBy similarity1
Modified residuei1051PhosphoserineBy similarity1
Modified residuei1062PhosphoserineBy similarity1
Modified residuei1139PhosphoserineCombined sources1
Modified residuei1156PhosphothreonineBy similarity1
Modified residuei1162PhosphothreonineBy similarity1
Modified residuei1187PhosphoserineBy similarity1
Modified residuei1324PhosphothreonineBy similarity1
Modified residuei1365PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1548Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1980PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Probably glycosylated as it reacts with wheat germ agglutinin (WGA).By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q80U93

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q80U93

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q80U93

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q80U93

PeptideAtlas

More...PeptideAtlasi		Q80U93

PRoteomics IDEntifications database

More...PRIDEi		Q80U93

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q80U93

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q80U93

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q80U93

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000001855, Expressed in zygote and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q80U93, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q80U93, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Part of the nuclear pore complex (NPC).

Interacts with NUP88.

Interacts with ZFP36; this interaction increases upon lipopolysaccharide (LPS) stimulation.

Interacts with DDX19.

Interacts with XPO1.

Interacts with XPO5.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		230673, 40 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4474, Nuclear pore complex

Protein interaction database and analysis system

More...IntActi		Q80U93, 30 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000066492

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q80U93, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q80U93

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati41 – 93Blade 1By similarityAdd BLAST53
Repeati94 – 150Blade 2By similarityAdd BLAST57
Repeati151 – 193Blade 3By similarityAdd BLAST43
Repeati194 – 239Blade 4By similarityAdd BLAST46
Repeati240 – 303Blade 5By similarityAdd BLAST64
Repeati304 – 359Blade 6By similarityAdd BLAST56
Repeati360 – 404Blade 7By similarityAdd BLAST45
Repeati482 – 4831Curated2
Repeati546 – 5472Curated2
Repeati1232 – 12333Curated2
Repeati1264 – 12654Curated2
Repeati1423 – 14245Curated2
Repeati1439 – 14406Curated2
Repeati1453 – 14547Curated2
Repeati1486 – 14878Curated2
Repeati1643 – 16449Curated2
Repeati1682 – 168310Curated2
Repeati1704 – 170511Curated2
Repeati1709 – 171012Curated2
Repeati1717 – 171813Curated2
Repeati1722 – 172314Curated2
Repeati1728 – 172915Curated2
Repeati1752 – 175316Curated2
Repeati1768 – 176917Curated2
Repeati1782 – 178318Curated2
Repeati1794 – 179519Curated2
Repeati1802 – 180320Curated2
Repeati1808 – 180921Curated2
Repeati1815 – 181622Curated2
Repeati1838 – 183923Curated2
Repeati1847 – 184824Curated2
Repeati1858 – 185925Curated2
Repeati1869 – 187026Curated2
Repeati1905 – 190627Curated2
Repeati1917 – 191828Curated2
Repeati1925 – 192629Curated2
Repeati1928 – 192930Curated2
Repeati1933 – 193431Curated2
Repeati1954 – 195532Curated2
Repeati1965 – 196633Curated2
Repeati1971 – 197234Curated2
Repeati1977 – 197835Curated2
Repeati1983 – 198436Curated2
Repeati1989 – 199037Curated2
Repeati2007 – 200838Curated2
Repeati2019 – 202039Curated2
Repeati2021 – 202240Curated2
Repeati2030 – 203141Curated2
Repeati2041 – 204242Curated2
Repeati2051 – 205243Curated2
Repeati2061 – 206244Curated2
Repeati2070 – 207145Curated2
Repeati2080 – 208146Curated2

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 404Seven-bladed beta propellerBy similarityAdd BLAST364
Regioni236 – 143046 X 2 AA repeats of F-GBy similarityAdd BLAST1195
Regioni479 – 207111 X 5 AA approximate repeatsAdd BLAST1593
Regioni734 – 762Leucine-zipper 1Add BLAST29
Regioni855 – 876Leucine-zipper 2Add BLAST22
Regioni1421 – 207918 X 4 AA approximate repeatsAdd BLAST659
Regioni1439 – 208011 X 3 AA approximate repeatsAdd BLAST642

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili674 – 1217By similarityAdd BLAST544

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1221 – 2085Pro/Ser/Thr-richAdd BLAST865

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.Curated
The beta-propeller contains long interblade connector loops, and mediates interaction with DDX19B.By similarity

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3630, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153253

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001606_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q80U93

KEGG Orthology (KO)

More...KOi		K14317

Identification of Orthologs from Complete Genome Data

More...OMAi		KCGCWSP

Database of Orthologous Groups

More...OrthoDBi		747759at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q80U93

TreeFam database of animal gene trees

More...TreeFami		TF323517

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026054, Nucleoporin
IPR041553, Nup214_FG
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat

