Rho family-interacting cell polarization regulator 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• 14-3-3 protein binding Source: UniProtKB
• identical protein binding Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 27269051

GO - Biological processⁱ

• auditory receptor cell stereocilium organization Source: UniProtKBInferred from mutant phenotypeⁱ
  • 27269051
• cell adhesion Source: UniProtKB-KW
• cellular response to chemokine Source: UniProtKBInferred from mutant phenotypeⁱ
  • 25588844
• cellular response to mechanical stimulus Source: UniProtKBInferred from mutant phenotypeⁱ
  • 27269051
• chemotaxis Source: UniProtKB-KW
• establishment of protein localization Source: UniProtKBInferred from mutant phenotypeⁱ
  • 27269051
• negative regulation of cell adhesion Source: UniProtKBInferred from mutant phenotypeⁱ
  • 25588844
• negative regulation of establishment of T cell polarity Source: UniProtKB
• negative regulation of protein localization to cell leading edge Source: UniProtKBInferred from mutant phenotypeⁱ
  • 25588844
• negative regulation of Rho guanyl-nucleotide exchange factor activity Source: UniProtKBInferred from mutant phenotypeⁱ
  • 25588844
• negative regulation of Rho protein signal transduction Source: UniProtKBInferred from mutant phenotypeⁱ
  • 25588844
• negative regulation of T cell migration Source: UniProtKB
• negative regulation of T cell proliferation Source: MGI
• positive regulation of cell cycle arrest Source: MGI
• positive regulation of filopodium assembly Source: UniProtKBInferred from mutant phenotypeⁱ
  • 17150207
• positive regulation of myoblast differentiation Source: UniProtKB
• positive regulation of myoblast fusion Source: UniProtKB
• positive regulation of neutrophil chemotaxis Source: UniProtKBInferred from mutant phenotypeⁱ
  • 25588844
• positive regulation of neutrophil extravasation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 25588844
• protein homooligomerization Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 27269051
• regulation of establishment of cell polarity Source: UniProtKBInferred from mutant phenotypeⁱ
  • 25588844
• regulation of mitotic spindle assembly Source: MGI
• sensory perception of sound Source: UniProtKBInferred from mutant phenotypeⁱ
  • 27269051
• skeletal muscle fiber development Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• 14-3-3 protein binding Source: UniProtKB
• identical protein binding Source: UniProtKBInferred from mutant phenotypeⁱ
  • 27269051

