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UniProtKB - Q80U12 (SGSM2_MOUSE)

Entry version 118 (07 Oct 2020)
Sequence version 2 (17 Apr 2007)
Previous versions | rss
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Protein

Small G protein signaling modulator 2

Gene

Sgsm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • Rab GTPase binding Source: MGI
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Small G protein signaling modulator 2
Alternative name(s):
RUN and TBC1 domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sgsm2
Synonyms:Kiaa0397, Rutbc1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2144695, Sgsm2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002846631 – 1005Small G protein signaling modulator 2Add BLAST1005

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei402PhosphoserineCombined sources1
Isoform 2 (identifier: Q80U12-2)
Modified residuei444PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q80U12

PeptideAtlas

More...PeptideAtlasi		Q80U12

PRoteomics IDEntifications database

More...PRIDEi		Q80U12

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q80U12

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q80U12

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000038351, Expressed in brain and 226 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q80U12, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAB4A, RAB11A, RAP1A, RAP1B, RAP2A and RAP2B. No interaction with RAB27A.

Interacts with RAB9A (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		220852, 3 interactors

Database of interacting proteins

More...DIPi		DIP-61071N

Protein interaction database and analysis system

More...IntActi		Q80U12, 2 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000050496

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q80U12, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q80U12

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 191RUNPROSITE-ProRule annotationAdd BLAST158
Domaini566 – 938Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST373

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Rab-GAP TBC domain possesses GTPase activator activity.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RUTBC family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1648, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159315

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006235_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q80U12

KEGG Orthology (KO)

More...KOi		K21851

Identification of Orthologs from Complete Genome Data

More...OMAi		FLATHPI

Database of Orthologous Groups

More...OrthoDBi		171826at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q80U12

TreeFam database of animal gene trees

More...TreeFami		TF318216

Family and domain databases

Conserved Domains Database

More...CDDi		cd15784, PH_RUTBC, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.58.900, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf
IPR004012, Run_dom
IPR037213, Run_dom_sf
IPR037745, SGSM1/2
IPR021935, SGSM1/2_RBD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12068, PH_RBD, 1 hit
PF00566, RabGAP-TBC, 1 hit
PF02759, RUN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00593, RUN, 1 hit
SM00164, TBC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF140741, SSF140741, 1 hit
SSF47923, SSF47923, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50826, RUN, 1 hit
PS50086, TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q80U12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSAEDAVKE KLLWNVKKEV KQIMEEAVTR KFVHEDSSHI IALCGAVEAC 
        60         70         80         90        100
LLHQLRRRAA GFLRSDKMAA LFTKVGKTCP VAEDICHKVQ ELQQQAEGRK 
       110        120        130        140        150
PSGGSQEALR KQGSTGGKAP ALSPQALKHI WVRTALMEKV LDRVVQYLAE 
       160        170        180        190        200
NCSKYYEKEA LLADPVFGPI LACLLVGPCA LEYTKLKTAD HYWTDPSADE 
       210        220        230        240        250
LVQRHRIRGP PNRQDSPAKR PALGIRKRHS SGSASEDRLA ACAREYVESL 
       260        270        280        290        300
HQNSRTRLLY GKNNVLVQPK EDMEAVPGYL SLHQSAENLT LKWTPNQLMN 
       310        320        330        340        350
GTLGDSELEK SVYWDYALVV PFSQIVCIHC HQQKSGGTLV LVSQDGIQRP 
       360        370        380        390        400
PLHFPQGGHL LSFLSCLENG LLPRGQLEPP LWTQQGKGKV FPKLRKRSSI 
       410        420        430        440        450
RSIDVEELGV GRATDYVFRI IYPGHRHEHN AGDMIEMQGF GPSLTAWHLE 
       460        470        480        490        500
PLCSQGSSCL SCSSSSSPYA TPSHCSCIPD RLPLRLLCES MKRQIVSRAF 
       510        520        530        540        550
YGWLAYCRHL STVRTHLSAL VHHNIIPPDR PPGASGGLTK DVWSKYQKDE 
       560        570        580        590        600
KNYKELELLR QVYYGGVEHE IRKDVWPFLL GHYKFGMSKK EMEQVDTAVA 
       610        620        630        640        650
ARYQQVLAEW KACEVVVRQR EREAHPATLT KFSSGSSIDS HVQRLVHRDS 
       660        670        680        690        700
TISNDVFISV DDLEPSGPQD LEDSKPKREQ EPGAGTPGIA AAEQQSVEFD 
       710        720        730        740        750
SPDSGLPSSR NYSVASGIQS SLDEAQSVGF EDDGAGEDGS EGPATAAHTF 
       760        770        780        790        800
PGPHDPGQET LAPASELEAG QELAAVCAAA YTIELLDTVA LNLHRIDKDV 
       810        820        830        840        850
QRCDRNYWYF TTSNLERLRD IMCSYVWEHL DMGYVQGMCD LLAPLLVILD 
       860        870        880        890        900
NDQLAYSCFS HLMKRMGQNF PSGGAMDSHF ANMRSLIQIL DSELFELMHQ 
       910        920        930        940        950
NGDYTHFYFC YRWFLLDFKR ELLYEDVFAV WEVIWAARRI SSEHFVLFIA 
       960        970        980        990       1000
LALVEAYREI IRDNNMDFTD IIKFFNERAE RHDAQEILRI ARDLVHKVQM 

