UniProtKB - Q80U72 (SCRIB_MOUSE)
Protein scribble homolog
Scrib
Functioni
Miscellaneous
GO - Biological processi
- activation of GTPase activity Source: UniProtKB
- apoptotic process involved in morphogenesis Source: UniProtKB
- astrocyte cell migration Source: MGI
- auditory receptor cell morphogenesis Source: MGI
- auditory receptor cell stereocilium organization Source: MGI
- camera-type eye morphogenesis Source: MGI
- cell-cell adhesion Source: UniProtKB
- cell migration Source: UniProtKB
- cell population proliferation Source: UniProtKB
- cochlear nucleus development Source: MGI
- epithelial cell morphogenesis Source: MGI
- establishment of apical/basal cell polarity Source: UniProtKB
- establishment of T cell polarity Source: UniProtKB
- establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
- inner ear receptor cell stereocilium organization Source: MGI
- mammary gland duct morphogenesis Source: UniProtKB
- morphogenesis of embryonic epithelium Source: MGI
- negative regulation of activated T cell proliferation Source: UniProtKB
- negative regulation of mitotic cell cycle Source: UniProtKB
- neural tube closure Source: MGI
- neurotransmitter receptor transport, endosome to postsynaptic membrane Source: MGI
- neurotransmitter receptor transport postsynaptic membrane to endosome Source: MGI
- polarized epithelial cell differentiation Source: MGI
- positive chemotaxis Source: UniProtKB
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of interferon-gamma production Source: UniProtKB
- positive regulation of receptor recycling Source: MGI
- post-anal tail morphogenesis Source: MGI
- protein localization Source: MGI
- protein localization to adherens junction Source: MGI
- receptor clustering Source: GO_Central
- receptor localization to synapse Source: GO_Central
- regulation of postsynaptic neurotransmitter receptor internalization Source: Ensembl
- synaptic vesicle endocytosis Source: SynGO
- synaptic vesicle targeting Source: UniProtKB
- wound healing Source: MGI
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation |
Names & Taxonomyi
Protein namesi | Recommended name: Protein scribble homologShort name: Scribble Alternative name(s): Protein LAP4 |
Gene namesi | Name:Scrib Synonyms:Kiaa0147, Lap4, Scrib1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2145950, Scrib |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
Other locations
- Cell junction By similarity
- adherens junction By similarity
- lamellipodium By similarity
- Cytoplasm By similarity
- postsynapse By similarity
- presynapse By similarity
Note: Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity (By similarity). In a subset of CD4+ T-cells, colocalizes with CRTAM at the immunological synapse during the late phase of T-cell activation (PubMed:18329370).By similarity1 Publication
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: MGI
Plasma Membrane
- apical plasma membrane Source: MGI
- basolateral plasma membrane Source: MGI
- extrinsic component of postsynaptic density membrane Source: MGI
- immunological synapse Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- adherens junction Source: UniProtKB
- cell junction Source: MGI
- cell-cell contact zone Source: MGI
- cell-cell junction Source: UniProtKB
- cytoplasm Source: MGI
- glutamatergic synapse Source: MGI
- lamellipodium Source: UniProtKB-SubCell
- myelin sheath abaxonal region Source: BHF-UCL
- postsynaptic density Source: MGI
- presynapse Source: UniProtKB-SubCell
- Scrib-APC-beta-catenin complex Source: MGI
- synapse Source: GO_Central
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000188304 | 1 – 1612 | Protein scribble homologAdd BLAST | 1612 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 37 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 378 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 475 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 583 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 674 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 675 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 694 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 750 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 812 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 821 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 861 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 925 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1126 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1206 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1209 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1212 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1218 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1262 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1265 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1284 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1292 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1325 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 1331 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1361 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1427 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1430 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1457 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1468 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1490 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1523 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1527 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 1529 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1543 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1548 | PhosphoserineCombined sources | 1 | ||
Isoform 4 (identifier: Q80U72-4) | |||||
Modified residuei | 1291 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 1299 | PhosphoserineCombined sources | 1 | ||
Isoform 3 (identifier: Q80U72-3) | |||||
Modified residuei | 1312 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 1320 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Lipoprotein, Methylation, Palmitate, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q80U72 |
jPOSTi | Q80U72 |
PaxDbi | Q80U72 |
PeptideAtlasi | Q80U72 |
PRIDEi | Q80U72 |
PTM databases
iPTMneti | Q80U72 |
PhosphoSitePlusi | Q80U72 |
SwissPalmi | Q80U72 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000022568, Expressed in ear vesicle and 296 other tissues |
ExpressionAtlasi | Q80U72, baseline and differential |
Genevisiblei | Q80U72, MM |
Interactioni
Subunit structurei
Interacts with UBE3A (By similarity).
