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Entry version 131 (07 Oct 2020)
Sequence version 2 (01 Mar 2004)
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Protein

Cullin-9

Gene

Cul9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1409Zinc 1PROSITE-ProRule annotation1
Metal bindingi1412Zinc 1PROSITE-ProRule annotation1
Metal bindingi1427Zinc 2PROSITE-ProRule annotation1
Metal bindingi1429Zinc 2; via pros nitrogenPROSITE-ProRule annotation1
Metal bindingi1432Zinc 1PROSITE-ProRule annotation1
Metal bindingi1435Zinc 1PROSITE-ProRule annotation1
Metal bindingi1454Zinc 2PROSITE-ProRule annotation1
Metal bindingi1459Zinc 2PROSITE-ProRule annotation1
Metal bindingi1499Zinc 3PROSITE-ProRule annotation1
Metal bindingi1505Zinc 3PROSITE-ProRule annotation1
Metal bindingi1520Zinc 3PROSITE-ProRule annotation1
Metal bindingi1523Zinc 3PROSITE-ProRule annotation1
Metal bindingi1528Zinc 4PROSITE-ProRule annotation1
Metal bindingi1531Zinc 4PROSITE-ProRule annotation1
Metal bindingi1537Zinc 4; via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi1542Zinc 4PROSITE-ProRule annotation1
Metal bindingi1575Zinc 5PROSITE-ProRule annotation1
Metal bindingi1578Zinc 5PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1588PROSITE-ProRule annotation1
Metal bindingi1593Zinc 5PROSITE-ProRule annotation1
Metal bindingi1596Zinc 5PROSITE-ProRule annotation1
Metal bindingi1601Zinc 6PROSITE-ProRule annotation1
Metal bindingi1604Zinc 6PROSITE-ProRule annotation1
Metal bindingi1612Zinc 6; via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi1618Zinc 6PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi700 – 707ATPSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1409 – 1459RING-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri1479 – 1542IBR-typePROSITE-ProRule annotationAdd BLAST64
Zinc fingeri1575 – 1604RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8951664, Neddylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cullin-9
Short name:
CUL-9
Alternative name(s):
p53-associated parkin-like cytoplasmic protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cul9
Synonyms:Kiaa0708, Parc
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1925559, Cul9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice were born at the expected Mendelian ratio and do not show apparent phenotype. They are however more susceptible to carcinogenesis and develop spontaneous tumor. Cells display polyploidy and aneuploidy.3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001198161 – 1865Cullin-9Add BLAST1865

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei313PhosphoserineBy similarity1
Modified residuei794PhosphoserineBy similarity1
Modified residuei1775PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80TT8

PeptideAtlas

More...
PeptideAtlasi
Q80TT8

PRoteomics IDEntifications database

More...
PRIDEi
Q80TT8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a Cul9-RING complex at least composed of CUL9 and RBX1.

Interacts with CUL7: interaction with CUL7 component of the 3M complex leads to inhibition of CUL9 activity. The CUL7-CUL9 heterodimer seems to interact specifically with TP53.

Forms a complex with p53/TP53 in the cytoplasm of unstressed cells.

Interacts with UBCH7 and UBCH8 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000138418

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q80TT8, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini480 – 659DOCPROSITE-ProRule annotationAdd BLAST180

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1405 – 1622TRIAD supradomainPROSITE-ProRule annotationAdd BLAST218

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1794 – 1835Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1426 – 1435Cys-rich10
Compositional biasi1800 – 1862Glu-richAdd BLAST63

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The IBR domain is required for interaction with UBCH7 and UBCH8.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cullin family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1409 – 1459RING-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri1479 – 1542IBR-typePROSITE-ProRule annotationAdd BLAST64
Zinc fingeri1575 – 1604RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1815, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80TT8

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80TT8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR016024, ARM-type_fold
IPR031222, CUL9
IPR016157, Cullin_CS
IPR016158, Cullin_homology
IPR036317, Cullin_homology_sf
IPR019559, Cullin_neddylation_domain
IPR008979, Galactose-bd-like_sf
IPR002867, IBR_dom
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

