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Entry version 134 (18 Sep 2019)
Sequence version 3 (27 Jul 2011)
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Protein

Calcium-dependent secretion activator 1

Gene

Cadps

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca2+-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca2+ triggering (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport
LigandCalcium, Lipid-binding, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-dependent secretion activator 1
Alternative name(s):
Calcium-dependent activator protein for secretion 1
Short name:
CAPS-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cadps
Synonyms:Caps, Caps1, Kiaa1121
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1350922 Cadps

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice die within 30 minutes after birth but do not display obvious developmental or biochemical abnormalities. They show a strong reduction in the frequency of amperometrically detectable release events of transmitter-filled vesicles, while the total number of fusing vesicles, as judged by capacitance recordings or total internal reflection microscopy, remains unchanged.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000538651 – 1355Calcium-dependent secretion activator 1Add BLAST1355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei34PhosphoserineCombined sources1
Modified residuei89PhosphoserineBy similarity1
Modified residuei96PhosphoserineBy similarity1
Modified residuei259PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80TJ1

PeptideAtlas

More...
PeptideAtlasi
Q80TJ1

PRoteomics IDEntifications database

More...
PRIDEi
Q80TJ1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80TJ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80TJ1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q80TJ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in brain and adrenal glands (at protein level). Specifically expressed in neural and endocrine secretory tissues. Strongly expressed in almost all nerve cells of the brain, although it is absent from glial cells. Expressed in the cardiac atria, but not ventricles.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During brain development, its expression is similar to that of synaptic markers. Expression is first detectable late in embryogenesis (14 dpc) and increases to reach a plateau about 20 days after birth, when most synapses have been formed (at protein level).

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In the heart, up-regulated by hypertrophic stimuli.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000054423 Expressed in 188 organ(s), highest expression level in dentate gyrus of hippocampal formation

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q80TJ1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80TJ1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with the dopamine receptor DRD2 (By similarity).

Interacts with RASL10B.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q80TJ1, 4 interactors

Molecular INTeraction database

More...
MINTi
Q80TJ1

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000064706

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q80TJ1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini398 – 479C2Add BLAST82
Domaini519 – 622PHPROSITE-ProRule annotationAdd BLAST104
Domaini933 – 1113MHD1PROSITE-ProRule annotationAdd BLAST181

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni792 – 1131Interaction with DRD2By similarityAdd BLAST340
Regioni1179 – 1355Mediates targeting and association with DCVsBy similarityAdd BLAST177

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PH domain is essential for regulated exocytosis and binds phospholipids and plasma membrane. It however does not mediate binding to DCVs (By similarity).By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3543 Eukaryota
ENOG410Y0FD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00590000083094

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000263607

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80TJ1

KEGG Orthology (KO)