The PANTHER Classification System

More...PANTHERi		PTHR23193, PTHR23193, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18617, Nup214_FG, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00320, WD40, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q80U93-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS VLTISNKYGM 
        60         70         80         90        100
LFAGGTNGLN VFPTKSLLIQ NKPGDDPNKI VDTIQGLNVP MKFPVHHLAL 
       110        120        130        140        150
SCDSLTLSAC MMSSEYGSII AFFDVRTFSN QAKPLKRPFT YHKVSNDASG 
       160        170        180        190        200
MVNDMKWNPT VPSMVAVCLA DGSISVLQVT DVVKVCATLP PSTGVTCVCW 
       210        220        230        240        250
SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP VRVLDVLWIG 
       260        270        280        290        300
TYVFTIVYAG ADGTLETCPD VVMALLPKKE EKHPEIFVNF MEPCYSSCTE 
       310        320        330        340        350
RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQNDQTNWES WLLEDSSRAE 
       360        370        380        390        400
LPVTDKSDDS LPMGVAIDYT NEVEVTINEE KTLPPAPVLL LLSTDGVLCP 
       410        420        430        440        450
FYMINQNPGV RSLIKTLELI STEGERQPKS SGSFPGTPSS PQAPQNLDAP 
       460        470        480        490        500
ATASSPLPPV SAAPTSTFPM PSAAGSPSVF SFGPSSFKSS ASVTGEPPLY 
       510        520        530        540        550
PTGSDSSRAA PGSGTSTFSF APPSKGSLAS TPAVAPVATS AAPFTFGFKP 
       560        570        580        590        600
TLESTPMSST PNTGMKPSFP PSASSVKVNL NEKFTAVASS APVHSSTSTP 
       610        620        630        640        650
SVLPFSSSPK PTASGPLSHP TPLPASSSSM PLKSSVSPSP AAGRSTQTAP 
       660        670        680        690        700
SSAPSTGQKS PRVNPPVPKS GSSQAKALQP PVTEKQRPQW KDSDPVLAGI 
       710        720        730        740        750
GEEIAHFQKE LEELKARTAK ACLQVGTSEE MKMLRTESDD LHTFLFEIRE 
       760        770        780        790        800
TTESLHGDIS TLKTTLLEGF AGVEEAREQH GRNHDSGYLH LLYKRPLDPK 
       810        820        830        840        850
SEAQLQEIRR LHQYVKFAVQ DVNDVLDLEW DRHLEQKKRQ RRLIVPERET 
       860        870        880        890        900
LFNTLANNRE IINQQRKRLN QLVDSLQQLR LYNHTAPWSL PSALSTQSNS 
       910        920        930        940        950
HSFDSDLECL LKTTIESHTK PSPRVPGKLS PAKQAQLRNF LAKRKTPPVR 
       960        970        980        990       1000
STAPASLSRS AFLSQRYYED LDEGSSASSV AQPLEGEDAR PTCTSVAQPL 
      1010       1020       1030       1040       1050
EGEDAQPICK EEEAVVPVPR HAPVVRTPSI QPSLLPQSMP FAKPHLIHSS 
      1060       1070       1080       1090       1100
SPAVMSSAVS TSATKVIPQG ADSTMLATKT VKHGAPGPSH TVAAPQAAAA 
      1110       1120       1130       1140       1150
AALRRQMASQ APAMSTLTES TLKTVPQVVN VQELRSNPSP PSAAMGSAVQ 
      1160       1170       1180       1190       1200
HSAAKTPHAV LTPVANSQAK QGSLINSFKP SGPTAASCQL SSGDKAVGQG 
      1210       1220       1230       1240       1250
TAKTESAATS TPSAAGQLNK PFSFASPGTF TFGTITPTPS SSFTATPGAG 
      1260       1270       1280       1290       1300
PPTKEPTQLE AFSFGGGGKP FSEAIPGNSP ATGATSAPST SVTAASLEDS 
      1310       1320       1330       1340       1350
APSSSKPAAP PETTVSSASS KLETPPSKLG ELLFPSSLAG ETLGSFSGLR 
      1360       1370       1380       1390       1400
VGQAEDSTKP VSKASSTNLA GAQPAKPSGV SFPNTSVLGK PVEPAVTSSV 
      1410       1420       1430       1440       1450
SPAPAAPASA LNVSTSSSSA TVFGSVPLTS AGPPGLISFG GAALASSKAS 
      1460       1470       1480       1490       1500
FSFGNQQTSS STASSATPTS TSVAPSLPAS FPTLSFGGLL SSPSASSLPV 
      1510       1520       1530       1540       1550
SSGKSTEEAA PPAVPDKSDS SEVSATTPSL PVQPQSTQAS LQTSDPVKKE 
      1560       1570       1580       1590       1600
PVLVQTTDSS PSRPASSASF VASTESMPVT LGAPDSKIEA VSPASTFAGP 
      1610       1620       1630       1640       1650
GQAAVATAVL PGAGSAATEA SGTPTTSTVS SSSPTSATET AVFGTATSGS 
      1660       1670       1680       1690       1700
SVFTQPPAAS SSSAFSQLSS NTATAPSATP VFGQVAASIT STAAATPQAS 
      1710       1720       1730       1740       1750
SSGFGSPAFG ASAPGVFGQT AFGQTPAFGQ ATSSPASGFS FSQPGFSSVP 
      1760       1770       1780       1790       1800
AFGQSVSSTP ASTSANVFGA TSSTSSPGSF SFGQASTNTG GTLFGQNNPP 
      1810       1820       1830       1840       1850
AFGQSPGFGQ GSSVFGGTSA TTSTAAPSGF SFCQASGFGS SNTGSVFGQA 
      1860       1870       1880       1890       1900
ANTGGSVFGQ SSTSSGGVFG SGNATRGGGF FSGLGGKPSQ DAANKNPFSS 
      1910       1920       1930       1940       1950
AGGGFGSTAA PNTSNLFGNS GAKTFGGFGS SSFGEQKPAG TFSSGGGSVA 
      1960       1970       1980       1990       2000
SQGFGFSTPN KTGGFGAAPV FGSPPTFGGS PGFGGVPAFG SAPAFTSPLG 
      2010       2020       2030       2040       2050
STGGKVFGEG TAAASAGGFG FGSSGNTASF GTLASQNAPT FGSLSQQTSG 
      2060       2070       2080 
FGTPSSGFAG FGSGTGAFTF GSSNSSVQGF GGWRS
Length:2,085
Mass (Da):212,979
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9998CC8BC27EE4A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ATN3A2ATN3_MOUSE
Nuclear pore complex protein Nup214
Nup214
581Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YW83A0A0A6YW83_MOUSE
Nuclear pore complex protein Nup214
Nup214
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YY32A0A0A6YY32_MOUSE
Nuclear pore complex protein Nup214
Nup214
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC65471 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1973S → G in BAC65471 (PubMed:12693553).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK122189 mRNA Translation: BAC65471.1 Different initiation.
AL928893 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS38098.1

