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Entry version 148 (18 Sep 2019)
Sequence version 2 (27 Sep 2005)
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Protein

E3 ubiquitin-protein ligase UBR5

Gene

Ubr5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (By similarity). Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Plays an essential role in extraembryonic development. Regulates DNA topoisomerase II binding protein (TopBP1) for the DNA damage response.By similarity2 Publications

Miscellaneous

A cysteine residue is required for ubiquitin-thioester formation.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2761Glycyl thioester intermediatePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1171 – 1239UBR-typePROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processDNA damage, DNA repair, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase UBR5 (EC:2.3.2.26)
Alternative name(s):
E3 ubiquitin-protein ligase, HECT domain-containing 1
HECT-type E3 ubiquitin transferase UBR5
Hyperplastic discs protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ubr5
Synonyms:Edd, Edd1, Kiaa0896
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918040 Ubr5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000869322 – 2792E3 ubiquitin-protein ligase UBR5Add BLAST2791

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylthreonineBy similarity1
Modified residuei110PhosphoserineBy similarity1
Modified residuei321PhosphoserineCombined sources1
Modified residuei346PhosphoserineBy similarity1
Modified residuei572PhosphoserineBy similarity1
Modified residuei606PhosphoserineBy similarity1
Modified residuei631PhosphothreonineBy similarity1
Modified residuei802PhosphoserineBy similarity1
Modified residuei922PhosphoserineBy similarity1
Modified residuei1012PhosphoserineBy similarity1
Modified residuei1109PhosphothreonineBy similarity1
Modified residuei1129PhosphothreonineBy similarity1
Modified residuei1221PhosphoserineBy similarity1
Modified residuei1302PhosphoserineBy similarity1
Modified residuei1349PhosphoserineBy similarity1
Modified residuei1369PhosphoserineBy similarity1
Modified residuei1475PhosphoserineBy similarity1
Modified residuei1543PhosphoserineBy similarity1
Modified residuei1730PhosphothreonineBy similarity1
Modified residuei1735PhosphoserineBy similarity1
Modified residuei1740PhosphotyrosineBy similarity1
Modified residuei1774PhosphoserineBy similarity1
Modified residuei1963PhosphothreonineBy similarity1
Modified residuei1984PhosphoserineBy similarity1
Modified residuei2020PhosphoserineBy similarity1
Modified residuei2022PhosphoserineBy similarity1
Modified residuei2024PhosphothreonineBy similarity1
Modified residuei2070PhosphoserineBy similarity1
Modified residuei2207PhosphothreonineBy similarity1
Modified residuei2235PhosphoserineBy similarity1
Modified residuei2283PhosphoserineBy similarity1
Modified residuei2463PhosphoserineBy similarity1
Modified residuei2477PhosphoserineBy similarity1
Modified residuei2479PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q80TP3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q80TP3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q80TP3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80TP3

PeptideAtlas

More...
PeptideAtlasi
Q80TP3

PRoteomics IDEntifications database

More...
PRIDEi
Q80TP3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80TP3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80TP3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q80TP3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds TOPBP1. Associates with CDK9 and TFIIS/TCEA1 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription by recruiting their promoters. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex).

Interacts directly with DYRK2.

Interacts with PIH1D1.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Otud5Q3U2S4-12EBI-2553642,EBI-16131219

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
214255, 33 interactors

Database of interacting proteins

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DIPi
DIP-56890N

Protein interaction database and analysis system

More...
IntActi
Q80TP3, 12 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000105965

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q80TP3

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2371 – 2448PABCPROSITE-ProRule annotationAdd BLAST78
Domaini2455 – 2792HECTPROSITE-ProRule annotationAdd BLAST338

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi934 – 939Poly-Glu6
Compositional biasi1523 – 1531Poly-Ser9
Compositional biasi1618 – 1675Ser-richAdd BLAST58
Compositional biasi1665 – 1675Poly-SerAdd BLAST11
Compositional biasi1756 – 1762Poly-Ala7
Compositional biasi1980 – 1991Asp/Glu-rich (acidic)Add BLAST12
Compositional biasi2030 – 2053Pro-richAdd BLAST24
Compositional biasi2323 – 2342Arg/Glu-rich (mixed charge)Add BLAST20
Compositional biasi2351 – 2360Arg/Asp-rich (mixed charge)10
Compositional biasi2422 – 2426Poly-Leu5
Compositional biasi2482 – 2493Asp/Glu-rich (acidic)Add BLAST12
Compositional biasi2730 – 2750Pro-richAdd BLAST21

