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Protein

Syntaphilin

Gene

Snph

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits SNARE complex formation by absorbing free syntaxin-1.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaphilin
Gene namesi
Name:Snph
Synonyms:Kiaa0374
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2139270 Snph

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei427 – 446HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell junction, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002841371 – 495SyntaphilinAdd BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei200PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei214PhosphothreonineCombined sources1
Modified residuei219PhosphoserineCombined sources1
Modified residuei235PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PeptideAtlasiQ80U23
PRIDEiQ80U23

PTM databases

iPTMnetiQ80U23
PhosphoSitePlusiQ80U23
SwissPalmiQ80U23

Expressioni

Gene expression databases

BgeeiENSMUSG00000027457 Expressed in 102 organ(s), highest expression level in visual cortex
CleanExiMM_SNPH
ExpressionAtlasiQ80U23 baseline and differential
GenevisibleiQ80U23 MM

Interactioni

Subunit structurei

Binds to syntaxin-1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ80U23, 1 interactor
MINTiQ80U23

Structurei

3D structure databases

SMRiQ80U23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili79 – 161Sequence analysisAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 42Poly-SerAdd BLAST11
Compositional biasi403 – 408Poly-Glu6
Compositional biasi409 – 412Poly-Ala4

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00520000055634
HOVERGENiHBG006785
InParanoidiQ80U23
OMAiYWSRHFI
OrthoDBiEOG091G07I1
PhylomeDBiQ80U23
TreeFamiTF332407

Family and domain databases

InterProiView protein in InterPro
IPR026196 Syntaphilin
IPR028197 Syntaphilin/Syntabulin
PANTHERiPTHR16208 PTHR16208, 1 hit
PTHR16208:SF1 PTHR16208:SF1, 1 hit
PfamiView protein in Pfam
PF15290 Syntaphilin, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80U23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAMSLQGSRR ASAGSRRRTS PPVSVRDAYG TSSLSSSSNS GSCKGSDSSP
60 70 80 90 100
TPRRSMKYTL CSDNHGIKPP TPEQYLTPLQ QKEVCIRHLK ARLKDTQDRL
110 120 130 140 150
QDRDTEIDDL KTQLSRMQED WIEEECHRVE AQLALKEARK EIRQLKQVID
160 170 180 190 200
TVKNNLIDKD KGLQKYFVDI NIQNKKLETL LHSMEVAQNG VAKEEGTGES
210 220 230 240 250
AGGSPARSLT RSSTYTKLSD PAVCGDRQPG DPSNTSAEDG ADSGYVAADD
260 270 280 290 300
TLSRTDALEA SSLLSSGVDC GLEEASLHSS FNLGPRFPAS NTYEKLLCGM
310 320 330 340 350
EAGVQVSCMQ ERAIQTDFVQ YQPDLNTILE KVGQAQVCGS VLKDRHSELD
360 370 380 390 400
PHPSGPRDPD SAVVVTVGDE LEAPEPITCG PATHRPAVNS NPGLPVSVVC
410 420 430 440 450
PVEEEEEEAA AATTTEKEPK SYWSRHYIVD LLAVVVPAVP TVAWLCRSQR
460 470 480 490
RQGQPIYNIS SLLRGCCTVA LHSIRRISCR SLGQPSSSTA GGSQL
Length:495
Mass (Da):53,753
Last modified:June 16, 2009 - v3
Checksum:iD1BA1C0702446C97
GO
Isoform 2 (identifier: Q80U23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-16: R → RSGGTLGRSGLAVFAQCPQVPASQNEQRPLLPAS

Show »
Length:528
Mass (Da):57,073
Checksum:i80BB016EEC7C0CA6
GO
Isoform 3 (identifier: Q80U23-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-52: Missing.

Show »
Length:459
Mass (Da):50,168
Checksum:i2B4D4FF0614DF892
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YN82Z4YN82_MOUSE
Syntaphilin
Snph
87Annotation score:
S4R180S4R180_MOUSE
Syntaphilin
Snph
60Annotation score:
A0A140T8V7A0A140T8V7_MOUSE
Syntaphilin
Snph
10Annotation score:

