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Entry version 131 (16 Oct 2019)
Sequence version 2 (22 Jul 2008)
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Protein

Nuclear pore complex protein Nup214

Gene

Nup214

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-159227 Transport of the SLBP independent Mature mRNA
R-MMU-159230 Transport of the SLBP Dependant Mature mRNA
R-MMU-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-191859 snRNP Assembly
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3301854 Nuclear Pore Complex (NPC) Disassembly
R-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-MMU-4615885 SUMOylation of DNA replication proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex protein Nup214
Alternative name(s):
214 kDa nucleoporin
Nucleoporin Nup214
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nup214
Synonyms:Kiaa0023
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1095411 Nup214

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003450142 – 2085Nuclear pore complex protein Nup214Add BLAST2084

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylglycineBy similarity1
Modified residuei30PhosphoserineBy similarity1
Modified residuei416PhosphothreonineBy similarity1
Modified residuei421PhosphoserineBy similarity1
Modified residuei430PhosphoserineBy similarity1
Modified residuei433PhosphoserineBy similarity1
Modified residuei437PhosphothreonineBy similarity1
Modified residuei645PhosphoserineBy similarity1
Modified residuei651PhosphoserineBy similarity1
Modified residuei660PhosphoserineBy similarity1
Modified residuei672PhosphoserineBy similarity1
Modified residuei754PhosphoserineBy similarity1
Modified residuei930PhosphoserineCombined sources1
Modified residuei960PhosphoserineBy similarity1
Modified residuei964PhosphoserineBy similarity1
Modified residuei979PhosphoserineBy similarity1
Modified residuei1027PhosphothreonineBy similarity1
Modified residuei1029PhosphoserineBy similarity1
Modified residuei1051PhosphoserineBy similarity1
Modified residuei1062PhosphoserineBy similarity1
Modified residuei1139PhosphoserineCombined sources1
Modified residuei1156PhosphothreonineBy similarity1
Modified residuei1162PhosphothreonineBy similarity1
Modified residuei1187PhosphoserineBy similarity1
Modified residuei1324PhosphothreonineBy similarity1
Modified residuei1365PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1548Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1980PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Probably glycosylated as it reacts with wheat germ agglutinin (WGA).By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q80U93

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q80U93

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q80U93

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80U93

PeptideAtlas

More...
PeptideAtlasi
Q80U93

PRoteomics IDEntifications database

More...
PRIDEi
Q80U93

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80U93

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80U93

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q80U93

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000001855 Expressed in 231 organ(s), highest expression level in cleaving embryo

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q80U93 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80U93 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with ZFP36; this interaction increases upon lipopolysaccharide (LPS) stimulation.

Interacts with DDX19.

Interacts with NUP88.

Interacts with XPO1.

Interacts with XPO5.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
230673, 34 interactors

Protein interaction database and analysis system

More...
IntActi
Q80U93, 30 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000066492

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80U93

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati41 – 93Blade 1By similarityAdd BLAST53
Repeati94 – 150Blade 2By similarityAdd BLAST57
Repeati151 – 193Blade 3By similarityAdd BLAST43
Repeati194 – 239Blade 4By similarityAdd BLAST46
Repeati240 – 303Blade 5By similarityAdd BLAST64
Repeati304 – 359Blade 6By similarityAdd BLAST56
Repeati360 – 404Blade 7By similarityAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 404Seven-bladed beta propellerBy similarityAdd BLAST364
Regioni479 – 207111 X 5 AA approximate repeatsAdd BLAST1593
Regioni734 – 762Leucine-zipper 1Add BLAST29
Regioni855 – 876Leucine-zipper 2Add BLAST22
Regioni1421 – 207918 X 4 AA approximate repeatsAdd BLAST659
Regioni1439 – 208011 X 3 AA approximate repeatsAdd BLAST642

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili674 – 1217By similarityAdd BLAST544

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1221 – 2085Pro/Ser/Thr-richAdd BLAST865

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains FG repeats.
The beta-propeller contains long interblade connector loops, and mediates interaction with DDX19B.By similarity

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3630 Eukaryota
ENOG410YBVS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153253

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113878

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80U93

KEGG Orthology (KO)

More...
KOi
K14317

Identification of Orthologs from Complete Genome Data

More...
OMAi
KCGCWSP

Database of Orthologous Groups

More...
OrthoDBi
1032285at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80U93

