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Entry version 116 (13 Feb 2019)
Sequence version 2 (24 Jan 2006)
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Protein

Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

Gene

Rubcn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process (PubMed:19270693). Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (By similarity).By similarity1 Publication
Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines. Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or DDX58/RIG-I-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy, Endocytosis, Immunity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Run domain Beclin-1-interacting and cysteine-rich domain-containing proteinBy similarity
Short name:
Rubicon
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RubcnBy similarity
Synonyms:Kiaa0226
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1915160 Rubcn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Lysosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000507371 – 956Run domain Beclin-1-interacting and cysteine-rich domain-containing proteinAdd BLAST956

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei198PhosphoserineBy similarity1
Modified residuei250PhosphoserineBy similarity1
Modified residuei268PhosphoserineBy similarity1
Modified residuei390PhosphoserineCombined sources1
Modified residuei412PhosphoserineCombined sources1
Modified residuei513PhosphoserineBy similarity1
Modified residuei547PhosphoserineBy similarity1
Modified residuei655PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q80U62

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q80U62

PRoteomics IDEntifications database

More...
PRIDEi
Q80U62

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80U62

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80U62

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000035629 Expressed in 226 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q80U62 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80U62 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex II (PI3KC3-C2) in which the core composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 is associated with UVRAG; in the complex interacts directly with PI3KC3 and UVRAG (PubMed:19270693). Interacts with Rab7 (RAB7A or RAB7B) (GTP-bound form); Rab7 and UVRAG compete for RUBCN binding; can interact simultaneously with Rab7 and the PI3K complex. Interacts with CYBA and CYBB; indicative for the association with the CYBA:CYBB NADPH oxidase heterodimer. Interacts with NOX4 and probably associates with the CYBA:NOX4 complex. Interacts with YWHAB and CARD9 in a competetive and stimulation-dependent manner; RUBCN exchanges interaction from YWHAB to CARD9 upon stimulation with beta-1,3-glucan (By similarity).By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-3506572,EBI-297353From Homo sapiens.

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q80U62, 5 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000087114

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q80U62

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q80U62

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 190RUNPROSITE-ProRule annotationAdd BLAST142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni50 – 181Interaction with PIK3C3By similarityAdd BLAST132
Regioni205 – 437Interaction with YWHABBy similarityAdd BLAST233
Regioni302 – 585Interaction with UVRAGBy similarityAdd BLAST284
Regioni490 – 542Interaction with BECN1By similarityAdd BLAST53
Regioni552 – 609Interaction with CYBABy similarityAdd BLAST58
Regioni656 – 744Interaction with CARD9By similarityAdd BLAST89
Regioni705 – 956Interaction with Rab7By similarityAdd BLAST252

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi226 – 392Ser-richAdd BLAST167
Compositional biasi552 – 555Poly-Ser4
Compositional biasi865 – 916Cys-richAdd BLAST52

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1829 Eukaryota
KOG4381 Eukaryota
ENOG410XQ7T LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160658

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG062207

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q80U62

KEGG Orthology (KO)

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KOi
K19330

Identification of Orthologs from Complete Genome Data

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OMAi
MELGGCE

Database of Orthologous Groups

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OrthoDBi
177737at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q80U62

TreeFam database of animal gene trees

More...
TreeFami
TF317067

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004012 Run_dom
IPR037213 Run_dom_sf
IPR025258 Zf-RING_9

