UniProtKB - Q80U72 (SCRIB_MOUSE)

>sp|Q80U72|SCRIB_MOUSE Protein scribble homolog OS=Mus musculus OX=10090 GN=Scrib PE=1 SV=2
MLKCIPLWRCNRHVESVDKRHCSLQVVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN
LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL
PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD
LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPVELG
GLALLTDLLLSQNLLQRLPEGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL
LTALPHSLGKLTKLTNLNVDRNHLEVLPPEIGGCVALSVLSLRDNRLAVLPPELAHTAEL
HVLDVAGNRLRSLPFALTHLNLKALWLAENQAQPMLRFQTEDDAQTGEKVLTCYLLPQQP
LPSLEDAGQQSSPSESCSDAPLSRVSVIQFEDTLEGEEDAEEAAAEKRGLQRRATPHPSE
LKVMKRGIEERRNEAFVCKPDPSPPSPSEEEKRLSAESALSGGSVPSASTASEGEPEILP
AEVQGLGQHEAMPAQEEYTEDDYNEPTVHFAEDTLIPREDGESEEGQPEAAWPLPSGRQR
LIRKDTPHYKKHFKISKLPQPEAVVALLQGVQTDREGPTAGWHNGPHTPWAPRAHEEEEE
EEEENRDEEEGEATTEEDDKEEAVASAPSVKGVSFDQANNLLIEPARIEEEELTLTIVRQ
TGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQDAEHH
EAVEALRGAGAAVQMRVWRERMVEPENAVTITPLRPEDDYSPREWRGGGLRLPLLQPETP
VSLRQRHAACLVRSEKGLGFSIAGGKGSTPYRAGDGGIFISRIAEGGAAHRAGTLQVGDR
VLSINGVDMTEARHDHAVSLLTAASPTISLLLERETGGTYPPSPPPHSSPTPAATVAATV
STAVPGEPLLPRLSPSLLATALEGPYPVEEICLPRAGGPLGLSIVGGSDHSSHPFGVQDP
GVFISKVLPRGLAARCGLRVGDRILAVNGQDVREATHQEAVSALLRPCLELCLLVRRDPP
PPGMRELCIQKAPGEKLGISIRGGAKGHAGNPCDPTDEGIFISKVSPTGAAGRDGRLRVG
LRLLEVNQQSLLGLTHAEAVQLLRSVGDTLTVLVCDGFDTSTTTALEVSPGVIANPFAAG
LGHRNSLESISSIDRELSPEGPGKEKELASQALPWESESAETTGRNLEPLKLDYRALAAL
PSAGSLQRGPSATTGGKTTEAPCSPGSQQPPSPDELPANVKQAYRAFAAVPTVHPPENSA
TQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQ
QKRAQMLREEAVTSGPDMGLASDRESPDDQQEAEQPWAVPSHAGGSSPSSPPPLGGNAPV
RTAKAERRHQERLRMQSPELPAPERALSPAERRALEAEKRALWRAARMKSLEQDALRAQM
VLSKSQEGRGKRGPLERLAEAPSPAPTPSPTPLEDFGLQTSASPGRLSPDFVEELRTLEA
SPSPGSQEEDGEVALVLLGRPSPGAVGPEDMTLCSSRRSVRPGRRGLGPVPS

Entry version 172 (10 Feb 2021)
Sequence version 2 (19 Jul 2004)
Previous versions | rss

Add a publication Feedback

Protein

Protein scribble homolog

Gene

Scrib

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:12499390, PubMed:18716323, PubMed:19041750, PubMed:18329370). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (PubMed:18329370). Most probably functions in the establishment of apico-basal cell polarity (PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:19041750). May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling (PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:19458197). Functions as an activator of Rac GTPase activity.5 Publications

Miscellaneous

The circletail (Crc) mice exhibit craniorachischisis, a severe form of neural tube defect. This is due to a single base insertion in the Scrib gene creating a frameshift which leads to synthesis of a truncated protein.

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Differentiation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein scribble homolog Short name: Scribble Alternative name(s): Protein LAP4
Gene namesⁱ	Name:Scrib Synonyms:Kiaa0147, Lap4, Scrib1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:2145950, Scrib

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000188304	1 – 1612	Protein scribble homologAdd BLAST		1612