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MPPGTKRLRA LGAFSAGLPT RLPEIMLVGS QSFSPGGPNG IIRSQSFAGF 
        60         70         80         90        100
SGLQERRSRC NSFIENASAL KKPQAKLKKM HNLGHKNNNT PKEPQPKRVE 
       110        120        130        140        150
EVYRALKNGL DEYLEFHQTE LDKLTAQLKD MKRNSRLGVL YDLDKQIKTI 
       160        170        180        190        200
ERYMRRLEFH ISKVDELYEA YCIQRRLQDG ASKMKQAFAT SPASKAARES 
       210        220        230        240        250
LSEINRSYKE YTENMCAIEA ELESLLGEFS IKMKGLAGFA RLCPGDQYEI 
       260        270        280        290        300
FMKYGRQRWK LKGKIEVNGK QSWDGAETVF LPLIVGFISI KVTELKGLAT 
       310        320        330        340        350
HILVGSVTCE TKELFAARPQ VVAVDINDLG TIKLNLEITW YPFDVEDTTP 
       360        370        380        390        400
SSGPGNKTAA LQRRMSMYSQ GTPETPTFKD QSFFRWLRLS VLSALRDTFF 
       410        420        430        440        450
ATLHHNHSVG DLPSLSLNPK ALLEFYSNLP DDIFESGKAA EEKRPLSLSF 
       460        470        480        490        500
SDLQDGDCVF TSSSATSPSS SHSAHPEITI TPAELTHSSL SSQNEGTEDS 
       510        520        530        540        550
SSASSRNSLG EDHEPKSHPK SDTVEPGKPG VATRSGTESL FLESSVAEAL 
       560        570        580        590        600
LQESDEASEL KPVELDTFEG NITKQLVKRL TSAEGPVTTD KLFFEGSVGS 
       610        620        630        640        650
ESEAGRSFLD GSLEDAFNGL FLALDPHKKQ YKEFQDLNQE VTHLDDVLKC 
       660        670        680        690        700
KPAGSRSRSS SLSLTVESAL ESFDFLNTSD FDEEEEDGDD VCHVGGGADS 
       710        720        730        740        750
VFSDTETEKS GYRSVHPEAR GHLSEALTED TGVGTSVAGS PLPLTTGNES 
       760        770        780        790        800
LDITIVKHLQ YCTQLIQQIV FSSKTPFVAR SLLEKLSRQV LVMQKLAAVS 
       810        820        830        840        850
DENLGNITSV VEAIPEFHKK LSLLAFWTKC CSPSGVYHSS AARLIKQLEA 
       860        870        880        890        900
SFARSINKDY PGLAEPVFRT LVSQILDRAE PLLSSSLSSE VITVFQYYSF 
       910        920        930        940        950
FTSHGVSDLE TYLGQLTRQV AMVQTLQSLR DEKLLQTMSD LAPSNLPAQQ 
       960        970        980        990       1000
EVLRTLALLL TRDDNEVSEA VTLYLAAASK NEHFREKALL YYCEALTKAN 
      1010       1020       1030       1040       1050
LQLQKAACLA LKSLEATESI KMLVTLCQSD TEEIRTVASE TLLSLGEDGR 
      1060       1070 
LAYEQLDKFP RDCVKVGGRH GTEVATAF                         

        10         20         30         40         50
MPPGTKRLRA LGAFSAGLPT RLPEIMLVGS QSFSPGGPNG IIRSQSFAGF 
        60         70         80         90        100
SGLQERRSRC NSFIENASAL KKPQAKLKKM HNLGHKNNNT PKEPQPKRVE 
       110        120        130        140        150
EVYRALKNGL DEYLEFHQTE LDKLTAQLKD MKRNSRLGVL YDLDKQIKTI 
       160        170        180        190        200
ERYMRRLEFH ISKVDELYEA YCIQRRLQDG ASKMKQAFAT SPASKAARES 
       210        220        230        240        250
LSEINRSYKE YTENMCAIEA ELESLLGEFS IKMKGLAGFA RLCPGDQYEI 
       260        270        280        290        300
FMKYGRQRWK LKGKIEVNGK QSWDGAETVF LPLIVGFISI KVTELKGLAT 
       310        320        330        340        350
HILVGSVTCE TKELFAARPQ VVAVDINDLG TIKLNLEITW YPFDVEDTTP 
       360        370        380        390        400
SSGPGNKTAA LQRRMSMYSQ GTPETPTFKD QSFFRWLRLS VLSALRDTFF 
       410        420        430        440        450
ATLHHNHSVG DLPSLSLNPK ALLEFYSNLP DDIFESGKAA EEKRPLSLSF 
       460        470        480        490        500
SDLQDGDCVF TSSSATSPSS SHSAHPEITI TPAELTHSSL SSQNEGTEDS 
       510        520        530        540        550
SSASSRNSLG EDHEPKSHPK SDTVEPGKPG VATRSGTESL FLESSVAEAL 
       560        570        580        590        600
LQESDEASEL KPVELDTFEG NITKQLVKRL TSAEGPVTTD KLFFEGSVGS 
       610        620        630        640        650
ESEAGRSFLD GSLEDAFNGL FLALDPHKKQ YKEFQDLNQE VTHLDDVLKD 
       660        670 
AKHLEDQRLN DAASRMEITE GE                               

