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Entry version 117 (10 Feb 2021)
Sequence version 2 (17 Apr 2007)
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Protein

RNA polymerase II-associated protein 1

Gene

Rpap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3 (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Nucleotidyltransferase, Transferase
Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA polymerase II-associated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rpap1
Synonyms:Kiaa1403
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1916175, Rpap1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002848421 – 1409RNA polymerase II-associated protein 1Add BLAST1409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei337PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q80TE0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q80TE0

PeptideAtlas

More...
PeptideAtlasi
Q80TE0

PRoteomics IDEntifications database

More...
PRIDEi
Q80TE0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q80TE0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q80TE0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034032, Expressed in ear vesicle and 303 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q80TE0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q80TE0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of an RNA polymerase II complex that contains POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, RPAP1, FCP1 plus the general transcription factors TFIIB and TFIIF.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
213120, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q80TE0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000097127

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q80TE0, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi843 – 1302Leu-richAdd BLAST460

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RPAP1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1894, Eukaryota
KOG4732, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007594

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005296_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q80TE0

Identification of Orthologs from Complete Genome Data

More...
OMAi
LRPRWCP

Database of Orthologous Groups

More...
OrthoDBi
25908at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q80TE0

TreeFam database of animal gene trees

More...
TreeFami
TF324391

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR013929, RNA_pol_II_AP1_C
IPR013930, RNA_pol_II_AP1_N
IPR039913, RPAP1/Rba50

The PANTHER Classification System

More...
PANTHERi
PTHR21483, PTHR21483, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08620, RPAP1_C, 1 hit
PF08621, RPAP1_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80TE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMLSRPKPGE SEVDLLRFQS QFLEAGAAPA VQLVKGSRRH GDAPPDRLPP
60 70 80 90 100
QDHRDVVMLD NLPDLPPALL PAPAKRARPS PGHPLPHDED PEERLNRHDQ
110 120 130 140 150
HITAVLSKIV ERDTSSVTVT LPVPSGVAFP PVFHRSQERQ VKPAASGKRS
160 170 180 190 200
IFAQEIAARR VSGNRVTSAE QVVPSLDTPE GAVPCETPSF RDRSNQLPGR
210 220 230 240 250
SHGFHRPNLV TGKGLRSKVA EQEVQTIHEE NVARLQAMDP EEILKEQQQL
260 270 280 290 300
LAQLDPSLVA FLRSHSQVQE QTGTKATKKQ SPKRPSVLVT KEEPVTSTRT
310 320 330 340 350
REPRTGDKLE EKPEATVEDK MEDKLQPRTP ALKLPMTPSK DWLHMDTVEL
360 370 380 390 400
DKLHWTQDLP PLRRQQTQER MQARFSLQGE LLAPDVDLPT HLGLHHHGEE
410 420 430 440 450
AERAGYSLQE LFHLTRSQVS QQRALALQVL SQIVGRAQAG EFGDRLVGSV
460 470 480 490 500
LRLLLDAGFL FLLRFSLDDR VDSVIAAAVR ALRTLLVAPG DEELLDRTFS
510 520 530 540 550
WYHGASVFPL MPSQDDKEDE DEDEELETEK VKRKTPEEGS RPPPDLARHD
560 570 580 590 600
VIKGLLATNL LPRLRYVLEV TCPGPSVILD ILAVLIRLAR HSLESAMRVL
610 620 630 640 650
ECPRLMETIV QEFLPTSWSP IGVGPTPSLY KVPCASAMKL LRVLASAGRN
660 670 680 690 700
IAARLLSGFD VRSRLCRFIA EAPHDLALPP EEAEILTTEA FRLWAVAASY
710 720 730 740 750
GQGGDLYREL YPVLLRALQT LPTELSAHPL QPLAMQRVAA LFTLLTQLTL
760 770 780 790 800
AASSIPPEPA SGPAESCVPA IPSSVTWTQV SGLKPLVEPC LKQTLKFLPR
810 820 830 840 850
PDVWNALGPV PSACLLFLGA YYQAWSRQSH LCPEDWLQDM ERLLDESLLP
860 870 880 890 900
LLSQPPLGSL WDSLRDCSPL CNPLSCASNP EALPSLVSLG CAGGCPPLSV
910 920 930 940 950
AGSASPFPFL TALLSLINTL VQSHKGLCGQ LSAVLTAPGL QNYFLQCVAP
960 970 980 990 1000
APAPQLTPFS AWALHHEYHL QYLVLSFAHK AATLQPEPAA STALHHAVAL
1010 1020 1030 1040 1050
VLLSRLLPGS EYLAQELLLS CVFRLEFLPE SASGGPEAAD FSDGLSLGSS
1060 1070 1080 1090 1100
GDPQCRRGAL LVQACRDLPS IRSCYLAHCS PARASLLSSQ ALYCGELLRV
1110 1120 1130 1140 1150
SSLLLPVPKE PLLATDWPFQ PLIHLYHRAS DTPSGPPAAD TVGVAMRVLQ
1160 1170 1180 1190 1200
WVLVLESWRP EVLWAVPPAA RLARLMCVYL VDSELFRETP IQRLVAALLA
1210 1220 1230 1240 1250
RLCRPQVLPN LKLDCPLPGL TSFPDLYASF LDHFEAVSFG DHLFGALVLL
1260 1270 1280 1290 1300
PLQRRFSVTL RLALFGEHVG VLRALGLPLT QLPVPLECYT EPAEDSLPLL
1310 1320 1330 1340 1350
QLYFRALVTG TLRARWCPIL YTVAVAHVNS FIFCQDPKSS DEVKTARRSM
1360 1370 1380 1390 1400
LQRTWLLTDE GLRQHLLHYK LPNSSLPEGF ELYSQLPRLR QQCLQTLPTE