TreeFam database of animal gene trees

More...
TreeFami
TF323517

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026054 Nucleoporin
IPR041553 Nup214_FG
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23193 PTHR23193, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18617 Nup214_FG, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q80U93-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS VLTISNKYGM
60 70 80 90 100
LFAGGTNGLN VFPTKSLLIQ NKPGDDPNKI VDTIQGLNVP MKFPVHHLAL
110 120 130 140 150
SCDSLTLSAC MMSSEYGSII AFFDVRTFSN QAKPLKRPFT YHKVSNDASG
160 170 180 190 200
MVNDMKWNPT VPSMVAVCLA DGSISVLQVT DVVKVCATLP PSTGVTCVCW
210 220 230 240 250
SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP VRVLDVLWIG
260 270 280 290 300
TYVFTIVYAG ADGTLETCPD VVMALLPKKE EKHPEIFVNF MEPCYSSCTE
310 320 330 340 350
RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQNDQTNWES WLLEDSSRAE
360 370 380 390 400
LPVTDKSDDS LPMGVAIDYT NEVEVTINEE KTLPPAPVLL LLSTDGVLCP
410 420 430 440 450
FYMINQNPGV RSLIKTLELI STEGERQPKS SGSFPGTPSS PQAPQNLDAP
460 470 480 490 500
ATASSPLPPV SAAPTSTFPM PSAAGSPSVF SFGPSSFKSS ASVTGEPPLY
510 520 530 540 550
PTGSDSSRAA PGSGTSTFSF APPSKGSLAS TPAVAPVATS AAPFTFGFKP
560 570 580 590 600
TLESTPMSST PNTGMKPSFP PSASSVKVNL NEKFTAVASS APVHSSTSTP
610 620 630 640 650
SVLPFSSSPK PTASGPLSHP TPLPASSSSM PLKSSVSPSP AAGRSTQTAP
660 670 680 690 700
SSAPSTGQKS PRVNPPVPKS GSSQAKALQP PVTEKQRPQW KDSDPVLAGI
710 720 730 740 750
GEEIAHFQKE LEELKARTAK ACLQVGTSEE MKMLRTESDD LHTFLFEIRE
760 770 780 790 800
TTESLHGDIS TLKTTLLEGF AGVEEAREQH GRNHDSGYLH LLYKRPLDPK
810 820 830 840 850
SEAQLQEIRR LHQYVKFAVQ DVNDVLDLEW DRHLEQKKRQ RRLIVPERET
860 870 880 890 900
LFNTLANNRE IINQQRKRLN QLVDSLQQLR LYNHTAPWSL PSALSTQSNS
910 920 930 940 950
HSFDSDLECL LKTTIESHTK PSPRVPGKLS PAKQAQLRNF LAKRKTPPVR
960 970 980 990 1000
STAPASLSRS AFLSQRYYED LDEGSSASSV AQPLEGEDAR PTCTSVAQPL
1010 1020 1030 1040 1050
EGEDAQPICK EEEAVVPVPR HAPVVRTPSI QPSLLPQSMP FAKPHLIHSS
1060 1070 1080 1090 1100
SPAVMSSAVS TSATKVIPQG ADSTMLATKT VKHGAPGPSH TVAAPQAAAA
1110 1120 1130 1140 1150
AALRRQMASQ APAMSTLTES TLKTVPQVVN VQELRSNPSP PSAAMGSAVQ
1160 1170 1180 1190 1200
HSAAKTPHAV LTPVANSQAK QGSLINSFKP SGPTAASCQL SSGDKAVGQG
1210 1220 1230 1240 1250
TAKTESAATS TPSAAGQLNK PFSFASPGTF TFGTITPTPS SSFTATPGAG
1260 1270 1280 1290 1300
PPTKEPTQLE AFSFGGGGKP FSEAIPGNSP ATGATSAPST SVTAASLEDS
1310 1320 1330 1340 1350
APSSSKPAAP PETTVSSASS KLETPPSKLG ELLFPSSLAG ETLGSFSGLR
1360 1370 1380 1390 1400
VGQAEDSTKP VSKASSTNLA GAQPAKPSGV SFPNTSVLGK PVEPAVTSSV
1410 1420 1430 1440 1450
SPAPAAPASA LNVSTSSSSA TVFGSVPLTS AGPPGLISFG GAALASSKAS
1460 1470 1480 1490 1500
FSFGNQQTSS STASSATPTS TSVAPSLPAS FPTLSFGGLL SSPSASSLPV
1510 1520 1530 1540 1550
SSGKSTEEAA PPAVPDKSDS SEVSATTPSL PVQPQSTQAS LQTSDPVKKE
1560 1570 1580 1590 1600
PVLVQTTDSS PSRPASSASF VASTESMPVT LGAPDSKIEA VSPASTFAGP
1610 1620 1630 1640 1650
GQAAVATAVL PGAGSAATEA SGTPTTSTVS SSSPTSATET AVFGTATSGS
1660 1670 1680 1690 1700
SVFTQPPAAS SSSAFSQLSS NTATAPSATP VFGQVAASIT STAAATPQAS
1710 1720 1730 1740 1750
SSGFGSPAFG ASAPGVFGQT AFGQTPAFGQ ATSSPASGFS FSQPGFSSVP
1760 1770 1780 1790 1800
AFGQSVSSTP ASTSANVFGA TSSTSSPGSF SFGQASTNTG GTLFGQNNPP
1810 1820 1830 1840 1850
AFGQSPGFGQ GSSVFGGTSA TTSTAAPSGF SFCQASGFGS SNTGSVFGQA
1860 1870 1880 1890 1900
ANTGGSVFGQ SSTSSGGVFG SGNATRGGGF FSGLGGKPSQ DAANKNPFSS
1910 1920 1930 1940 1950
AGGGFGSTAA PNTSNLFGNS GAKTFGGFGS SSFGEQKPAG TFSSGGGSVA
1960 1970 1980 1990 2000
SQGFGFSTPN KTGGFGAAPV FGSPPTFGGS PGFGGVPAFG SAPAFTSPLG
2010 2020 2030 2040 2050
STGGKVFGEG TAAASAGGFG FGSSGNTASF GTLASQNAPT FGSLSQQTSG
2060 2070 2080
FGTPSSGFAG FGSGTGAFTF GSSNSSVQGF GGWRS
Length:2,085
Mass (Da):212,979
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9998CC8BC27EE4A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ATN3A2ATN3_MOUSE
Nuclear pore complex protein Nup214
Nup214
581Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YW83A0A0A6YW83_MOUSE
Nuclear pore complex protein Nup214
Nup214
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YY32A0A0A6YY32_MOUSE
Nuclear pore complex protein Nup214
Nup214
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC65471 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1973S → G in BAC65471 (PubMed:12693553).Curated1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK122189 mRNA Translation: BAC65471.1 Different initiation.
AL928893 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS38098.1