Interacts with PAK1 and PAK2 (PubMed:18716323).
Interacts (via PDZ domains) with VANGL2 (PubMed:16687519).
Interacts (via PDZ domains) with LPP and TRIP6; the interaction is direct (By similarity).
Interacts (via PDZ domains) with TJP2 (By similarity).
Interacts (via PDZ domains) with APC; may mediate APC targeting to adherens junctions of epithelial cells (PubMed:16611247).
Interacts (via PDZ domains) with TSHR; regulates TSHR trafficking and function (By similarity).
Interacts with ARHGEF7 and GIT1; interacts directly with ARHGEF7 (PubMed:15182672).
Interacts with CTNNB1 (PubMed:16611247, PubMed:19458197).
Interacts with MAPK12 (PubMed:15878399).
Interacts (via PDZ domains 1 and 3) with MCC (By similarity).
Interacts with DLG5 (By similarity).
Interacts with STK4/MST1 and LATS1 in the presence of DLG5 (By similarity).
Interacts (via PDZ domain 3) with CRTAM (via PDZ-binding motif); the interaction promotes CRTAM and SCRIB polarization in a subset of CD4+ T-cells (PubMed:18329370).
By similarity7 PublicationsBinary interactionsi
Hide detailsQ80U72
With | #Exp. | IntAct |
---|---|---|
Crtam [Q149L7] | 4 | EBI-1766028,EBI-1766072 |
PHLPP1 [O60346] from Homo sapiens. | 2 | EBI-1766028,EBI-2511516 |
Protein-protein interaction databases
BioGRIDi | 222921, 9 interactors |
CORUMi | Q80U72 |
DIPi | DIP-40660N |
IntActi | Q80U72, 16 interactors |
MINTi | Q80U72 |
STRINGi | 10090.ENSMUSP00000002603 |
Miscellaneous databases
RNActi | Q80U72, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 37 – 58 | LRR 1Add BLAST | 22 | |
Repeati | 60 – 81 | LRR 2Add BLAST | 22 | |
Repeati | 83 – 104 | LRR 3Add BLAST | 22 | |
Repeati | 106 – 127 | LRR 4Add BLAST | 22 | |
Repeati | 129 – 150 | LRR 5Add BLAST | 22 | |
Repeati | 152 – 174 | LRR 6Add BLAST | 23 | |
Repeati | 175 – 197 | LRR 7Add BLAST | 23 | |
Repeati | 198 – 219 | LRR 8Add BLAST | 22 | |
Repeati | 221 – 243 | LRR 9Add BLAST | 23 | |
Repeati | 244 – 265 | LRR 10Add BLAST | 22 | |
Repeati | 267 – 288 | LRR 11Add BLAST | 22 | |
Repeati | 290 – 312 | LRR 12Add BLAST | 23 | |
Repeati | 313 – 334 | LRR 13Add BLAST | 22 | |
Repeati | 336 – 357 | LRR 14Add BLAST | 22 | |
Repeati | 359 – 381 | LRR 15Add BLAST | 23 | |
Repeati | 382 – 402 | LRR 16Add BLAST | 21 | |
Domaini | 714 – 801 | PDZ 1PROSITE-ProRule annotationAdd BLAST | 88 | |
Domaini | 848 – 936 | PDZ 2PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 990 – 1079 | PDZ 3PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 1086 – 1180 | PDZ 4PROSITE-ProRule annotationAdd BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 804 | Sufficient for targeting to adherens junction and to inhibit cell proliferationBy similarityAdd BLAST | 804 | |