NCBI Reference Sequences

More...RefSeqi		NP_758472.2, NM_172268.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000065398; ENSMUSP00000066492; ENSMUSG00000001855

Database of genes from NCBI RefSeq genomes

More...GeneIDi		227720

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:227720

UCSC genome browser

More...UCSCi		uc008jeh.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122189 mRNA Translation: BAC65471.1 Different initiation.
AL928893 Genomic DNA No translation available.
CCDSiCCDS38098.1
RefSeqiNP_758472.2, NM_172268.2

3D structure databases

SMRiQ80U93
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi230673, 40 interactors
ComplexPortaliCPX-4474, Nuclear pore complex
IntActiQ80U93, 30 interactors
STRINGi10090.ENSMUSP00000066492

PTM databases

iPTMnetiQ80U93
PhosphoSitePlusiQ80U93
SwissPalmiQ80U93

Proteomic databases

EPDiQ80U93
jPOSTiQ80U93
MaxQBiQ80U93
PaxDbiQ80U93
PeptideAtlasiQ80U93
PRIDEiQ80U93

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18059, 62 antibodies

Genome annotation databases

EnsembliENSMUST00000065398; ENSMUSP00000066492; ENSMUSG00000001855
GeneIDi227720
KEGGimmu:227720
UCSCiuc008jeh.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8021
MGIiMGI:1095411, Nup214

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG3630, Eukaryota
GeneTreeiENSGT00940000153253
HOGENOMiCLU_001606_0_0_1
InParanoidiQ80U93
KOiK14317
OMAiKCGCWSP
OrthoDBi747759at2759
PhylomeDBiQ80U93
TreeFamiTF323517

Enzyme and pathway databases

ReactomeiR-MMU-159227, Transport of the SLBP independent Mature mRNA
R-MMU-159230, Transport of the SLBP Dependant Mature mRNA
R-MMU-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-MMU-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein
R-MMU-191859, snRNP Assembly
R-MMU-3108214, SUMOylation of DNA damage response and repair proteins
R-MMU-3232142, SUMOylation of ubiquitinylation proteins
R-MMU-3301854, Nuclear Pore Complex (NPC) Disassembly
R-MMU-3371453, Regulation of HSF1-mediated heat shock response
R-MMU-4085377, SUMOylation of SUMOylation proteins
R-MMU-450520, HuR (ELAVL1) binds and stabilizes mRNA
R-MMU-4551638, SUMOylation of chromatin organization proteins
R-MMU-4570464, SUMOylation of RNA binding proteins
R-MMU-4615885, SUMOylation of DNA replication proteins
R-MMU-5578749, Transcriptional regulation by small RNAs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		227720, 7 hits in 20 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Nup214, mouse

Protein Ontology

More...PROi		PR:Q80U93
RNActiQ80U93, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000001855, Expressed in zygote and 250 other tissues
ExpressionAtlasiQ80U93, baseline and differential
GenevisibleiQ80U93, MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR026054, Nucleoporin
IPR041553, Nup214_FG
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
PANTHERiPTHR23193, PTHR23193, 1 hit
PfamiView protein in Pfam
PF18617, Nup214_FG, 1 hit
SMARTiView protein in SMART
SM00320, WD40, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU214_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80U93
Secondary accession number(s): A2ATN2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: August 12, 2020
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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