The PANTHER Classification System

More...
PANTHERi
PTHR22771:SF2, PTHR22771:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03256, ANAPC10, 1 hit
PF01485, IBR, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01337, APC10, 1 hit
SM00884, Cullin_Nedd8, 1 hit
SM00647, IBR, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF49785, SSF49785, 1 hit
SSF75632, SSF75632, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01256, CULLIN_1, 1 hit
PS50069, CULLIN_2, 1 hit
PS51284, DOC, 1 hit
PS51873, TRIAD, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80TT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARALRGPGP RSSLDQHVAA VLATVQISSL DTNLQLSGLC ALSQAVEEVT
60 70 80 90 100
ERDHPLVRPD RPLREKLVKT LVDLLTNQVG EKMVVVMALR LLYLLMTKHE
110 120 130 140 150
WRPLFAREGG IYAVLICMQE YKTSVLVQQA GLAALKMLAI ANSSDVPTFI
160 170 180 190 200
PSRDSIQPLF DTQMTREIFA SIDSATRPGS ESLLLSVPAA VVLMLNTEGC
210 220 230 240 250
SSAVRNGLLL LNLLLCNHHT LGDQIITQEL RDTLFRHSGI APGTEPMPTT
260 270 280 290 300
RTILTMLLSR YSEPRGSPER AVLETPSTQG QDGSPESLIR SLVGDLSAEL
310 320 330 340 350
FLDLERVLCH EGSPPAAVRP LLRRLQQETQ PFLLLLRTLD APGPNRTLLL
360 370 380 390 400
TILRVMTRLL DHPETMVLPW HEVLEPCLNC LNGPSSDSEV VQEVTCFLHR
410 420 430 440 450
LALMQKDYAV VLCCLGGKEA LSKVLDKHST QLLLASELRH LVAECEKYSQ
460 470 480 490 500
LCSNLTSSIL AGCIQMVLGQ IEDHRRTYKP ITIPFFDVFL RHLCQGSSVE
510 520 530 540 550
VKEDRCWEKV EVSSNPHRAS KLTDRNPKTY WESNGSTGSH SITLHMHRGV
560 570 580 590 600
LIRQLTLLVA SEDSSYMPAR VVVFGGDNVG CISTELNTVN VMPSASRVTL
610 620 630 640 650
LENLTRFWPI IQIRIKRCQQ GGIDTRVRGV EVLGPKPTFW PLFREQLCRR
660 670 680 690 700
TCLFYTIRAQ AWSRDIAEDR QRLLQLYPRL NRVLRHEQNF ADRFLPDDEA
710 720 730 740 750
AQALGKTCWE ALVSPLVQNI TSPDAGGVSS LGWLLDQYLE HRESTRSRQG
760 770 780 790 800
PAASFASQVR RLCHLLVHVE APPGPSPEPS SQPLSKNSKG QDGSPTPAPT
810 820 830 840 850
PVCPSTSLRN LTQCWLSVVQ GQVSRFLAAA WRASDFVPRY CSLYQRLQSA
860 870 880 890 900
GSELFGPRAA FTLALRSGFS GALLQQSFLT AAHISEQFAR HIDQQIHGGL
910 920 930 940 950
LGGAAGVGML GRLQRHLEPI MVLSGLELAT TFEHFYQHYM ADRLLSLGSS
960 970 980 990 1000
WLEGAVLEQI GPCFPNRLPQ LMLQSLHTSE ELQHRFHLFQ LQQLDRQLLE
1010 1020 1030 1040 1050
QGDQEEWRPE KVEEDDEGQE TGRELFTDPG PAISVLVLSP RCWPVSPLCY
1060 1070 1080 1090 1100
LHHPRKHLQA ELCDALERFS SFYSHSQNCP VLDIGPHRRL QWTWLGRAEL
1110 1120 1130 1140 1150
QLGDQTLHVS LNTVQMWLLF NQSEEVSVET LLRNSDLSPE LLHQALLPLT
1160 1170 1180 1190 1200
SDNGPLTLEE TQDYPQGGVL RLREPRSQTH EEFLWLIPPQ TYLSVEKDEG
1210 1220 1230 1240 1250
RTLEQKRNLL SCLLVRILKA HREKGLHIDQ LVCLVLEAWQ KGPDPPGRLG
1260 1270 1280 1290 1300
NAAAVGVACS STDVLSCILH LLGQGYVERR DDRPQVLMYA TPEPMGPCRG
1310 1320 1330 1340 1350
QADVPFCGNK NTETSRPSPE AVVALASLQL PAGRTMSPQE VEGLMEQTVR
1360 1370 1380 1390 1400
QVQETLNLEP DVAQHLLAHS HWGTEQLLQS YSDDPEPLLL AAGLRVPQAQ
1410 1420 1430 1440 1450
VVPTRPDQCP VCVTPLGPHD DSPSLCCLHC CCKSCWNEYL TTRIEQNFVL
1460 1470 1480 1490 1500
NCTCPIADCP AQPTGAFIRN IVSSPEVISK YEKALLRGYV ESCSNLTWCT
1510 1520 1530 1540 1550
NPQGCDRILC RQGLGSGTTC SKCGWASCFS CSFPEAHYPA SCGHMSQWVD
1560 1570 1580 1590 1600
DGGYYDGMSV EAQSKHLAKL ISKRCPSCQA PIEKNEGCLH MTCARCNHGF
1610 1620 1630 1640 1650
CWRCLKSWKP SHKDYYNCSA MVSKAARQEK RFQDYNERCT FHHQAREFAV
1660 1670 1680 1690 1700
NLRNQASAIQ EVPPPKSFTF LQDACRALEQ ARKVLAYACV YSFYSQDTEY
1710 1720 1730 1740 1750
MDVVEQQTEN LELHTNALQI LLEETLLRCR DLASSLRFLR ADCLSTGTEL
1760 1770 1780 1790 1800
LRRIQERLLA ILQHSTQDFR VGLQSPSVET REVKGSNVPS DQPQGSSGLE
1810 1820 1830 1840 1850
VEDEEEEEEE EEEEEEEEEE DVPEWQHEFD EELDNDSFSY DEESENLDRE
1860
TFFFGDEDED DESYD
Length:1,865
Mass (Da):209,160
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9956A32BE5BC5803
GO
Isoform 2 (identifier: Q80TT8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-908: Missing.

