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Entry version 115 (02 Dec 2020)
Sequence version 2 (29 May 2007)
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Protein

Rho family-interacting cell polarization regulator 2

Gene

Ripor2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:25588844, PubMed:27269051). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (By similarity). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (PubMed:25588844). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (PubMed:27269051). Plays a role for maintaining the structural organization of the basal domain of stereocilia (PubMed:27269051). Involved in mechanosensory hair cell function (PubMed:27269051). Required for normal hearing (PubMed:27269051).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 14-3-3 protein binding Source: UniProtKB
  • identical protein binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionSignal transduction inhibitor
Biological processCell adhesion, Chemotaxis, Differentiation, Hearing, Myogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho family-interacting cell polarization regulator 2By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ripor2By similarity
Synonyms:Fam65b, Kiaa0386
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444879, Ripor2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are deaf at 4 weeks of age (PubMed:27269051). Show abnormal hair bundle morphology and polarity and stereociliary growth in the cochlea of the inner ear (PubMed:27269051). Display mislocalization of protein TPRN to the base of stereocilia (PubMed:27269051). Show reduced mechanotransduction currents in hair bundles of outer hair cells (PubMed:27269051). Mice show impaired neutrophil chemotaxis, increased neutrophil adhesion to endothelial cell and reduced neutrophil infiltration into inflamed peritonea (PubMed:25588844). Display increased chemokine-induced RHOA activity and mislocalization of myosin light chain MYL2 in neutrophils (PubMed:25588844).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi176 – 177RL → AA: Inhibits interaction with RHOC. Reduces homooligomerization activity. Inhibits RHOC-dependent homooligomerization activity. Abolishes ability to rescue the morphological hair bundle defect in hair cell of RIPOR2-deficient mice. 1 Publication2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002891151 – 1078Rho family-interacting cell polarization regulator 2Add BLAST1078

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei46PhosphoserineCombined sources1
Modified residuei62PhosphoserineBy similarity1
Modified residuei366PhosphoserineCombined sources1
Modified residuei582PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Chemokine-induced phosphorylation in neutrophils occurs in a PKC- and AKT-dependent manner, resulting in RIPOR2 interaction with YWHAB and stabilization. Phosphorylated by PKCA, AKT1 and MAPKAPK1A; in vitro.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q80U16

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q80U16

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80U16

PRoteomics IDEntifications database

More...
PRIDEi
Q80U16

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80U16

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80U16

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the cochlea (PubMed:24958875). Expressed in inner hair cells and outer hair cells and Hensen's cells (at protein level) (PubMed:27269051). Expressed in the brain, cerebellum, spinal cord, retina, heart, spleen liver, kidney, bladder, muscle and lung ((PubMed:24958875), PubMed:27269051). Expressed in the cochlea of the inner ear ((PubMed:24958875), PubMed:27269051).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during regenerating muscle tissue.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036006, Expressed in blood and 269 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80U16, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer; homooligomerization is regulated by RHOC and leads to the formation of concatemers through the association of N- and C-termini (PubMed:27269051).

Interacts (phosphorylated form) with 14-3-3 proteins; these interactions occur during myogenic cell differentiation and also induces T cell proliferation arrest (By similarity).

Interacts (phosphorylated form) with HDAC6; this interaction occurs during early myogenic differentiation, prevents HDAC6 to deacetylate tubulin and also induces T cell proliferation arrest (By similarity).

Interacts with DYSF; this interaction occurs during early myogenic differentiation (PubMed:24687993).

Interacts with MYOF (By similarity).

Interacts (via active GTP- or inactive GDP-bound forms) with RHOA; this interaction is direct, blocks the loading of GTP to RHOA and decreases upon chemokine CCL19 stimulation in primary T lymphocytes (PubMed:27269051).

Interacts with RHOC (PubMed:27269051).

Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (By similarity).

Interacts with YWHAE (By similarity).

