UniProtKB - Q80TN7 (NAV3_MOUSE)
Protein
Neuron navigator 3
Gene
Nav3
Organism
Mus musculus (Mouse)
Status
Functioni
May regulate IL2 production by T-cells. May be involved in neuron regeneration.1 Publication
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: InterPro
- microtubule binding Source: MGI
GO - Biological processi
- negative regulation of cell migration Source: MGI
- negative regulation of interleukin-2 production Source: MGI
- negative regulation of microtubule depolymerization Source: MGI
- nervous system development Source: GO_Central
- neurogenesis Source: InterPro
- positive regulation of microtubule polymerization Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Neuron navigator 3Alternative name(s): Pore membrane and/or filament-interacting-like protein 1 |
Gene namesi | Name:Nav3 Synonyms:Kiaa0938, Pomfil1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2183703, Nav3 |
Subcellular locationi
Nucleus
- Nucleus outer membrane 1 Publication
Nucleus
- nuclear envelope Source: MGI
- nuclear outer membrane Source: UniProtKB-SubCell
- nucleus Source: MGI
Keywords - Cellular componenti
Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286977 | 1 – 2359 | Neuron navigator 3Add BLAST | 2359 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1462 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1466 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q80TN7 |
MaxQBi | Q80TN7 |
PaxDbi | Q80TN7 |
PRIDEi | Q80TN7 |
ProteomicsDBi | 287444 |
PTM databases
iPTMneti | Q80TN7 |
PhosphoSitePlusi | Q80TN7 |
Expressioni
Tissue specificityi
Present in neurons from central and peripheral nervous systems (at protein level). Highly expressed in brain cortex, midbrain, cerebellum and hippocampus.1 Publication
Developmental stagei
Specifically expressed in neuronal cells during development. First detectable at 9.5 dpc in prosencephalon. At 16.5 dpc, expressed in all brain areas, spinal cord and spinal ganglia. Within the brain, highest expression is found in maturing zones where neurons differentiate and lowest expression is found in ventricular zones where proliferation takes place. Brain expression remains high at later embryonic stages and during postnatal brain development.1 Publication
Inductioni
In astrocytes after brain injury.1 Publication
Interactioni
GO - Molecular functioni
- microtubule binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 234432, 6 interactors |
IntActi | Q80TN7, 2 interactors |
STRINGi | 10090.ENSMUSP00000032719 |
Miscellaneous databases
RNActi | Q80TN7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 77 – 184 | Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST | 108 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 680 – 708 | Sequence analysisAdd BLAST | 29 | |
Coiled coili | 1565 – 1656 | Sequence analysisAdd BLAST | 92 | |
Coiled coili | 1768 – 1835 | Sequence analysisAdd BLAST | 68 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 619 – 622 | Poly-Gln | 4 | |
Compositional biasi | 1035 – 1563 | Ser-richAdd BLAST | 529 | |
Compositional biasi | 1697 – 1702 | Poly-Lys | 6 |
Sequence similaritiesi
Belongs to the Nav/unc-53 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QPT3, Eukaryota |
InParanoidi | Q80TN7 |