NCBI Reference Sequences

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RefSeqi
NP_758472.2, NM_172268.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000065398; ENSMUSP00000066492; ENSMUSG00000001855

Database of genes from NCBI RefSeq genomes

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GeneIDi
227720

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:227720

UCSC genome browser

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UCSCi
uc008jeh.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122189 mRNA Translation: BAC65471.1 Different initiation.
AL928893 Genomic DNA No translation available.
CCDSiCCDS38098.1
RefSeqiNP_758472.2, NM_172268.2

3D structure databases

SMRiQ80U93
ModBaseiSearch...

Protein-protein interaction databases

BioGridi230673, 34 interactors
IntActiQ80U93, 30 interactors
STRINGi10090.ENSMUSP00000066492

PTM databases

iPTMnetiQ80U93
PhosphoSitePlusiQ80U93
SwissPalmiQ80U93

Proteomic databases

EPDiQ80U93
jPOSTiQ80U93
MaxQBiQ80U93
PaxDbiQ80U93
PeptideAtlasiQ80U93
PRIDEiQ80U93

Genome annotation databases

EnsembliENSMUST00000065398; ENSMUSP00000066492; ENSMUSG00000001855
GeneIDi227720
KEGGimmu:227720
UCSCiuc008jeh.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8021
MGIiMGI:1095411 Nup214

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG3630 Eukaryota
ENOG410YBVS LUCA
GeneTreeiENSGT00940000153253
HOGENOMiHOG000113878
InParanoidiQ80U93
KOiK14317
OMAiKCGCWSP
OrthoDBi1032285at2759
PhylomeDBiQ80U93
TreeFamiTF323517

Enzyme and pathway databases

ReactomeiR-MMU-159227 Transport of the SLBP independent Mature mRNA
R-MMU-159230 Transport of the SLBP Dependant Mature mRNA
R-MMU-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-191859 snRNP Assembly
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3301854 Nuclear Pore Complex (NPC) Disassembly
R-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-MMU-4615885 SUMOylation of DNA replication proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Nup214 mouse

Protein Ontology

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PROi
PR:Q80U93

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000001855 Expressed in 231 organ(s), highest expression level in cleaving embryo
ExpressionAtlasiQ80U93 baseline and differential
GenevisibleiQ80U93 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR026054 Nucleoporin
IPR041553 Nup214_FG
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
PANTHERiPTHR23193 PTHR23193, 1 hit
PfamiView protein in Pfam
PF18617 Nup214_FG, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU214_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80U93
Secondary accession number(s): A2ATN2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: October 16, 2019
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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