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Entry version 163 (16 Oct 2019)
Sequence version 2 (19 Jul 2004)
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Protein

Protein scribble homolog

Gene

Scrib

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.4 Publications

Miscellaneous

The circletail (Crc) mice exhibit craniorachishicisis a severe form of neural tube defect. This is due to a single base insertion in the Scrib gene creating a frameshift which leads to synthesis of a truncated protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein scribble homolog
Short name:
Scribble
Alternative name(s):
Protein LAP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Scrib
Synonyms:Kiaa0147, Lap4, Scrib1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2145950 Scrib

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001883041 – 1612Protein scribble homologAdd BLAST1612

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei37PhosphoserineBy similarity1
Modified residuei378PhosphothreonineBy similarity1
Modified residuei475PhosphothreonineBy similarity1
Modified residuei583PhosphoserineCombined sources1
Modified residuei674PhosphothreonineCombined sources1
Modified residuei675PhosphothreonineCombined sources1
Modified residuei694PhosphoserineBy similarity1
Modified residuei750PhosphoserineBy similarity1
Modified residuei812PhosphothreonineBy similarity1
Modified residuei821PhosphoserineBy similarity1
Modified residuei861PhosphoserineBy similarity1
Modified residuei925PhosphoserineCombined sources1
Modified residuei1126PhosphoserineBy similarity1
Modified residuei1206PhosphoserineCombined sources1
Modified residuei1209PhosphoserineBy similarity1
Modified residuei1212PhosphoserineBy similarity1
Modified residuei1218PhosphoserineBy similarity1
Modified residuei1262PhosphoserineBy similarity1
Modified residuei1265PhosphoserineBy similarity1
Modified residuei1284PhosphoserineBy similarity1
Modified residuei1292PhosphoserineCombined sources1
Modified residuei1325PhosphothreonineBy similarity1
Modified residuei1331PhosphoserineBy similarity1
Modified residuei1361PhosphoserineCombined sources1
Modified residuei1427PhosphoserineBy similarity1
Modified residuei1430PhosphoserineBy similarity1
Modified residuei1457PhosphoserineCombined sources1
Modified residuei1468PhosphoserineBy similarity1
Modified residuei1490PhosphoserineCombined sources1
Modified residuei1523PhosphoserineBy similarity1
Modified residuei1527PhosphothreonineBy similarity1
Modified residuei1529PhosphoserineCombined sources1
Modified residuei1543PhosphoserineCombined sources1
Modified residuei1548PhosphoserineCombined sources1
Isoform 4 (identifier: Q80U72-4)
Modified residuei1291Omega-N-methylarginineCombined sources1
Modified residuei1299PhosphoserineCombined sources1
Isoform 3 (identifier: Q80U72-3)
Modified residuei1312Omega-N-methylarginineCombined sources1
Modified residuei1320PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; targeted for UBE3A-dependent multiubiquitination and degraded.By similarity

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q80U72

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q80U72

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80U72

PeptideAtlas

More...
PeptideAtlasi
Q80U72

PRoteomics IDEntifications database

More...
PRIDEi
Q80U72

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80U72

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80U72

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q80U72

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in a wide range of tissues including liver, brain, kidney and spleen.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected at 7.5 dpc in the neuroepithelium at the time of initial neural tube closure. Also expressed in cranial mesenchyme, branchial arches, somitic mesoderm and lateral mesoderm. At later stages it is expressed in the eyelid epithelium, submandibular glands, whisker and hair follicles, sympathetic glanglia, inner ear, thymus, testis, kidney, esophagus, lung, stomach, trigeminal and dorsal root glanglia.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022568 Expressed in 281 organ(s), highest expression level in ear vesicle

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q80U72 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80U72 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with UBE3A.

Interacts with PAK1 and PAK2.

Interacts (via PDZ domains) with LPP and TRIP6; the interaction is direct.

Interacts (via PDZ domains) with TJP2.

Interacts (via PDZ domains) with TSHR; regulates TSHR trafficking and function (By similarity).

Interacts (via PDZ domains) with VANGL2.

Interacts with ARHGEF7 and GIT1; interacts directly with ARHGEF7.

Interacts (via PDZ domains) with APC; may mediate APC targeting to adherens junctions of epithelial cells.

Interacts with CTNNB1 and MAPK12.

Interacts (via PDZ domains 1 and 3) with MCC (By similarity).

Interacts with DLG5 (By similarity).

Interacts with STK4/MST1 and LATS1 in the presence of DLG5 (By similarity).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
222921, 7 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q80U72

Database of interacting proteins

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DIPi
DIP-40660N

Protein interaction database and analysis system

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IntActi
Q80U72, 16 interactors

Molecular INTeraction database

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MINTi
Q80U72

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000002603

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q80U72

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati37 – 58LRR 1Add BLAST22
Repeati60 – 81LRR 2Add BLAST22
Repeati83 – 104LRR 3Add BLAST22
Repeati106 – 127LRR 4Add BLAST22
Repeati129 – 150LRR 5Add BLAST22
Repeati152 – 174LRR 6Add BLAST23
Repeati175 – 197LRR 7Add BLAST23
Repeati198 – 219LRR 8Add BLAST22
Repeati221 – 243LRR 9Add BLAST23
Repeati244 – 265LRR 10Add BLAST22
Repeati267 – 288LRR 11Add BLAST22
Repeati290 – 312LRR 12Add BLAST23
Repeati313 – 334LRR 13Add BLAST22
Repeati336 – 357LRR 14Add BLAST22
Repeati359 – 381LRR 15Add BLAST23
Repeati382 – 402LRR 16Add BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini714 – 801PDZ 1PROSITE-ProRule annotationAdd BLAST88
Domaini848 – 936PDZ 2PROSITE-ProRule annotationAdd BLAST89
Domaini990 – 1079PDZ 3PROSITE-ProRule annotationAdd BLAST90
Domaini1086 – 1180PDZ 4PROSITE-ProRule annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 804Sufficient for targeting to adherens junction and to inhibit cell proliferationBy similarityAdd BLAST804
Regioni703 – 1215Interaction with ARHGEF7By similarityAdd BLAST513

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili455 – 475Sequence analysisAdd BLAST21
Coiled coili653 – 687Sequence analysisAdd BLAST35
Coiled coili1362 – 1393Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi656 – 682Glu-richAdd BLAST27
Compositional biasi656 – 664Poly-Glu9
Compositional biasi709 – 712Poly-Glu4
Compositional biasi1079 – 1082Poly-Pro4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LAP (LRR and PDZ) protein family.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410KCZ0 Eukaryota
COG4886 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154025

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q80U72

KEGG Orthology (KO)

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KOi
K16175

Identification of Orthologs from Complete Genome Data

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OMAi
VQMRLWR

Database of Orthologous Groups

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OrthoDBi
284114at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q80U72

TreeFam database of animal gene trees

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TreeFami
TF351429

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 3 hits
PF00595 PDZ, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00369 LRR_TYP, 12 hits
SM00228 PDZ, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50156 SSF50156, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 13 hits
PS50106 PDZ, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80U72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLKCIPLWRC NRHVESVDKR HCSLQVVPEE IYRYSRSLEE LLLDANQLRE
60 70 80 90 100
LPKPFFRLLN LRKLGLSDNE IQRLPPEVAN FMQLVELDVS RNDIPEIPES
110 120 130 140 150
IKFCKALEIA DFSGNPLSRL PDGFTQLRSL AHLALNDVSL QALPGDVGNL
160 170 180 190 200
ANLVTLELRE NLLKSLPASL SFLVKLEQLD LGGNDLEVLP DTLGALPNLR
210 220 230 240 250
ELWLDRNQLS ALPPELGNLR RLVCLDVSEN RLEELPVELG GLALLTDLLL
260 270 280 290 300
SQNLLQRLPE GIGQLKQLSI LKVDQNRLCE VTEAIGDCEN LSELILTENL
310 320 330 340 350
LTALPHSLGK LTKLTNLNVD RNHLEVLPPE IGGCVALSVL SLRDNRLAVL
360 370 380 390 400
PPELAHTAEL HVLDVAGNRL RSLPFALTHL NLKALWLAEN QAQPMLRFQT
410 420 430 440 450
EDDAQTGEKV LTCYLLPQQP LPSLEDAGQQ SSPSESCSDA PLSRVSVIQF
460 470 480 490 500
EDTLEGEEDA EEAAAEKRGL QRRATPHPSE LKVMKRGIEE RRNEAFVCKP
510 520 530 540 550
DPSPPSPSEE EKRLSAESAL SGGSVPSAST ASEGEPEILP AEVQGLGQHE
560 570 580 590 600
AMPAQEEYTE DDYNEPTVHF AEDTLIPRED GESEEGQPEA AWPLPSGRQR
610 620 630 640 650
LIRKDTPHYK KHFKISKLPQ PEAVVALLQG VQTDREGPTA GWHNGPHTPW
660 670 680 690 700
APRAHEEEEE EEEENRDEEE GEATTEEDDK EEAVASAPSV KGVSFDQANN
710 720 730 740 750
LLIEPARIEE EELTLTIVRQ TGGLGISIAG GKGSTPYKGD DEGIFISRVS
760 770 780 790 800
EEGPAARAGV RVGDKLLEVN GVALQDAEHH EAVEALRGAG AAVQMRVWRE
810 820 830 840 850
RMVEPENAVT ITPLRPEDDY SPREWRGGGL RLPLLQPETP VSLRQRHAAC
860 870 880 890 900
LVRSEKGLGF SIAGGKGSTP YRAGDGGIFI SRIAEGGAAH RAGTLQVGDR
910 920 930 940 950
VLSINGVDMT EARHDHAVSL LTAASPTISL LLERETGGTY PPSPPPHSSP
960 970 980 990 1000
TPAATVAATV STAVPGEPLL PRLSPSLLAT ALEGPYPVEE ICLPRAGGPL
1010 1020 1030 1040 1050
GLSIVGGSDH SSHPFGVQDP GVFISKVLPR GLAARCGLRV GDRILAVNGQ
1060 1070 1080 1090 1100
DVREATHQEA VSALLRPCLE LCLLVRRDPP PPGMRELCIQ KAPGEKLGIS
1110 1120 1130 1140 1150
IRGGAKGHAG NPCDPTDEGI FISKVSPTGA AGRDGRLRVG LRLLEVNQQS
1160 1170 1180 1190 1200
LLGLTHAEAV QLLRSVGDTL TVLVCDGFDT STTTALEVSP GVIANPFAAG
1210 1220 1230 1240 1250
LGHRNSLESI SSIDRELSPE GPGKEKELAS QALPWESESA ETTGRNLEPL
1260 1270 1280 1290 1300
KLDYRALAAL PSAGSLQRGP SATTGGKTTE APCSPGSQQP PSPDELPANV
1310 1320 1330 1340 1350
KQAYRAFAAV PTVHPPENSA TQPPTPGPAA SPEQLSFRER QKYFELEVRV
1360 1370 1380 1390 1400
PQAEGPPKRV SLVGADDLRK MQEEEARKLQ QKRAQMLREE AVTSGPDMGL
1410 1420 1430 1440 1450
ASDRESPDDQ QEAEQPWAVP SHAGGSSPSS PPPLGGNAPV RTAKAERRHQ
1460 1470 1480 1490 1500
ERLRMQSPEL PAPERALSPA ERRALEAEKR ALWRAARMKS LEQDALRAQM
1510 1520 1530 1540 1550
VLSKSQEGRG KRGPLERLAE APSPAPTPSP TPLEDFGLQT SASPGRLSPD
1560 1570 1580 1590 1600
FVEELRTLEA SPSPGSQEED GEVALVLLGR PSPGAVGPED MTLCSSRRSV
1610
RPGRRGLGPV PS
Length:1,612
Mass (Da):174,059
Last modified:July 19, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C85DB322D738EDE
GO
Isoform 2 (identifier: Q80U72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1547-1547: L → LPLSGKKFDYRAFAALPSSRPVYDIQ

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Length:1,637
Mass (Da):176,868
Checksum:i46D6D137902F4D6B
GO
Isoform 3 (identifier: Q80U72-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1289-1289: Q → QTKPGVIQPLAQAWPRNSPAPRGRGGPCS
     1547-1547: L → LPLSGKKFDYRAFAALPSSRPVYDIQ

Show »
Length:1,665
Mass (Da):179,750
Checksum:iBE1272F4ECBF010E
GO
Isoform 4 (identifier: Q80U72-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     692-712: Missing.
     1289-1289: Q → QTKPGVIQPLAQAWPRNSPAPRGRGGPCS