Interacts with YWHAQ (By similarity).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
228735, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000106013

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q80U16, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80U16

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni80 – 138Involved in cell filopodia formationBy similarityAdd BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili108 – 137Sequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RIPOR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQ7T, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153717

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_432085_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80U16

Database of Orthologous Groups

More...
OrthoDBi
1121546at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80U16

TreeFam database of animal gene trees

More...
TreeFami
TF329332

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR031780, FAM65_N
IPR033035, FAM65B
IPR026136, RIPOR3

The PANTHER Classification System

More...
PANTHERi
PTHR15829, PTHR15829, 1 hit
PTHR15829:SF2, PTHR15829:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15903, PL48, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80U16-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPPGTKRLRA LGAFSAGLPT RLPEIMLVGS QSFSPGGPNG IIRSQSFAGF
60 70 80 90 100
SGLQERRSRC NSFIENASAL KKPQAKLKKM HNLGHKNNNT PKEPQPKRVE
110 120 130 140 150
EVYRALKNGL DEYLEFHQTE LDKLTAQLKD MKRNSRLGVL YDLDKQIKTI
160 170 180 190 200
ERYMRRLEFH ISKVDELYEA YCIQRRLQDG ASKMKQAFAT SPASKAARES
210 220 230 240 250
LSEINRSYKE YTENMCAIEA ELESLLGEFS IKMKGLAGFA RLCPGDQYEI
260 270 280 290 300
FMKYGRQRWK LKGKIEVNGK QSWDGAETVF LPLIVGFISI KVTELKGLAT
310 320 330 340 350
HILVGSVTCE TKELFAARPQ VVAVDINDLG TIKLNLEITW YPFDVEDTTP
360 370 380 390 400
SSGPGNKTAA LQRRMSMYSQ GTPETPTFKD QSFFRWLRLS VLSALRDTFF
410 420 430 440 450
ATLHHNHSVG DLPSLSLNPK ALLEFYSNLP DDIFESGKAA EEKRPLSLSF
460 470 480 490 500
SDLQDGDCVF TSSSATSPSS SHSAHPEITI TPAELTHSSL SSQNEGTEDS
510 520 530 540 550
SSASSRNSLG EDHEPKSHPK SDTVEPGKPG VATRSGTESL FLESSVAEAL
560 570 580 590 600
LQESDEASEL KPVELDTFEG NITKQLVKRL TSAEGPVTTD KLFFEGSVGS
610 620 630 640 650
ESEAGRSFLD GSLEDAFNGL FLALDPHKKQ YKEFQDLNQE VTHLDDVLKC
660 670 680 690 700
KPAGSRSRSS SLSLTVESAL ESFDFLNTSD FDEEEEDGDD VCHVGGGADS
710 720 730 740 750
VFSDTETEKS GYRSVHPEAR GHLSEALTED TGVGTSVAGS PLPLTTGNES
760 770 780 790 800
LDITIVKHLQ YCTQLIQQIV FSSKTPFVAR SLLEKLSRQV LVMQKLAAVS
810 820 830 840 850
DENLGNITSV VEAIPEFHKK LSLLAFWTKC CSPSGVYHSS AARLIKQLEA
860 870 880 890 900
SFARSINKDY PGLAEPVFRT LVSQILDRAE PLLSSSLSSE VITVFQYYSF
910 920 930 940 950
FTSHGVSDLE TYLGQLTRQV AMVQTLQSLR DEKLLQTMSD LAPSNLPAQQ
960 970 980 990 1000
EVLRTLALLL TRDDNEVSEA VTLYLAAASK NEHFREKALL YYCEALTKAN
1010 1020 1030 1040 1050
LQLQKAACLA LKSLEATESI KMLVTLCQSD TEEIRTVASE TLLSLGEDGR
1060 1070
LAYEQLDKFP RDCVKVGGRH GTEVATAF
Length:1,078
Mass (Da):118,970
Last modified:May 29, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i207E1F6172144E2C
GO
Isoform 2 (identifier: Q80U16-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     650-672: CKPAGSRSRSSSLSLTVESALES → DAKHLEDQRLNDAASRMEITEGE
     673-1078: Missing.

Show »
Length:672
Mass (Da):74,628
Checksum:i8E924B06A47E3FBD
GO
Isoform 3 (identifier: Q80U16-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     385-389: RWLRL → VGNGT
     390-1078: Missing.

Show »
Length:389
Mass (Da):43,711
Checksum:i876770C69269A3A6
GO
Isoform 4 (identifier: Q80U16-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     385-388: RWLR → VSSV
     389-1078: Missing.

