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Entry version 109 (16 Oct 2019)
Sequence version 2 (20 Feb 2007)
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Protein

MAP kinase-activating death domain protein

Gene

Madd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5357905 Regulation of TNFR1 signaling
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MAP kinase-activating death domain protein
Alternative name(s):
Rab3 GDP/GTP exchange factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MaddImported
Synonyms:Kiaa0358Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444672 Madd

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002781391 – 1577MAP kinase-activating death domain proteinBy similarityAdd BLAST1577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei155PhosphoserineBy similarity1
Modified residuei688PhosphoserineBy similarity1
Modified residuei691PhosphoserineBy similarity1
Modified residuei812PhosphoserineBy similarity1
Modified residuei817PhosphoserineCombined sources1
Modified residuei819PhosphoserineCombined sources1
Modified residuei857PhosphoserineBy similarity1
Modified residuei861PhosphoserineBy similarity1
Modified residuei915PhosphoserineBy similarity1
Modified residuei920PhosphoserineBy similarity1
Modified residuei929PhosphoserineBy similarity1
Modified residuei1058PhosphoserineCombined sources1
Modified residuei1060PhosphothreonineBy similarity1
Modified residuei1065PhosphothreonineCombined sources1
Modified residuei1109PhosphoserineCombined sources1
Modified residuei1235PhosphothreonineCombined sources1
Modified residuei1237PhosphoserineCombined sources1
Modified residuei1266PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q80U28

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80U28

PeptideAtlas

More...
PeptideAtlasi
Q80U28

PRoteomics IDEntifications database

More...
PRIDEi
Q80U28

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80U28

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80U28

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the death domain of TNFRSF1A through its own death domain.

Interacts with PIDD1.

Interacts with YWHAZ.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
230724, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q80U28, 2 interactors

Molecular INTeraction database

More...
MINTi
Q80U28

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000077094

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 267uDENNPROSITE-ProRule annotationAdd BLAST255
Domaini288 – 428cDENNPROSITE-ProRule annotationAdd BLAST141
Domaini430 – 564dDENNPROSITE-ProRule annotationAdd BLAST135
Domaini1336 – 1411DeathSequence analysisAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1156 – 1248Ser-richSequence analysisAdd BLAST93

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MADD family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3570 Eukaryota
ENOG410XP23 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80U28