Regioni | 703 – 1215 | Interaction with ARHGEF7By similarityAdd BLAST | 513 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 455 – 475 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 653 – 687 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 1362 – 1393 | Sequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 656 – 682 | Glu-richAdd BLAST | 27 | |
Compositional biasi | 656 – 664 | Poly-Glu | 9 | |
Compositional biasi | 709 – 712 | Poly-Glu | 4 | |
Compositional biasi | 1079 – 1082 | Poly-Pro | 4 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000154025 |
HOGENOMi | CLU_000288_18_20_1 |
InParanoidi | Q80U72 |
OMAi | NNFHPKQ |
OrthoDBi | 284114at2759 |
PhylomeDBi | Q80U72 |
TreeFami | TF351429 |
Family and domain databases
Gene3Di | 2.30.42.10, 4 hits 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits PF00595, PDZ, 4 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 12 hits SM00228, PDZ, 4 hits |
SUPFAMi | SSF50156, SSF50156, 4 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 13 hits PS50106, PDZ, 4 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLKCIPLWRC NRHVESVDKR HCSLQVVPEE IYRYSRSLEE LLLDANQLRE
60 70 80 90 100
LPKPFFRLLN LRKLGLSDNE IQRLPPEVAN FMQLVELDVS RNDIPEIPES
110 120 130 140 150
IKFCKALEIA DFSGNPLSRL PDGFTQLRSL AHLALNDVSL QALPGDVGNL
160 170 180 190 200
ANLVTLELRE NLLKSLPASL SFLVKLEQLD LGGNDLEVLP DTLGALPNLR
210 220 230 240 250
ELWLDRNQLS ALPPELGNLR RLVCLDVSEN RLEELPVELG GLALLTDLLL
260 270 280 290 300
SQNLLQRLPE GIGQLKQLSI LKVDQNRLCE VTEAIGDCEN LSELILTENL
310 320 330 340 350
LTALPHSLGK LTKLTNLNVD RNHLEVLPPE IGGCVALSVL SLRDNRLAVL
360 370 380 390 400
PPELAHTAEL HVLDVAGNRL RSLPFALTHL NLKALWLAEN QAQPMLRFQT
410 420 430 440 450
EDDAQTGEKV LTCYLLPQQP LPSLEDAGQQ SSPSESCSDA PLSRVSVIQF
460 470 480 490 500
EDTLEGEEDA EEAAAEKRGL QRRATPHPSE LKVMKRGIEE RRNEAFVCKP
510 520 530 540 550
DPSPPSPSEE EKRLSAESAL SGGSVPSAST ASEGEPEILP AEVQGLGQHE
560 570 580 590 600
AMPAQEEYTE DDYNEPTVHF AEDTLIPRED GESEEGQPEA AWPLPSGRQR
610 620 630 640 650
LIRKDTPHYK KHFKISKLPQ PEAVVALLQG VQTDREGPTA GWHNGPHTPW
660 670 680 690 700
APRAHEEEEE EEEENRDEEE GEATTEEDDK EEAVASAPSV KGVSFDQANN
710 720 730 740 750
LLIEPARIEE EELTLTIVRQ TGGLGISIAG GKGSTPYKGD DEGIFISRVS
760 770 780 790 800
EEGPAARAGV RVGDKLLEVN GVALQDAEHH EAVEALRGAG AAVQMRVWRE
810 820 830 840 850
RMVEPENAVT ITPLRPEDDY SPREWRGGGL RLPLLQPETP VSLRQRHAAC
860 870 880 890 900
LVRSEKGLGF SIAGGKGSTP YRAGDGGIFI SRIAEGGAAH RAGTLQVGDR
910 920 930 940 950
VLSINGVDMT EARHDHAVSL LTAASPTISL LLERETGGTY PPSPPPHSSP
960 970 980 990 1000
TPAATVAATV STAVPGEPLL PRLSPSLLAT ALEGPYPVEE ICLPRAGGPL
1010 1020 1030 1040 1050
GLSIVGGSDH SSHPFGVQDP GVFISKVLPR GLAARCGLRV GDRILAVNGQ
1060 1070 1080 1090 1100
DVREATHQEA VSALLRPCLE LCLLVRRDPP PPGMRELCIQ KAPGEKLGIS
1110 1120 1130 1140 1150
IRGGAKGHAG NPCDPTDEGI FISKVSPTGA AGRDGRLRVG LRLLEVNQQS