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	37	PhosphoserineBy similarity	1
Modified residueⁱ	378	PhosphothreonineBy similarity	1
Modified residueⁱ	475	PhosphothreonineBy similarity	1
Modified residueⁱ	583	PhosphoserineCombined sources	1
Modified residueⁱ	674	PhosphothreonineCombined sources	1
Modified residueⁱ	675	PhosphothreonineCombined sources	1
Modified residueⁱ	694	PhosphoserineBy similarity	1
Modified residueⁱ	750	PhosphoserineBy similarity	1
Modified residueⁱ	812	PhosphothreonineBy similarity	1
Modified residueⁱ	821	PhosphoserineBy similarity	1
Modified residueⁱ	861	PhosphoserineBy similarity	1
Modified residueⁱ	925	PhosphoserineCombined sources	1
Modified residueⁱ	1126	PhosphoserineBy similarity	1
Modified residueⁱ	1206	PhosphoserineCombined sources	1
Modified residueⁱ	1209	PhosphoserineBy similarity	1
Modified residueⁱ	1212	PhosphoserineBy similarity	1
Modified residueⁱ	1218	PhosphoserineBy similarity	1
Modified residueⁱ	1262	PhosphoserineBy similarity	1
Modified residueⁱ	1265	PhosphoserineBy similarity	1
Modified residueⁱ	1284	PhosphoserineBy similarity	1
Modified residueⁱ	1292	PhosphoserineCombined sources	1
Modified residueⁱ	1325	PhosphothreonineBy similarity	1
Modified residueⁱ	1331	PhosphoserineBy similarity	1
Modified residueⁱ	1361	PhosphoserineCombined sources	1
Modified residueⁱ	1427	PhosphoserineBy similarity	1
Modified residueⁱ	1430	PhosphoserineBy similarity	1
Modified residueⁱ	1457	PhosphoserineCombined sources	1
Modified residueⁱ	1468	PhosphoserineBy similarity	1
Modified residueⁱ	1490	PhosphoserineCombined sources	1
Modified residueⁱ	1523	PhosphoserineBy similarity	1
Modified residueⁱ	1527	PhosphothreonineBy similarity	1
Modified residueⁱ	1529	PhosphoserineCombined sources	1
Modified residueⁱ	1543	PhosphoserineCombined sources	1
Modified residueⁱ	1548	PhosphoserineCombined sources	1
Isoform 4 (identifier: Q80U72-4)
Modified residueⁱ	1291	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	1299	PhosphoserineCombined sources	1
Isoform 3 (identifier: Q80U72-3)
Modified residueⁱ	1312	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	1320	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Ubiquitinated; targeted for UBE3A-dependent multiubiquitination and degraded.By similarity

Palmitoylated. Could be depalmitoylated by LYPLA1 and/or LYPLA2. Palmitoylation of SCRIB by ZDHHC7 is required for its localization to cell-cell junctions, function in the establishement of epithelial cell polarity and the regulation of downstream signaling pathways important for epithelial cell differentiation.By similarity

Keywords - PTMⁱ

Lipoprotein, Methylation, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q80U72
jPOSTⁱ	Q80U72
PaxDbⁱ	Q80U72
PeptideAtlas More...PeptideAtlasⁱ	Q80U72
PRIDEⁱ	Q80U72

PTM databases

iPTMnetⁱ	Q80U72
PhosphoSitePlusⁱ	Q80U72
SwissPalmⁱ	Q80U72

Expressionⁱ

Tissue specificityⁱ

Developmental stageⁱ

First detected at 7.5 dpc in the neuroepithelium at the time of initial neural tube closure. Also expressed in cranial mesenchyme, branchial arches, somitic mesoderm and lateral mesoderm. At later stages it is expressed in the eyelid epithelium, submandibular glands, whisker and hair follicles, sympathetic glanglia, inner ear, thymus, testis, kidney, esophagus, lung, stomach, trigeminal and dorsal root glanglia.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000022568, Expressed in ear vesicle and 296 other tissues
ExpressionAtlasⁱ	Q80U72, baseline and differential
Genevisibleⁱ	Q80U72, MM

Interactionⁱ

Subunit structureⁱ

Interacts with UBE3A (By similarity).

Interacts with PAK1 and PAK2 (PubMed:18716323).

Interacts (via PDZ domains) with VANGL2 (PubMed:16687519).

Interacts (via PDZ domains) with LPP and TRIP6; the interaction is direct (By similarity).

Interacts (via PDZ domains) with TJP2 (By similarity).

Interacts (via PDZ domains) with APC; may mediate APC targeting to adherens junctions of epithelial cells (PubMed:16611247).

Interacts (via PDZ domains) with TSHR; regulates TSHR trafficking and function (By similarity).

Interacts with ARHGEF7 and GIT1; interacts directly with ARHGEF7 (PubMed:15182672).

Interacts with CTNNB1 (PubMed:16611247, PubMed:19458197).

Interacts with MAPK12 (PubMed:15878399).

Interacts (via PDZ domains 1 and 3) with MCC (By similarity).

Interacts with DLG5 (By similarity).

Interacts with STK4/MST1 and LATS1 in the presence of DLG5 (By similarity).

Interacts (via PDZ domain 3) with CRTAM (via PDZ-binding motif); the interaction promotes CRTAM and SCRIB polarization in a subset of CD4+ T-cells (PubMed:18329370).

By similarity7 Publications

Binary interactionsⁱ

Hide details

Q80U72

With	#Exp.	IntAct
Crtam [Q149L7]	4	EBI-1766028,EBI-1766072
PHLPP1 [O60346] from Homo sapiens.	2	EBI-1766028,EBI-2511516

Protein-protein interaction databases

BioGRIDⁱ	222921, 9 interactors
CORUMⁱ	Q80U72
Database of interacting proteins More...DIPⁱ	DIP-40660N
IntActⁱ	Q80U72, 16 interactors
Molecular INTeraction database More...MINTⁱ	Q80U72
STRINGⁱ	10090.ENSMUSP00000002603

