Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Palmitoyltransferase ZDHHC17

Gene

Zdhhc17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15489887, PubMed:15603741, PubMed:25253725). Palmitoylates MPP1 in erythrocytes (By similarity). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (By similarity). May play a role in Mg2+ transport (By similarity).By similarity3 Publications

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei467S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • lipoprotein transport Source: MGI
  • protein palmitoylation Source: UniProtKB

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC17Curated (EC:2.3.1.2253 Publications)
Alternative name(s):
Huntingtin-interacting protein 141 Publication
Zinc finger DHHC domain-containing protein 17Imported
Short name:
DHHC-171 Publication
Gene namesi
Name:Zdhhc17Imported
Synonyms:Hip141 Publication, Kiaa0946Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2445110 Zdhhc17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 304CytoplasmicSequence analysisAdd BLAST304
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Topological domaini347 – 357CytoplasmicSequence analysisAdd BLAST11
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
Topological domaini379 – 381LumenalSequence analysis3
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Topological domaini403 – 480CytoplasmicSequence analysisAdd BLAST78
Transmembranei481 – 501HelicalSequence analysisAdd BLAST21
Topological domaini502 – 529LumenalSequence analysisAdd BLAST28
Transmembranei530 – 550HelicalSequence analysisAdd BLAST21
Topological domaini551 – 632CytoplasmicSequence analysisAdd BLAST82

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi465H → Q: Loss of palmitoyltransferase activity toward DNAJC5 and SNAP25. 1 Publication1
Mutagenesisi467C → A: No effect on interaction with DNAJC5 and SNAP25. 1 Publication1

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129011 – 632Palmitoyltransferase ZDHHC17Add BLAST632

Post-translational modificationi

Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg2+ transport.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ80TN5
PeptideAtlasiQ80TN5
PRIDEiQ80TN5

PTM databases

iPTMnetiQ80TN5
PhosphoSitePlusiQ80TN5
SwissPalmiQ80TN5

Expressioni

Tissue specificityi

Expressed in liver, testis, kidney, heart, pancreas and brain. Highest expression was seen in the brain. Localized predominantly in the perinuclear regions of neurons from the cortex, striatum and hippocampus. Colocalized with HTT in the medium spiny neurons of the striatum and the spiny neurons that project into the globus pallidus.1 Publication

Inductioni

Up-regulated by low extracellular Mg2+.1 Publication

Gene expression databases

BgeeiENSMUSG00000035798
CleanExiMM_ZDHHC17
ExpressionAtlasiQ80TN5 baseline and differential
GenevisibleiQ80TN5 MM

Interactioni

Subunit structurei

Interacts (via ANK repeats) with numerous proteins (via the consensus sequence motif [VIAP]-[VIT]-x-x-Q-P) (By similarity). Interacts (via ANK repeats) with CLIP3 (PubMed:26198635). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (PubMed:25253725, PubMed:26198635). Interacts (via ANK repeats) with HTT (PubMed:26198635). Interacts (via ANK repeats) with MAP6 (PubMed:26198635). Interacts (via ANK repeats) with SNAP23 (PubMed:26198635). Interacts (via ANK repeats) with SNAP25 (PubMed:25253725, PubMed:26198635). Interacts (via ANK repeats) with EVL (By similarity). May interact (via ANK repeats) with SPRED2 (PubMed:28882895).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043279

Structurei

3D structure databases

ProteinModelPortaliQ80TN5
SMRiQ80TN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 86ANK 1By similarityAdd BLAST36
Repeati89 – 118ANK 2Sequence analysisAdd BLAST30
Repeati123 – 152ANK 3Sequence analysisAdd BLAST30
Repeati156 – 185ANK 4Sequence analysisAdd BLAST30
Repeati189 – 219ANK 5Sequence analysisAdd BLAST31
Repeati224 – 253ANK 6Sequence analysisAdd BLAST30
Repeati257 – 286ANK 7Sequence analysisAdd BLAST30
Domaini437 – 487DHHCPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 305Necessary and sufficient for interaction with DNAJC5 and SNAP251 PublicationAdd BLAST295

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0509 Eukaryota
COG0666 LUCA
COG5273 LUCA
GeneTreeiENSGT00530000063074
HOGENOMiHOG000290181
HOVERGENiHBG051907
InParanoidiQ80TN5
KOiK20032
OMAiHLNFLFI
OrthoDBiEOG091G056H
PhylomeDBiQ80TN5
TreeFamiTF317342

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001594 Palmitoyltrfase_DHHC
IPR030289 ZDHHC17
PANTHERiPTHR24161:SF18 PTHR24161:SF18, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF01529 DHHC, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50216 DHHC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80TN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQREEGFNTK MADGPDEYET ETGCVPLLHP EEIKPQSHYN HGYGEPLGRK
60 70 80 90 100
THIDDYSTWD IVKATQYGIY ERCRELVEAG YDVRQPDKEN VTLLHWAAIN
110 120 130 140 150
NRIDLVKYYI SKGAIVDQLG GDLNSTPLHW ATRQGHLSMV VQLMKYGADP
160 170 180 190 200
SLIDGEGCSC IHLAAQFGHT SIVAYLIAKG QDVDMMDQNG MTPLMWAAYR
210 220 230 240 250
THSVDPTRLL LTFNVSVNLG DKYHKNTALH WAVLAGNTTV ISLLLEAGGN
260 270 280 290 300
VDAQNVKGES ALDLAKQRKN VWMINHLQEA RQAKGYDNPS FLRKLKADKE
310 320 330 340 350
FRQKVMLGTP FLVIWLVGFI ADLDIDSWLI KGLMYGGVWA TVQFLSKSFF
360 370 380 390 400
DHSMHSALPL GIYLATKFWM YVTWFFWFWN DLNFLFIHLP FLANSVALFY
410 420 430 440 450
NFGKSWKSDP GIIKATEEQK KKTIVELAET GSLDLSIFCS TCLIRKPVRS
460 470 480 490 500
KHCGVCNRCI AKFDHHCPWV GNCVGAGNHR YFMGYLFFLL FMICWMIYGC
510 520 530 540 550
VSYWGLHCET TYTKDGFWTY ITQIATCSPW MFWMFLNSVF HFLWVAVLLM
560 570 580 590 600
CQLYQITCLG ITTNERMNAR RYKHFKVTTT SIESPFNHGC VRNIIDFFEF
610 620 630
RCCGLFRPVI VDWTRQYTIE YDQISGSGYQ LV
Length:632
Mass (Da):72,621
Last modified:April 13, 2004 - v2
Checksum:i323EFD47790750DC
GO
Isoform 2 (identifier: Q80TN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     423-429: TIVELAE → VVMYPAN
     430-632: Missing.

Show »
Length:429
Mass (Da):48,784
Checksum:iFE0E0E96934E4FC9
GO

Sequence cautioni

The sequence AAH58772 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC30090 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC30097 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC32912 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC65688 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti288N → K in BAC32912 (PubMed:12693553).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010026423 – 429TIVELAE → VVMYPAN in isoform 2. 1 Publication7
Alternative sequenceiVSP_010027430 – 632Missing in isoform 2. 1 PublicationAdd BLAST203

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122406 mRNA Translation: BAC65688.1 Different initiation.
AK038670 mRNA Translation: BAC30090.2 Different initiation.
AK038681 mRNA Translation: BAC30097.2 Different initiation.
AK046891 mRNA Translation: BAC32912.1 Different initiation.
BC058772 mRNA Translation: AAH58772.1 Sequence problems.
CCDSiCCDS56748.1 [Q80TN5-1]
RefSeqiNP_766142.2, NM_172554.2 [Q80TN5-1]
UniGeneiMm.339281

Genome annotation databases

EnsembliENSMUST00000041723; ENSMUSP00000043279; ENSMUSG00000035798 [Q80TN5-1]
GeneIDi320150
KEGGimmu:320150
UCSCiuc007gzw.2 mouse [Q80TN5-2]
uc033fsq.1 mouse [Q80TN5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZDH17_MOUSE
AccessioniPrimary (citable) accession number: Q80TN5
Secondary accession number(s): Q8BJ08, Q8BYQ2, Q8BYQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: March 28, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health