Database of Orthologous Groups

More...
OrthoDBi
162625at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR039980 MADD
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13008 PTHR13008, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211 DENN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (15+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 15 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 15 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q80U28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVQKKFCPRL LDYLVIVGAR HPSSDSVAQT PELLRRYPLE DHPEFPLPPD
60 70 80 90 100
VVFFCQPEGC LSVRQRRMSL RDDTSFVFTL TDKDTGVTRY GICVNFYRSF
110 120 130 140 150
QKRMPKEKVE GGAGPRGKEG AHTSGASEEA ATGSSESGST LQPPSADSTP
160 170 180 190 200
DINQSPWGKR RAKAGSRSRN STLTSLCVLS HYPFFSTFRE CLYTLKRLVD
210 220 230 240 250
CCSERLLGKK LGIPRGVQRD TMWRIFTGSL LVEEKSSALL QDLREIEAWI
260 270 280 290 300
YRLLRSPVPV SGQKRVDIEV LPQELQQALT FALPDPSRFT LVDFPLHLPL
310 320 330 340 350
ELLGVDACLQ VLTCILLEHK VVLQSRDYNA LSMSVMAFVA MIYPLEYMFP
360 370 380 390 400
VIPLLPTCMA SAEQLLLAPT PYIIGVPASF FLYKLDFKMP DDVWLVDLDS
410 420 430 440 450
NRVIAPTNAE VLPILPEPES LELKKHLKQA LASMSLNTQP ILNLEKFHEG
460 470 480 490 500
QEIPLLLGRP SNDLQSTPST EFNPLIYGND VDSVDVATRV AMVRFFNSAN
510 520 530 540 550
VLQGFQMHTR TLRLFPRPVV AFQAGSFLAS RPRQTPFAEK LARTQAVEYF
560 570 580 590 600
GEWILNPSNY AFQRIHNNTF DPALIGDKPK WYAHQLQPIH YRVYDGNSQL
610 620 630 640 650
AEALSVPPER DSDSDPTEDS GSDSQDYDDS SSSYSSLGDF VSEMMKCDIN
660 670 680 690 700
GDTPNVDPLT HAALGDASEV EIDELQPQKE GEEPGPDSEN SQENPPLRSS
710 720 730 740 750
SSTTASSSPS TVVHSAHSEA ADSTEMGDKA TAGISKPLPP VPPSICKSTV
760 770 780 790 800
DRRQTETGEG SVCQRTYDNP YFEPQYGFPP EEDEEEQGES YTPRFSQHVS
810 820 830 840 850
GSRAQKLLRP NSLKLASDSD AESDSRASSP NSTVSNNSTE GFGGIMSFAS
860 870 880 890 900
SLYRNHSTSF SLSNLTLPTK GAREKTTPFP SLKVFGLNTL MEIVTEAGPG
910 920 930 940 950
SGEGNRRALV DQKSSVIKHS PTVKREPSSP QGRSSNSSEN QQFLKEVVHS
960 970 980 990 1000
VLDGQGVGWL NMKKVRRLLE SEQLRVFVLS KLNRAVQSED DARQDVIQDV
1010 1020 1030 1040 1050
EISRKVYKGM LDLLKCTVLS LEQSYAHAGL GGMASIFGLL EIAQTHYYSK
1060 1070 1080 1090 1100
EPDKRKRSPT ENVNTPVGKD PGLAGRGDPK AMAQLRVPQL GPRAPSATGK
1110 1120 1130 1140 1150
GPKELDTRSL KEENFVASVE LWNKHQEVKK QKALEKQRPE GIKPVFDLGE
1160 1170 1180 1190 1200
TEEKKSQMSA DSGVSLTSAS QRTDQDSVIG VSPAVMIRSS SQDSEVSTVS
1210 1220 1230 1240 1250
NSSGETLGAD SDLSSNAGDG PGGEGSAHLA SSRATLSDSE IETNSATSAI
1260 1270 1280 1290 1300
FGKAHSLKPK EKPAGSPIRS SEDVSQRVYL YEGLLGRDKG SMWDQLEDAA
1310 1320 1330 1340 1350
METFSLSKER STLWDQMQFW EDAFLDAVML EREGMGMDQG PQEMIDRYLS
1360 1370 1380 1390 1400
LGEHDRKRLE DDEDRLLATL LHNLISYMLL MKVNKNDIRK KVRRLMGKSH
1410 1420 1430 1440 1450
IGLVYSQQVN EVLDQLNSLN GRDLSIRSSG SRHMKKQTFV VHAGTDTNGD
1460 1470 1480 1490 1500
IFFMEVCDDC VVLRSNIGTV YERWWYEKLI NMTYCPKTKV LCLWRRNGSE
1510 1520 1530 1540 1550
TQLNKFYTKK CRELYYCVKD SMERAAARQQ SIKPGPELGG EFPVQDMKTG
1560 1570
EGGLLQVTLE GINLKFMHNQ FLKLKKW
Note: No experimental confirmation available.Curated
Length:1,577
Mass (Da):175,180
Last modified:February 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D604F8DDD1EF481
GO
Isoform 21 Publication (identifier: Q80U28-2) [UniParc]FASTAAdd to basket
Also known as: IG201 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1199-1199: V → VV
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHAQPGFHRAESH

Show »
Length:1,567
Mass (Da):173,703
Checksum:i82A821B9418F929E
GO
Isoform 31 Publication (identifier: Q80U28-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     884-903: Missing.
     1199-1199: V → VV

Note: No experimental confirmation available.Curated
Show »
Length:1,558
Mass (Da):173,276
Checksum:i8291C95AE140A9A3
GO
Isoform 41 Publication (identifier: Q80U28-4) [UniParc]FASTAAdd to basket
Also known as: IG20-PASV1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1199-1199: V → VV
     1287-1307: Missing.
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHAQPGFHRAESH

Show »
Length:1,528
Mass (Da):168,957
Checksum:i370F12A91BA83F02
GO
Isoform 51 Publication (identifier: Q80U28-5) [UniParc]FASTAAdd to basket
Also known as: IG20-SV41 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     719-743: Missing.
     884-903: Missing.
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1199-1199: V → VV
     1287-1307: Missing.
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHA...LRTPPRPVSS

Show »
Length:1,525
Mass (Da):169,203
Checksum:i2F7BE597770239C9
GO
Isoform 61 Publication (identifier: Q80U28-6) [UniParc]FASTAAdd to basket
Also known as: IG20-SV51 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     719-743: Missing.
     884-903: Missing.
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1198-1200: Missing.
     1287-1307: Missing.
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHA...LRTPPRPVSS

Show »
Length:1,521
Mass (Da):168,816
Checksum:iDB43A1308E2B5E01
GO
Isoform 71 Publication (identifier: Q80U28-7) [UniParc]FASTAAdd to basket
Also known as: IG20-SV21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     719-744: EAADSTEMGDKATAGISKPLPPVPPS → VREHLAG
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1199-1199: V → VV
     1287-1307: Missing.
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHAQPGFHRAESH

Show »
Length:1,509
Mass (Da):167,171
Checksum:iB3E5492FEAAB6368
GO
Isoform 81 Publication (identifier: Q80U28-8) [UniParc]FASTAAdd to basket
Also known as: IG20-SV11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     884-903: Missing.
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1199-1199: V → VV
     1287-1307: Missing.
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHAQPGFHRAESH

Show »
Length:1,508
Mass (Da):166,954
Checksum:i6122B73F9651FBBF
GO
Isoform 91 Publication (identifier: Q80U28-9) [UniParc]FASTAAdd to basket
Also known as: IG20-SV61 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     719-743: Missing.
     884-903: Missing.
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1183-1200: Missing.
     1287-1307: Missing.
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHA...LRTPPRPVSS

Show »
Length:1,506
Mass (Da):167,242
Checksum:iC0304173486A15B1
GO
Isoform 101 Publication (identifier: Q80U28-10) [UniParc]FASTAAdd to basket
Also known as: IG20-SV71 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     719-743: Missing.
     884-903: Missing.
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1172-1198: Missing.
     1287-1307: Missing.
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHA...LRTPPRPVSS

Show »
Length:1,497
Mass (Da):166,270
Checksum:i6D669FD76AAE3DE6
GO
Isoform 111 Publication (identifier: Q80U28-11) [UniParc]FASTAAdd to basket
Also known as: IG20-SV31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     719-744: EAADSTEMGDKATAGISKPLPPVPPS → VREHLAG
     884-903: Missing.
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1199-1199: V → VV
     1287-1307: Missing.
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHAQPGFHRAESH

Show »
Length:1,489
Mass (Da):165,168
Checksum:i2A32B8899E4A502A
GO
Isoform 121 Publication (identifier: Q80U28-12) [UniParc]FASTAAdd to basket
Also known as: IG20-SV81 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     719-743: Missing.
     884-903: Missing.
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1172-1198: Missing.
     1219-1577: Missing.

Show »
Length:1,128
Mass (Da):124,520
Checksum:i983116C5660A386C
GO
Isoform 131 Publication (identifier: Q80U28-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     884-903: Missing.
     1120-1135: ELWNKHQEVKKQKALE → DLTENLLMFGVSLFTL
     1136-1577: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,115
Mass (Da):123,434
Checksum:i2D48347DBAC3FFE8
GO
Isoform 141 Publication (identifier: Q80U28-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     884-903: Missing.
     1199-1199: V → VV
     1571-1577: FLKLKKW → ERKVFIELNH...LRTPPRPVSS

