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UniProtKB - Q80U72 (SCRIB_MOUSE)

Entry version 175 (29 Sep 2021)
Sequence version 2 (19 Jul 2004)
Previous versions | rss
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Protein

Protein scribble homolog

Gene

Scrib

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:12499390, PubMed:18716323, PubMed:19041750, PubMed:18329370).

Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (PubMed:18329370).

Most probably functions in the establishment of apico-basal cell polarity (PubMed:19041750).

May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:19041750).

May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling (PubMed:18716323).

May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:19458197).

Functions as an activator of Rac GTPase activity.

5 Publications

Miscellaneous

The circletail (Crc) mice exhibit craniorachischisis, a severe form of neural tube defect. This is due to a single base insertion in the Scrib gene creating a frameshift which leads to synthesis of a truncated protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-9013148, CDC42 GTPase cycle
R-MMU-9013406, RHOQ GTPase cycle
R-MMU-9696264, RND3 GTPase cycle
R-MMU-9696270, RND2 GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein scribble homolog
Short name:
Scribble
Alternative name(s):
Protein LAP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Scrib
Synonyms:Kiaa0147, Lap4, Scrib1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2145950, Scrib

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000022568

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001883041 – 1612Protein scribble homologAdd BLAST1612

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei37PhosphoserineBy similarity1
Modified residuei378PhosphothreonineBy similarity1
Modified residuei475PhosphothreonineBy similarity1
Modified residuei583PhosphoserineCombined sources1
Modified residuei674PhosphothreonineCombined sources1
Modified residuei675PhosphothreonineCombined sources1
Modified residuei694PhosphoserineBy similarity1
Modified residuei750PhosphoserineBy similarity1
Modified residuei812PhosphothreonineBy similarity1
Modified residuei821PhosphoserineBy similarity1
Modified residuei861PhosphoserineBy similarity1
Modified residuei925PhosphoserineCombined sources1
Modified residuei1126PhosphoserineBy similarity1
Modified residuei1206PhosphoserineCombined sources1
Modified residuei1209PhosphoserineBy similarity1
Modified residuei1212PhosphoserineBy similarity1
Modified residuei1218PhosphoserineBy similarity1
Modified residuei1262PhosphoserineBy similarity1
Modified residuei1265PhosphoserineBy similarity1
Modified residuei1284PhosphoserineBy similarity1
Modified residuei1292PhosphoserineCombined sources1
Modified residuei1325PhosphothreonineBy similarity1
Modified residuei1331PhosphoserineBy similarity1
Modified residuei1361PhosphoserineCombined sources1
Modified residuei1427PhosphoserineBy similarity1
Modified residuei1430PhosphoserineBy similarity1
Modified residuei1457PhosphoserineCombined sources1
Modified residuei1468PhosphoserineBy similarity1
Modified residuei1490PhosphoserineCombined sources1
Modified residuei1523PhosphoserineBy similarity1
Modified residuei1527PhosphothreonineBy similarity1
Modified residuei1529PhosphoserineCombined sources1
Modified residuei1543PhosphoserineCombined sources1
Modified residuei1548PhosphoserineCombined sources1
Isoform 4 (identifier: Q80U72-4)
Modified residuei1291Omega-N-methylarginineCombined sources1
Modified residuei1299PhosphoserineCombined sources1
Isoform 3 (identifier: Q80U72-3)
Modified residuei1312Omega-N-methylarginineCombined sources1
Modified residuei1320PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; targeted for UBE3A-dependent multiubiquitination and degraded.By similarity
Palmitoylated. Could be depalmitoylated by LYPLA1 and/or LYPLA2. Palmitoylation of SCRIB by ZDHHC7 is required for its localization to cell-cell junctions, function in the establishement of epithelial cell polarity and the regulation of downstream signaling pathways important for epithelial cell differentiation.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q80U72

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q80U72

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q80U72

PeptideAtlas

More...PeptideAtlasi		Q80U72

PRoteomics IDEntifications database

More...PRIDEi		Q80U72

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		261137 [Q80U72-1]
261138 [Q80U72-2]
261139 [Q80U72-3]
261140 [Q80U72-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q80U72

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q80U72

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q80U72

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in CD4+ T-cells (at protein level) (PubMed:18329370). Found in a wide range of tissues including liver, kidney and spleen (PubMed:15806148). Also expressed in the brain (at protein level) (PubMed:15182672, PubMed:15806148).3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected at 7.5 dpc in the neuroepithelium at the time of initial neural tube closure. Also expressed in cranial mesenchyme, branchial arches, somitic mesoderm and lateral mesoderm. At later stages it is expressed in the eyelid epithelium, submandibular glands, whisker and hair follicles, sympathetic glanglia, inner ear, thymus, testis, kidney, esophagus, lung, stomach, trigeminal and dorsal root glanglia.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000022568, Expressed in ear vesicle and 304 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q80U72, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q80U72, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with UBE3A (By similarity).

