Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q80TQ2 (CYLD_MOUSE)

Protein

Ubiquitin carboxyl-terminal hydrolase CYLD

Gene

Cyld

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:17548520, PubMed:28701375, PubMed:29291351). Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:16713561). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:16713561). Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:16713561, PubMed:20194890, PubMed:19893491). Required for normal cell cycle progress and normal cytokinesis (PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (By similarity). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (By similarity). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (PubMed:16501569, PubMed:18643924). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (PubMed:18382763). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (PubMed:25134987). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:28701375). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (By similarity). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (PubMed:28701375). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:17548520, PubMed:29291351).By similarity10 Publications

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei597NucleophilePROSITE-ProRule annotation1
Metal bindingi784Zinc 1By similarity1
Metal bindingi787Zinc 1By similarity1
Metal bindingi795Zinc 2By similarity1
Metal bindingi798Zinc 2By similarity1
Metal bindingi813Zinc 1By similarity1
Metal bindingi816Zinc 1By similarity1
Metal bindingi821Zinc 2By similarity1
Metal bindingi829Zinc 2By similarity1
Active sitei867Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processImmunity, Innate immunity, Ubl conjugation pathway, Wnt signaling pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.19.12 3474
ReactomeiR-MMU-168638 NOD1/2 Signaling Pathway
R-MMU-5357786 TNFR1-induced proapoptotic signaling
R-MMU-5357905 Regulation of TNFR1 signaling
R-MMU-5357956 TNFR1-induced NFkappaB signaling pathway
R-MMU-5689880 Ub-specific processing proteases
R-MMU-936440 Negative regulators of DDX58/IFIH1 signaling

Protein family/group databases

MEROPSiC67.001

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase CYLD (EC:3.4.19.12By similarity)
Alternative name(s):
Deubiquitinating enzyme CYLD
Ubiquitin thioesterase CYLD
Ubiquitin-specific-processing protease CYLD
Gene namesi
Name:Cyld
Synonyms:Cyld1, Kiaa0849
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1921506 Cyld

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Microtubule

Pathology & Biotechi

Disruption phenotypei

No obvious phenotype, but mice are highly susceptible to carcinogens and are prone to chemically induced skin tumors. The number of natural killer T-cells is much reduced. Animals are highly susceptible to bacteria-induced pneumonia, due to an over active innate immune response. Animals spontaneously develop colonic inflammation, due to constitutive expression of several proinflammatory genes in the colon. Animals exhibit abnormal osteoclast differentiation, leading to osteoporosis (PubMed:16501569, PubMed:16713561, PubMed:17548520, PubMed:18382763, PubMed:18643924). Hepatocyte-specific knockout mice do not exhibit any liver-related pathological phenotype under unstressed conditions. In response to a 24-week high fat dier, they exhibit higher body and liver weight as well as reduced glucose tolerance and insulin resistance compared to controls. They also show a considerable inflammatory response, including elevation of cytokine and chemokine concentrations in serum and mRNA expression in liver (PubMed:29291351).6 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806991 – 952Ubiquitin carboxyl-terminal hydrolase CYLDAdd BLAST952

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei383PhosphoserineBy similarity1
Modified residuei414PhosphoserineCombined sources1
Modified residuei418PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on several serine residues by IKKA and/or IKKB in response to immune stimuli. Phosphorylation requires IKBKG. Phosphorylation abolishes TRAF2 deubiquitination, interferes with the activation of Jun kinases, and strongly reduces CD40-dependent gene activation by NF-kappa-B (By similarity).By similarity
Ubiquitinated. Polyubiquitinated in hepatocytes treated with palmitic acid. Ubiquitination is mediated by E3 ligase TRIM47 and leads to proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ80TQ2
PaxDbiQ80TQ2
PeptideAtlasiQ80TQ2
PRIDEiQ80TQ2

PTM databases

iPTMnetiQ80TQ2
PhosphoSitePlusiQ80TQ2
SwissPalmiQ80TQ2

Expressioni

Inductioni

Up-regulated by TNFRSF11A.1 Publication

Gene expression databases

BgeeiENSMUSG00000036712 Expressed in 247 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_CYLD
ExpressionAtlasiQ80TQ2 baseline and differential
GenevisibleiQ80TQ2 MM