Show »
Length:388
Mass (Da):43,655
Checksum:iDDD12B5269A3A6B2
GO
Isoform 5 (identifier: Q80U16-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MPPGTKRLRALGAFSA → MQFLDPEDLLDEEDDIFGE
     385-426: Missing.
     650-672: CKPAGSRSRSSSLSLTVESALES → DAKHLEDQRLNDAASRMEITEGE
     673-1078: Missing.

Show »
Length:633
Mass (Da):70,407
Checksum:i1CE9B5CE340351F8
GO
Isoform 6 (identifier: Q80U16-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MPPGTKRLRALGAFSA → MQFLDPEDLLDEEDDIFGE
     385-426: Missing.
     650-668: CKPAGSRSRSSSLSLTVES → VSTFLGKKKKSDLVWKNAS
     669-1078: Missing.

Show »
Length:629
Mass (Da):69,915
Checksum:i4D1898FF789914F6
GO
Isoform 7 (identifier: Q80U16-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.
     385-426: Missing.
     650-672: CKPAGSRSRSSSLSLTVESALES → DAKHLEDQRLNDAASRMEITEGE
     673-1078: Missing.

Show »
Length:605
Mass (Da):67,177
Checksum:i05CFCB94CEB87FB6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6PW28A6PW28_MOUSE
Rho family-interacting cell polariz...
Ripor2 Fam65b, RP23-461O24.1
1,053Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8MPY8A0A5F8MPY8_MOUSE
Rho family-interacting cell polariz...
Ripor2
639Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3V4F2Z3V4_MOUSE
Rho family-interacting cell polariz...
Ripor2 Fam65b
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC65551 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti534R → S in BAC65551 (PubMed:12693553).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0259071 – 25Missing in isoform 7. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0259081 – 16MPPGT…GAFSA → MQFLDPEDLLDEEDDIFGE in isoform 5 and isoform 6. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_025909385 – 426Missing in isoform 5, isoform 6 and isoform 7. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_025910385 – 389RWLRL → VGNGT in isoform 3. 1 Publication5
Alternative sequenceiVSP_025911385 – 388RWLR → VSSV in isoform 4. 1 Publication4
Alternative sequenceiVSP_025912389 – 1078Missing in isoform 4. 1 PublicationAdd BLAST690
Alternative sequenceiVSP_025913390 – 1078Missing in isoform 3. 1 PublicationAdd BLAST689
Alternative sequenceiVSP_025914650 – 672CKPAG…SALES → DAKHLEDQRLNDAASRMEIT EGE in isoform 2, isoform 5 and isoform 7. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_025915650 – 668CKPAG…LTVES → VSTFLGKKKKSDLVWKNAS in isoform 6. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_025916669 – 1078Missing in isoform 6. 1 PublicationAdd BLAST410
Alternative sequenceiVSP_025917673 – 1078Missing in isoform 2, isoform 5 and isoform 7. 1 PublicationAdd BLAST406

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK122269 mRNA Translation: BAC65551.1 Different initiation.
AK031928 mRNA Translation: BAC27606.1
AK036452 mRNA Translation: BAC29436.1
AK039271 mRNA Translation: BAC30301.1
AK040887 mRNA Translation: BAC30732.1
AK041665 mRNA Translation: BAC31025.1
AK163880 mRNA Translation: BAE37527.1
AL591851, AL513014 Genomic DNA Translation: CAI25708.2
AL513014, AL589699 Genomic DNA Translation: CAI25774.2
AL513014, AL591851 Genomic DNA Translation: CAI25775.2
AL589699, AL513014 Genomic DNA Translation: CAI26080.2
AL513014 Genomic DNA Translation: CAO77914.1
AL513014, AL589699 Genomic DNA Translation: CAO77916.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS26377.2 [Q80U16-5]
CCDS36622.1 [Q80U16-1]
CCDS36623.1 [Q80U16-2]

NCBI Reference Sequences

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RefSeqi
NP_001073850.1, NM_001080381.1 [Q80U16-2]
NP_001273029.1, NM_001286100.1
NP_001273030.1, NM_001286101.1 [Q80U16-7]
NP_083955.1, NM_029679.2 [Q80U16-1]
NP_848773.3, NM_178658.5 [Q80U16-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000038477; ENSMUSP00000043663; ENSMUSG00000036006 [Q80U16-2]
ENSMUST00000058009; ENSMUSP00000051342; ENSMUSG00000036006 [Q80U16-3]
ENSMUST00000091694; ENSMUSP00000089286; ENSMUSG00000036006 [Q80U16-5]
ENSMUST00000110384; ENSMUSP00000106013; ENSMUSG00000036006 [Q80U16-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
193385