Miscellaneous databases

RNActⁱ	Q80U72, protein

RNActⁱ

Q80U72, protein

Structureⁱ

3D structure databases

SMRⁱ	Q80U72
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	37 – 58	LRR 1Add BLAST	22
Repeatⁱ	60 – 81	LRR 2Add BLAST	22
Repeatⁱ	83 – 104	LRR 3Add BLAST	22
Repeatⁱ	106 – 127	LRR 4Add BLAST	22
Repeatⁱ	129 – 150	LRR 5Add BLAST	22
Repeatⁱ	152 – 174	LRR 6Add BLAST	23
Repeatⁱ	175 – 197	LRR 7Add BLAST	23
Repeatⁱ	198 – 219	LRR 8Add BLAST	22
Repeatⁱ	221 – 243	LRR 9Add BLAST	23
Repeatⁱ	244 – 265	LRR 10Add BLAST	22
Repeatⁱ	267 – 288	LRR 11Add BLAST	22
Repeatⁱ	290 – 312	LRR 12Add BLAST	23
Repeatⁱ	313 – 334	LRR 13Add BLAST	22
Repeatⁱ	336 – 357	LRR 14Add BLAST	22
Repeatⁱ	359 – 381	LRR 15Add BLAST	23
Repeatⁱ	382 – 402	LRR 16Add BLAST	21
Domainⁱ	714 – 801	PDZ 1PROSITE-ProRule annotationAdd BLAST	88
Domainⁱ	848 – 936	PDZ 2PROSITE-ProRule annotationAdd BLAST	89
Domainⁱ	990 – 1079	PDZ 3PROSITE-ProRule annotationAdd BLAST	90
Domainⁱ	1086 – 1180	PDZ 4PROSITE-ProRule annotationAdd BLAST	95

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 804	Sufficient for targeting to adherens junction and to inhibit cell proliferationBy similarityAdd BLAST		804
Regionⁱ	703 – 1215	Interaction with ARHGEF7By similarityAdd BLAST		513

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	455 – 475	Sequence analysisAdd BLAST	21
Coiled coilⁱ	653 – 687	Sequence analysisAdd BLAST	35
Coiled coilⁱ	1362 – 1393	Sequence analysisAdd BLAST	32

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	656 – 682	Glu-richAdd BLAST	27
Compositional biasⁱ	656 – 664	Poly-Glu	9
Compositional biasⁱ	709 – 712	Poly-Glu	4
Compositional biasⁱ	1079 – 1082	Poly-Pro	4

Sequence similaritiesⁱ

Belongs to the LAP (LRR and PDZ) protein family.Curated

Keywords - Domainⁱ

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0619, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000154025
HOGENOMⁱ	CLU_000288_18_20_1
InParanoidⁱ	Q80U72
OMAⁱ	NNFHPKQ
Database of Orthologous Groups More...OrthoDBⁱ	284114at2759
PhylomeDBⁱ	Q80U72
TreeFamⁱ	TF351429

Family and domain databases

Gene3Dⁱ	2.30.42.10, 4 hits 3.80.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR001478, PDZ IPR036034, PDZ_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13855, LRR_8, 2 hits PF00595, PDZ, 4 hits
SMARTⁱ	View protein in SMART SM00369, LRR_TYP, 12 hits SM00228, PDZ, 4 hits
SUPFAMⁱ	SSF50156, SSF50156, 4 hits
PROSITEⁱ	View protein in PROSITE PS51450, LRR, 13 hits PS50106, PDZ, 4 hits

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q80U72-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKCIPLWRC NRHVESVDKR HCSLQVVPEE IYRYSRSLEE LLLDANQLRE 
        60         70         80         90        100
LPKPFFRLLN LRKLGLSDNE IQRLPPEVAN FMQLVELDVS RNDIPEIPES 
       110        120        130        140        150
IKFCKALEIA DFSGNPLSRL PDGFTQLRSL AHLALNDVSL QALPGDVGNL 
       160        170        180        190        200
ANLVTLELRE NLLKSLPASL SFLVKLEQLD LGGNDLEVLP DTLGALPNLR 
       210        220        230        240        250
ELWLDRNQLS ALPPELGNLR RLVCLDVSEN RLEELPVELG GLALLTDLLL 
       260        270        280        290        300
SQNLLQRLPE GIGQLKQLSI LKVDQNRLCE VTEAIGDCEN LSELILTENL 
       310        320        330        340        350
LTALPHSLGK LTKLTNLNVD RNHLEVLPPE IGGCVALSVL SLRDNRLAVL 
       360        370        380        390        400
PPELAHTAEL HVLDVAGNRL RSLPFALTHL NLKALWLAEN QAQPMLRFQT 
       410        420        430        440        450
EDDAQTGEKV LTCYLLPQQP LPSLEDAGQQ SSPSESCSDA PLSRVSVIQF 
       460        470        480        490        500
EDTLEGEEDA EEAAAEKRGL QRRATPHPSE LKVMKRGIEE RRNEAFVCKP 
       510        520        530        540        550
DPSPPSPSEE EKRLSAESAL SGGSVPSAST ASEGEPEILP AEVQGLGQHE 
       560        570        580        590        600
AMPAQEEYTE DDYNEPTVHF AEDTLIPRED GESEEGQPEA AWPLPSGRQR 
       610        620        630        640        650
LIRKDTPHYK KHFKISKLPQ PEAVVALLQG VQTDREGPTA GWHNGPHTPW 
       660        670        680        690        700
APRAHEEEEE EEEENRDEEE GEATTEEDDK EEAVASAPSV KGVSFDQANN 
       710        720        730        740        750
LLIEPARIEE EELTLTIVRQ TGGLGISIAG GKGSTPYKGD DEGIFISRVS 
       760        770        780        790        800
EEGPAARAGV RVGDKLLEVN GVALQDAEHH EAVEALRGAG AAVQMRVWRE 
       810        820        830        840        850
RMVEPENAVT ITPLRPEDDY SPREWRGGGL RLPLLQPETP VSLRQRHAAC 
       860        870        880        890        900
LVRSEKGLGF SIAGGKGSTP YRAGDGGIFI SRIAEGGAAH RAGTLQVGDR 
       910        920        930        940        950
VLSINGVDMT EARHDHAVSL LTAASPTISL LLERETGGTY PPSPPPHSSP 
       960        970        980        990       1000
TPAATVAATV STAVPGEPLL PRLSPSLLAT ALEGPYPVEE ICLPRAGGPL 
      1010       1020       1030       1040       1050
GLSIVGGSDH SSHPFGVQDP GVFISKVLPR GLAARCGLRV GDRILAVNGQ 
      1060       1070       1080       1090       1100
DVREATHQEA VSALLRPCLE LCLLVRRDPP PPGMRELCIQ KAPGEKLGIS 
      1110       1120       1130       1140       1150
IRGGAKGHAG NPCDPTDEGI FISKVSPTGA AGRDGRLRVG LRLLEVNQQS 
      1160       1170       1180       1190       1200
LLGLTHAEAV QLLRSVGDTL TVLVCDGFDT STTTALEVSP GVIANPFAAG 
      1210       1220       1230       1240       1250
LGHRNSLESI SSIDRELSPE GPGKEKELAS QALPWESESA ETTGRNLEPL 
      1260       1270       1280       1290       1300
KLDYRALAAL PSAGSLQRGP SATTGGKTTE APCSPGSQQP PSPDELPANV 
      1310       1320       1330       1340       1350
KQAYRAFAAV PTVHPPENSA TQPPTPGPAA SPEQLSFRER QKYFELEVRV 
      1360       1370       1380       1390       1400
PQAEGPPKRV SLVGADDLRK MQEEEARKLQ QKRAQMLREE AVTSGPDMGL 
      1410       1420       1430       1440       1450
ASDRESPDDQ QEAEQPWAVP SHAGGSSPSS PPPLGGNAPV RTAKAERRHQ 
      1460       1470       1480       1490       1500
ERLRMQSPEL PAPERALSPA ERRALEAEKR ALWRAARMKS LEQDALRAQM 
      1510       1520       1530       1540       1550
VLSKSQEGRG KRGPLERLAE APSPAPTPSP TPLEDFGLQT SASPGRLSPD 
      1560       1570       1580       1590       1600
FVEELRTLEA SPSPGSQEED GEVALVLLGR PSPGAVGPED MTLCSSRRSV 
      1610 
RPGRRGLGPV PS

Length:1,612

Mass (Da):174,059

Last modified:July 19, 2004 - v2

Checksum:ⁱ8C85DB322D738EDE

Isoform 2 (identifier: Q80U72-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1547-1547: L → LPLSGKKFDYRAFAALPSSRPVYDIQ