Interactioni

Subunit structurei

Interacts (via CAP-Gly domain) with IKBKG/NEMO (via proline-rich C-terminal region) (By similarity). Interacts with TRAF2 and TRIP (By similarity). Interacts with PLK1, DVL1, DVL3, MAVS, TBK1, IKKE and DDX58 (By similarity). Interacts (via CAP-Gly domain) with microtubules (PubMed:19893491). Interacts with HDAC6 and BCL3 (PubMed:16713561, PubMed:19893491). Interacts with MAP3K7 (PubMed:17548520). Identified in a complex with TRAF6 and SQSTM1 (PubMed:18382763). Interacts with CEP350 (By similarity). Interacts with RNF31; the interaction is indirect and is mediated via SPATA2 (By similarity). Interacts with SPATA2 (via the PUB domain); the interaction is direct and recruits CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (By similarity).By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi216612, 17 interactors
DIPiDIP-35656N
IntActiQ80TQ2, 7 interactors
MINTiQ80TQ2
STRINGi10090.ENSMUSP00000096119

Structurei

3D structure databases

ProteinModelPortaliQ80TQ2
SMRiQ80TQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 198CAP-Gly 1PROSITE-ProRule annotationAdd BLAST46
Domaini253 – 286CAP-Gly 2PROSITE-ProRule annotationAdd BLAST34
Domaini488 – 531CAP-Gly 3PROSITE-ProRule annotationAdd BLAST44
Domaini588 – 946USPAdd BLAST359

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 589Interaction with TRIPBy similarityAdd BLAST484
Regioni390 – 465Interaction with TRAF2By similarityAdd BLAST76
Regioni466 – 680Interaction with IKBKG/NEMOBy similarityAdd BLAST215
Regioni777 – 829B-boxBy similarityAdd BLAST53

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3556 Eukaryota
ENOG410XP6I LUCA
GeneTreeiENSGT00390000018123
HOGENOMiHOG000006796
HOVERGENiHBG051281
InParanoidiQ80TQ2
KOiK08601
OrthoDBiEOG091G015D
PhylomeDBiQ80TQ2

Family and domain databases

Gene3Di2.30.30.190, 3 hits
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF01302 CAP_GLY, 2 hits
PF00443 UCH, 1 hit
SMARTiView protein in SMART
SM01052 CAP_GLY, 3 hits
SUPFAMiSSF54001 SSF54001, 1 hit
SSF74924 SSF74924, 3 hits
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 1 hit
PS50245 CAP_GLY_2, 2 hits
PS00972 USP_1, 1 hit
PS50235 USP_3, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q80TQ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQYI 
        60         70         80         90        100
QDRSVGHSRV PSTKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL 
       110        120        130        140        150
LAITNCEERL SLFRNRLRLS KGLQVDVGSP VKVQLRSGEE KFPGVVRFRG 
       160        170        180        190        200
PLLAERTVSG IFFGVELLEE GRGQGFTDGV YQGKQLFQCD EDCGVFVALD 
       210        220        230        240        250
KLELIEDDDN GLESDFAGPG DTMQVEPPPL EINSRVSLKV GESTESGTVI 
       260        270        280        290        300
FCDVLPGKES LGYFVGVDMD NPIGNWDGRF DGVQLCSFAS VESTILLHIN 
       310        320        330        340        350
DIIPDSVTQE RRPPKLAFMS RGVGDKGSSS HNKPKVTGST SDPGSRNRSE 
       360        370        380        390        400
LFYTLNGSSV DSQQSKSKNP WYIDEVAEDP AKSLTEMSSD FGHSSPPPQP 
       410        420        430        440        450
PSMNSLSSEN RFHSLPFSLT KMPNTNGSMA HSPLSLSVQS VMGELNSTPV 
       460        470        480        490        500
QESPPLPISS GNAHGLEVGS LAEVKENPPF YGVIRWIGQP PGLSDVLAGL 
       510        520        530        540        550
ELEDECAGCT DGTFRGTRYF TCALKKALFV KLKSCRPDSR FASLQPVSNQ 
       560        570        580        590        600
IERCNSLAFG GYLSEVVEEN TPPKMEKEGL EIMIGKKKGI QGHYNSCYLD 
       610        620        630        640        650
STLFCLFAFS SALDTVLLRP KEKNDIEYYS ETQELLRTEI VNPLRIYGYV 
       660        670        680        690        700
CATKIMKLRK ILEKVEAASG FTSEEKDPEE FLNILFHDIL RVEPLLKIRS 
       710        720        730        740        750
AGQKVQDCNF YQIFMEKNEK VGVPTIQQLL EWSFINSNLK FAEAPSCLII 
       760        770        780        790        800
QMPRFGKDFK LFKKIFPSLE LNITDLLEDT PRQCRICGGL AMYECRECYD 
       810        820        830        840        850
DPDISAGKIK QFCKTCSTQV HLHPRRLNHS YHPVSLPKDL PDWDWRHGCI 
       860        870        880        890        900
PCQKMELFAV LCIETSHYVA FVKYGKDDSA WLFFDSMADR DGGQNGFNIP 
       910        920        930        940        950
QVTPCPEVGE YLKMSLEDLH SLDSRRIQGC ARRLLCDAYM CMYQSPTMSL 