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1171 – 1239UBR-typePROSITE-ProRule annotationAdd BLAST69

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0943 Eukaryota
COG5021 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80TP3

KEGG Orthology (KO)

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KOi
K10593

Database of Orthologous Groups

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OrthoDBi
717at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q80TP3

Family and domain databases

Conserved Domains Database

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CDDi
cd14423 CUE_UBR5, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024725 E3_UbLigase_EDD_UBA
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR036053 PABP-dom
IPR002004 PABP_HYD
IPR009091 RCC1/BLIP-II
IPR003126 Znf_UBR

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11547 E3_UbLigase_EDD, 1 hit
PF00632 HECT, 1 hit
PF00658 PABP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00119 HECTc, 1 hit
SM00517 PolyA, 1 hit
SM00396 ZnF_UBR1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50985 SSF50985, 1 hit
SSF56204 SSF56204, 1 hit
SSF63570 SSF63570, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237 HECT, 1 hit
PS51309 PABC, 1 hit
PS51157 ZF_UBR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q80TP3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYNLNSHPPL NVLEQATIKQ
60 70 80 90 100
CVVGPNHAAF LLEDGRICRI GFSVQPDRLE LGKPDNNDGS KLNSSSGTGR
110 120 130 140 150
TSRPGRTSDS PWFLSGSETL GRLAGNTLGS RWSSGVGGSG GGSSGRSSAG
160 170 180 190 200
ARDSRRQTRV IRTGRDRGSG LLGSQPQPVI PASVIPEELI SQAQVVLQGK
210 220 230 240 250
SRSVIIRELQ RTNLDVNLAV NNLLSRDDED GDDGDDTASE SYLPGEDLMS
260 270 280 290 300
LLDADIHSAH PSVIIDADAM FSEDISYFGY PSFRRSSLSR LGSSRERDSE
310 320 330 340 350
LLRERESVLR LRERRWLDGA SFDNERGSTS KEGESNPDKK NTPVQSPVSL
360 370 380 390 400
GEDLQWWPDK DGTKFTCIGA LYSELLAVSS KGELYQWKWS ESEPYRNAQN
410 420 430 440 450
PSLHHPRATF LGLTNEKIVL LSANSIRATV ATENNKVATW VDETLSSVAS
460 470 480 490 500
KLEHTAQTYS ELQGERIVSL HCCALYTCAQ LENNLYWWGV VPFSQRKKML
510 520 530 540 550
EKARAKNKKP KSSAGISSMP NITVGTQVCL RNNPLYHAGA VAFSISAGIP
560 570 580 590 600
KVGVLMESVW NMNDSCRFQL RSPESLKSME KASKTLETKP ESKQEPVKTE
610 620 630 640 650
MGPPPSPAST CSDASSIASS ASMPYKRRRS TPAPREEEKV NEEQWPLREV
660 670 680 690 700
VFVEDVKNVP VGKVLKVDGA YVAVKFPGTS TNTTCQNSSG PDADPSSLLQ
710 720 730 740 750
DCRLLRIDEL QVVKTGGTPK VPDCFQRTPK KLCIPEKTEI LAVNVDSKGV
760 770 780 790 800
HAVLKTGSWV RYCVFDLATG KAEQENNFPT SSVAFLGQDE RSVAIFTAGQ
810 820 830 840 850
ESPIVLRDGN GTIYPMAKDC MGGIRDPDWL DLPPISSLGM GVHSLINLPA
860 870 880 890 900
NSTIKKKAAI IIMAVEKQTL MQHILRCDYE ACRQYLVNLE QAVVLEQNRQ
910 920 930 940 950
MLQTFISHRC DGNRNILHAC VSVCFPTSNK ETKEEEEAER SERNTFAERL
960 970 980 990 1000
SAVEAIANAI SVVSSNGPGN RAGSSNSRSL RLREMMRRSL RAAGLGRHEA
1010 1020 1030 1040 1050
GASSSDHQDP VSPPIAPPSW VPDPPSMDPD GDIDFILAPA VGSLTTAATG
1060 1070 1080 1090 1100
SGQGPSTSTI PGPSTEPSVV ESKDRKANAH FILKLLCDSA VLQPYLRELL
1110 1120 1130 1140 1150
SAKDARGMTP FMSAVSGRAY SAAITILETA QKIAKAEVSA SEKEEDVFMG
1160 1170 1180 1190 1200
MVCPSGTNPD DSPLYVLCCN DTCSFTWTGA EHINQDIFEC RTCGLLESLC
1210 1220 1230 1240 1250
CCTECARVCH KGHDCKLKRT SPTAYCDCWE KCKCKTLIAG QKSARLDLLY
1260 1270 1280 1290 1300
RLLTATNLVT LPNSRGEHLL LFLVQTVARQ TVEHCQYRPP RIREDRNRKT
1310 1320 1330 1340 1350