« Hide

        10         20         30         40         50
MLKCIPLWRC NRHVESVDKR HCSLQVVPEE IYRYSRSLEE LLLDANQLRE 
        60         70         80         90        100
LPKPFFRLLN LRKLGLSDNE IQRLPPEVAN FMQLVELDVS RNDIPEIPES 
       110        120        130        140        150
IKFCKALEIA DFSGNPLSRL PDGFTQLRSL AHLALNDVSL QALPGDVGNL 
       160        170        180        190        200
ANLVTLELRE NLLKSLPASL SFLVKLEQLD LGGNDLEVLP DTLGALPNLR 
       210        220        230        240        250
ELWLDRNQLS ALPPELGNLR RLVCLDVSEN RLEELPVELG GLALLTDLLL 
       260        270        280        290        300
SQNLLQRLPE GIGQLKQLSI LKVDQNRLCE VTEAIGDCEN LSELILTENL 
       310        320        330        340        350
LTALPHSLGK LTKLTNLNVD RNHLEVLPPE IGGCVALSVL SLRDNRLAVL 
       360        370        380        390        400
PPELAHTAEL HVLDVAGNRL RSLPFALTHL NLKALWLAEN QAQPMLRFQT 
       410        420        430        440        450
EDDAQTGEKV LTCYLLPQQP LPSLEDAGQQ SSPSESCSDA PLSRVSVIQF 
       460        470        480        490        500
EDTLEGEEDA EEAAAEKRGL QRRATPHPSE LKVMKRGIEE RRNEAFVCKP 
       510        520        530        540        550
DPSPPSPSEE EKRLSAESAL SGGSVPSAST ASEGEPEILP AEVQGLGQHE 
       560        570        580        590        600
AMPAQEEYTE DDYNEPTVHF AEDTLIPRED GESEEGQPEA AWPLPSGRQR 
       610        620        630        640        650
LIRKDTPHYK KHFKISKLPQ PEAVVALLQG VQTDREGPTA GWHNGPHTPW 
       660        670        680        690        700
APRAHEEEEE EEEENRDEEE GEATTEEDDK EEAVASAPSV KGVSFDQANN 
       710        720        730        740        750
LLIEPARIEE EELTLTIVRQ TGGLGISIAG GKGSTPYKGD DEGIFISRVS 
       760        770        780        790        800
EEGPAARAGV RVGDKLLEVN GVALQDAEHH EAVEALRGAG AAVQMRVWRE 
       810        820        830        840        850
RMVEPENAVT ITPLRPEDDY SPREWRGGGL RLPLLQPETP VSLRQRHAAC 
       860        870        880        890        900
LVRSEKGLGF SIAGGKGSTP YRAGDGGIFI SRIAEGGAAH RAGTLQVGDR 
       910        920        930        940        950
VLSINGVDMT EARHDHAVSL LTAASPTISL LLERETGGTY PPSPPPHSSP 
       960        970        980        990       1000
TPAATVAATV STAVPGEPLL PRLSPSLLAT ALEGPYPVEE ICLPRAGGPL 
      1010       1020       1030       1040       1050
GLSIVGGSDH SSHPFGVQDP GVFISKVLPR GLAARCGLRV GDRILAVNGQ 
      1060       1070       1080       1090       1100
DVREATHQEA VSALLRPCLE LCLLVRRDPP PPGMRELCIQ KAPGEKLGIS 
      1110       1120       1130       1140       1150
IRGGAKGHAG NPCDPTDEGI FISKVSPTGA AGRDGRLRVG LRLLEVNQQS 
      1160       1170       1180       1190       1200
LLGLTHAEAV QLLRSVGDTL TVLVCDGFDT STTTALEVSP GVIANPFAAG 
      1210       1220       1230       1240       1250
LGHRNSLESI SSIDRELSPE GPGKEKELAS QALPWESESA ETTGRNLEPL 
      1260       1270       1280       1290       1300
KLDYRALAAL PSAGSLQRGP SATTGGKTTE APCSPGSQQP PSPDELPANV 
      1310       1320       1330       1340       1350
KQAYRAFAAV PTVHPPENSA TQPPTPGPAA SPEQLSFRER QKYFELEVRV 
      1360       1370       1380       1390       1400
PQAEGPPKRV SLVGADDLRK MQEEEARKLQ QKRAQMLREE AVTSGPDMGL 
      1410       1420       1430       1440       1450
ASDRESPDDQ QEAEQPWAVP SHAGGSSPSS PPPLGGNAPV RTAKAERRHQ 
      1460       1470       1480       1490       1500
ERLRMQSPEL PAPERALSPA ERRALEAEKR ALWRAARMKS LEQDALRAQM 
      1510       1520       1530       1540       1550
VLSKSQEGRG KRGPLERLAE APSPAPTPSP TPLEDFGLQT SASPGRLPLS 
      1560       1570       1580       1590       1600
GKKFDYRAFA ALPSSRPVYD IQSPDFVEEL RTLEASPSPG SQEEDGEVAL 
      1610       1620       1630 
VLLGRPSPGA VGPEDMTLCS SRRSVRPGRR GLGPVPS

Show »

Length:1,637

Mass (Da):176,868

Checksum:ⁱ46D6D137902F4D6B

Isoform 3 (identifier: Q80U72-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1289-1289: Q → QTKPGVIQPLAQAWPRNSPAPRGRGGPCS
1547-1547: L → LPLSGKKFDYRAFAALPSSRPVYDIQ