Sequence cautioni

The sequence AAH72567 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH96541 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI39793 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC33090 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC65544 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156L → V in BAC33090 (PubMed:16141072).Curated1
Sequence conflicti165K → M in AAH96541 (PubMed:15489334).Curated1
Sequence conflicti358D → Y in BAC33090 (PubMed:16141072).Curated1
Sequence conflicti456I → V in AAI17897 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03743916R → RSGGTLGRSGLAVFAQCPQV PASQNEQRPLLPAS in isoform 2. 3 Publications1
Alternative sequenceiVSP_03744017 – 52Missing in isoform 3. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122262 mRNA Translation: BAC65544.1 Different initiation.
AK047568 mRNA Translation: BAC33090.1 Different initiation.
AL928719 Genomic DNA No translation available.
BC072567 mRNA Translation: AAH72567.1 Different initiation.
BC096541 mRNA Translation: AAH96541.1 Different initiation.
BC117896 mRNA Translation: AAI17897.1
BC117897 mRNA Translation: AAI17898.1
BC139792 mRNA Translation: AAI39793.1 Different initiation.
CCDSiCCDS16871.1 [Q80U23-2]
CCDS71161.1 [Q80U23-3]
CCDS71162.1 [Q80U23-1]
RefSeqiNP_001278005.1, NM_001291076.1 [Q80U23-1]
NP_001278006.1, NM_001291077.1 [Q80U23-3]
NP_937857.1, NM_198214.3 [Q80U23-2]
XP_011237840.1, XM_011239538.1 [Q80U23-2]
UniGeneiMm.39312

Genome annotation databases

EnsembliENSMUST00000028951; ENSMUSP00000028951; ENSMUSG00000027457 [Q80U23-2]
ENSMUST00000094456; ENSMUSP00000092026; ENSMUSG00000027457 [Q80U23-1]
ENSMUST00000109875; ENSMUSP00000105501; ENSMUSG00000027457 [Q80U23-2]
ENSMUST00000109877; ENSMUSP00000105503; ENSMUSG00000027457 [Q80U23-3]
GeneIDi241727
KEGGimmu:241727
UCSCiuc008ned.2 mouse [Q80U23-2]
uc008nee.2 mouse [Q80U23-1]
uc008nef.2 mouse [Q80U23-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122262 mRNA Translation: BAC65544.1 Different initiation.
AK047568 mRNA Translation: BAC33090.1 Different initiation.
AL928719 Genomic DNA No translation available.
BC072567 mRNA Translation: AAH72567.1 Different initiation.
BC096541 mRNA Translation: AAH96541.1 Different initiation.
BC117896 mRNA Translation: AAI17897.1
BC117897 mRNA Translation: AAI17898.1
BC139792 mRNA Translation: AAI39793.1 Different initiation.
CCDSiCCDS16871.1 [Q80U23-2]
CCDS71161.1 [Q80U23-3]
CCDS71162.1 [Q80U23-1]
RefSeqiNP_001278005.1, NM_001291076.1 [Q80U23-1]
NP_001278006.1, NM_001291077.1 [Q80U23-3]
NP_937857.1, NM_198214.3 [Q80U23-2]
XP_011237840.1, XM_011239538.1 [Q80U23-2]
UniGeneiMm.39312

3D structure databases

SMRiQ80U23
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80U23, 1 interactor
MINTiQ80U23

PTM databases

iPTMnetiQ80U23
PhosphoSitePlusiQ80U23
SwissPalmiQ80U23

Proteomic databases

PeptideAtlasiQ80U23
PRIDEiQ80U23

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028951; ENSMUSP00000028951; ENSMUSG00000027457 [Q80U23-2]
ENSMUST00000094456; ENSMUSP00000092026; ENSMUSG00000027457 [Q80U23-1]
ENSMUST00000109875; ENSMUSP00000105501; ENSMUSG00000027457 [Q80U23-2]
ENSMUST00000109877; ENSMUSP00000105503; ENSMUSG00000027457 [Q80U23-3]
GeneIDi241727
KEGGimmu:241727
UCSCiuc008ned.2 mouse [Q80U23-2]
uc008nee.2 mouse [Q80U23-1]
uc008nef.2 mouse [Q80U23-3]

Organism-specific databases

CTDi9751
MGIiMGI:2139270 Snph
RougeiSearch...

Phylogenomic databases

GeneTreeiENSGT00520000055634
HOVERGENiHBG006785
InParanoidiQ80U23
OMAiYWSRHFI
OrthoDBiEOG091G07I1
PhylomeDBiQ80U23
TreeFamiTF332407

Miscellaneous databases

PROiPR:Q80U23
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027457 Expressed in 102 organ(s), highest expression level in visual cortex
CleanExiMM_SNPH
ExpressionAtlasiQ80U23 baseline and differential
GenevisibleiQ80U23 MM

Family and domain databases

InterProiView protein in InterPro
IPR026196 Syntaphilin
IPR028197 Syntaphilin/Syntabulin
PANTHERiPTHR16208 PTHR16208, 1 hit
PTHR16208:SF1 PTHR16208:SF1, 1 hit
PfamiView protein in Pfam
PF15290 Syntaphilin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNPH_MOUSE
AccessioniPrimary (citable) accession number: Q80U23
Secondary accession number(s): A2AT08
, A2AT09, A2AT10, A2AT11, A4FUV3, A4VCI7, Q4VA51, Q6GQX4, Q8C8B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 16, 2009
Last modified: November 7, 2018
This is version 97 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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