ASPEDSDMPD HDLEPPRFAQ LALERVLQDW NALRSMIMFG SQENKDPLSA
1360 1370 1380 1390 1400
SSRIGHLLPE EQVYLNQQSG TIRLDCFTHC LIVKCTADIL LLDTLLGTLV
1410 1420 1430 1440 1450
KELQNKYTPG RREEAIAVTM RFLRSVARVF VILSVEMASS KKKNNFIPQP
1460 1470 1480 1490 1500
IGKCKRVFQA LLPYAVEELC NVAESLIVPV RMGIARPTAP FTLASTSIDA
1510 1520 1530 1540 1550
MQGSEELFSV EPLPPRPSSD QASSSSQSQS SYIIRNPQQR RISQSQPVRG
1560 1570 1580 1590 1600
RDEEQDDIVS ADVEEVEVVE GVAGEEDHHD EQEEHGEENA EAEGHHDEHD
1610 1620 1630 1640 1650
EDGSDMELDL LAAAETESDS ESNHSNQDNA SGRRSVVTAA TAGSEAGASS
1660 1670 1680 1690 1700
VPAFFSEDDS QSNDSSDSDS SSSQSDDIEQ ETFMLDEPLE RTTNSSHANG
1710 1720 1730 1740 1750
AAQAPRSMQW AVRNPQHQRA ASTAPSSTST PAASSAGLIY IDPSNLRRSG
1760 1770 1780 1790 1800
TISTSAAAAA AALEASNASS YLTSASSLAR AYSIVIRQIS DLMGLIPKYN
1810 1820 1830 1840 1850
HLVYSQIPAA VKLTYQDAVN LQNYVEEKLI PTWNWMVSVM DSTEAQLRYG
1860 1870 1880 1890 1900
SALASAGDPG HPNHPLHASQ NSARRERMTA REEASLRTLE GRRRATLLSA
1910 1920 1930 1940 1950
RQGMMSARGD FLNYALSLMR SHNDEHSDVL PVLDVCSLKH VAYVFQALIY
1960 1970 1980 1990 2000
WIKAMNQQTT LDTPQLERKR TRELLELGID NEDSEHENDD DTSQSATLND
2010 2020 2030 2040 2050
KDDDSLPAET GQNHPFFRRS DSMTFLGCIP PNPFEVPLAE AIPLADQPHL
2060 2070 2080 2090 2100
LQPNARKEDL FGRPSQGLYS SSAGSGKCIV EVTMDRNCLE VLPTKMSYAA
2110 2120 2130 2140 2150
NLKNVMNMQN RQKKEGEEQS LLAEEADSSK PGPSAPDVAA QLKSSLLAEI
2160 2170 2180 2190 2200
GLTESEGPPL TSFRPQCSFM GMVISHDMLL GRWRLSLELF GRVFMEDVGA
2210 2220 2230 2240 2250
EPGSILTELG GFEVKESKFR REMEKLRNQQ SRDLSLEVDR DRDLLIQQTM
2260 2270 2280 2290 2300
RQLNNHFGRR CATTPMAVHR VKVTFKDEPG EGSGVARSFY TAIAQAFLSN
2310 2320 2330 2340 2350
EKLPNLDCIQ NANKGTHTSL MQRLRNRGER DREREREREM RRSSGLRAGS
2360 2370 2380 2390 2400
RRDRDRDFRR QLSIDTRPFR PASEGNPSDD PDPLPAHRQA LGERLYPRVQ
2410 2420 2430 2440 2450
AMQPAFASKI TGMLLELSPA QLLLLLASED SLRARVDEAM ELIIAHGREN
2460 2470 2480 2490 2500
GADSILDLGL LDSSEKVQEN RKRHGSSRSV VDMDLEDTDD GDDNAPLFYQ
2510 2520 2530 2540 2550
PGKRGFYTPR PGKNTEARLN CFRNIGRILG LCLLQNELCP ITLNRHVIKV
2560 2570 2580 2590 2600
LLGRKVNWHD FAFFDPVMYE SLRQLILASQ SSDADAVFSA MDLAFAIDLC
2610 2620 2630 2640 2650
KEEGGGQVEL IPNGVNIPVT PQNVYEYVRK YAEHRMLVVA EQPLHAMRKG
2660 2670 2680 2690 2700
LLDVLPKNSL EDLTAEDFRL LVNGCGEVNV QMLISFTSFN DESGENAEKL
2710 2720 2730 2740 2750
LQFKRWFWSI VEKMSMTERQ DLVYFWTSSP SLPASEEGFQ PMPSITIRPP
2760 2770 2780 2790
DDQHLPTANT CISRLYVPLY SSKQILKQKL LLAIKTKNFG FV
Length:2,792
Mass (Da):308,352
Last modified:September 27, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19E5E56E5094F5B6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BQS6A0A2I3BQS6_MOUSE
E3 ubiquitin-protein ligase UBR5
Ubr5
2,798Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q2H1E9Q2H1_MOUSE
E3 ubiquitin-protein ligase UBR5
Ubr5
2,792Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BPG8A0A2I3BPG8_MOUSE
E3 ubiquitin-protein ligase UBR5
Ubr5
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQC1A0A2I3BQC1_MOUSE
E3 ubiquitin-protein ligase UBR5
Ubr5
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1121S → P in AAT28194 (PubMed:15282321).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY550908 mRNA Translation: AAT28194.1
AK122398 mRNA Translation: BAC65680.1
BC049162 mRNA Translation: AAH49162.1
BC049224 mRNA Translation: AAH49224.1
BC057458 mRNA Translation: AAH57458.1
BC057923 mRNA Translation: AAH57923.1
AK014485 mRNA Translation: BAB29387.1

NCBI Reference Sequences

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RefSeqi
NP_001074828.2, NM_001081359.3
NP_001106192.1, NM_001112721.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
70790

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:70790

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY550908 mRNA Translation: AAT28194.1
AK122398 mRNA Translation: BAC65680.1
BC049162 mRNA Translation: AAH49162.1
BC049224 mRNA Translation: AAH49224.1
BC057458 mRNA Translation: AAH57458.1
BC057923 mRNA Translation: AAH57923.1
AK014485 mRNA Translation: BAB29387.1
RefSeqiNP_001074828.2, NM_001081359.3
NP_001106192.1, NM_001112721.2

3D structure databases

SMRiQ80TP3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi214255, 33 interactors
DIPiDIP-56890N
IntActiQ80TP3, 12 interactors
STRINGi10090.ENSMUSP00000105965

PTM databases

iPTMnetiQ80TP3
PhosphoSitePlusiQ80TP3
SwissPalmiQ80TP3

Proteomic databases

EPDiQ80TP3
jPOSTiQ80TP3
MaxQBiQ80TP3
PaxDbiQ80TP3
PeptideAtlasiQ80TP3
PRIDEiQ80TP3

Genome annotation databases

GeneIDi70790
KEGGimmu:70790

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51366
MGIiMGI:1918040 Ubr5

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG0943 Eukaryota
COG5021 LUCA
InParanoidiQ80TP3
KOiK10593
OrthoDBi717at2759
PhylomeDBiQ80TP3

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ubr5 mouse

Protein Ontology

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PROi
PR:Q80TP3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

CDDicd14423 CUE_UBR5, 1 hit
InterProiView protein in InterPro
IPR024725 E3_UbLigase_EDD_UBA
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR036053 PABP-dom
IPR002004 PABP_HYD
IPR009091 RCC1/BLIP-II
IPR003126 Znf_UBR
PfamiView protein in Pfam
PF11547 E3_UbLigase_EDD, 1 hit
PF00632 HECT, 1 hit
PF00658 PABP, 1 hit
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SM00517 PolyA, 1 hit
SM00396 ZnF_UBR1, 1 hit
SUPFAMiSSF50985 SSF50985, 1 hit
SSF56204 SSF56204, 1 hit
SSF63570 SSF63570, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit
PS51309 PABC, 1 hit
PS51157 ZF_UBR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBR5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80TP3
Secondary accession number(s): Q698K9
, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2005
Last modified: September 18, 2019
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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