« Hide

        10         20         30         40         50
MLKCIPLWRC NRHVESVDKR HCSLQVVPEE IYRYSRSLEE LLLDANQLRE 
        60         70         80         90        100
LPKPFFRLLN LRKLGLSDNE IQRLPPEVAN FMQLVELDVS RNDIPEIPES 
       110        120        130        140        150
IKFCKALEIA DFSGNPLSRL PDGFTQLRSL AHLALNDVSL QALPGDVGNL 
       160        170        180        190        200
ANLVTLELRE NLLKSLPASL SFLVKLEQLD LGGNDLEVLP DTLGALPNLR 
       210        220        230        240        250
ELWLDRNQLS ALPPELGNLR RLVCLDVSEN RLEELPVELG GLALLTDLLL 
       260        270        280        290        300
SQNLLQRLPE GIGQLKQLSI LKVDQNRLCE VTEAIGDCEN LSELILTENL 
       310        320        330        340        350
LTALPHSLGK LTKLTNLNVD RNHLEVLPPE IGGCVALSVL SLRDNRLAVL 
       360        370        380        390        400
PPELAHTAEL HVLDVAGNRL RSLPFALTHL NLKALWLAEN QAQPMLRFQT 
       410        420        430        440        450
EDDAQTGEKV LTCYLLPQQP LPSLEDAGQQ SSPSESCSDA PLSRVSVIQF 
       460        470        480        490        500
EDTLEGEEDA EEAAAEKRGL QRRATPHPSE LKVMKRGIEE RRNEAFVCKP 
       510        520        530        540        550
DPSPPSPSEE EKRLSAESAL SGGSVPSAST ASEGEPEILP AEVQGLGQHE 
       560        570        580        590        600
AMPAQEEYTE DDYNEPTVHF AEDTLIPRED GESEEGQPEA AWPLPSGRQR 
       610        620        630        640        650
LIRKDTPHYK KHFKISKLPQ PEAVVALLQG VQTDREGPTA GWHNGPHTPW 
       660        670        680        690        700
APRAHEEEEE EEEENRDEEE GEATTEEDDK EEAVASAPSV KGVSFDQANN 
       710        720        730        740        750
LLIEPARIEE EELTLTIVRQ TGGLGISIAG GKGSTPYKGD DEGIFISRVS 
       760        770        780        790        800
EEGPAARAGV RVGDKLLEVN GVALQDAEHH EAVEALRGAG AAVQMRVWRE 
       810        820        830        840        850
RMVEPENAVT ITPLRPEDDY SPREWRGGGL RLPLLQPETP VSLRQRHAAC 
       860        870        880        890        900
LVRSEKGLGF SIAGGKGSTP YRAGDGGIFI SRIAEGGAAH RAGTLQVGDR 
       910        920        930        940        950
VLSINGVDMT EARHDHAVSL LTAASPTISL LLERETGGTY PPSPPPHSSP 
       960        970        980        990       1000
TPAATVAATV STAVPGEPLL PRLSPSLLAT ALEGPYPVEE ICLPRAGGPL 
      1010       1020       1030       1040       1050
GLSIVGGSDH SSHPFGVQDP GVFISKVLPR GLAARCGLRV GDRILAVNGQ 
      1060       1070       1080       1090       1100
DVREATHQEA VSALLRPCLE LCLLVRRDPP PPGMRELCIQ KAPGEKLGIS 
      1110       1120       1130       1140       1150
IRGGAKGHAG NPCDPTDEGI FISKVSPTGA AGRDGRLRVG LRLLEVNQQS 
      1160       1170       1180       1190       1200
LLGLTHAEAV QLLRSVGDTL TVLVCDGFDT STTTALEVSP GVIANPFAAG 
      1210       1220       1230       1240       1250
LGHRNSLESI SSIDRELSPE GPGKEKELAS QALPWESESA ETTGRNLEPL 
      1260       1270       1280       1290       1300
KLDYRALAAL PSAGSLQRGP SATTGGKTTE APCSPGSQQT KPGVIQPLAQ 
      1310       1320       1330       1340       1350
AWPRNSPAPR GRGGPCSPPS PDELPANVKQ AYRAFAAVPT VHPPENSATQ 
      1360       1370       1380       1390       1400
PPTPGPAASP EQLSFRERQK YFELEVRVPQ AEGPPKRVSL VGADDLRKMQ 
      1410       1420       1430       1440       1450
EEEARKLQQK RAQMLREEAV TSGPDMGLAS DRESPDDQQE AEQPWAVPSH 
      1460       1470       1480       1490       1500
AGGSSPSSPP PLGGNAPVRT AKAERRHQER LRMQSPELPA PERALSPAER 
      1510       1520       1530       1540       1550
RALEAEKRAL WRAARMKSLE QDALRAQMVL SKSQEGRGKR GPLERLAEAP 
      1560       1570       1580       1590       1600
SPAPTPSPTP LEDFGLQTSA SPGRLPLSGK KFDYRAFAAL PSSRPVYDIQ 
      1610       1620       1630       1640       1650
SPDFVEELRT LEASPSPGSQ EEDGEVALVL LGRPSPGAVG PEDMTLCSSR 
      1660 
RSVRPGRRGL GPVPS

Show »

Length:1,665

Mass (Da):179,750

Checksum:ⁱBE1272F4ECBF010E

Isoform 4 (identifier: Q80U72-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
692-712: Missing.
1289-1289: Q → QTKPGVIQPLAQAWPRNSPAPRGRGGPCS