1160 1170 1180 1190 1200
LLGLTHAEAV QLLRSVGDTL TVLVCDGFDT STTTALEVSP GVIANPFAAG
1210 1220 1230 1240 1250
LGHRNSLESI SSIDRELSPE GPGKEKELAS QALPWESESA ETTGRNLEPL
1260 1270 1280 1290 1300
KLDYRALAAL PSAGSLQRGP SATTGGKTTE APCSPGSQQP PSPDELPANV
1310 1320 1330 1340 1350
KQAYRAFAAV PTVHPPENSA TQPPTPGPAA SPEQLSFRER QKYFELEVRV
1360 1370 1380 1390 1400
PQAEGPPKRV SLVGADDLRK MQEEEARKLQ QKRAQMLREE AVTSGPDMGL
1410 1420 1430 1440 1450
ASDRESPDDQ QEAEQPWAVP SHAGGSSPSS PPPLGGNAPV RTAKAERRHQ
1460 1470 1480 1490 1500
ERLRMQSPEL PAPERALSPA ERRALEAEKR ALWRAARMKS LEQDALRAQM
1510 1520 1530 1540 1550
VLSKSQEGRG KRGPLERLAE APSPAPTPSP TPLEDFGLQT SASPGRLSPD
1560 1570 1580 1590 1600
FVEELRTLEA SPSPGSQEED GEVALVLLGR PSPGAVGPED MTLCSSRRSV
1610
RPGRRGLGPV PS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YU97 | D3YU97_MOUSE | Protein scribble homolog | Scrib | 113 | Annotation score: | ||
D3YVA3 | D3YVA3_MOUSE | Protein scribble homolog | Scrib | 90 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 588 | P → L in AAH62888 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 676 – 683 | EEDDKEEA → GRVGGRVG in AAH06859 (PubMed:15489334).Curated | 8 | |
Sequence conflicti | 947 – 949 | HSS → RVR in AAH37480 (PubMed:15489334).Curated | 3 | |
Sequence conflicti | 1080 | P → H in AAP88019 (PubMed:15649318).Curated | 1 | |
Sequence conflicti | 1109 | A → T in AAP88019 (PubMed:15649318).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010909 | 692 – 712 | Missing in isoform 4. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_010910 | 1289 | Q → QTKPGVIQPLAQAWPRNSPA PRGRGGPCS in isoform 3 and isoform 4. 2 Publications | 1 | |
Alternative sequenceiVSP_010911 | 1547 | L → LPLSGKKFDYRAFAALPSSR PVYDIQ in isoform 2 and isoform 3. 3 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF441233 mRNA Translation: AAL32469.1 AK122211 mRNA Translation: BAC65493.1 Different initiation. BC006859 mRNA Translation: AAH06859.1 BC037480 mRNA Translation: AAH37480.1 BC049942 mRNA Translation: AAH49942.1 BC062888 mRNA Translation: AAH62888.1 AF271735 mRNA Translation: AAP88019.1 |
CCDSi | CCDS27560.1 [Q80U72-3] CCDS79381.1 [Q80U72-1] CCDS79382.1 [Q80U72-2] |
RefSeqi | NP_001297471.1, NM_001310542.1 [Q80U72-2] NP_001297472.1, NM_001310543.1 [Q80U72-1] NP_598850.1, NM_134089.2 [Q80U72-3] XP_017171844.1, XM_017316355.1 [Q80U72-4] |
Genome annotation databases
Ensembli | ENSMUST00000002603; ENSMUSP00000002603; ENSMUSG00000022568 [Q80U72-3] ENSMUST00000063747; ENSMUSP00000068056; ENSMUSG00000022568 [Q80U72-1] ENSMUST00000109946; ENSMUSP00000105572; ENSMUSG00000022568 [Q80U72-2] |
GeneIDi | 105782 |
KEGGi | mmu:105782 |