Pfam protein domain database

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Pfami
View protein in Pfam
PF02759 RUN, 1 hit
PF13901 zf-RING_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01175 DUF4206, 1 hit
SM00593 RUN, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF140741 SSF140741, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50826 RUN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80U62-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPEGAGMDL GGGDGERLLE KSRREHWQLL GNLKTTVEGL VSANCPNVWS
60 70 80 90 100
KYGGLERLCR DMQNILYHGL IHDQVCCRQA DYWQFVKDIR WLSPHSALHV
110 120 130 140 150
EKFISLHESD QSDTDSVSER AVAELWLQHS LQCHCLSAQL RPLLGDRQYI
160 170 180 190 200
RKFYTETAFL LSDAHVTAML QCLEAVEQNN PRLLAQIDAS MFARKQESPL
210 220 230 240 250
LVTKSQSLTA LPGSTYTPPA SYAQHSYFGS SSSLQSMPQS SHSSERRSTS
260 270 280 290 300
FSLSGPSWQP QEDRECLSPA ETQTTPAPLP SDSTLAQDSP LTAQEMSDST
310 320 330 340 350
LTSPLEASWV SSQNDSPSDV SEGPEYLAIG NPAPHGRTAS CESHSSNGES
360 370 380 390 400
SSSHLFSSSS SQKLESAASS LGDQEEGRQS QAGSVLRRSS FSEGQTAPVA
410 420 430 440 450
SGTKKSHIRS HSDTNIASRG AAGGPRNITI IVEDPIAEGG QYLCSGEGMF
460 470 480 490 500
RRPSEGQSLI SYLSEQDFGS CADLEKENAH FSISESLIAA IELMKCNMMS
510 520 530 540 550
QCLEEEEVEE EDSDREIQEL KQKIRLRRQQ IRTKNLLPAY RETENGSFRV
560 570 580 590 600
TSSSSQFSSR DSTQLSESGS AEDADDLEIQ DADIRRSAVS NGKSSFSQNL
610 620 630 640 650
SHCFLHSTSA EAVAMGLLKQ FEGMQLPAAS ELEWLVPEHD APQKLLPIPD
660 670 680 690 700
SLPISPDDGQ HADIYKLRIR VRGNLEWAPP RPQIIFNVHP APTRKIAVAK
710 720 730 740 750
QNYRCAGCGI RTDPDYIKRL RYCEYLGKYF CQCCHENAQM VVPSRILRKW
760 770 780 790 800
DFSKYYVSNF SKDLLLKIWN DPLFNVQDIN SALYRKVKLL NQVRLLRVQL
810 820 830 840 850
YHMKNMFKTC RLAKELLDSF DVVPGHLTED LHLYSLSDLT ATKKGELGPR
860 870 880 890 900
LAELTRAGAA HVERCMLCQA KGFICEFCQN EEDVIFPFEL HKCRTCEECK
910 920 930 940 950
ACYHKTCFKS GRCPRCERLQ ARRELLAKQS LESYLSDYEE EPTEALALEA

TVLETT
Length:956
Mass (Da):106,860
Last modified:January 24, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5D8CD691C0D5184
GO
Isoform 2 (identifier: Q80U62-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     423-437: Missing.

Show »
Length:941
Mass (Da):105,313
Checksum:iD3B091AE60EF0A3B
GO
Isoform 3 (identifier: Q80U62-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-360: Missing.
     423-437: Missing.

Show »
Length:927
Mass (Da):103,919
Checksum:i384DB3B3F5448D8D
GO
Isoform 4 (identifier: Q80U62-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
     347-360: Missing.
     423-437: Missing.

Note: No experimental confirmation available.
Show »
Length:866
Mass (Da):97,179
Checksum:iA2E4D53DF257399A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z7B1D3Z7B1_MOUSE
Run domain Beclin-1-interacting and...
Rubcn 1700021K19Rik
880Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH57307 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC65503 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5G → S in BAE41507 (PubMed:16141072).Curated1
Sequence conflicti5G → S in BAE41645 (PubMed:16141072).Curated1
Sequence conflicti88D → G in AAH67390 (PubMed:19468303).Curated1
Sequence conflicti217T → N in BAE41507 (PubMed:16141072).Curated1
Sequence conflicti217T → N in BAE41645 (PubMed:16141072).Curated1
Sequence conflicti217T → N in BAE41708 (PubMed:16141072).Curated1
Sequence conflicti248S → P in BAE41645 (PubMed:16141072).Curated1
Sequence conflicti298D → G in BAE41708 (PubMed:16141072).Curated1
Sequence conflicti304P → S in AAH67390 (PubMed:19468303).Curated1
Sequence conflicti379Q → L in AAH67390 (PubMed:19468303).Curated1
Sequence conflicti470S → G in BAE42541 (PubMed:16141072).Curated1
Sequence conflicti628A → T in AAH67390 (PubMed:19468303).Curated1
Sequence conflicti661H → Q in BAE42541 (PubMed:16141072).Curated1
Sequence conflicti865C → R in AAH67390 (PubMed:19468303).Curated1
Sequence conflicti901A → T in BAE41708 (PubMed:16141072).Curated1
Sequence conflicti951T → P in BAC31257 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0394741 – 61Missing in isoform 4. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_017110347 – 360Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_017111423 – 437Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK122221 mRNA Translation: BAC65503.1 Different initiation.
AK030368 mRNA Translation: BAC26925.1
AK042428 mRNA Translation: BAC31257.1
AK170002 mRNA Translation: BAE41507.1
AK170223 mRNA Translation: BAE41645.1
AK170312 mRNA Translation: BAE41708.1
AK171583 mRNA Translation: BAE42541.1
AC139244 Genomic DNA No translation available.
BC057307 mRNA Translation: AAH57307.1 Different initiation.
BC060601 mRNA Translation: AAH60601.1
BC067390 mRNA Translation: AAH67390.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS28124.1 [Q80U62-2]
CCDS49832.1 [Q80U62-1]

NCBI Reference Sequences

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RefSeqi
NP_001186967.1, NM_001200038.1 [Q80U62-1]
NP_766203.1, NM_172615.4 [Q80U62-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.327319

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000040986; ENSMUSP00000048811; ENSMUSG00000035629 [Q80U62-2]
ENSMUST00000089684; ENSMUSP00000087114; ENSMUSG00000035629 [Q80U62-1]
ENSMUST00000115105; ENSMUSP00000110757; ENSMUSG00000035629 [Q80U62-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
100502698

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:100502698

UCSC genome browser

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UCSCi
uc007yzk.2 mouse [Q80U62-1]
uc007yzl.2 mouse [Q80U62-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122221 mRNA Translation: BAC65503.1 Different initiation.
AK030368 mRNA Translation: BAC26925.1
AK042428 mRNA Translation: BAC31257.1
AK170002 mRNA Translation: BAE41507.1
AK170223 mRNA Translation: BAE41645.1
AK170312 mRNA Translation: BAE41708.1
AK171583 mRNA Translation: BAE42541.1
AC139244 Genomic DNA No translation available.
BC057307 mRNA Translation: AAH57307.1 Different initiation.
BC060601 mRNA Translation: AAH60601.1
BC067390 mRNA Translation: AAH67390.1
CCDSiCCDS28124.1 [Q80U62-2]
CCDS49832.1 [Q80U62-1]
RefSeqiNP_001186967.1, NM_001200038.1 [Q80U62-1]
NP_766203.1, NM_172615.4 [Q80U62-2]
UniGeneiMm.327319

3D structure databases

ProteinModelPortaliQ80U62
SMRiQ80U62
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80U62, 5 interactors
STRINGi10090.ENSMUSP00000087114

PTM databases

iPTMnetiQ80U62
PhosphoSitePlusiQ80U62

Proteomic databases

jPOSTiQ80U62
PaxDbiQ80U62
PRIDEiQ80U62

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040986; ENSMUSP00000048811; ENSMUSG00000035629 [Q80U62-2]
ENSMUST00000089684; ENSMUSP00000087114; ENSMUSG00000035629 [Q80U62-1]
ENSMUST00000115105; ENSMUSP00000110757; ENSMUSG00000035629 [Q80U62-3]
GeneIDi100502698
KEGGimmu:100502698
UCSCiuc007yzk.2 mouse [Q80U62-1]
uc007yzl.2 mouse [Q80U62-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9711
MGIiMGI:1915160 Rubcn

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG1829 Eukaryota
KOG4381 Eukaryota
ENOG410XQ7T LUCA
GeneTreeiENSGT00940000160658
HOVERGENiHBG062207
InParanoidiQ80U62
KOiK19330
OMAiMELGGCE
OrthoDBi177737at2759
PhylomeDBiQ80U62
TreeFamiTF317067

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Rubcn mouse

Protein Ontology

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PROi
PR:Q80U62

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000035629 Expressed in 226 organ(s), highest expression level in embryo
ExpressionAtlasiQ80U62 baseline and differential
GenevisibleiQ80U62 MM

Family and domain databases

InterProiView protein in InterPro
IPR004012 Run_dom
IPR037213 Run_dom_sf
IPR025258 Zf-RING_9
PfamiView protein in Pfam
PF02759 RUN, 1 hit
PF13901 zf-RING_9, 1 hit
SMARTiView protein in SMART
SM01175 DUF4206, 1 hit
SM00593 RUN, 1 hit
SUPFAMiSSF140741 SSF140741, 1 hit
PROSITEiView protein in PROSITE
PS50826 RUN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRUBIC_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80U62
Secondary accession number(s): Q3TAX3
, Q3TD96, Q3TDF7, Q3TDU2, Q6NWW8, Q6P9T7, Q6PG18, Q8BMP7, Q8BY22
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: February 13, 2019
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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