« Hide

        10         20         30         40         50
MLKCIPLWRC NRHVESVDKR HCSLQVVPEE IYRYSRSLEE LLLDANQLRE 
        60         70         80         90        100
LPKPFFRLLN LRKLGLSDNE IQRLPPEVAN FMQLVELDVS RNDIPEIPES 
       110        120        130        140        150
IKFCKALEIA DFSGNPLSRL PDGFTQLRSL AHLALNDVSL QALPGDVGNL 
       160        170        180        190        200
ANLVTLELRE NLLKSLPASL SFLVKLEQLD LGGNDLEVLP DTLGALPNLR 
       210        220        230        240        250
ELWLDRNQLS ALPPELGNLR RLVCLDVSEN RLEELPVELG GLALLTDLLL 
       260        270        280        290        300
SQNLLQRLPE GIGQLKQLSI LKVDQNRLCE VTEAIGDCEN LSELILTENL 
       310        320        330        340        350
LTALPHSLGK LTKLTNLNVD RNHLEVLPPE IGGCVALSVL SLRDNRLAVL 
       360        370        380        390        400
PPELAHTAEL HVLDVAGNRL RSLPFALTHL NLKALWLAEN QAQPMLRFQT 
       410        420        430        440        450
EDDAQTGEKV LTCYLLPQQP LPSLEDAGQQ SSPSESCSDA PLSRVSVIQF 
       460        470        480        490        500
EDTLEGEEDA EEAAAEKRGL QRRATPHPSE LKVMKRGIEE RRNEAFVCKP 
       510        520        530        540        550
DPSPPSPSEE EKRLSAESAL SGGSVPSAST ASEGEPEILP AEVQGLGQHE 
       560        570        580        590        600
AMPAQEEYTE DDYNEPTVHF AEDTLIPRED GESEEGQPEA AWPLPSGRQR 
       610        620        630        640        650
LIRKDTPHYK KHFKISKLPQ PEAVVALLQG VQTDREGPTA GWHNGPHTPW 
       660        670        680        690        700
APRAHEEEEE EEEENRDEEE GEATTEEDDK EEAVASAPSV KLTLTIVRQT 
       710        720        730        740        750
GGLGISIAGG KGSTPYKGDD EGIFISRVSE EGPAARAGVR VGDKLLEVNG 
       760        770        780        790        800
VALQDAEHHE AVEALRGAGA AVQMRVWRER MVEPENAVTI TPLRPEDDYS 
       810        820        830        840        850
PREWRGGGLR LPLLQPETPV SLRQRHAACL VRSEKGLGFS IAGGKGSTPY 
       860        870        880        890        900
RAGDGGIFIS RIAEGGAAHR AGTLQVGDRV LSINGVDMTE ARHDHAVSLL 
       910        920        930        940        950
TAASPTISLL LERETGGTYP PSPPPHSSPT PAATVAATVS TAVPGEPLLP 
       960        970        980        990       1000
RLSPSLLATA LEGPYPVEEI CLPRAGGPLG LSIVGGSDHS SHPFGVQDPG 
      1010       1020       1030       1040       1050
VFISKVLPRG LAARCGLRVG DRILAVNGQD VREATHQEAV SALLRPCLEL 
      1060       1070       1080       1090       1100
CLLVRRDPPP PGMRELCIQK APGEKLGISI RGGAKGHAGN PCDPTDEGIF 
      1110       1120       1130       1140       1150
ISKVSPTGAA GRDGRLRVGL RLLEVNQQSL LGLTHAEAVQ LLRSVGDTLT 
      1160       1170       1180       1190       1200
VLVCDGFDTS TTTALEVSPG VIANPFAAGL GHRNSLESIS SIDRELSPEG 
      1210       1220       1230       1240       1250
PGKEKELASQ ALPWESESAE TTGRNLEPLK LDYRALAALP SAGSLQRGPS 
      1260       1270       1280       1290       1300
ATTGGKTTEA PCSPGSQQTK PGVIQPLAQA WPRNSPAPRG RGGPCSPPSP 
      1310       1320       1330       1340       1350
DELPANVKQA YRAFAAVPTV HPPENSATQP PTPGPAASPE QLSFRERQKY 
      1360       1370       1380       1390       1400
FELEVRVPQA EGPPKRVSLV GADDLRKMQE EEARKLQQKR AQMLREEAVT 
      1410       1420       1430       1440       1450
SGPDMGLASD RESPDDQQEA EQPWAVPSHA GGSSPSSPPP LGGNAPVRTA 
      1460       1470       1480       1490       1500
KAERRHQERL RMQSPELPAP ERALSPAERR ALEAEKRALW RAARMKSLEQ 
      1510       1520       1530       1540       1550
DALRAQMVLS KSQEGRGKRG PLERLAEAPS PAPTPSPTPL EDFGLQTSAS 
      1560       1570       1580       1590       1600
PGRLSPDFVE ELRTLEASPS PGSQEEDGEV ALVLLGRPSP GAVGPEDMTL 
      1610 
CSSRRSVRPG RRGLGPVPS

Show »

Length:1,619

Mass (Da):174,585

Checksum:ⁱF667D8CA5592E8D9

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3YU97	D3YU97_MOUSE	Protein scribble homolog Protein scribble homolog	Scrib	113	Annotation score:
D3YVA3	D3YVA3_MOUSE	Protein scribble homolog Protein scribble homolog	Scrib	90	Annotation score:

Sequence cautionⁱ

The sequence BAC65493 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	588	P → L in AAH62888 (PubMed:15489334).Curated	1
Sequence conflictⁱ	676 – 683	EEDDKEEA → GRVGGRVG in AAH06859 (PubMed:15489334).Curated	8
Sequence conflictⁱ	947 – 949	HSS → RVR in AAH37480 (PubMed:15489334).Curated	3
Sequence conflictⁱ	1080	P → H in AAP88019 (PubMed:15649318).Curated	1
Sequence conflictⁱ	1109	A → T in AAP88019 (PubMed:15649318).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_010909	692 – 712	Missing in isoform 4. 1 PublicationAdd BLAST	21
Alternative sequenceⁱVSP_010910	1289	Q → QTKPGVIQPLAQAWPRNSPA PRGRGGPCS in isoform 3 and isoform 4. 2 Publications	1
Alternative sequenceⁱVSP_010911	1547	L → LPLSGKKFDYRAFAALPSSR PVYDIQ in isoform 2 and isoform 3. 3 Publications	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF441233 mRNA Translation: AAL32469.1 AK122211 mRNA Translation: BAC65493.1 Different initiation. BC006859 mRNA Translation: AAH06859.1 BC037480 mRNA Translation: AAH37480.1 BC049942 mRNA Translation: AAH49942.1 BC062888 mRNA Translation: AAH62888.1 AF271735 mRNA Translation: AAP88019.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27560.1 [Q80U72-3] CCDS79381.1 [Q80U72-1] CCDS79382.1 [Q80U72-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001297471.1, NM_001310542.1 [Q80U72-2] NP_001297472.1, NM_001310543.1 [Q80U72-1] NP_598850.1, NM_134089.2 [Q80U72-3] XP_017171844.1, XM_017316355.1 [Q80U72-4]