UCSCi | uc007wig.1, mouse [Q80U72-3] uc007wih.1, mouse [Q80U72-2] uc007wii.1, mouse [Q80U72-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF441233 mRNA Translation: AAL32469.1 AK122211 mRNA Translation: BAC65493.1 Different initiation. BC006859 mRNA Translation: AAH06859.1 BC037480 mRNA Translation: AAH37480.1 BC049942 mRNA Translation: AAH49942.1 BC062888 mRNA Translation: AAH62888.1 AF271735 mRNA Translation: AAP88019.1 |
CCDSi | CCDS27560.1 [Q80U72-3] CCDS79381.1 [Q80U72-1] CCDS79382.1 [Q80U72-2] |
RefSeqi | NP_001297471.1, NM_001310542.1 [Q80U72-2] NP_001297472.1, NM_001310543.1 [Q80U72-1] NP_598850.1, NM_134089.2 [Q80U72-3] XP_017171844.1, XM_017316355.1 [Q80U72-4] |
3D structure databases
SMRi | Q80U72 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 222921, 9 interactors |
CORUMi | Q80U72 |
DIPi | DIP-40660N |
IntActi | Q80U72, 16 interactors |
MINTi | Q80U72 |
STRINGi | 10090.ENSMUSP00000002603 |
PTM databases
iPTMneti | Q80U72 |
PhosphoSitePlusi | Q80U72 |
SwissPalmi | Q80U72 |
Proteomic databases
EPDi | Q80U72 |
jPOSTi | Q80U72 |
PaxDbi | Q80U72 |
PeptideAtlasi | Q80U72 |
PRIDEi | Q80U72 |
Protocols and materials databases
Antibodypediai | 43533, 129 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000002603; ENSMUSP00000002603; ENSMUSG00000022568 [Q80U72-3] ENSMUST00000063747; ENSMUSP00000068056; ENSMUSG00000022568 [Q80U72-1] ENSMUST00000109946; ENSMUSP00000105572; ENSMUSG00000022568 [Q80U72-2] |
GeneIDi | 105782 |
KEGGi | mmu:105782 |
UCSCi | uc007wig.1, mouse [Q80U72-3] uc007wih.1, mouse [Q80U72-2] uc007wii.1, mouse [Q80U72-1] |
Organism-specific databases
CTDi | 23513 |
MGIi | MGI:2145950, Scrib |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000154025 |
HOGENOMi | CLU_000288_18_20_1 |
InParanoidi | Q80U72 |
OMAi | NNFHPKQ |
OrthoDBi | 284114at2759 |
PhylomeDBi | Q80U72 |
TreeFami | TF351429 |
Miscellaneous databases
BioGRID-ORCSi | 105782, 4 hits in 19 CRISPR screens |
ChiTaRSi | Scrib, mouse |
PROi | PR:Q80U72 |
RNActi | Q80U72, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022568, Expressed in ear vesicle and 296 other tissues |
ExpressionAtlasi | Q80U72, baseline and differential |
Genevisiblei | Q80U72, MM |
Family and domain databases
Gene3Di | 2.30.42.10, 4 hits 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits PF00595, PDZ, 4 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 12 hits SM00228, PDZ, 4 hits |
SUPFAMi | SSF50156, SSF50156, 4 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 13 hits PS50106, PDZ, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCRIB_MOUSE | |
Accessioni | Q80U72Primary (citable) accession number: Q80U72 Secondary accession number(s): Q6P5H7 Q922S3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | July 19, 2004 | |
Last modified: | February 10, 2021 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families