GLQNGGVKT
Length:1,409
Mass (Da):155,270
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E49F6D8A2D31687
GO
Isoform 2 (identifier: Q80TE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1282-1290: LPVPLECYT → VCPTLSRPS
     1291-1409: Missing.

Show »
Length:1,290
Mass (Da):141,601
Checksum:i357BD5B9357A9C8C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GWX3V9GWX3_MOUSE
RNA polymerase II-associated protei...
Rpap1
869Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2F2S4R2F2_MOUSE
RNA polymerase II-associated protei...
Rpap1
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC65787 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti83H → R in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti83H → R in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti83H → R in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti126G → S in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti126G → S in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti190F → V in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti190F → V in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti190F → V in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti283K → E in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti283K → E in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti283K → E in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti432Q → R in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti527E → T in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti527E → T in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti527E → T in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti560L → Q in BAE39647 (PubMed:16141072).Curated1
Sequence conflicti578I → V in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti578I → V in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti578I → V in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti879N → T in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti879N → T in BAE38647 (PubMed:16141072).Curated1
Sequence conflicti879N → T in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti879N → T in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti880P → Q in BAE39647 (PubMed:16141072).Curated1
Sequence conflicti942N → K in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti942N → K in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti942N → K in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti942N → K in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti977F → L in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti977F → L in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti977F → L in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti977F → L in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti1066R → Q in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti1066R → Q in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti1066R → Q in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti1066R → Q in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti1094C → R in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti1094C → R in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti1094C → R in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti1094C → R in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti1183S → N in BAE39647 (PubMed:16141072).Curated1
Sequence conflicti1263A → T in BAE38647 (PubMed:16141072).Curated1
Sequence conflicti1305R → W in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti1311T → S in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti1311T → S in AAH12218 (PubMed:15489334).Curated1
Sequence conflicti1311T → S in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti1311T → S in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti1311T → S in AAI17975 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0246821282 – 1290LPVPLECYT → VCPTLSRPS in isoform 2. 1 Publication9
Alternative sequenceiVSP_0246831291 – 1409Missing in isoform 2. 1 PublicationAdd BLAST119

