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UniProtKB - Q80TL7 (MON2_MOUSE)

Protein

Protein MON2 homolog

Gene

Mon2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be required for traffic between late Golgi and early endosomes.By similarity

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MON2 homolog
Alternative name(s):
Protein SF21
Gene namesi
Name:Mon2
Synonyms:Kiaa1040, Sf21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1914324 Mon2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002979032 – 1715Protein MON2 homologAdd BLAST1714

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei534PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ80TL7
PeptideAtlasiQ80TL7
PRIDEiQ80TL7

PTM databases

iPTMnetiQ80TL7
PhosphoSitePlusiQ80TL7

Expressioni

Gene expression databases

BgeeiENSMUSG00000034602 Expressed in 246 organ(s), highest expression level in blastocyst
CleanExiMM_MON2
ExpressionAtlasiQ80TL7 baseline and differential
GenevisibleiQ80TL7 MM

Interactioni

Protein-protein interaction databases

BioGridi211921, 1 interactor
STRINGi10090.ENSMUSP00000073462

Structurei

3D structure databases

ProteinModelPortaliQ80TL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MON2 family.Curated

Phylogenomic databases

eggNOGiKOG0929 Eukaryota
KOG1848 Eukaryota
ENOG410XQA8 LUCA
GeneTreeiENSGT00390000013286
HOGENOMiHOG000008113
HOVERGENiHBG108142
InParanoidiQ80TL7
OMAiNICYESD
OrthoDBiEOG091G00D1
PhylomeDBiQ80TL7
TreeFamiTF314287

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR026829 Mon2-like
IPR032817 Mon2_C
IPR015403 Sec7_C
IPR032691 Sec7_N
PANTHERiPTHR44195 PTHR44195, 1 hit
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF16206 Mon2_C, 1 hit
PF12783 Sec7_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80TL7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSCTNSPEAV KKLLENMQSD LRALSLECKK KFPPVKEAAE SGIIKVKTIA 
        60         70         80         90        100
ARNTEILAAL KENSSEVVQP FLMGCGTKEP KITQLCLAAI QRLMSHEVVS 
       110        120        130        140        150
ETAAGNIINM LWQLMENSLE ELKLLQTVLV LLTTNTVVHD EALSKAIVLC 
       160        170        180        190        200
FRLHFTKDNI TNNTAAATVR QVVTVVFERM VAEDDRHRDI EPPVPIQGNS 
       210        220        230        240        250
NRRSVSTLRP CAKDAYMLFQ DLCQLVNADA PYWLVGMTEM TRTFGLELLE 
       260        270        280        290        300
SVLNDFPQVF LQHQEFSFLL KERVCPLVIK LFSPNIKFRQ GSSTSSSPAP 
       310        320        330        340        350
VEKPYFPICM RLLRVVSVLI KQFYSLLVTE CEIFLSLLVK FLDSDKPQWL 
       360        370        380        390        400
RAVAVESIHR LCVQPQLLRS FCQSYDMKQH STKVFRDIVN ALGSFIQSLF 
       410        420        430        440        450
LVPPTGNPAT ANQAGNNNAG GPASAPANSG VVGVGGGVTL LPAFEYRGAW 
       460        470        480        490        500
IPILTVTVQG SAKATYLEML DKVEPPTIPE GYAMSVAFHC LLDLVRGITT 
       510        520        530        540        550
MIEGELGEVE AEGPSVTEGA SSQSSERRDE QAASDPMDQE TVSRAVWEEM 
       560        570        580        590        600
VSACWCGLLA ALSLLLDAST DEAATENILK AELTMAALCG RLGLVTSRDA 
       610        620        630        640        650
FITAICKGSL PPHYALTVLN ATTAATLSNK SYSIQGQSVM MISPSSESHQ 
       660        670        680        690        700
QVVAVGQPLA VQPQGTVMLT SKNIQCMRTL LNLAHCHGAV LGTSWQLVLA 
       710        720        730        740        750
TLQHLVWILG LKPSSGGALK PGRAVEGPST VLTTAVMTDL PVISNILSRL 
       760        770        780        790        800
FESSQYLDDV SLHHLINALC SLSLEAMDMA YGNNKEPSLF AVAKLLETGL 
       810        820        830        840        850
VNMHRIEILW RPLTGHLLEK VCQHPNSRMR EWGAEALTSL IRAGLTFSHE 
       860        870        880        890        900
PPLPQNQRLQ LLLLNPLKEM SNINHPDIRL KQLECVLQIL QSQGDSLGPG 
       910        920        930        940        950
WPLVLGVMGA IRNDQGESLI RTAFQCLQLV VTDFLPTMPC SCLQIVVDVA 
       960        970        980        990       1000
GSFGLHNQEL NISLTSIGLL WNISDYFFQR GETIEKELNK EEAAQQKQAE 
      1010       1020       1030       1040       1050
EKGVSLNRPF HPAPPFDCLW LCLYAKLGEL CVDPRPAVRK SAGQTLFSTI 
      1060       1070       1080       1090       1100
GAHGTLLQHS TWHTVIWKVL FHLLDRVRES STTADKEKIE SGGGNILIHH 
      1110       1120       1130       1140       1150
SRDTAEKQWA ETWVLTLAGV ARIFNTRRYL LQPLGDFSRA WDVLLDHIQS 
      1160       1170       1180       1190       1200
AALSKNNEVS LAALKSFQEI LQIVSPVRDS EKPEPPAVSV PVPVLLGNLS 
      1210       1220       1230       1240       1250
GPGLSRPFVR TDSIGEKLGR CGSETPVVTD ELEDLKLWWA AWNTWHRTGS 
      1260       1270       1280       1290       1300
ESTEPPSSVD ELTFIPSQPF LTALVQIFPA LYQHIKAGFS MADLQKLGVI 
      1310       1320       1330       1340       1350
LHSAVSVPIS SDASPFILPS YTEAVLTSLQ EAVLTALDVL QKAICVGPEN 
      1360       1370       1380       1390       1400
MQIMYPAIFD QLLAFVEFSC KPPQYGQLET KHIANAKYNQ IQLFAPAEWV 
      1410       1420       1430       1440       1450
ALNYVPFAER SLEVVVDLYQ KTACHKAVVN EKVLQNIIKT LRVPLSLKYS 
      1460       1470       1480       1490       1500
CPSESTWKLA VASLLKVLSI GLPVARQHAS SGKFDSMWPE LASTLEDFLF 
      1510       1520       1530       1540       1550
TKSIPPDNLS IQEFQRNESI DVEVVQLISA EILPYANLIP KAFVGQMMTM 
      1560       1570       1580       1590       1600
LNKGSIHSQP CSFTEAEIDI RLREEFSKMC FETLLQFSFS NKVTTPQEGY 
      1610       1620       1630       1640       1650
ISRMALSVLL KRSQDVLHRY IEDERLSGKC PLPRQQVTEI IFVLKAVSTL 
      1660       1670       1680       1690       1700
IDSLKKTQPE NVDGNTWSQV IALYPTLVEC ITCSSSDVGS ALKEALAPFK 
      1710 
DFMQPPASRV QNGES
Length:1,715
Mass (Da):189,078
Last modified:August 21, 2007 - v2
Checksum:i0D4761F77C7A6490
GO
Isoform 2 (identifier: Q80TL7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     820-820: Missing.
     1391-1396: Missing.