Interacts with PAK1 and PAK2 (PubMed:18716323).

Interacts (via PDZ domains) with VANGL2 (PubMed:16687519).

Interacts (via PDZ domains) with LPP and TRIP6; the interaction is direct (By similarity).

Interacts (via PDZ domains) with TJP2 (By similarity).

Interacts (via PDZ domains) with APC; may mediate APC targeting to adherens junctions of epithelial cells (PubMed:16611247).

Interacts (via PDZ domains) with TSHR; regulates TSHR trafficking and function (By similarity).

Interacts with ARHGEF7 and GIT1; interacts directly with ARHGEF7 (PubMed:15182672).

Interacts with CTNNB1 (PubMed:16611247, PubMed:19458197).

Interacts with MAPK12 (PubMed:15878399).

Interacts (via PDZ domains 1 and 3) with MCC (By similarity).

Interacts with DLG5 (By similarity).

Interacts with STK4/MST1 and LATS1 in the presence of DLG5 (By similarity).

Interacts (via PDZ domain 3) with CRTAM (via PDZ-binding motif); the interaction promotes CRTAM and SCRIB polarization in a subset of CD4+ T-cells (PubMed:18329370).

By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		222921, 9 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q80U72

Database of interacting proteins

More...DIPi		DIP-40660N

Protein interaction database and analysis system

More...IntActi		Q80U72, 15 interactors

Molecular INTeraction database

More...MINTi		Q80U72

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000002603

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q80U72, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati37 – 58LRR 1Add BLAST22
Repeati60 – 81LRR 2Add BLAST22
Repeati83 – 104LRR 3Add BLAST22
Repeati106 – 127LRR 4Add BLAST22
Repeati129 – 150LRR 5Add BLAST22
Repeati152 – 174LRR 6Add BLAST23
Repeati175 – 197LRR 7Add BLAST23
Repeati198 – 219LRR 8Add BLAST22
Repeati221 – 243LRR 9Add BLAST23
Repeati244 – 265LRR 10Add BLAST22
Repeati267 – 288LRR 11Add BLAST22
Repeati290 – 312LRR 12Add BLAST23
Repeati313 – 334LRR 13Add BLAST22
Repeati336 – 357LRR 14Add BLAST22
Repeati359 – 381LRR 15Add BLAST23
Repeati382 – 402LRR 16Add BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini714 – 801PDZ 1PROSITE-ProRule annotationAdd BLAST88
Domaini848 – 936PDZ 2PROSITE-ProRule annotationAdd BLAST89
Domaini990 – 1079PDZ 3PROSITE-ProRule annotationAdd BLAST90
Domaini1086 – 1180PDZ 4PROSITE-ProRule annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 804Sufficient for targeting to adherens junction and to inhibit cell proliferationBy similarityAdd BLAST804
Regioni422 – 615DisorderedSequence analysisAdd BLAST194
Regioni635 – 689DisorderedSequence analysisAdd BLAST55
Regioni703 – 1215Interaction with ARHGEF7By similarityAdd BLAST513
Regioni1213 – 1246DisorderedSequence analysisAdd BLAST34
Regioni1263 – 1297DisorderedSequence analysisAdd BLAST35
Regioni1310 – 1473DisorderedSequence analysisAdd BLAST164
Regioni1500 – 1550DisorderedSequence analysisAdd BLAST51
Regioni1579 – 1612DisorderedSequence analysisAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili455 – 475Sequence analysisAdd BLAST21
Coiled coili653 – 687Sequence analysisAdd BLAST35
Coiled coili1362 – 1393Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi423 – 443Polar residuesSequence analysisAdd BLAST21
Compositional biasi461 – 497Basic and acidic residuesSequence analysisAdd BLAST37
Compositional biasi562 – 585Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi656 – 679Acidic residuesSequence analysisAdd BLAST24
Compositional biasi1266 – 1285Polar residuesSequence analysisAdd BLAST20
Compositional biasi1363 – 1385Basic and acidic residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LAP (LRR and PDZ) protein family.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0619, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154025

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_18_20_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q80U72

Identification of Orthologs from Complete Genome Data

More...OMAi		HGLASQC

Database of Orthologous Groups

More...OrthoDBi		284114at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q80U72

TreeFam database of animal gene trees

More...TreeFami		TF351429

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 4 hits
3.80.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR001478, PDZ
IPR036034, PDZ_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13855, LRR_8, 2 hits
PF00595, PDZ, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00369, LRR_TYP, 12 hits
SM00228, PDZ, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50156, SSF50156, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51450, LRR, 13 hits
PS50106, PDZ, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80U72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLKCIPLWRC NRHVESVDKR HCSLQVVPEE IYRYSRSLEE LLLDANQLRE 
        60         70         80         90        100
LPKPFFRLLN LRKLGLSDNE IQRLPPEVAN FMQLVELDVS RNDIPEIPES 
       110        120        130        140        150
IKFCKALEIA DFSGNPLSRL PDGFTQLRSL AHLALNDVSL QALPGDVGNL 
       160        170        180        190        200
ANLVTLELRE NLLKSLPASL SFLVKLEQLD LGGNDLEVLP DTLGALPNLR 
       210        220        230        240        250
ELWLDRNQLS ALPPELGNLR RLVCLDVSEN RLEELPVELG GLALLTDLLL 
       260        270        280        290        300
SQNLLQRLPE GIGQLKQLSI LKVDQNRLCE VTEAIGDCEN LSELILTENL 
       310        320        330        340        350
LTALPHSLGK LTKLTNLNVD RNHLEVLPPE IGGCVALSVL SLRDNRLAVL 
       360        370        380        390        400
PPELAHTAEL HVLDVAGNRL RSLPFALTHL NLKALWLAEN QAQPMLRFQT 
       410        420        430        440        450
EDDAQTGEKV LTCYLLPQQP LPSLEDAGQQ SSPSESCSDA PLSRVSVIQF 
       460        470        480        490        500
EDTLEGEEDA EEAAAEKRGL QRRATPHPSE LKVMKRGIEE RRNEAFVCKP 
       510        520        530        540        550
DPSPPSPSEE EKRLSAESAL SGGSVPSAST ASEGEPEILP AEVQGLGQHE 
       560        570        580        590        600
AMPAQEEYTE DDYNEPTVHF AEDTLIPRED GESEEGQPEA AWPLPSGRQR 
       610        620        630        640        650
LIRKDTPHYK KHFKISKLPQ PEAVVALLQG VQTDREGPTA GWHNGPHTPW 
       660        670        680        690        700
APRAHEEEEE EEEENRDEEE GEATTEEDDK EEAVASAPSV KGVSFDQANN 
       710        720        730        740        750
LLIEPARIEE EELTLTIVRQ TGGLGISIAG GKGSTPYKGD DEGIFISRVS 
       760        770        780        790        800
EEGPAARAGV RVGDKLLEVN GVALQDAEHH EAVEALRGAG AAVQMRVWRE 
       810        820        830        840        850
RMVEPENAVT ITPLRPEDDY SPREWRGGGL RLPLLQPETP VSLRQRHAAC 
       860        870        880        890        900
LVRSEKGLGF SIAGGKGSTP YRAGDGGIFI SRIAEGGAAH RAGTLQVGDR 
       910        920        930        940        950
VLSINGVDMT EARHDHAVSL LTAASPTISL LLERETGGTY PPSPPPHSSP 
       960        970        980        990       1000
TPAATVAATV STAVPGEPLL PRLSPSLLAT ALEGPYPVEE ICLPRAGGPL 
      1010       1020       1030       1040       1050
GLSIVGGSDH SSHPFGVQDP GVFISKVLPR GLAARCGLRV GDRILAVNGQ 
      1060       1070       1080       1090       1100
DVREATHQEA VSALLRPCLE LCLLVRRDPP PPGMRELCIQ KAPGEKLGIS 
      1110       1120       1130       1140       1150
IRGGAKGHAG NPCDPTDEGI FISKVSPTGA AGRDGRLRVG LRLLEVNQQS 
      1160       1170       1180       1190       1200
LLGLTHAEAV QLLRSVGDTL TVLVCDGFDT STTTALEVSP GVIANPFAAG 
      1210       1220       1230       1240       1250
LGHRNSLESI SSIDRELSPE GPGKEKELAS QALPWESESA ETTGRNLEPL 
      1260       1270       1280       1290       1300
KLDYRALAAL PSAGSLQRGP SATTGGKTTE APCSPGSQQP PSPDELPANV 
      1310       1320       1330       1340       1350
KQAYRAFAAV PTVHPPENSA TQPPTPGPAA SPEQLSFRER QKYFELEVRV 
      1360       1370       1380       1390       1400
PQAEGPPKRV SLVGADDLRK MQEEEARKLQ QKRAQMLREE AVTSGPDMGL 
      1410       1420       1430       1440       1450
ASDRESPDDQ QEAEQPWAVP SHAGGSSPSS PPPLGGNAPV RTAKAERRHQ 
      1460       1470       1480       1490       1500
ERLRMQSPEL PAPERALSPA ERRALEAEKR ALWRAARMKS LEQDALRAQM 
      1510       1520       1530       1540       1550
VLSKSQEGRG KRGPLERLAE APSPAPTPSP TPLEDFGLQT SASPGRLSPD 
      1560       1570       1580       1590       1600
FVEELRTLEA SPSPGSQEED GEVALVLLGR PSPGAVGPED MTLCSSRRSV 
      1610 
RPGRRGLGPV PS
Length:1,612
Mass (Da):174,059
Last modified:July 19, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C85DB322D738EDE
GO
Isoform 2 (identifier: Q80U72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1547-1547: L → LPLSGKKFDYRAFAALPSSRPVYDIQ