YK
Length:952
Mass (Da):106,586
Last modified:August 16, 2004 - v2
Checksum:i0AC0C7D4FF215A9C
GO
Isoform 1 (identifier: Q80TQ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-304: P → PALS

Show »
Length:955
Mass (Da):106,857
Checksum:iE8D55AE26D90241F
GO
Isoform 3 (identifier: Q80TQ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-318: DSVTQERRPPKLAF → GTSKNILDQQLKGK
     319-952: Missing.

Show »
Length:318
Mass (Da):35,288
Checksum:i23465D36304356BF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GSE5A0A1B0GSE5_MOUSE
Ubiquitin carboxyl-terminal hydrola...
Cyld
770Annotation score:
Z4YJJ5Z4YJJ5_MOUSE
Ubiquitin carboxyl-terminal hydrola...
Cyld
955Annotation score:

Sequence cautioni

The sequence BAC65671 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti403M → V in BAC30222 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011278304P → PALS in isoform 1. 1 Publication1
Alternative sequenceiVSP_011279305 – 318DSVTQ…PKLAF → GTSKNILDQQLKGK in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_011280319 – 952Missing in isoform 3. 1 PublicationAdd BLAST634

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122389 mRNA Translation: BAC65671.1 Different initiation.
AK039054 mRNA Translation: BAC30222.1
AK042764 mRNA Translation: BAC31357.1
BC042438 mRNA Translation: AAH42438.1
BC049879 mRNA Translation: AAH49879.1
CCDSiCCDS22513.1 [Q80TQ2-1]
CCDS52633.1 [Q80TQ2-2]
RefSeqiNP_001121642.1, NM_001128170.2 [Q80TQ2-2]
NP_001121643.1, NM_001128171.2 [Q80TQ2-1]
NP_775545.1, NM_173369.3 [Q80TQ2-1]
XP_006531477.1, XM_006531414.1 [Q80TQ2-2]
XP_006531478.1, XM_006531415.1 [Q80TQ2-2]
XP_006531479.1, XM_006531416.3 [Q80TQ2-2]
XP_006531480.1, XM_006531417.2 [Q80TQ2-2]
XP_006531481.1, XM_006531418.2 [Q80TQ2-2]
XP_011246825.1, XM_011248523.2 [Q80TQ2-2]
XP_011246826.1, XM_011248524.1 [Q80TQ2-2]
XP_011246827.1, XM_011248525.2 [Q80TQ2-2]
XP_017168478.1, XM_017312989.1 [Q80TQ2-2]
UniGeneiMm.490395

