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Protein

CLIP-associating protein 1

Gene

Clasp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
CLIP-associating protein 1
Alternative name(s):
Cytoplasmic linker-associated protein 1
Gene namesi
Name:Clasp1
Synonyms:Kiaa0622
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1923957 Clasp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Golgi apparatus, Kinetochore, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002722741 – 1535CLIP-associating protein 1Add BLAST1535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei246PhosphoserineCombined sources1
Modified residuei545PhosphoserineCombined sources1
Modified residuei548PhosphoserineCombined sources1
Modified residuei558PhosphoserineBy similarity1
Modified residuei559PhosphoserineBy similarity1
Modified residuei568PhosphoserineBy similarity1
Modified residuei600PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei646PhosphoserineBy similarity1
Modified residuei647PhosphoserineBy similarity1
Modified residuei649PhosphoserineBy similarity1
Modified residuei656PhosphothreonineBy similarity1
Modified residuei684PhosphoserineBy similarity1
Modified residuei688PhosphoserineCombined sources1
Modified residuei695PhosphoserineBy similarity1
Modified residuei702PhosphoserineBy similarity1
Modified residuei708PhosphothreonineBy similarity1
Modified residuei711PhosphoserineBy similarity1
Modified residuei784PhosphoserineBy similarity1
Modified residuei794PhosphoserineBy similarity1
Modified residuei820PhosphoserineCombined sources1
Modified residuei1088PhosphoserineCombined sources1
Modified residuei1092PhosphothreonineCombined sources1
Modified residuei1096PhosphothreonineBy similarity1
Modified residuei1110PhosphoserineCombined sources1
Modified residuei1193PhosphoserineBy similarity1
Modified residuei1220PhosphoserineCombined sources1
Isoform 2 (identifier: Q80TV8-2)
Modified residuei1139PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80TV8
PaxDbiQ80TV8
PeptideAtlasiQ80TV8
PRIDEiQ80TV8

PTM databases

iPTMnetiQ80TV8
PhosphoSitePlusiQ80TV8
SwissPalmiQ80TV8

Expressioni

Tissue specificityi

Highly expressed in brain and heart and at lower levels in kidney, lung, skeletal muscle and testis.1 Publication

Gene expression databases

CleanExiMM_CLASP1

Interactioni

Subunit structurei

Interacts with ERC1, MAPRE1, MAPRE3, microtubules, and PHLDB2. The interaction with ERC1 may be mediated by PHLDB2. Interacts with GCC2; recruits CLASP1 to Golgi membranes (By similarity). Interacts with CLIP2 and RSN. Interacts with MACF1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Clip2O551563EBI-908322,EBI-349416From Rattus norvegicus.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218270, 11 interactors
IntActiQ80TV8, 12 interactors
MINTiQ80TV8
STRINGi10090.ENSMUSP00000042266

Structurei

3D structure databases

ProteinModelPortaliQ80TV8
SMRiQ80TV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati87 – 124HEAT 1Add BLAST38
Repeati163 – 200HEAT 2Add BLAST38
Repeati405 – 440HEAT 3Add BLAST36
Repeati441 – 477HEAT 4Add BLAST37
Repeati971 – 1008HEAT 5Add BLAST38
Repeati1339 – 1376HEAT 6Add BLAST38
Repeati1457 – 1494HEAT 7Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni662 – 782Interaction with microtubules, MAPRE1 and MAPRE3By similarityAdd BLAST121
Regioni1251 – 1535Interaction with CLIP2 and RSN1 PublicationAdd BLAST285
Regioni1251 – 1535Interaction with PHLDB2By similarityAdd BLAST285
Regioni1253 – 1535Localization to kinetochoresBy similarityAdd BLAST283

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1296 – 1327Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi530 – 762Ser-richAdd BLAST233

Sequence similaritiesi

Belongs to the CLASP family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG2956 Eukaryota
ENOG410ZMY0 LUCA
HOVERGENiHBG079692
InParanoidiQ80TV8
KOiK16578
PhylomeDBiQ80TV8

Family and domain databases

Gene3Di1.25.10.10, 4 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR028399 CLASP_1
IPR024395 CLASP_N_dom
IPR021133 HEAT_type_2
IPR034085 TOG
PANTHERiPTHR21567:SF28 PTHR21567:SF28, 1 hit
PfamiView protein in Pfam
PF12348 CLASP_N, 2 hits
SMARTiView protein in SMART
SM01349 TOG, 4 hits
SUPFAMiSSF48371 SSF48371, 5 hits
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 17 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q80TV8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPRMESCLA QVLQKDVGKR LQVGQELIDY FSDRQKSADL EHDQTLLDKL
60 70 80 90 100
VDGLATSWVN SSNYKVVLLG MDILSALVTR LQDRFKAQIG TVLPSLIDRL
110 120 130 140 150
GDAKDSVREQ DQTLLLKIMD QAANPQYVWD RMLGGFKHKN FRTREGICLC
160 170 180 190 200
LIATLNASGA QTLTLSKIVP HICNLLGDPN SQVRDAAINS LVEIYRHVGE
210 220 230 240 250
RVRADLSKKG LPQSRLNVIF TKFDEVQKSG NMIQSANEKN FDDEDSVDGN
260 270 280 290 300
RPSSASSSSS KAPSSSRRNV NLGTTRRLMS SSLGSKSSAA KEGAGAVDEE
310 320 330 340 350
DFIKAFDDVP VVQIYSSRDL EESINKIREI LSDDKHDWEQ RVNALKKIRS
360 370 380 390 400
LLLAGAAEYD NFFQHLRLLD GAFKLSAKDL RSQVVREACI TLGHLSSVLG
410 420 430 440 450
NKFDHGAEAI MPTIFNLIPN SAKIMATSGV VAVRLIIRHT HIPRLIPVIT
460 470 480 490 500
SNCTSKSVAV RRRCFEFLDL LLQEWQTHSL ERHISVLAET IKKGIHDADS
510 520 530 540 550
EARIEARKCY WGFHSHFSRE AEHLYHTLES SYQKALQSHL KNSDSIVSLP
560 570 580 590 600
QSDRSSSSSQ ESLNRPLSAK RSPTGSTASR GSTVSTKSVS TTGSLQRSRS
610 620 630 640 650
DIDVNAAASA KSKVSSSSGS PAFSSAAALP PGSYASLGRI RTRRQSSGST
660 670 680 690 700
TNVASTPDSR GRSRAKVVSQ SQRSRSANPA GAGSRSSSPG KLLGSGLAGG
710 720 730 740 750
SSRGPPVTPS SEKRSKIPRS QGCSRETSPN RIGLARSSRI PRPSMSQGCS
760 770 780 790 800
RDTSRESSRD TSPARGFTPL DRFGLGQSGR IPGSVNAMRV LSTSTDLEAA
810 820 830 840 850
VADALKKPVR RRYEPYGMYS DDDANSDASS VCSERSYGSR NGGIPHYLRQ
860 870 880 890 900
TEDVAEVLNH CASSNWSERK EGLLGLQNLL KSQRTLSRVE LKRLCEIFTR
910 920 930 940 950
MFADPHSKRV FSMFLETLVD FIIIHKDDLQ DWLFVLLTQL LKKMGADLLG
960 970 980 990 1000
SVQAKVQKAL DVTRDSFPFD QQFNILMRFI VDQTQTPNLK VKVAILKYIE
1010 1020 1030 1040 1050
SLARQMDPTD FVNSSETRLA VSRIITWTTE PKSSDVRKAA QIVLISLFEL
1060 1070 1080 1090 1100
NTPEFTMLLG ALPKTFQDGA TKLLHNHLKN SSNTGVGSPS NTIGRTPSRH
1110 1120 1130 1140 1150
PSSRTSPLTS PTNCSHGGLS PSRLWGWSAD GLSKPPPPFS QPNSIPTAPS
1160 1170 1180 1190 1200
HKTLRRSYSP SMLDYDTENL NSEEIYSSLR GVTEAIEKFS FRSQEDLNEP
1210 1220 1230 1240 1250
IKRDGKKDCD IVSRDGGAAS PATEGRGGSE IEGGRMALDN KTSLLNTQPP
1260 1270 1280 1290 1300
RAFPGPRARE YNPYPYSDTI NTYDKTALKE AVFDDDMEQL RDVPIDHSDL
1310 1320 1330 1340 1350
VADLLKELSN HNERVEERKG ALLELLKITR EDSLGVWEEH FKTILLLLLE
1360 1370 1380 1390 1400
TLGDKDHSIR ALALRVLREI LRNQPARFKN YAELTIMKTL EAHKDSHKEV
1410 1420 1430 1440 1450
VRAAEEAAST LASSIHPEQC IKVLCPIIQT ADYPINLAAI KMQTKVVERI
1460 1470 1480 1490 1500
TKESLLQLLV DIIPGLLQGY DNTESSVRKA SVFCLVAIYS VIGEDLKPHL
1510 1520 1530
AQLTGSKMKL LNLYIKRAQT TNSNSSSSSD VSTHS
Length:1,535
Mass (Da):169,227
Last modified:January 23, 2007 - v2
Checksum:i5EE40CCE493C64D2
GO
Isoform 2 (identifier: Q80TV8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     770-770: L → LASRRHSRSTSALSTAESVGQS
     805-805: L → LLLGDARSK
     1120-1158: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:1,525
Mass (Da):167,939
Checksum:iCA1BA686C4C8CB03
GO

Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WQF1A0A087WQF1_MOUSE
CLIP-associating protein 1
Clasp1
1,468Annotation score:
A0A087WQ31A0A087WQ31_MOUSE
CLIP-associating protein 1
Clasp1
1,552Annotation score:
E9Q6L0E9Q6L0_MOUSE
CLIP-associating protein 1
Clasp1
1,452Annotation score:
A0A087WRK0A0A087WRK0_MOUSE
CLIP-associating protein 1
Clasp1
1,477Annotation score:
A0A087WS18A0A087WS18_MOUSE
CLIP-associating protein 1
Clasp1
1,460Annotation score:
A0A087WRE8A0A087WRE8_MOUSE
CLIP-associating protein 1
Clasp1
1,526Annotation score:
E9QNY9E9QNY9_MOUSE
CLIP-associating protein 1
Clasp1
1,526Annotation score:
J3QP81J3QP81_MOUSE
CLIP-associating protein 1
Clasp1
1,459Annotation score:
E9QKH0E9QKH0_MOUSE
CLIP-associating protein 1
Clasp1
1,536Annotation score:
A0A087WQ95A0A087WQ95_MOUSE
CLIP-associating protein 1
Clasp1
1,469Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence BAB24639 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC38020 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1231I → K in BAB24639 (PubMed:16141072).Curated1
Sequence conflicti1417P → S in AAH75708 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022390770L → LASRRHSRSTSALSTAESVG QS in isoform 2. 2 Publications1
Alternative sequenceiVSP_022391805L → LLLGDARSK in isoform 2. 2 Publications1
Alternative sequenceiVSP_0223921120 – 1158Missing in isoform 2. 2 PublicationsAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC109294 Genomic DNA No translation available.
AC131804 Genomic DNA No translation available.
AC136636 Genomic DNA No translation available.
AJ276962 mRNA Translation: CAC35162.1
AJ288061 mRNA Translation: CAC35163.1
AK006534 mRNA Translation: BAB24639.2 Different initiation.
AK080782 mRNA Translation: BAC38020.1 Sequence problems.
AK122330 mRNA Translation: BAC65612.1
BC057312 mRNA Translation: AAH57312.1
BC075708 mRNA Translation: AAH75708.1
BC094554 mRNA Translation: AAH94554.1
RefSeqiNP_001280229.1, NM_001293300.1
NP_001280230.1, NM_001293301.1
NP_083985.2, NM_029709.2
UniGeneiMm.138740

Genome annotation databases

GeneIDi76707
KEGGimmu:76707

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCLAP1_MOUSE
AccessioniPrimary (citable) accession number: Q80TV8
Secondary accession number(s): Q505G6
, Q6DI75, Q6PG14, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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