Show »
Length:1,637
Mass (Da):176,868
Checksum:i46D6D137902F4D6B
GO
Isoform 3 (identifier: Q80U72-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1289-1289: Q → QTKPGVIQPLAQAWPRNSPAPRGRGGPCS
     1547-1547: L → LPLSGKKFDYRAFAALPSSRPVYDIQ

Show »
Length:1,665
Mass (Da):179,750
Checksum:iBE1272F4ECBF010E
GO
Isoform 4 (identifier: Q80U72-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     692-712: Missing.
     1289-1289: Q → QTKPGVIQPLAQAWPRNSPAPRGRGGPCS

Show »
Length:1,619
Mass (Da):174,585
Checksum:iF667D8CA5592E8D9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YU97D3YU97_MOUSE
Protein scribble homolog
Scrib
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YVA3D3YVA3_MOUSE
Protein scribble homolog
Scrib
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC65493 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti588P → L in AAH62888 (PubMed:15489334).Curated1
Sequence conflicti676 – 683EEDDKEEA → GRVGGRVG in AAH06859 (PubMed:15489334).Curated8
Sequence conflicti947 – 949HSS → RVR in AAH37480 (PubMed:15489334).Curated3
Sequence conflicti1080P → H in AAP88019 (PubMed:15649318).Curated1
Sequence conflicti1109A → T in AAP88019 (PubMed:15649318).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010909692 – 712Missing in isoform 4. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0109101289Q → QTKPGVIQPLAQAWPRNSPA PRGRGGPCS in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_0109111547L → LPLSGKKFDYRAFAALPSSR PVYDIQ in isoform 2 and isoform 3. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF441233 mRNA Translation: AAL32469.1
AK122211 mRNA Translation: BAC65493.1 Different initiation.
BC006859 mRNA Translation: AAH06859.1
BC037480 mRNA Translation: AAH37480.1
BC049942 mRNA Translation: AAH49942.1
BC062888 mRNA Translation: AAH62888.1
AF271735 mRNA Translation: AAP88019.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS27560.1 [Q80U72-3]
CCDS79381.1 [Q80U72-1]
CCDS79382.1 [Q80U72-2]