PhylomeDBi | Q80TN7 |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003959, ATPase_AAA_core IPR001715, CH-domain IPR036872, CH_dom_sf IPR039041, Nav/unc-53 IPR027417, P-loop_NTPase |
PANTHERi | PTHR12784, PTHR12784, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF00307, CH, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00033, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q80TN7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVLGVASKL RQPAVGPKPV HAALPIPNLG ISVSRRCSSR PLEFATPERS
60 70 80 90 100
MLSCQLTLKS TCEFGEKKAL QGTAKEIEDS KIYTDWANHY LAKSGHKRLI
110 120 130 140 150
KDLQQDIADG VLLADIIQII ANEKVEDING CPRSQSQMIE NVDVCLSFLA
160 170 180 190 200
ARGVNVQGLS AEEIRNGNLK AILGLFFSLS RYKQQQHHQQ QYYQSLVELQ
210 220 230 240 250
QRVTHTAPQS EASQAKTQQD MQSSLTARYA AQSKHSGIAT SQKKPTRLPG
260 270 280 290 300
PSRVPAASSS NKAQGASNLN RRSQSFNSID KNKPPNYANG NEKDSPKGPQ
310 320 330 340 350
PSSGINGNTQ PPSTSGQPPA SAIPSPSASK PWRSKSMNVK HSATSTMLTV
360 370 380 390 400
KQPSPATSPT PSSDRLKPPV TEGVKSAPSG QKSMLEKFKL VNARTALRPP
410 420 430 440 450
QAPSSGPNDG GREDDAFSES GEMEGFNSGL NSGGSTNSSP KVSPKLTPPK
460 470 480 490 500
AGSKNFSNKK SLLQPKEKEE KTRDKNKACA EKSGKEEKDQ VTTEAAPKKT
510 520 530 540 550
SKIASLIPKG SKTAAAKKES LIPSSSGIPK PGSKVPTPKQ TISPGSAASK
560 570 580 590 600
ESEKFRTSKG SSSQAFPKAI TAEKASTPSL STPLDGREAG QASPSSSCVM
610 620 630 640 650
QVTHSSGQSP GNGAVQLPQQ QQHSHPNTAT VAPFIYRAHS ENEGTSLPPA
660 670 680 690 700
DSCTSPTKMD SSYSKTAKQC LEEISGEDPE ARRMRTVKNI ADLRQNLEET
710 720 730 740 750
MSSLRGTQIS HSTLETTFDT TVTTEVNGRA IPNLTSRPSP MTWRLGQACP
760 770 780 790 800
RLQAGDAPSM GAGYSRSGTS RFIHTDPSRF MYTTPLRRAA VSRLGNMSQI
810 820 830 840 850
DMSEKASSDL DVSSEVDVGG YMSDGDILGK SLRADDINSG YMTDGGLNLY
860 870 880 890 900
TRSLNRVPDT ATSRDVIQRG VHDVTVDADS WDDSSSVSSG LSDTLDNIST
910 920 930 940 950
DDLNTTSSIS SYSNITVPSR KNTQLKTDAE KRSTTDETWD SPEELKKAEG
960 970 980 990 1000
DCDSHGDGAA KWKGATSGLA EDSEKTGQKA SLSVSQTGSW RRGMSAQGGT
1010 1020 1030 1040 1050
PATARQKTST SALKTPGKTD DAKASEKGKT PLKGSSLQRS PSDAGKSSGD
1060 1070 1080 1090 1100
EGKKPPSGIG RSTASSSFGY KKPSGVGAST MITSSGATIT SGSATLGKIP
1110 1120 1130 1140 1150
KSAAIGGKSN AGRKTSLDGS QNQDDVVLHV SSKTTLQYRS LPRPSKSSTS
1160 1170 1180 1190 1200
GIPGRGGHRS STSSIDSNVS SKSAGATTSK LREPTKIGSG RSSPVTVNQT
1210 1220 1230 1240 1250
DKEKEKVAVS DSESVSLSGS PKSSPTSASA CGTQGLRQPG SKYPDIASPT
1260 1270 1280 1290 1300
FRRLFGAKAG GKSASAPNTE GAKSSSVVLS PSTSLARQGS LESPSSGTGS
1310 1320 1330 1340 1350
MGSAGGLSGS SSPLFNKPSD LTTDVISLSH SLASSPASVH SFTSGGLVWA
1360 1370 1380 1390 1400
ANLSSSSAGS KDTPSYQSMT SLHTSSESID LPLSHHGSLS GLTTGTHEVQ
1410 1420 1430 1440 1450
SLLMRTGSVR STLSESMQLD RNTLPKKGLR YTPSSRQANQ EEGKEWLRSH
1460 1470 1480 1490 1500
STGGLQDTGN QSPLVSPSAM SSSATGKYHF SNLVSPTNLS QFNLPAPSMM
1510 1520 1530 1540 1550
RSSSIPAQDS SFDLYDDAQL CGSATSLEER PRAVSHSGSF RDSMEEVHGS
1560 1570 1580 1590 1600
SLSLVSSTSS LYSTAEEKAH SEQIHKLRRE LVASQEKVAT LTSQLSANAH
1610 1620 1630 1640 1650
LVAAFEKSLG NMTGRLQSLT MTAEQKESEL IELRETIEML KAQNSAAQAA
1660 1670 1680 1690 1700
IQGALNGPDH PPKDLRIRRQ HSSESVSSIN SATSHSSIGS GNDADSKKKK
1710 1720 1730 1740 1750
KKNWLRSSFK QAFGKKKSTK PPSSHSDIEE LTDSSLPASP KLPHNAGESG
1760 1770 1780 1790 1800
SSSMKPSQSA SAICECTEAE AEIILQLKSE LREKELKLTD IRLEALSSAH
1810 1820 1830 1840 1850
HLDQIREAMN RMQNEIEILK AENDRLKAET GNTAKPARPP SDSSSTASSS
1860 1870 1880 1890 1900
SSRQSLGLSL NNLNITESVT SDILLDDTGD ATGHKDGRSV KIIVSISKGY
1910 1920 1930 1940 1950
GRAKDQKSQA YLIGSIGVSG KTKWDVLDGV IRRLFKEYVF RIDTSSSLGL
1960 1970 1980 1990 2000
SSDCIASYCI GDLIRSHNLE VPELLPCGYL VGDNNIITVN LKGVEENSLD
2010 2020 2030 2040 2050
SFVFDTLIPK PITQRYFNLL MEHHRIILSG PSGTGKTYLA NKLAEYVITK
2060 2070 2080 2090 2100
SGRKKTEDAI ATFNVDHKSS KELQQYLANL AEQCSADNNG VELPVVIILD
2110 2120 2130 2140 2150
NLHHVGSLSD IFNGFLNCKY NKCPYIIGTM NQGVSSSPNL ELHHNFRWVL
2160 2170 2180 2190 2200
CANHTEPVKG FLGRYLRRKL IEMEIERNIR NNDLVKIIDW IPKTWHHLNS
2210 2220 2230 2240 2250
FLETHSSSDV TIGPRLFLPC PMDVEGSRVW FMDLWNYSLV PYVLEAVREG
2260 2270 2280 2290 2300
LQMYGKRAPW EDPSKWVLDT YPWSSASLPQ EGPALLQLRP EDVGYEACTS
2310 2320 2330 2340 2350
TKEATTSKHI PQTDTEGDPL MNMLMKLQEA ANYPSTQSCD GDSVSHREDI
LDTSIESTL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9QMF5 | E9QMF5_MOUSE | Neuron navigator 3 | Nav3 | 2,366 | Annotation score: | ||
A0A668KM70 | A0A668KM70_MOUSE | Neuron navigator 3 | Nav3 | 2,309 | Annotation score: | ||
A0A571BDN3 | A0A571BDN3_MOUSE | Neuron navigator 3 | Nav3 | 1,844 | Annotation score: |
Sequence cautioni
The sequence BAC65686 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC100120 Genomic DNA No translation available. AC122011 Genomic DNA No translation available. AC129336 Genomic DNA No translation available. AK122404 mRNA Translation: BAC65686.1 Sequence problems. |
RefSeqi | XP_006513738.1, XM_006513675.3 |
Genome annotation databases
UCSCi | uc007gzk.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC100120 Genomic DNA No translation available. AC122011 Genomic DNA No translation available. AC129336 Genomic DNA No translation available. AK122404 mRNA Translation: BAC65686.1 Sequence problems. |
RefSeqi | XP_006513738.1, XM_006513675.3 |
3D structure databases
SMRi | Q80TN7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 234432, 6 interactors |
IntActi | Q80TN7, 2 interactors |
STRINGi | 10090.ENSMUSP00000032719 |
PTM databases
iPTMneti | Q80TN7 |
PhosphoSitePlusi | Q80TN7 |
Proteomic databases
jPOSTi | Q80TN7 |
MaxQBi | Q80TN7 |
PaxDbi | Q80TN7 |
PRIDEi | Q80TN7 |
ProteomicsDBi | 287444 |
Genome annotation databases
UCSCi | uc007gzk.1, mouse |
Organism-specific databases
MGIi | MGI:2183703, Nav3 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPT3, Eukaryota |
InParanoidi | Q80TN7 |
PhylomeDBi | Q80TN7 |
Miscellaneous databases
BioGRID-ORCSi | 260315, 2 hits in 52 CRISPR screens |
ChiTaRSi | Nav3, mouse |
PROi | PR:Q80TN7 |
RNActi | Q80TN7, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003959, ATPase_AAA_core IPR001715, CH-domain IPR036872, CH_dom_sf IPR039041, Nav/unc-53 IPR027417, P-loop_NTPase |
PANTHERi | PTHR12784, PTHR12784, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF00307, CH, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00033, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NAV3_MOUSE | |
Accessioni | Q80TN7Primary (citable) accession number: Q80TN7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | May 15, 2007 | |
Last modified: | April 7, 2021 | |
This is version 111 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families