Genome annotation databases

Ensemblⁱ	ENSMUST00000002603; ENSMUSP00000002603; ENSMUSG00000022568 [Q80U72-3] ENSMUST00000063747; ENSMUSP00000068056; ENSMUSG00000022568 [Q80U72-1] ENSMUST00000109946; ENSMUSP00000105572; ENSMUSG00000022568 [Q80U72-2]
GeneIDⁱ	105782
KEGGⁱ	mmu:105782
UCSC genome browser More...UCSCⁱ	uc007wig.1, mouse [Q80U72-3] uc007wih.1, mouse [Q80U72-2] uc007wii.1, mouse [Q80U72-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q80U72-3	protein scribble homolog isoform X1		MUSCR		1665	UniRef90_Q80U72-3
protein scribble homolog isoform X2		MUSCR		1664
protein scribble homolog isoform X3		MUSCR		1644
protein scribble homolog isoform X4		MUSCR		1640
protein scribble homolog isoform X6		MUSCR		1619
+14

Protein	Similar proteins		Species	Score	Length	Source
Q80U72	protein scribble homolog		VULVU		1614	UniRef50_Q80U72
Uncharacterized protein		LATCA		1648
LOW QUALITY PROTEIN: protein scribble homolog		LIPVE		1659
Protein scribble homolog (Fragment)		HUMAN		140
SCRIB isoform 8 (Fragment)		PANTR		140
+546

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF441233 mRNA Translation: AAL32469.1 AK122211 mRNA Translation: BAC65493.1 Different initiation. BC006859 mRNA Translation: AAH06859.1 BC037480 mRNA Translation: AAH37480.1 BC049942 mRNA Translation: AAH49942.1 BC062888 mRNA Translation: AAH62888.1 AF271735 mRNA Translation: AAP88019.1
CCDSⁱ	CCDS27560.1 [Q80U72-3] CCDS79381.1 [Q80U72-1] CCDS79382.1 [Q80U72-2]
RefSeqⁱ	NP_001297471.1, NM_001310542.1 [Q80U72-2] NP_001297472.1, NM_001310543.1 [Q80U72-1] NP_598850.1, NM_134089.2 [Q80U72-3] XP_017171844.1, XM_017316355.1 [Q80U72-4]

3D structure databases

SMRⁱ	Q80U72
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	222921, 9 interactors
CORUMⁱ	Q80U72
DIPⁱ	DIP-40660N
IntActⁱ	Q80U72, 16 interactors
MINTⁱ	Q80U72
STRINGⁱ	10090.ENSMUSP00000002603

PTM databases

iPTMnetⁱ	Q80U72
PhosphoSitePlusⁱ	Q80U72
SwissPalmⁱ	Q80U72

Proteomic databases

EPDⁱ	Q80U72
jPOSTⁱ	Q80U72
PaxDbⁱ	Q80U72
PeptideAtlasⁱ	Q80U72
PRIDEⁱ	Q80U72

Protocols and materials databases

Antibodypediaⁱ	43533, 129 antibodies

Antibodypediaⁱ

43533, 129 antibodies

Genome annotation databases

Ensemblⁱ	ENSMUST00000002603; ENSMUSP00000002603; ENSMUSG00000022568 [Q80U72-3] ENSMUST00000063747; ENSMUSP00000068056; ENSMUSG00000022568 [Q80U72-1] ENSMUST00000109946; ENSMUSP00000105572; ENSMUSG00000022568 [Q80U72-2]
GeneIDⁱ	105782
KEGGⁱ	mmu:105782
UCSCⁱ	uc007wig.1, mouse [Q80U72-3] uc007wih.1, mouse [Q80U72-2] uc007wii.1, mouse [Q80U72-1]

Organism-specific databases

CTDⁱ	23513
MGIⁱ	MGI:2145950, Scrib
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0619, Eukaryota
GeneTreeⁱ	ENSGT00940000154025
HOGENOMⁱ	CLU_000288_18_20_1
InParanoidⁱ	Q80U72
OMAⁱ	NNFHPKQ
OrthoDBⁱ	284114at2759
PhylomeDBⁱ	Q80U72
TreeFamⁱ	TF351429

Miscellaneous databases

BioGRID-ORCSⁱ	105782, 4 hits in 19 CRISPR screens
ChiTaRSⁱ	Scrib, mouse
Protein Ontology More...PROⁱ	PR:Q80U72
RNActⁱ	Q80U72, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000022568, Expressed in ear vesicle and 296 other tissues
ExpressionAtlasⁱ	Q80U72, baseline and differential
Genevisibleⁱ	Q80U72, MM

Family and domain databases

Gene3Dⁱ	2.30.42.10, 4 hits 3.80.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR001478, PDZ IPR036034, PDZ_sf
Pfamⁱ	View protein in Pfam PF13855, LRR_8, 2 hits PF00595, PDZ, 4 hits
SMARTⁱ	View protein in SMART SM00369, LRR_TYP, 12 hits SM00228, PDZ, 4 hits
SUPFAMⁱ	SSF50156, SSF50156, 4 hits
PROSITEⁱ	View protein in PROSITE PS51450, LRR, 13 hits PS50106, PDZ, 4 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SCRIB_MOUSE
Accessionⁱ	Q80U72Primary (citable) accession number: Q80U72 Secondary accession number(s): Q6P5H7 , Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	July 19, 2004
	Last modified:	February 10, 2021
	This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q80U72 (SCRIB_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Protein scribble homolog

Scrib

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q80U72

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