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Protein

Protein MON2 homolog

Gene

Mon2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be required for traffic between late Golgi and early endosomes.By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MON2 homolog
Alternative name(s):
Protein SF21
Gene namesi
Name:Mon2
Synonyms:Kiaa1040, Sf21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1914324 Mon2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002979032 – 1715Protein MON2 homologAdd BLAST1714

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei534PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ80TL7
PeptideAtlasiQ80TL7
PRIDEiQ80TL7

PTM databases

iPTMnetiQ80TL7
PhosphoSitePlusiQ80TL7

Expressioni

Gene expression databases

BgeeiENSMUSG00000034602 Expressed in 246 organ(s), highest expression level in blastocyst
CleanExiMM_MON2
ExpressionAtlasiQ80TL7 baseline and differential
GenevisibleiQ80TL7 MM

Interactioni

Protein-protein interaction databases

BioGridi211921, 1 interactor
STRINGi10090.ENSMUSP00000073462

Structurei

3D structure databases

ProteinModelPortaliQ80TL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MON2 family.Curated

Phylogenomic databases

eggNOGiKOG0929 Eukaryota
KOG1848 Eukaryota
ENOG410XQA8 LUCA
GeneTreeiENSGT00390000013286
HOGENOMiHOG000008113
HOVERGENiHBG108142
InParanoidiQ80TL7
OMAiNICYESD
OrthoDBiEOG091G00D1
PhylomeDBiQ80TL7
TreeFamiTF314287

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR026829 Mon2-like
IPR032817 Mon2_C
IPR015403 Sec7_C
IPR032691 Sec7_N
PANTHERiPTHR44195 PTHR44195, 1 hit
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF16206 Mon2_C, 1 hit
PF12783 Sec7_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80TL7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSCTNSPEAV KKLLENMQSD LRALSLECKK KFPPVKEAAE SGIIKVKTIA
60 70 80 90 100
ARNTEILAAL KENSSEVVQP FLMGCGTKEP KITQLCLAAI QRLMSHEVVS
110 120 130 140 150
ETAAGNIINM LWQLMENSLE ELKLLQTVLV LLTTNTVVHD EALSKAIVLC
160 170 180 190 200
FRLHFTKDNI TNNTAAATVR QVVTVVFERM VAEDDRHRDI EPPVPIQGNS
210 220 230 240 250
NRRSVSTLRP CAKDAYMLFQ DLCQLVNADA PYWLVGMTEM TRTFGLELLE
260 270 280 290 300
SVLNDFPQVF LQHQEFSFLL KERVCPLVIK LFSPNIKFRQ GSSTSSSPAP
310 320 330 340 350
VEKPYFPICM RLLRVVSVLI KQFYSLLVTE CEIFLSLLVK FLDSDKPQWL
360 370 380 390 400
RAVAVESIHR LCVQPQLLRS FCQSYDMKQH STKVFRDIVN ALGSFIQSLF
410 420 430 440 450
LVPPTGNPAT ANQAGNNNAG GPASAPANSG VVGVGGGVTL LPAFEYRGAW
460 470 480 490 500
IPILTVTVQG SAKATYLEML DKVEPPTIPE GYAMSVAFHC LLDLVRGITT
510 520 530 540 550
MIEGELGEVE AEGPSVTEGA SSQSSERRDE QAASDPMDQE TVSRAVWEEM
560 570 580 590 600
VSACWCGLLA ALSLLLDAST DEAATENILK AELTMAALCG RLGLVTSRDA
610 620 630 640 650
FITAICKGSL PPHYALTVLN ATTAATLSNK SYSIQGQSVM MISPSSESHQ
660 670 680 690 700
QVVAVGQPLA VQPQGTVMLT SKNIQCMRTL LNLAHCHGAV LGTSWQLVLA
710 720 730 740 750
TLQHLVWILG LKPSSGGALK PGRAVEGPST VLTTAVMTDL PVISNILSRL
760 770 780 790 800
FESSQYLDDV SLHHLINALC SLSLEAMDMA YGNNKEPSLF AVAKLLETGL
810 820 830 840 850
VNMHRIEILW RPLTGHLLEK VCQHPNSRMR EWGAEALTSL IRAGLTFSHE
860 870 880 890 900
PPLPQNQRLQ LLLLNPLKEM SNINHPDIRL KQLECVLQIL QSQGDSLGPG
910 920 930 940 950
WPLVLGVMGA IRNDQGESLI RTAFQCLQLV VTDFLPTMPC SCLQIVVDVA
960 970 980 990 1000
GSFGLHNQEL NISLTSIGLL WNISDYFFQR GETIEKELNK EEAAQQKQAE
1010 1020 1030 1040 1050
EKGVSLNRPF HPAPPFDCLW LCLYAKLGEL CVDPRPAVRK SAGQTLFSTI
1060 1070 1080 1090 1100
GAHGTLLQHS TWHTVIWKVL FHLLDRVRES STTADKEKIE SGGGNILIHH
1110 1120 1130 1140 1150
SRDTAEKQWA ETWVLTLAGV ARIFNTRRYL LQPLGDFSRA WDVLLDHIQS
1160 1170 1180 1190 1200
AALSKNNEVS LAALKSFQEI LQIVSPVRDS EKPEPPAVSV PVPVLLGNLS
1210 1220 1230 1240 1250
GPGLSRPFVR TDSIGEKLGR CGSETPVVTD ELEDLKLWWA AWNTWHRTGS
1260 1270 1280 1290 1300
ESTEPPSSVD ELTFIPSQPF LTALVQIFPA LYQHIKAGFS MADLQKLGVI
1310 1320 1330 1340 1350
LHSAVSVPIS SDASPFILPS YTEAVLTSLQ EAVLTALDVL QKAICVGPEN
1360 1370 1380 1390 1400
MQIMYPAIFD QLLAFVEFSC KPPQYGQLET KHIANAKYNQ IQLFAPAEWV
1410 1420 1430 1440 1450
ALNYVPFAER SLEVVVDLYQ KTACHKAVVN EKVLQNIIKT LRVPLSLKYS
1460 1470 1480 1490 1500
CPSESTWKLA VASLLKVLSI GLPVARQHAS SGKFDSMWPE LASTLEDFLF
1510 1520 1530 1540 1550
TKSIPPDNLS IQEFQRNESI DVEVVQLISA EILPYANLIP KAFVGQMMTM
1560 1570 1580 1590 1600
LNKGSIHSQP CSFTEAEIDI RLREEFSKMC FETLLQFSFS NKVTTPQEGY
1610 1620 1630 1640 1650
ISRMALSVLL KRSQDVLHRY IEDERLSGKC PLPRQQVTEI IFVLKAVSTL
1660 1670 1680 1690 1700
IDSLKKTQPE NVDGNTWSQV IALYPTLVEC ITCSSSDVGS ALKEALAPFK
1710
DFMQPPASRV QNGES
Length:1,715
Mass (Da):189,078
Last modified:August 21, 2007 - v2
Checksum:i0D4761F77C7A6490
GO
Isoform 2 (identifier: Q80TL7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     820-820: Missing.
     1391-1396: Missing.

Show »
Length:1,708
Mass (Da):188,280
Checksum:i81992862F2D39AE6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P878A0A1W2P878_MOUSE
Protein MON2 homolog
Mon2
436Annotation score:
B9EKJ3B9EKJ3_MOUSE
Mon2 protein
Mon2
1,709Annotation score:

Sequence cautioni

The sequence BAC25345 differs from that shown. Reason: Frameshift at position 1122.Curated
The sequence BAC65707 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1065V → I in BAC11706 (Ref. 1) Curated1
Sequence conflicti1126T → N in BAE37087 (PubMed:16141072).Curated1
Sequence conflicti1195L → F in BAC11706 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027394820Missing in isoform 2. 2 Publications1
Alternative sequenceiVSP_0273951391 – 1396Missing in isoform 2. 2 Publications6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014059 mRNA Translation: BAC11706.1
AK011826 mRNA Translation: BAC25345.1 Frameshift.
AK122425 mRNA Translation: BAC65707.1 Different initiation.
AK162859 mRNA Translation: BAE37087.1
CCDSiCCDS24216.1 [Q80TL7-2]
CCDS48707.1 [Q80TL7-1]
RefSeqiNP_001156496.1, NM_001163024.1 [Q80TL7-1]
NP_700444.2, NM_153395.2 [Q80TL7-2]
UniGeneiMm.169924
Mm.478725

Genome annotation databases

EnsembliENSMUST00000037557; ENSMUSP00000037568; ENSMUSG00000034602 [Q80TL7-2]
ENSMUST00000073792; ENSMUSP00000073462; ENSMUSG00000034602 [Q80TL7-1]
GeneIDi67074
KEGGimmu:67074
UCSCiuc007hgj.2 mouse [Q80TL7-1]
uc007hgk.2 mouse [Q80TL7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014059 mRNA Translation: BAC11706.1
AK011826 mRNA Translation: BAC25345.1 Frameshift.
AK122425 mRNA Translation: BAC65707.1 Different initiation.
AK162859 mRNA Translation: BAE37087.1
CCDSiCCDS24216.1 [Q80TL7-2]
CCDS48707.1 [Q80TL7-1]
RefSeqiNP_001156496.1, NM_001163024.1 [Q80TL7-1]
NP_700444.2, NM_153395.2 [Q80TL7-2]
UniGeneiMm.169924
Mm.478725

3D structure databases

ProteinModelPortaliQ80TL7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211921, 1 interactor
STRINGi10090.ENSMUSP00000073462

PTM databases

iPTMnetiQ80TL7
PhosphoSitePlusiQ80TL7

Proteomic databases

PaxDbiQ80TL7
PeptideAtlasiQ80TL7
PRIDEiQ80TL7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037557; ENSMUSP00000037568; ENSMUSG00000034602 [Q80TL7-2]
ENSMUST00000073792; ENSMUSP00000073462; ENSMUSG00000034602 [Q80TL7-1]
GeneIDi67074
KEGGimmu:67074
UCSCiuc007hgj.2 mouse [Q80TL7-1]
uc007hgk.2 mouse [Q80TL7-2]

Organism-specific databases

CTDi23041
MGIiMGI:1914324 Mon2
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0929 Eukaryota
KOG1848 Eukaryota
ENOG410XQA8 LUCA
GeneTreeiENSGT00390000013286
HOGENOMiHOG000008113
HOVERGENiHBG108142
InParanoidiQ80TL7
OMAiNICYESD
OrthoDBiEOG091G00D1
PhylomeDBiQ80TL7
TreeFamiTF314287

Miscellaneous databases

ChiTaRSiMon2 mouse
PROiPR:Q80TL7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034602 Expressed in 246 organ(s), highest expression level in blastocyst
CleanExiMM_MON2
ExpressionAtlasiQ80TL7 baseline and differential
GenevisibleiQ80TL7 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR026829 Mon2-like
IPR032817 Mon2_C
IPR015403 Sec7_C
IPR032691 Sec7_N
PANTHERiPTHR44195 PTHR44195, 1 hit
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF16206 Mon2_C, 1 hit
PF12783 Sec7_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMON2_MOUSE
AccessioniPrimary (citable) accession number: Q80TL7
Secondary accession number(s): Q3TRE3, Q8BTA8, Q8K4V3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 7, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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