Note: No experimental confirmation available.Combined sources
Show »
Length:1,619
Mass (Da):174,585
Checksum:iF667D8CA5592E8D9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YU97D3YU97_MOUSE
Protein scribble homolog
Scrib
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YVA3D3YVA3_MOUSE
Protein scribble homolog
Scrib
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC65493 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti588P → L in AAH62888 (PubMed:15489334).Curated1
Sequence conflicti676 – 683EEDDKEEA → GRVGGRVG in AAH06859 (PubMed:15489334).Curated8
Sequence conflicti947 – 949HSS → RVR in AAH37480 (PubMed:15489334).Curated3
Sequence conflicti1080P → H in AAP88019 (PubMed:15649318).Curated1
Sequence conflicti1109A → T in AAP88019 (PubMed:15649318).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010909692 – 712Missing in isoform 4. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0109101289Q → QTKPGVIQPLAQAWPRNSPA PRGRGGPCS in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_0109111547L → LPLSGKKFDYRAFAALPSSR PVYDIQ in isoform 2 and isoform 3. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF441233 mRNA Translation: AAL32469.1
AK122211 mRNA Translation: BAC65493.1 Different initiation.
BC006859 mRNA Translation: AAH06859.1
BC037480 mRNA Translation: AAH37480.1
BC049942 mRNA Translation: AAH49942.1
BC062888 mRNA Translation: AAH62888.1
AF271735 mRNA Translation: AAP88019.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS27560.1 [Q80U72-3]
CCDS79381.1 [Q80U72-1]
CCDS79382.1 [Q80U72-2]

NCBI Reference Sequences

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RefSeqi
NP_001297471.1, NM_001310542.1 [Q80U72-2]
NP_001297472.1, NM_001310543.1 [Q80U72-1]
NP_598850.1, NM_134089.2 [Q80U72-3]
XP_017171844.1, XM_017316355.1 [Q80U72-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000002603; ENSMUSP00000002603; ENSMUSG00000022568 [Q80U72-3]
ENSMUST00000063747; ENSMUSP00000068056; ENSMUSG00000022568 [Q80U72-1]
ENSMUST00000109946; ENSMUSP00000105572; ENSMUSG00000022568 [Q80U72-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
105782

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:105782

UCSC genome browser

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UCSCi
uc007wig.1 mouse [Q80U72-3]
uc007wih.1 mouse [Q80U72-2]
uc007wii.1 mouse [Q80U72-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441233 mRNA Translation: AAL32469.1
AK122211 mRNA Translation: BAC65493.1 Different initiation.
BC006859 mRNA Translation: AAH06859.1
BC037480 mRNA Translation: AAH37480.1
BC049942 mRNA Translation: AAH49942.1
BC062888 mRNA Translation: AAH62888.1
AF271735 mRNA Translation: AAP88019.1
CCDSiCCDS27560.1 [Q80U72-3]
CCDS79381.1 [Q80U72-1]
CCDS79382.1 [Q80U72-2]
RefSeqiNP_001297471.1, NM_001310542.1 [Q80U72-2]
NP_001297472.1, NM_001310543.1 [Q80U72-1]
NP_598850.1, NM_134089.2 [Q80U72-3]
XP_017171844.1, XM_017316355.1 [Q80U72-4]

3D structure databases

SMRiQ80U72
ModBaseiSearch...

Protein-protein interaction databases

BioGridi222921, 7 interactors
CORUMiQ80U72
DIPiDIP-40660N
IntActiQ80U72, 16 interactors
MINTiQ80U72
STRINGi10090.ENSMUSP00000002603

PTM databases

iPTMnetiQ80U72
PhosphoSitePlusiQ80U72
SwissPalmiQ80U72

Proteomic databases

EPDiQ80U72
jPOSTiQ80U72
PaxDbiQ80U72
PeptideAtlasiQ80U72
PRIDEiQ80U72

Genome annotation databases

EnsembliENSMUST00000002603; ENSMUSP00000002603; ENSMUSG00000022568 [Q80U72-3]
ENSMUST00000063747; ENSMUSP00000068056; ENSMUSG00000022568 [Q80U72-1]
ENSMUST00000109946; ENSMUSP00000105572; ENSMUSG00000022568 [Q80U72-2]
GeneIDi105782
KEGGimmu:105782
UCSCiuc007wig.1 mouse [Q80U72-3]
uc007wih.1 mouse [Q80U72-2]
uc007wii.1 mouse [Q80U72-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23513
MGIiMGI:2145950 Scrib

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiENOG410KCZ0 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000154025
InParanoidiQ80U72
KOiK16175
OMAiVQMRLWR
OrthoDBi284114at2759
PhylomeDBiQ80U72
TreeFamiTF351429

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Scrib mouse

Protein Ontology

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PROi
PR:Q80U72

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022568 Expressed in 281 organ(s), highest expression level in ear vesicle
ExpressionAtlasiQ80U72 baseline and differential
GenevisibleiQ80U72 MM

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF00595 PDZ, 4 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 12 hits
SM00228 PDZ, 4 hits
SUPFAMiSSF50156 SSF50156, 4 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 13 hits
PS50106 PDZ, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCRIB_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80U72
Secondary accession number(s): Q6P5H7
, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: October 16, 2019
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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