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:193385

UCSC genome browser

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UCSCi
uc007pwa.2, mouse [Q80U16-6]
uc007pwb.2, mouse [Q80U16-5]
uc007pwc.1, mouse [Q80U16-4]
uc007pwd.1, mouse [Q80U16-2]
uc007pwe.1, mouse [Q80U16-1]
uc011yxo.2, mouse [Q80U16-7]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122269 mRNA Translation: BAC65551.1 Different initiation.
AK031928 mRNA Translation: BAC27606.1
AK036452 mRNA Translation: BAC29436.1
AK039271 mRNA Translation: BAC30301.1
AK040887 mRNA Translation: BAC30732.1
AK041665 mRNA Translation: BAC31025.1
AK163880 mRNA Translation: BAE37527.1
AL591851, AL513014 Genomic DNA Translation: CAI25708.2
AL513014, AL589699 Genomic DNA Translation: CAI25774.2
AL513014, AL591851 Genomic DNA Translation: CAI25775.2
AL589699, AL513014 Genomic DNA Translation: CAI26080.2
AL513014 Genomic DNA Translation: CAO77914.1
AL513014, AL589699 Genomic DNA Translation: CAO77916.1
CCDSiCCDS26377.2 [Q80U16-5]
CCDS36622.1 [Q80U16-1]
CCDS36623.1 [Q80U16-2]
RefSeqiNP_001073850.1, NM_001080381.1 [Q80U16-2]
NP_001273029.1, NM_001286100.1
NP_001273030.1, NM_001286101.1 [Q80U16-7]
NP_083955.1, NM_029679.2 [Q80U16-1]
NP_848773.3, NM_178658.5 [Q80U16-5]

3D structure databases

SMRiQ80U16
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi228735, 2 interactors
STRINGi10090.ENSMUSP00000106013

PTM databases

iPTMnetiQ80U16
PhosphoSitePlusiQ80U16

Proteomic databases

EPDiQ80U16
jPOSTiQ80U16
PaxDbiQ80U16
PRIDEiQ80U16

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25358, 162 antibodies

Genome annotation databases

EnsembliENSMUST00000038477; ENSMUSP00000043663; ENSMUSG00000036006 [Q80U16-2]
ENSMUST00000058009; ENSMUSP00000051342; ENSMUSG00000036006 [Q80U16-3]
ENSMUST00000091694; ENSMUSP00000089286; ENSMUSG00000036006 [Q80U16-5]
ENSMUST00000110384; ENSMUSP00000106013; ENSMUSG00000036006 [Q80U16-1]
GeneIDi193385
KEGGimmu:193385
UCSCiuc007pwa.2, mouse [Q80U16-6]
uc007pwb.2, mouse [Q80U16-5]
uc007pwc.1, mouse [Q80U16-4]
uc007pwd.1, mouse [Q80U16-2]
uc007pwe.1, mouse [Q80U16-1]
uc011yxo.2, mouse [Q80U16-7]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9750
MGIiMGI:2444879, Ripor2

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG502QQ7T, Eukaryota
GeneTreeiENSGT00940000153717
HOGENOMiCLU_432085_0_0_1
InParanoidiQ80U16
OrthoDBi1121546at2759
PhylomeDBiQ80U16
TreeFamiTF329332

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
193385, 0 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Fam65b, mouse

Protein Ontology

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PROi
PR:Q80U16
RNActiQ80U16, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036006, Expressed in blood and 269 other tissues
GenevisibleiQ80U16, MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR031780, FAM65_N
IPR033035, FAM65B
IPR026136, RIPOR3
PANTHERiPTHR15829, PTHR15829, 1 hit
PTHR15829:SF2, PTHR15829:SF2, 1 hit
PfamiView protein in Pfam
PF15903, PL48, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIPR2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80U16
Secondary accession number(s): A6PW01
, A6PW03, Q3TQ58, Q5SY29, Q5SZV4, Q5T0J1, Q8BIM7, Q8BJ19, Q8BJ22, Q8BJ32, Q8BJ54
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: December 2, 2020
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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