        10         20         30         40         50
MPPGTKRLRA LGAFSAGLPT RLPEIMLVGS QSFSPGGPNG IIRSQSFAGF 
        60         70         80         90        100
SGLQERRSRC NSFIENASAL KKPQAKLKKM HNLGHKNNNT PKEPQPKRVE 
       110        120        130        140        150
EVYRALKNGL DEYLEFHQTE LDKLTAQLKD MKRNSRLGVL YDLDKQIKTI 
       160        170        180        190        200
ERYMRRLEFH ISKVDELYEA YCIQRRLQDG ASKMKQAFAT SPASKAARES 
       210        220        230        240        250
LSEINRSYKE YTENMCAIEA ELESLLGEFS IKMKGLAGFA RLCPGDQYEI 
       260        270        280        290        300
FMKYGRQRWK LKGKIEVNGK QSWDGAETVF LPLIVGFISI KVTELKGLAT 
       310        320        330        340        350
HILVGSVTCE TKELFAARPQ VVAVDINDLG TIKLNLEITW YPFDVEDTTP 
       360        370        380 
SSGPGNKTAA LQRRMSMYSQ GTPETPTFKD QSFFVGNGT             

        10         20         30         40         50
MPPGTKRLRA LGAFSAGLPT RLPEIMLVGS QSFSPGGPNG IIRSQSFAGF 
        60         70         80         90        100
SGLQERRSRC NSFIENASAL KKPQAKLKKM HNLGHKNNNT PKEPQPKRVE 
       110        120        130        140        150
EVYRALKNGL DEYLEFHQTE LDKLTAQLKD MKRNSRLGVL YDLDKQIKTI 
       160        170        180        190        200
ERYMRRLEFH ISKVDELYEA YCIQRRLQDG ASKMKQAFAT SPASKAARES 
       210        220        230        240        250
LSEINRSYKE YTENMCAIEA ELESLLGEFS IKMKGLAGFA RLCPGDQYEI 
       260        270        280        290        300
FMKYGRQRWK LKGKIEVNGK QSWDGAETVF LPLIVGFISI KVTELKGLAT 
       310        320        330        340        350
HILVGSVTCE TKELFAARPQ VVAVDINDLG TIKLNLEITW YPFDVEDTTP 
       360        370        380 
SSGPGNKTAA LQRRMSMYSQ GTPETPTFKD QSFFVSSV              

        10         20         30         40         50
MQFLDPEDLL DEEDDIFGEG LPTRLPEIML VGSQSFSPGG PNGIIRSQSF 
        60         70         80         90        100
AGFSGLQERR SRCNSFIENA SALKKPQAKL KKMHNLGHKN NNTPKEPQPK 
       110        120        130        140        150
RVEEVYRALK NGLDEYLEFH QTELDKLTAQ LKDMKRNSRL GVLYDLDKQI 
       160        170        180        190        200
KTIERYMRRL EFHISKVDEL YEAYCIQRRL QDGASKMKQA FATSPASKAA 
       210        220        230        240        250
RESLSEINRS YKEYTENMCA IEAELESLLG EFSIKMKGLA GFARLCPGDQ 
       260        270        280        290        300
YEIFMKYGRQ RWKLKGKIEV NGKQSWDGAE TVFLPLIVGF ISIKVTELKG 
       310        320        330        340        350
LATHILVGSV TCETKELFAA RPQVVAVDIN DLGTIKLNLE ITWYPFDVED 
       360        370        380        390        400
TTPSSGPGNK TAALQRRMSM YSQGTPETPT FKDQSFFSNL PDDIFESGKA 
       410        420        430        440        450
AEEKRPLSLS FSDLQDGDCV FTSSSATSPS SSHSAHPEIT ITPAELTHSS 
       460        470        480        490        500
LSSQNEGTED SSSASSRNSL GEDHEPKSHP KSDTVEPGKP GVATRSGTES 
       510        520        530        540        550
LFLESSVAEA LLQESDEASE LKPVELDTFE GNITKQLVKR LTSAEGPVTT 
       560        570        580        590        600
DKLFFEGSVG SESEAGRSFL DGSLEDAFNG LFLALDPHKK QYKEFQDLNQ 
       610        620        630 
EVTHLDDVLK DAKHLEDQRL NDAASRMEIT EGE                   