Note: No experimental confirmation available.Curated
Show »
Length:1,627
Mass (Da):181,095
Checksum:i490E2FB090295D61
GO
Isoform 151 Publication (identifier: Q80U28-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1196-1198: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,574
Mass (Da):174,892
Checksum:iE2937BB33AC89625
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QN47E9QN47_MOUSE
MAP kinase-activating death domain ...
Madd
1,627Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AGR0A2AGR0_MOUSE
MAP kinase-activating death domain ...
Madd
1,577Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AGQ4A2AGQ4_MOUSE
MAP kinase-activating death domain ...
Madd
1,632Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AGQ3A2AGQ3_MOUSE
MAP kinase-activating death domain ...
Madd
1,541Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AGQ6A2AGQ6_MOUSE
MAP kinase-activating death domain ...
Madd
1,602Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J1F4A0A0R4J1F4_MOUSE
MAP kinase-activating death domain ...
Madd
1,558Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AGQ2A2AGQ2_MOUSE
MAP kinase-activating death domain ...
Madd
1,554Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AGQ5A2AGQ5_MOUSE
MAP kinase-activating death domain ...
Madd
1,593Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AGQ7A2AGQ7_MOUSE
MAP kinase-activating death domain ...
Madd
1,573Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AGQ8A2AGQ8_MOUSE
MAP kinase-activating death domain ...
Madd
1,562Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC65539 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti132T → A in BAC29392 (PubMed:16141072).Curated1
Sequence conflicti132T → A in CAM17578 (PubMed:19468303).Curated1
Sequence conflicti132T → A in AAH63386 (PubMed:15489334).Curated1
Sequence conflicti152I → V in BAC29392 (PubMed:16141072).Curated1
Sequence conflicti152I → V in CAM17578 (PubMed:19468303).Curated1
Sequence conflicti152I → V in AAH63386 (PubMed:15489334).Curated1
Sequence conflicti157W → R in AAP22159 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22160 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22161 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22162 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22163 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22164 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22165 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22166 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22167 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22168 (Ref. 1) Curated1
Sequence conflicti157W → R in BAC29392 (PubMed:16141072).Curated1
Sequence conflicti157W → R in CAM17578 (PubMed:19468303).Curated1
Sequence conflicti157W → R in AAH63386 (PubMed:15489334).Curated1
Sequence conflicti1159S → R in BAE37379 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052299719 – 744EAADS…PVPPS → VREHLAG in isoform 7 and isoform 11. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_052300719 – 743Missing in isoform 5, isoform 6, isoform 9, isoform 10 and isoform 12. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_052301884 – 903Missing in isoform 3, isoform 5, isoform 6, isoform 8, isoform 9, isoform 10, isoform 11, isoform 12, isoform 13 and isoform 14. 3 PublicationsAdd BLAST20
Alternative sequenceiVSP_0523021120 – 1138ELWNK…LEKQR → G in isoform 4, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0523031120 – 1135ELWNK…QKALE → DLTENLLMFGVSLFTL in isoform 13. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0523041136 – 1577Missing in isoform 13. 1 PublicationAdd BLAST442
Alternative sequenceiVSP_0523051172 – 1198Missing in isoform 10 and isoform 12. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_0523061183 – 1200Missing in isoform 9. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0523071196 – 1198Missing in isoform 15. 1 Publication3
Alternative sequenceiVSP_0523081198 – 1200Missing in isoform 6. 1 Publication3
Alternative sequenceiVSP_0523091199V → VV in isoform 2, isoform 3, isoform 4, isoform 5, isoform 7, isoform 8, isoform 11 and isoform 14. 2 Publications1
Alternative sequenceiVSP_0523101219 – 1577Missing in isoform 12. 1 PublicationAdd BLAST359
Alternative sequenceiVSP_0523111287 – 1307Missing in isoform 4, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10 and isoform 11. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0523121511 – 1534CRELY…QSIKP → VLRVCVWAGDWI in isoform 2, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10 and isoform 11. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0523131559 – 1577LEGIN…KLKKW → PGRDQSQVHAQPGFHRAESH in isoform 2, isoform 4, isoform 7, isoform 8 and isoform 11. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0523141559 – 1577LEGIN…KLKKW → PGRDQSQVHAQPVPEIKEVV SHKYKTPMAHEICYSVLCLF SYVAAVRSSEEDLRTPPRPV SS in isoform 5, isoform 6, isoform 9 and isoform 10. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0523151571 – 1577FLKLKKW → ERKVFIELNHIKKCNTVRGV FVLEEFVPEIKEVVSHKYKT PMAHEICYSVLCLFSYVAAV RSSEEDLRTPPRPVSS in isoform 14. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY263980 mRNA Translation: AAP22159.1
AY263981 mRNA Translation: AAP22160.1
AY263982 mRNA Translation: AAP22161.1
AY263983 mRNA Translation: AAP22162.1
AY263984 mRNA Translation: AAP22163.1
AY263985 mRNA Translation: AAP22164.1
AY263986 mRNA Translation: AAP22165.1
AY263987 mRNA Translation: AAP22166.1
AY263988 mRNA Translation: AAP22167.1
AY263989 mRNA Translation: AAP22168.1
AK122257 mRNA Translation: BAC65539.1 Different initiation.
AK036347 mRNA Translation: BAC29392.1
AK163518 mRNA Translation: BAE37379.1
AL691450 Genomic DNA Translation: CAM17578.1
BC042212 mRNA Translation: AAH42212.1
BC063386 mRNA Translation: AAH63386.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38178.1 [Q80U28-3]
CCDS50635.1 [Q80U28-14]
CCDS50638.1 [Q80U28-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001171190.1, NM_001177719.1
NP_001171191.1, NM_001177720.1
NP_663502.3, NM_145527.4
XP_017173117.1, XM_017317628.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
228355

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:228355

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY263980 mRNA Translation: AAP22159.1
AY263981 mRNA Translation: AAP22160.1
AY263982 mRNA Translation: AAP22161.1
AY263983 mRNA Translation: AAP22162.1
AY263984 mRNA Translation: AAP22163.1
AY263985 mRNA Translation: AAP22164.1
AY263986 mRNA Translation: AAP22165.1
AY263987 mRNA Translation: AAP22166.1
AY263988 mRNA Translation: AAP22167.1
AY263989 mRNA Translation: AAP22168.1
AK122257 mRNA Translation: BAC65539.1 Different initiation.
AK036347 mRNA Translation: BAC29392.1
AK163518 mRNA Translation: BAE37379.1
AL691450 Genomic DNA Translation: CAM17578.1
BC042212 mRNA Translation: AAH42212.1
BC063386 mRNA Translation: AAH63386.1
CCDSiCCDS38178.1 [Q80U28-3]
CCDS50635.1 [Q80U28-14]
CCDS50638.1 [Q80U28-1]
RefSeqiNP_001171190.1, NM_001177719.1
NP_001171191.1, NM_001177720.1
NP_663502.3, NM_145527.4
XP_017173117.1, XM_017317628.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi230724, 1 interactor
IntActiQ80U28, 2 interactors
MINTiQ80U28
STRINGi10090.ENSMUSP00000077094

PTM databases

iPTMnetiQ80U28
PhosphoSitePlusiQ80U28

Proteomic databases

jPOSTiQ80U28
PaxDbiQ80U28
PeptideAtlasiQ80U28
PRIDEiQ80U28

Genome annotation databases

GeneIDi228355
KEGGimmu:228355

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8567
MGIiMGI:2444672 Madd

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG3570 Eukaryota
ENOG410XP23 LUCA
InParanoidiQ80U28
OrthoDBi162625at2759

Enzyme and pathway databases

ReactomeiR-MMU-5357905 Regulation of TNFR1 signaling
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Madd mouse

Protein Ontology

More...
PROi
PR:Q80U28

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR039980 MADD
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PANTHERiPTHR13008 PTHR13008, 1 hit
PfamiView protein in Pfam
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMADD_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80U28
Secondary accession number(s): Q3TQK3
, Q6P4I6, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 16, 2019
This is version 109 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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