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK122505 mRNA Translation: BAC65787.1 Different initiation.
AK161487 mRNA Translation: BAE36419.1
AK166232 mRNA Translation: BAE38647.1
AK167589 mRNA Translation: BAE39647.1
AL844536 Genomic DNA No translation available.
BC012218 mRNA Translation: AAH12218.1
BC051680 mRNA Translation: AAH51680.1
BC117973 mRNA Translation: AAI17974.1
BC117974 mRNA Translation: AAI17975.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16610.1 [Q80TE0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001157173.1, NM_001163701.1 [Q80TE0-1]
NP_796268.3, NM_177294.5 [Q80TE0-1]
XP_006500184.1, XM_006500121.3 [Q80TE0-1]
XP_011238061.1, XM_011239759.2 [Q80TE0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000048493; ENSMUSP00000037275; ENSMUSG00000034032 [Q80TE0-1]
ENSMUST00000099529; ENSMUSP00000097127; ENSMUSG00000034032 [Q80TE0-1]
ENSMUST00000110793; ENSMUSP00000106420; ENSMUSG00000034032 [Q80TE0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
68925

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:68925

UCSC genome browser

More...
UCSCi
uc008luk.2, mouse [Q80TE0-1]
uc008lun.2, mouse [Q80TE0-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122505 mRNA Translation: BAC65787.1 Different initiation.
AK161487 mRNA Translation: BAE36419.1
AK166232 mRNA Translation: BAE38647.1
AK167589 mRNA Translation: BAE39647.1
AL844536 Genomic DNA No translation available.
BC012218 mRNA Translation: AAH12218.1
BC051680 mRNA Translation: AAH51680.1
BC117973 mRNA Translation: AAI17974.1
BC117974 mRNA Translation: AAI17975.1
CCDSiCCDS16610.1 [Q80TE0-1]
RefSeqiNP_001157173.1, NM_001163701.1 [Q80TE0-1]
NP_796268.3, NM_177294.5 [Q80TE0-1]
XP_006500184.1, XM_006500121.3 [Q80TE0-1]
XP_011238061.1, XM_011239759.2 [Q80TE0-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi213120, 10 interactors
IntActiQ80TE0, 1 interactor
STRINGi10090.ENSMUSP00000097127

PTM databases

iPTMnetiQ80TE0
PhosphoSitePlusiQ80TE0

Proteomic databases

EPDiQ80TE0
PaxDbiQ80TE0
PeptideAtlasiQ80TE0
PRIDEiQ80TE0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
42079, 118 antibodies

Genome annotation databases

EnsembliENSMUST00000048493; ENSMUSP00000037275; ENSMUSG00000034032 [Q80TE0-1]
ENSMUST00000099529; ENSMUSP00000097127; ENSMUSG00000034032 [Q80TE0-1]
ENSMUST00000110793; ENSMUSP00000106420; ENSMUSG00000034032 [Q80TE0-1]
GeneIDi68925
KEGGimmu:68925
UCSCiuc008luk.2, mouse [Q80TE0-1]
uc008lun.2, mouse [Q80TE0-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26015
MGIiMGI:1916175, Rpap1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG1894, Eukaryota
KOG4732, Eukaryota
GeneTreeiENSGT00390000007594
HOGENOMiCLU_005296_1_0_1
InParanoidiQ80TE0
OMAiLRPRWCP
OrthoDBi25908at2759
PhylomeDBiQ80TE0
TreeFamiTF324391

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
68925, 8 hits in 16 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Rpap1, mouse

Protein Ontology

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PROi
PR:Q80TE0
RNActiQ80TE0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000034032, Expressed in ear vesicle and 303 other tissues
ExpressionAtlasiQ80TE0, baseline and differential
GenevisibleiQ80TE0, MM

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR013929, RNA_pol_II_AP1_C
IPR013930, RNA_pol_II_AP1_N
IPR039913, RPAP1/Rba50
PANTHERiPTHR21483, PTHR21483, 1 hit
PfamiView protein in Pfam
PF08620, RPAP1_C, 1 hit
PF08621, RPAP1_N, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPAP1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q80TE0
Secondary accession number(s): A2AQ24
, Q148U0, Q148U1, