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Entry version 88 (03 Jul 2019)
Sequence version 1 (01 Jun 2003)
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Protein
Submitted name:

MKIAA0357 protein

Gene

mKIAA0357

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MKIAA0357 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mKIAA0357Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q80U29

PRoteomics IDEntifications database

More...
PRIDEi
Q80U29

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 187GCP_N_terminalInterPro annotationAdd BLAST161
Domaini190 – 500GCP_C_terminalInterPro annotationAdd BLAST311
Domaini566 – 892AAA_6InterPro annotationAdd BLAST327
Domaini1050 – 1167Dynein_AAA_lidInterPro annotationAdd BLAST118
Domaini1385 – 1471AAA_lid_1InterPro annotationAdd BLAST87

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili432 – 452Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595 Eukaryota
COG5245 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000237308

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.1900, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035699 AAA_6
IPR026983 DHC_fam
IPR041589 DNAH3_AAA_lid_1
IPR030443 DNAH9
IPR041466 Dynein_AAA5_ext
IPR040457 GCP_C
IPR042241 GCP_C_sf
IPR041470 GCP_N
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR10676 PTHR10676, 1 hit
PTHR10676:SF257 PTHR10676:SF257, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774 AAA_6, 1 hit
PF17857 AAA_lid_1, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF04130 GCP_C_terminal, 1 hit
PF17681 GCP_N_terminal, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q80U29-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
CLVIGLCHEF KFGYFCVFFS PFPLGRKGGE LASAVHAYTK TGDPYMKSLV
60 70 80 90 100
QHILSLVSHP VLSFLYRWIY DGELEDTYHE FFVASDPTVK TDRLWHDKYT
110 120 130 140 150
LRKSMIPSFI TMDQSRKVLL IGKSINFLHQ VCHDQTPTTK MIAVTKSAES
160 170 180 190 200
PRDAADLFTD LENAFQGKID AAYFETSKYL LDVLNKKYSL LEHMQAMRRY
210 220 230 240 250
LLLGQGDFIR HLMDLLKPEL VRPATTLYQH NLTGILETAV RATNAQFDSP
260 270 280 290 300
EILKRLDVRL LEVSPGDTGW DVFSLDYHVD GPIATVFTRE CMSHYLRVFN
310 320 330 340 350
FLWRAKRMEY ILTDIRKGHM CNAKLLRNMP EFSGVLHQCH ILASEMVHFI
360 370 380 390 400
HQMQYYITFE VLECSWDELW NRVQQAQDLD HIIAAHEAFL NTITSRCLLD
410 420 430 440 450
SNSRVLLNQL RAVFDQIIEL QNAQDVMYRA ALEELQRRLQ FEEKKKQREI
460 470 480 490 500
EVALTCTQIW WTTEVGIAFA RLEEGYESAM KDYYKKQVAQ LKTLITMLIG
510 520 530 540 550
PLSKGDRQKI MTICTIDVHA RDVVAKMIAQ KVDNAQAFLW LSQLRHRWDD
560 570 580 590 600
EAKHCFANIC DAQFLYSYEY LGNTPRLVIT PLTDRCYITL TQSLHLTMSG
610 620 630 640 650
APAGPAGTGK TETTKDLGRA LGIMVYVFNC SEQMDYKSCG NIYKGLAQTG
660 670 680 690 700
AWGCFDEFNR ISVEVLSVVA VQVKSIQDAI RDKKQRFSFL GEEISLDPSV
710 720 730 740 750
GIFITMNPGY AGRTELPENL KALFRPCAMV VPDFELISEI MLVAEGFIEA
760 770 780 790 800
RLLARKFITL YRLCKELLSK QDHYDWGLRA IKSVLVVAGS LKRGDPDRPE
810 820 830 840 850
DQVLMRSLRD FNIPKIVTDD MPVFMGLIGD LFPALDVPRK RDLDFEAVVR
860 870 880 890 900
KAIVDLKLQA EDNFVLKVVQ LEELLAVRHS VFVVGGAGTG KSQVLRSLHK
910 920 930 940 950
TYQIMRRRPV WTDLNPKAVT NDELFGIINP ATREWKDGLF SSIMRELAII
960 970 980 990 1000
SHDGPKWILL DGDIDPMWIE SLNTVMDDNK VLTLASNERI PLNPTMRLLF
1010 1020 1030 1040 1050
EISHLRTATP ATVSRAGILY INPADLGWNP PVSSWIDQRE VQTERANLTI
1060 1070 1080 1090 1100
LFDKYLPTCL DTLRTRFKKI IPVPEQSMIQ MLCYLLECLL TKEDIPADCP
1110 1120 1130 1140 1150
KEIYELYFVF AAIWAFGSAV IQDQLVDYRA EFSKWWLTEF KTVKFPSQGT
1160 1170 1180 1190 1200
VFDYYIDPET KKFEPWAKLI PQFEFDPEMP LQACLVHTSE TIRVCYFMER
1210 1220 1230 1240 1250
LMQWRRPVML VGPAGSGKSV LVGAKLSSLN PEEYMVKNVP FNYYTTSAML
1260 1270 1280 1290 1300
QAVLEKPLEK KAGRNYGPPG NRKLIYFIDD MNMPEVDAYG TVQPHTVIRQ
1310 1320 1330 1340 1350
HLDYGHWYDR NKLSLKEIMN VQYISCMNPT AGSFTINPRL QRHFSVFALC
1360 1370 1380 1390 1400
FPGADALSSI YSTILTHHLK FGNFPTTLQK SIPPLINLAV TFHQKIATTF
1410 1420 1430 1440 1450
LPTAIKFHYI FNLRDFANIF QGILFSSVEC VKSTQDLVKL YLHESSRVYR
1460 1470
DKMVEEKDFN LFDKIQTEFL K
Length:1,471
Mass (Da):169,047
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC68B37165A4B386C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei1471Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK122256 mRNA Translation: BAC65538.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122256 mRNA Translation: BAC65538.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ80U29
PRIDEiQ80U29

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
HOGENOMiHOG000237308

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Dnah9 mouse

Family and domain databases

Gene3Di1.20.120.1900, 1 hit
InterProiView protein in InterPro
IPR035699 AAA_6
IPR026983 DHC_fam
IPR041589 DNAH3_AAA_lid_1
IPR030443 DNAH9
IPR041466 Dynein_AAA5_ext
IPR040457 GCP_C
IPR042241 GCP_C_sf
IPR041470 GCP_N
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 1 hit
PTHR10676:SF257 PTHR10676:SF257, 1 hit
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF17857 AAA_lid_1, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF04130 GCP_C_terminal, 1 hit
PF17681 GCP_N_terminal, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ80U29_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80U29
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 3, 2019
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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