Show »
Length:957
Mass (Da):108,659
Checksum:i7344868C43F23A9B
GO
Isoform 3 (identifier: Q80TT8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-144: ALKMLAIANSS → VSTLGRAGQSD
     145-1865: Missing.

Show »
Length:144
Mass (Da):15,833
Checksum:i6975CFF80F6A72D9
GO
Isoform 4 (identifier: Q80TT8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     944-1009: LLSLGSSWLE...EQGDQEEWRP → RLEENSLQTQ...VRSWGQEAGA
     1010-1865: Missing.

Show »
Length:1,009
Mass (Da):111,882
Checksum:i85D860EC1C6BA8D4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R1Y1S4R1Y1_MOUSE
Cullin-9
Cul9
2,530Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QP09E9QP09_MOUSE
Cullin-9
Cul9
2,520Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AK051474 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1102L → F in AK051474 (PubMed:16141072).Curated1
Sequence conflicti1104 – 1119Missing in BAC65633 (PubMed:12693553).CuratedAdd BLAST16
Sequence conflicti1111 – 1119LNTVQMWLL → TVQMWLLLN in AK051474 (PubMed:16141072).Curated9
Sequence conflicti1183F → V in AK051474 (PubMed:16141072).Curated1
Sequence conflicti1592T → N in AK051474 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0095761 – 908Missing in isoform 2. 1 PublicationAdd BLAST908
Alternative sequenceiVSP_009577134 – 144ALKMLAIANSS → VSTLGRAGQSD in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_009578145 – 1865Missing in isoform 3. 1 PublicationAdd BLAST1721
Alternative sequenceiVSP_009579944 – 1009LLSLG…EEWRP → RLEENSLQTQDQPFPSWSCH RAAGRSPHCAICTTPESTYR RSSAMPWSASPASTATVRSW GQEAGA in isoform 4. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_0095801010 – 1865Missing in isoform 4. 1 PublicationAdd BLAST856

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK051474 mRNA No translation available.
BC026469 mRNA Translation: AAH26469.1
BC041674 mRNA Translation: AAH41674.1
AK122351 Transcribed RNA Translation: BAC65633.1

Genome annotation databases

UCSC genome browser

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UCSCi
uc008ctb.2, mouse [Q80TT8-1]
uc008ctf.2, mouse [Q80TT8-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK051474 mRNA No translation available.
BC026469 mRNA Translation: AAH26469.1
BC041674 mRNA Translation: AAH41674.1
AK122351 Transcribed RNA Translation: BAC65633.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000138418

Proteomic databases

PaxDbiQ80TT8
PeptideAtlasiQ80TT8
PRIDEiQ80TT8

Genome annotation databases

UCSCiuc008ctb.2, mouse [Q80TT8-1]
uc008ctf.2, mouse [Q80TT8-3]

Organism-specific databases

MGIiMGI:1925559, Cul9

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG1815, Eukaryota
InParanoidiQ80TT8
PhylomeDBiQ80TT8

Enzyme and pathway databases

ReactomeiR-MMU-8951664, Neddylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cul9, mouse

Protein Ontology

More...
PROi
PR:Q80TT8
RNActiQ80TT8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

Gene3Di2.60.120.260, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR016024, ARM-type_fold
IPR031222, CUL9
IPR016157, Cullin_CS
IPR016158, Cullin_homology
IPR036317, Cullin_homology_sf
IPR019559, Cullin_neddylation_domain
IPR008979, Galactose-bd-like_sf
IPR002867, IBR_dom
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PANTHERiPTHR22771:SF2, PTHR22771:SF2, 1 hit
PfamiView protein in Pfam
PF03256, ANAPC10, 1 hit
PF01485, IBR, 2 hits
SMARTiView protein in SMART
SM01337, APC10, 1 hit
SM00884, Cullin_Nedd8, 1 hit
SM00647, IBR, 2 hits
SUPFAMiSSF48371, SSF48371, 1 hit
SSF49785, SSF49785, 1 hit
SSF75632, SSF75632, 1 hit
PROSITEiView protein in PROSITE
PS01256, CULLIN_1, 1 hit
PS50069, CULLIN_2, 1 hit
PS51284, DOC, 1 hit
PS51873, TRIAD, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUL9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80TT8
Secondary accession number(s): Q8BKL9, Q8CGC0, Q8R363
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: October 7, 2020
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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