Genome annotation databases

EnsembliENSMUST00000098519; ENSMUSP00000096119; ENSMUSG00000036712 [Q80TQ2-2]
ENSMUST00000109626; ENSMUSP00000105254; ENSMUSG00000036712 [Q80TQ2-1]
ENSMUST00000209532; ENSMUSP00000147654; ENSMUSG00000036712 [Q80TQ2-2]
ENSMUST00000209559; ENSMUSP00000147426; ENSMUSG00000036712 [Q80TQ2-1]
ENSMUST00000211554; ENSMUSP00000148037; ENSMUSG00000036712 [Q80TQ2-1]
GeneIDi74256
KEGGimmu:74256
UCSCiuc009mrt.3 mouse [Q80TQ2-1]
uc033jgq.1 mouse [Q80TQ2-3]
uc033jgr.1 mouse [Q80TQ2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122389 mRNA Translation: BAC65671.1 Different initiation.
AK039054 mRNA Translation: BAC30222.1
AK042764 mRNA Translation: BAC31357.1
BC042438 mRNA Translation: AAH42438.1
BC049879 mRNA Translation: AAH49879.1
CCDSiCCDS22513.1 [Q80TQ2-1]
CCDS52633.1 [Q80TQ2-2]
RefSeqiNP_001121642.1, NM_001128170.2 [Q80TQ2-2]
NP_001121643.1, NM_001128171.2 [Q80TQ2-1]
NP_775545.1, NM_173369.3 [Q80TQ2-1]
XP_006531477.1, XM_006531414.1 [Q80TQ2-2]
XP_006531478.1, XM_006531415.1 [Q80TQ2-2]
XP_006531479.1, XM_006531416.3 [Q80TQ2-2]
XP_006531480.1, XM_006531417.2 [Q80TQ2-2]
XP_006531481.1, XM_006531418.2 [Q80TQ2-2]
XP_011246825.1, XM_011248523.2 [Q80TQ2-2]
XP_011246826.1, XM_011248524.1 [Q80TQ2-2]
XP_011246827.1, XM_011248525.2 [Q80TQ2-2]
XP_017168478.1, XM_017312989.1 [Q80TQ2-2]
UniGeneiMm.490395

3D structure databases

ProteinModelPortaliQ80TQ2
SMRiQ80TQ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216612, 17 interactors
DIPiDIP-35656N
IntActiQ80TQ2, 7 interactors
MINTiQ80TQ2
STRINGi10090.ENSMUSP00000096119

Protein family/group databases

MEROPSiC67.001

PTM databases

iPTMnetiQ80TQ2
PhosphoSitePlusiQ80TQ2
SwissPalmiQ80TQ2

Proteomic databases

EPDiQ80TQ2
PaxDbiQ80TQ2
PeptideAtlasiQ80TQ2
PRIDEiQ80TQ2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098519; ENSMUSP00000096119; ENSMUSG00000036712 [Q80TQ2-2]
ENSMUST00000109626; ENSMUSP00000105254; ENSMUSG00000036712 [Q80TQ2-1]
ENSMUST00000209532; ENSMUSP00000147654; ENSMUSG00000036712 [Q80TQ2-2]
ENSMUST00000209559; ENSMUSP00000147426; ENSMUSG00000036712 [Q80TQ2-1]
ENSMUST00000211554; ENSMUSP00000148037; ENSMUSG00000036712 [Q80TQ2-1]
GeneIDi74256
KEGGimmu:74256
UCSCiuc009mrt.3 mouse [Q80TQ2-1]
uc033jgq.1 mouse [Q80TQ2-3]
uc033jgr.1 mouse [Q80TQ2-2]

Organism-specific databases

CTDi1540
MGIiMGI:1921506 Cyld
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3556 Eukaryota
ENOG410XP6I LUCA
GeneTreeiENSGT00390000018123
HOGENOMiHOG000006796
HOVERGENiHBG051281
InParanoidiQ80TQ2
KOiK08601
OrthoDBiEOG091G015D
PhylomeDBiQ80TQ2

Enzyme and pathway databases

BRENDAi3.4.19.12 3474
ReactomeiR-MMU-168638 NOD1/2 Signaling Pathway
R-MMU-5357786 TNFR1-induced proapoptotic signaling
R-MMU-5357905 Regulation of TNFR1 signaling
R-MMU-5357956 TNFR1-induced NFkappaB signaling pathway
R-MMU-5689880 Ub-specific processing proteases
R-MMU-936440 Negative regulators of DDX58/IFIH1 signaling

Miscellaneous databases

PROiPR:Q80TQ2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036712 Expressed in 247 organ(s), highest expression level in utricle of membranous labyrinth
CleanExiMM_CYLD
ExpressionAtlasiQ80TQ2 baseline and differential
GenevisibleiQ80TQ2 MM

Family and domain databases

Gene3Di2.30.30.190, 3 hits
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF01302 CAP_GLY, 2 hits
PF00443 UCH, 1 hit
SMARTiView protein in SMART
SM01052 CAP_GLY, 3 hits
SUPFAMiSSF54001 SSF54001, 1 hit
SSF74924 SSF74924, 3 hits
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 1 hit
PS50245 CAP_GLY_2, 2 hits
PS00972 USP_1, 1 hit
PS50235 USP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYLD_MOUSE
AccessioniPrimary (citable) accession number: Q80TQ2
Secondary accession number(s): Q80VB3
, Q8BXZ3, Q8BYL9, Q8CGB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again