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KOi
K19933

Identification of Orthologs from Complete Genome Data

More...
OMAi
YISADPC

Database of Orthologous Groups

More...
OrthoDBi
138870at2759

TreeFam database of animal gene trees

More...
TreeFami
TF312963

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033227 CAPS
IPR010439 CAPS_dom
IPR014770 Munc13_1
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR12166 PTHR12166, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06292 DUF1041, 1 hit
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01145 DUF1041, 1 hit
SM00233 PH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51258 MHD1, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80TJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLDPSSSEEE SDEILEEERG KDVLGSAASG ARLSPSRTSE GSAGSAGMGG
60 70 80 90 100
SGAGAGVGAG GGGGSGASSG GGAGGLQPSS RAGGGRPSSP SPSVVSEKEK
110 120 130 140 150
EELERLQKEE EERKKRLQLY VFVMRCIAYP FNAKQPTDMA RRQQKISKQQ
160 170 180 190 200
LQTVKDRFQA FLNGETQIVA DEAFMNAVQS YYEVFLKSDR VARMVQSGGC
210 220 230 240 250
SANDSREVFK KHIEKRVRSL PEIDGLSKET VLSSWMAKFD AIYRGEEDPR
260 270 280 290 300
KQQARMTASA ASELILSKEQ LYEMFQNILG IKKFEHQLLY NACQLDNPDE
310 320 330 340 350
QAAQIRRELD GRLQMADQIA RERKFPKFVS KEMENMYIEE LKSSVNLLMA
360 370 380 390 400
NLESMPVSKG GEFKLQKLKR SHNASIIDMG EESENQLSKS DVLLSFSLEV
410 420 430 440 450
VIMEVQGLKS LAPNRIVYCT MEVEGGEKLQ TDQAEASKPT WGTQGDFSTT
460 470 480 490 500
HALPAVKVKL FTESTGVLAL EDKELGRVIL HPTPNSPKQS EWHKMTVSKN
510 520 530 540 550
CPDQDLKIKL AVRMDKPQNM KHSGYLWTIG KNVWKRWKKR FFVLVQVSQY
560 570 580 590 600
TFAMCSYREK KAEPQELLQL DGYTVDYTDP QPGLEGGRAF FNAVKEGDTV
610 620 630 640 650
IFASDDEQDR ILWVQAMYRA TGQSHKPVPP TQVQKLNAKG GNVPQLDAPI
660 670 680 690 700
SQFSGLKDAD RAQKHGMDEF ISSNPCNFDH ASLFEMVQRL TLDHRLNDSY
710 720 730 740 750
SCLGWFSPGQ VFVLDEYCAR NGVRGCHRHL CYLRDLLERA ENGAMIDPTL
760 770 780 790 800
LHYSFAFCAS HVHGNRPDGI GTVTVEEKER FEEIKERLRV LLENQITHFR
810 820 830 840 850
YCFPFGRPEG ALKATLSLLE RVLMKDIVTP VPQEEVKTVI RKCLEQAALV
860 870 880 890 900
NYSRLSEYAK IEENQKDAEN VGRLITPAKK LEDTIRLAEL VIEVLQQNEE
910 920 930 940 950
HHAEPHVDKG EAFAWWSDLM VEHAETFLSL FAVDMDAALE VQPPDTWDSF
960 970 980 990 1000
PLFQLLNDFL RTDYNLCNGK FHKHLQDLFA PLVVRYVDLM ESSIAQSIHR
1010 1020 1030 1040 1050
GFERESWEPV KSLTSNLPNV NLPNVNLPKV PNLPVNIPLG IPQMPTFSAP
1060 1070 1080 1090 1100
SWMAAIYDAD NGSGTSEDLF WKLDALQTFI RDLHWPEEEF GKHLEQRLKL
1110 1120 1130 1140 1150
MASDMIESCV KRTRIAFEVK LQKTSRSTDF RVPQSICTMF NVMVDAKAQS
1160 1170 1180 1190 1200
TKLCSMEMGQ EHQYHSKIDE LIEETVKEMI TLLVAKFVTI LEGVLAKLSR
1210 1220 1230 1240 1250
YDEGTLFSSF LSFTVKAASK YVDVPKPGMD VADAYVTFVR HSQDVLRDKV
1260 1270 1280 1290 1300
NEEMYIERLF DQWYNSSMNI ICTWLTDRMD LQLHIYQLKT LIRMVKKTYR
1310 1320 1330 1340 1350
DFRLQGVLDS TLNSKTYETI RNRLTVEEAT ASVSEGGGLQ GISMKDSDEE

DEEDD
Length:1,355
Mass (Da):153,113
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59596BAD74C6AE56
GO
Isoform 2 (identifier: Q80TJ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     654-658: SGLKD → Y
     863-869: ENQKDAE → GKKREMYEHPVFCLASQVMDLTIQ
     904-910: Missing.

Show »
Length:1,361
Mass (Da):154,004
Checksum:iC601C07CCC8D01F3
GO
Isoform 4 (identifier: Q80TJ1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     905-910: PHVDKG → GK

Note: No experimental confirmation available.
Show »
Length:1,351
Mass (Da):152,664
Checksum:iE61DA7F964FE89FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QJW3J3QJW3_MOUSE
Calcium-dependent secretion activat...
Cadps
1,356Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K4DI76K4DI76_MOUSE
Calcium-dependent secretion activat...
Cadps
1,354Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YDH6A0A286YDH6_MOUSE
Calcium-dependent secretion activat...
Cadps
867Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YE00A0A286YE00_MOUSE
Calcium-dependent secretion activat...
Cadps
402Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13044 differs from that shown. The sequence differs from that shown due to a duplication of 90 bp after position 107.Curated
The sequence BAC65735 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19R → S in BAA13044 (Ref. 1) Curated1
Sequence conflicti19R → S in BAC65735 (PubMed:12693553).Curated1
Sequence conflicti86R → W in BAC65735 (PubMed:12693553).Curated1
Sequence conflicti908D → V in BAE36633 (PubMed:16141072).Curated1
Sequence conflicti1034P → S in BAE36633 (PubMed:16141072).Curated1
Sequence conflicti1252E → G in BAE36633 (PubMed:16141072).Curated1
Sequence conflicti1354D → E in BAA13044 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016809654 – 658SGLKD → Y in isoform 2. 1 Publication5
Alternative sequenceiVSP_016811863 – 869ENQKDAE → GKKREMYEHPVFCLASQVMD LTIQ in isoform 2. 1 Publication7
Alternative sequenceiVSP_016813904 – 910Missing in isoform 2. 1 Publication7
Alternative sequenceiVSP_016814905 – 910PHVDKG → GK in isoform 4. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D86214 mRNA Translation: BAA13044.1 Sequence problems.
AK122453 mRNA Translation: BAC65735.1 Different initiation.
AC116395 Genomic DNA No translation available.
AC154250 Genomic DNA No translation available.
AC154592 Genomic DNA No translation available.
AC156025 Genomic DNA No translation available.
AK161919 mRNA Translation: BAE36633.1
BC057065 mRNA Translation: AAH57065.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS36806.1 [Q80TJ1-2]
CCDS36807.1 [Q80TJ1-1]

NCBI Reference Sequences

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RefSeqi
NP_001036082.1, NM_001042617.1 [Q80TJ1-1]
NP_036191.2, NM_012061.3 [Q80TJ1-2]
XP_006518098.1, XM_006518035.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000067491; ENSMUSP00000064706; ENSMUSG00000054423 [Q80TJ1-2]
ENSMUST00000112658; ENSMUSP00000108277; ENSMUSG00000054423 [Q80TJ1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
27062

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:27062

UCSC genome browser

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UCSCi
uc007sfu.1 mouse [Q80TJ1-1]
uc007sfv.1 mouse [Q80TJ1-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86214 mRNA Translation: BAA13044.1 Sequence problems.
AK122453 mRNA Translation: BAC65735.1 Different initiation.
AC116395 Genomic DNA No translation available.
AC154250 Genomic DNA No translation available.
AC154592 Genomic DNA No translation available.
AC156025 Genomic DNA No translation available.
AK161919 mRNA Translation: BAE36633.1
BC057065 mRNA Translation: AAH57065.1
CCDSiCCDS36806.1 [Q80TJ1-2]
CCDS36807.1 [Q80TJ1-1]
RefSeqiNP_001036082.1, NM_001042617.1 [Q80TJ1-1]
NP_036191.2, NM_012061.3 [Q80TJ1-2]
XP_006518098.1, XM_006518035.3

3D structure databases

SMRiQ80TJ1
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ80TJ1, 4 interactors
MINTiQ80TJ1
STRINGi10090.ENSMUSP00000064706

PTM databases

iPTMnetiQ80TJ1
PhosphoSitePlusiQ80TJ1
SwissPalmiQ80TJ1

Proteomic databases

PaxDbiQ80TJ1
PeptideAtlasiQ80TJ1
PRIDEiQ80TJ1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067491; ENSMUSP00000064706; ENSMUSG00000054423 [Q80TJ1-2]
ENSMUST00000112658; ENSMUSP00000108277; ENSMUSG00000054423 [Q80TJ1-1]
GeneIDi27062
KEGGimmu:27062
UCSCiuc007sfu.1 mouse [Q80TJ1-1]
uc007sfv.1 mouse [Q80TJ1-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8618
MGIiMGI:1350922 Cadps

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG3543 Eukaryota
ENOG410Y0FD LUCA
GeneTreeiENSGT00590000083094
HOGENOMiHOG000263607
InParanoidiQ80TJ1
KOiK19933
OMAiYISADPC
OrthoDBi138870at2759
TreeFamiTF312963

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Cadps mouse

Protein Ontology

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PROi
PR:Q80TJ1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000054423 Expressed in 188 organ(s), highest expression level in dentate gyrus of hippocampal formation
ExpressionAtlasiQ80TJ1 baseline and differential
GenevisibleiQ80TJ1 MM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR033227 CAPS
IPR010439 CAPS_dom
IPR014770 Munc13_1
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR12166 PTHR12166, 1 hit
PfamiView protein in Pfam
PF06292 DUF1041, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM01145 DUF1041, 1 hit
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS51258 MHD1, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAPS1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80TJ1
Secondary accession number(s): E9QN90
, Q3TSP2, Q61374, Q6AXB4, Q6PGF0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 27, 2011
Last modified: September 18, 2019
This is version 134 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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