        10         20         30         40         50
MQFLDPEDLL DEEDDIFGEG LPTRLPEIML VGSQSFSPGG PNGIIRSQSF 
        60         70         80         90        100
AGFSGLQERR SRCNSFIENA SALKKPQAKL KKMHNLGHKN NNTPKEPQPK 
       110        120        130        140        150
RVEEVYRALK NGLDEYLEFH QTELDKLTAQ LKDMKRNSRL GVLYDLDKQI 
       160        170        180        190        200
KTIERYMRRL EFHISKVDEL YEAYCIQRRL QDGASKMKQA FATSPASKAA 
       210        220        230        240        250
RESLSEINRS YKEYTENMCA IEAELESLLG EFSIKMKGLA GFARLCPGDQ 
       260        270        280        290        300
YEIFMKYGRQ RWKLKGKIEV NGKQSWDGAE TVFLPLIVGF ISIKVTELKG 
       310        320        330        340        350
LATHILVGSV TCETKELFAA RPQVVAVDIN DLGTIKLNLE ITWYPFDVED 
       360        370        380        390        400
TTPSSGPGNK TAALQRRMSM YSQGTPETPT FKDQSFFSNL PDDIFESGKA 
       410        420        430        440        450
AEEKRPLSLS FSDLQDGDCV FTSSSATSPS SSHSAHPEIT ITPAELTHSS 
       460        470        480        490        500
LSSQNEGTED SSSASSRNSL GEDHEPKSHP KSDTVEPGKP GVATRSGTES 
       510        520        530        540        550
LFLESSVAEA LLQESDEASE LKPVELDTFE GNITKQLVKR LTSAEGPVTT 
       560        570        580        590        600
DKLFFEGSVG SESEAGRSFL DGSLEDAFNG LFLALDPHKK QYKEFQDLNQ 
       610        620 
EVTHLDDVLK VSTFLGKKKK SDLVWKNAS                        

        10         20         30         40         50
MLVGSQSFSP GGPNGIIRSQ SFAGFSGLQE RRSRCNSFIE NASALKKPQA 
        60         70         80         90        100
KLKKMHNLGH KNNNTPKEPQ PKRVEEVYRA LKNGLDEYLE FHQTELDKLT 
       110        120        130        140        150
AQLKDMKRNS RLGVLYDLDK QIKTIERYMR RLEFHISKVD ELYEAYCIQR 
       160        170        180        190        200
RLQDGASKMK QAFATSPASK AARESLSEIN RSYKEYTENM CAIEAELESL 
       210        220        230        240        250
LGEFSIKMKG LAGFARLCPG DQYEIFMKYG RQRWKLKGKI EVNGKQSWDG 
       260        270        280        290        300
AETVFLPLIV GFISIKVTEL KGLATHILVG SVTCETKELF AARPQVVAVD 
       310        320        330        340        350
INDLGTIKLN LEITWYPFDV EDTTPSSGPG NKTAALQRRM SMYSQGTPET 
       360        370        380        390        400
PTFKDQSFFS NLPDDIFESG KAAEEKRPLS LSFSDLQDGD CVFTSSSATS 
       410        420        430        440        450
PSSSHSAHPE ITITPAELTH SSLSSQNEGT EDSSSASSRN SLGEDHEPKS 
       460        470        480        490        500
HPKSDTVEPG KPGVATRSGT ESLFLESSVA EALLQESDEA SELKPVELDT 
       510        520        530        540        550
FEGNITKQLV KRLTSAEGPV TTDKLFFEGS VGSESEAGRS FLDGSLEDAF 
       560        570        580        590        600
NGLFLALDPH KKQYKEFQDL NQEVTHLDDV LKDAKHLEDQ RLNDAASRME 

ITEGE                                                  

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot