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UniProtKB - Q80TJ5 (Q80TJ5_MOUSE)

Entry version 66 (10 Feb 2021)
Sequence version 1 (01 Jun 2003)
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Protein
Submitted name:

MKIAA1114 protein

Gene

Tro

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MKIAA1114 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TroImported
Synonyms:mKIAA1114Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1928994, Tro

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		Q80TJ5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini258 – 456MAGEInterPro annotationAdd BLAST199

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 179DisorderedSequence analysisAdd BLAST179
Regioni214 – 246DisorderedSequence analysisAdd BLAST33
Regioni646 – 671DisorderedSequence analysisAdd BLAST26
Regioni1576 – 1685DisorderedSequence analysisAdd BLAST110
Regioni1704 – 1736DisorderedSequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 106PolarSequence analysisAdd BLAST106
Compositional biasi124 – 152PolarSequence analysisAdd BLAST29
Compositional biasi1576 – 1610PolarSequence analysisAdd BLAST35

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.1200, 1 hit
1.10.10.1210, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037445, MAGE
IPR041898, MAGE_WH1
IPR041899, MAGE_WH2
IPR002190, MHD_dom

The PANTHER Classification System

More...PANTHERi		PTHR11736, PTHR11736, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01454, MAGE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01373, MAGE, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50838, MAGE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q80TJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
IGASNRQIEA SNRQIGASNR QTEVSSRQIE ASNRQIGASN RQTEASNRQI 
        60         70         80         90        100
GASNRQTEAS NRQIGASNRQ TDASNRQTEA SSRQTEASSR QTEASSRQTE 
       110        120        130        140        150
ASSRQIEASA AAVRPKKPRG KKGNNKGSNS ASEPSEAPPA IQTVTNHALS 
       160        170        180        190        200
VTVRIRRGSR ARKAANKNRA TESQAQIAEQ GAQASEASIS ALETQVAAAV 
       210        220        230        240        250
QALADDYLAQ LSLEPTTRTR GKRNRKSKHP NGEERTGNNY RRIPWGRRLP 
       260        270        280        290        300
PPRDVAILQE RANKLVKYLL VKDQTKIPIK RSDMLKDVIQ EYEDYFPEII 
       310        320        330        340        350
ERASYALEKM FRVNLKEIDK QNNLYILIST QESSAGIMGT TKDTPKLGLL 
       360        370        380        390        400
MVILSVIFMN GNKASEAVIW EVLRKLGLHP GVKHSLFGEV KKLITDEFVK 
       410        420        430        440        450
QKYLEYKRVP NSRPPEYEFF WGLRSYHETS KMKVLKFACK VQKKDPKDWA 
       460        470        480        490        500
AQYREAVEMD IQAAAVAVAE AKARAEARAQ MGIGEEAVAG PWNWDDMDIN 
       510        520        530        540        550
CLTREELGDD AQAWSRFSFE IEPRAQENAD PTTNVLFNQG ATTRNSFSDG 
       560        570        580        590        600
AGISFGGITN PSGGFGGISN PSGGFGGISN PSGGFGGISN PSGGFGGISN 
       610        620        630        640        650
PSGGFGGISN PSGGFGGISN PSGGFGGISN PSGGFGGISN PSGGFGGISN 
       660        670        680        690        700
PSGGFGGISN PSGGFGGISN PSGGFGGRNS ITFGSVPNTS ANFSSAPSIS 
       710        720        730        740        750
FGDTPNTSTS FSGGANSSFS GTPSTSAPFC NTASISFGGA PSTSTSFSTA 
       760        770        780        790        800
SISFGGAPST STSLSTASIS FGGAPSTSTS FSTASISFGG APSTSTSLST 
       810        820        830        840        850
ASISFGGAPS INSSSGGSSV SFGGAPTTST SFSGGPCISF GGAPCTTASI 
       860        870        880        890        900
SGGASSGFGS TLCSTNPGFS ALSTNTSFGS APTTSTVFSG AVSTTTGFGG 
       910        920        930        940        950
TLSTSVCFGS SPYSGAGFGG TLSTSISFGG SPSTNTGFGG TLSTSVSFGA 
       960        970        980        990       1000
SSSTSSDFGG TLSTSVSFGG SSGANAGFGG TLNSSTSFGG AISTSTGFGS 
      1010       1020       1030       1040       1050
ALNNSANFGG AISTSFSGVL NSSASFGGAI NTSAGFGSTL NSSASFGSAL 
      1060       1070       1080       1090       1100
STSASFGGVL NGSAGFGGAL NTNATFGGVL NGSAGFGGAM NTNATFGGAL 
      1110       1120       1130       1140       1150
NSNAGFGGAI STSTNFGGAL NNSAGFGGAM NTSASFGGAL NNSAGFGGAI 
      1160       1170       1180       1190       1200
STNATFGGAL NNSAGFGGAI STNATFGGAL NNSAGFGGAI STSASFGGTL 
      1210       1220       1230       1240       1250
NNSASFGGAI NTSASFGGVL NNSAGFGGAI NTSANFGGAL TNSAGFGGAI 
      1260       1270       1280       1290       1300
STSASFGGAL NNSAGFGGAI STSASFGGAL NNSAGFGGAI STNASFGGAI 
      1310       1320       1330       1340       1350
SNSPDFGGAF STSVGFGGTL NTTDFGSNHS NSISFGSAPT TSVSFGGSHS 
      1360       1370       1380       1390       1400
TNLCFGGAPS TSLCFGSASN TNLCFGGSNS TNCFSGATSA NFNEGHSISF 
      1410       1420       1430       1440       1450
GNGLSTSAGF GNGLGTSAGF GSSLGTSTGF GGSLGPSASF NGGLGTSTGF 
      1460       1470       1480       1490       1500
GGGLGTSTDF SGGLNHNADF NGGLGNSAGF NGGLNTNTDF GGELGTSAGF 
      1510       1520       1530       1540       1550
GDGLGSSTSF GAGLVTSDGF AGNLGTNTGF GGTLGTGAGF SVSLNNGNGF 
      1560       1570       1580       1590       1600
GNGPNASFNR GLNTIIGFGS GSNTSNGFTG EPNTGSSFSN GPSSIVGFSG 
      1610       1620       1630       1640       1650
GPSTGAGFCS GPSTGGFGGG PSTGPGFGGP STGPGFGGPS TGGGFGGPNT 
      1660       1670       1680       1690       1700
GGGFGGPSTG GGFGGPSTGG GFGGPSTGGG FGGPSTAAGF GSGLSTSTGF 
      1710       1720       1730 
GGGLNTSAGF SGGPPSTGTG FGGGASSHGG CGFPYG
Length:1,736
Mass (Da):169,313
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE94E8DAD2E50B2CF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK122449 mRNA Translation: BAC65731.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122449 mRNA Translation: BAC65731.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ80TJ5

Organism-specific databases

MGIiMGI:1928994, Tro

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Tro, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Family and domain databases

Gene3Di1.10.10.1200, 1 hit
1.10.10.1210, 1 hit
InterProiView protein in InterPro
IPR037445, MAGE
IPR041898, MAGE_WH1
IPR041899, MAGE_WH2
IPR002190, MHD_dom
PANTHERiPTHR11736, PTHR11736, 1 hit
PfamiView protein in Pfam
PF01454, MAGE, 1 hit
SMARTiView protein in SMART
SM01373, MAGE, 1 hit
PROSITEiView protein in PROSITE
PS50838, MAGE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ80TJ5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80TJ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: February 10, 2021
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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