NCBI Reference Sequences

More...RefSeqi		NP_001297471.1, NM_001310542.1 [Q80U72-2]
NP_001297472.1, NM_001310543.1 [Q80U72-1]
NP_598850.1, NM_134089.2 [Q80U72-3]
XP_017171844.1, XM_017316355.1 [Q80U72-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000002603; ENSMUSP00000002603; ENSMUSG00000022568 [Q80U72-3]
ENSMUST00000063747; ENSMUSP00000068056; ENSMUSG00000022568 [Q80U72-1]
ENSMUST00000109946; ENSMUSP00000105572; ENSMUSG00000022568 [Q80U72-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		105782

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:105782

UCSC genome browser

More...UCSCi		uc007wig.1, mouse [Q80U72-3]
uc007wih.1, mouse [Q80U72-2]
uc007wii.1, mouse [Q80U72-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441233 mRNA Translation: AAL32469.1
AK122211 mRNA Translation: BAC65493.1 Different initiation.
BC006859 mRNA Translation: AAH06859.1
BC037480 mRNA Translation: AAH37480.1
BC049942 mRNA Translation: AAH49942.1
BC062888 mRNA Translation: AAH62888.1
AF271735 mRNA Translation: AAP88019.1
CCDSiCCDS27560.1 [Q80U72-3]
CCDS79381.1 [Q80U72-1]
CCDS79382.1 [Q80U72-2]
RefSeqiNP_001297471.1, NM_001310542.1 [Q80U72-2]
NP_001297472.1, NM_001310543.1 [Q80U72-1]
NP_598850.1, NM_134089.2 [Q80U72-3]
XP_017171844.1, XM_017316355.1 [Q80U72-4]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi222921, 9 interactors
CORUMiQ80U72
DIPiDIP-40660N
IntActiQ80U72, 15 interactors
MINTiQ80U72
STRINGi10090.ENSMUSP00000002603

PTM databases

iPTMnetiQ80U72
PhosphoSitePlusiQ80U72
SwissPalmiQ80U72

Proteomic databases

EPDiQ80U72
jPOSTiQ80U72
PaxDbiQ80U72
PeptideAtlasiQ80U72
PRIDEiQ80U72
ProteomicsDBi261137 [Q80U72-1]
261138 [Q80U72-2]
261139 [Q80U72-3]
261140 [Q80U72-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		43533, 133 antibodies

The DNASU plasmid repository

More...DNASUi		105782

Genome annotation databases

EnsembliENSMUST00000002603; ENSMUSP00000002603; ENSMUSG00000022568 [Q80U72-3]
ENSMUST00000063747; ENSMUSP00000068056; ENSMUSG00000022568 [Q80U72-1]
ENSMUST00000109946; ENSMUSP00000105572; ENSMUSG00000022568 [Q80U72-2]
GeneIDi105782
KEGGimmu:105782
UCSCiuc007wig.1, mouse [Q80U72-3]
uc007wih.1, mouse [Q80U72-2]
uc007wii.1, mouse [Q80U72-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23513
MGIiMGI:2145950, Scrib
VEuPathDBiHostDB:ENSMUSG00000022568

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
GeneTreeiENSGT00940000154025
HOGENOMiCLU_000288_18_20_1
InParanoidiQ80U72
OMAiHGLASQC
OrthoDBi284114at2759
PhylomeDBiQ80U72
TreeFamiTF351429

Enzyme and pathway databases

ReactomeiR-MMU-9013148, CDC42 GTPase cycle
R-MMU-9013406, RHOQ GTPase cycle
R-MMU-9696264, RND3 GTPase cycle
R-MMU-9696270, RND2 GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		105782, 7 hits in 63 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Scrib, mouse

Protein Ontology

More...PROi		PR:Q80U72
RNActiQ80U72, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000022568, Expressed in ear vesicle and 304 other tissues
ExpressionAtlasiQ80U72, baseline and differential
GenevisibleiQ80U72, MM

Family and domain databases

Gene3Di2.30.42.10, 4 hits
3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR001478, PDZ
IPR036034, PDZ_sf
PfamiView protein in Pfam
PF13855, LRR_8, 2 hits
PF00595, PDZ, 4 hits
SMARTiView protein in SMART
SM00369, LRR_TYP, 12 hits
SM00228, PDZ, 4 hits
SUPFAMiSSF50156, SSF50156, 4 hits
PROSITEiView protein in PROSITE
PS51450, LRR, 13 hits
PS50106, PDZ, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCRIB_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80U72
Secondary accession number(s): Q6P5H7
, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: September 29, 2021
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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