LIDNK
Length:1,005
Mass (Da):113,076
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5902EC20348D031F
GO
Isoform 2 (identifier: Q80U12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     430-430: N → ITINYHHLAASRAASVDDDEEEEDKLHAMLSMICSRNLTAPNPMKD

Show »
Length:1,050
Mass (Da):118,099
Checksum:i237DCC61FD8EDD69
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH58414 differs from that shown. Reason: Frameshift.Curated
The sequence AAH60163 differs from that shown. Reason: Frameshift.Curated
The sequence BAC65555 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024599430N → ITINYHHLAASRAASVDDDE EEEDKLHAMLSMICSRNLTA PNPMKD in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK122273 mRNA Translation: BAC65555.1 Different initiation.
AL604066 Genomic DNA No translation available.
BC058414 mRNA Translation: AAH58414.1 Frameshift.
BC060163 mRNA Translation: AAH60163.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS36224.1 [Q80U12-1]
CCDS88189.1 [Q80U12-2]

NCBI Reference Sequences

More...RefSeqi		NP_922934.2, NM_197943.2 [Q80U12-1]
XP_006534644.1, XM_006534581.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000057631; ENSMUSP00000050496; ENSMUSG00000038351 [Q80U12-1]
ENSMUST00000081799; ENSMUSP00000080489; ENSMUSG00000038351 [Q80U12-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		97761

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:97761

UCSC genome browser

More...UCSCi		uc007kck.1, mouse [Q80U12-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122273 mRNA Translation: BAC65555.1 Different initiation.
AL604066 Genomic DNA No translation available.
BC058414 mRNA Translation: AAH58414.1 Frameshift.
BC060163 mRNA Translation: AAH60163.1 Frameshift.
CCDSiCCDS36224.1 [Q80U12-1]
CCDS88189.1 [Q80U12-2]
RefSeqiNP_922934.2, NM_197943.2 [Q80U12-1]
XP_006534644.1, XM_006534581.3

3D structure databases

SMRiQ80U12
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi220852, 3 interactors
DIPiDIP-61071N
IntActiQ80U12, 2 interactors
STRINGi10090.ENSMUSP00000050496

PTM databases

iPTMnetiQ80U12
PhosphoSitePlusiQ80U12

Proteomic databases

PaxDbiQ80U12
PeptideAtlasiQ80U12
PRIDEiQ80U12

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10736, 80 antibodies

Genome annotation databases

EnsembliENSMUST00000057631; ENSMUSP00000050496; ENSMUSG00000038351 [Q80U12-1]
ENSMUST00000081799; ENSMUSP00000080489; ENSMUSG00000038351 [Q80U12-2]
GeneIDi97761
KEGGimmu:97761
UCSCiuc007kck.1, mouse [Q80U12-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9905
MGIiMGI:2144695, Sgsm2

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG1648, Eukaryota
GeneTreeiENSGT00940000159315
HOGENOMiCLU_006235_0_0_1
InParanoidiQ80U12
KOiK21851
OMAiFLATHPI
OrthoDBi171826at2759
PhylomeDBiQ80U12
TreeFamiTF318216

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		97761, 2 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Sgsm2, mouse

Protein Ontology

More...PROi		PR:Q80U12
RNActiQ80U12, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000038351, Expressed in brain and 226 other tissues
GenevisibleiQ80U12, MM

Family and domain databases

CDDicd15784, PH_RUTBC, 1 hit
Gene3Di1.20.58.900, 1 hit
InterProiView protein in InterPro
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf
IPR004012, Run_dom
IPR037213, Run_dom_sf
IPR037745, SGSM1/2
IPR021935, SGSM1/2_RBD
PfamiView protein in Pfam
PF12068, PH_RBD, 1 hit
PF00566, RabGAP-TBC, 1 hit
PF02759, RUN, 1 hit
SMARTiView protein in SMART
SM00593, RUN, 1 hit
SM00164, TBC, 1 hit
SUPFAMiSSF140741, SSF140741, 1 hit
SSF47923, SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50826, RUN, 1 hit
PS50086, TBC_RABGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSGSM2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80U12
Secondary accession number(s): Q5SWE0, Q5SWE1, Q6PAP8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: October 7, 2020
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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