Show »
Length:1,708
Mass (Da):188,280
Checksum:i81992862F2D39AE6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P878A0A1W2P878_MOUSE
Protein MON2 homolog
Mon2
436Annotation score:
B9EKJ3B9EKJ3_MOUSE
Mon2 protein
Mon2
1,709Annotation score:

Sequence cautioni

The sequence BAC25345 differs from that shown. Reason: Frameshift at position 1122.Curated
The sequence BAC65707 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1065V → I in BAC11706 (Ref. 1) Curated1
Sequence conflicti1126T → N in BAE37087 (PubMed:16141072).Curated1
Sequence conflicti1195L → F in BAC11706 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027394820Missing in isoform 2. 2 Publications1
Alternative sequenceiVSP_0273951391 – 1396Missing in isoform 2. 2 Publications6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014059 mRNA Translation: BAC11706.1
AK011826 mRNA Translation: BAC25345.1 Frameshift.
AK122425 mRNA Translation: BAC65707.1 Different initiation.
AK162859 mRNA Translation: BAE37087.1
CCDSiCCDS24216.1 [Q80TL7-2]
CCDS48707.1 [Q80TL7-1]
RefSeqiNP_001156496.1, NM_001163024.1 [Q80TL7-1]
NP_700444.2, NM_153395.2 [Q80TL7-2]
UniGeneiMm.169924
Mm.478725

Genome annotation databases

EnsembliENSMUST00000037557; ENSMUSP00000037568; ENSMUSG00000034602 [Q80TL7-2]
ENSMUST00000073792; ENSMUSP00000073462; ENSMUSG00000034602 [Q80TL7-1]
GeneIDi67074
KEGGimmu:67074
UCSCiuc007hgj.2 mouse [Q80TL7-1]
uc007hgk.2 mouse [Q80TL7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014059 mRNA Translation: BAC11706.1
AK011826 mRNA Translation: BAC25345.1 Frameshift.
AK122425 mRNA Translation: BAC65707.1 Different initiation.
AK162859 mRNA Translation: BAE37087.1
CCDSiCCDS24216.1 [Q80TL7-2]
CCDS48707.1 [Q80TL7-1]
RefSeqiNP_001156496.1, NM_001163024.1 [Q80TL7-1]
NP_700444.2, NM_153395.2 [Q80TL7-2]
UniGeneiMm.169924
Mm.478725

3D structure databases

ProteinModelPortaliQ80TL7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211921, 1 interactor
STRINGi10090.ENSMUSP00000073462

PTM databases

iPTMnetiQ80TL7
PhosphoSitePlusiQ80TL7

Proteomic databases

PaxDbiQ80TL7
PeptideAtlasiQ80TL7
PRIDEiQ80TL7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037557; ENSMUSP00000037568; ENSMUSG00000034602 [Q80TL7-2]
ENSMUST00000073792; ENSMUSP00000073462; ENSMUSG00000034602 [Q80TL7-1]
GeneIDi67074
KEGGimmu:67074
UCSCiuc007hgj.2 mouse [Q80TL7-1]
uc007hgk.2 mouse [Q80TL7-2]

Organism-specific databases

CTDi23041
MGIiMGI:1914324 Mon2
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0929 Eukaryota
KOG1848 Eukaryota
ENOG410XQA8 LUCA
GeneTreeiENSGT00390000013286
HOGENOMiHOG000008113
HOVERGENiHBG108142
InParanoidiQ80TL7
OMAiNICYESD
OrthoDBiEOG091G00D1
PhylomeDBiQ80TL7
TreeFamiTF314287

Miscellaneous databases

ChiTaRSiMon2 mouse
PROiPR:Q80TL7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034602 Expressed in 246 organ(s), highest expression level in blastocyst
CleanExiMM_MON2
ExpressionAtlasiQ80TL7 baseline and differential
GenevisibleiQ80TL7 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR026829 Mon2-like
IPR032817 Mon2_C
IPR015403 Sec7_C
IPR032691 Sec7_N
PANTHERiPTHR44195 PTHR44195, 1 hit
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF16206 Mon2_C, 1 hit
PF12783 Sec7_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMON2_MOUSE
AccessioniPrimary (citable) accession number: Q80TL7
Secondary accession number(s): Q3TRE3, Q8BTA8, Q8K4V3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 7, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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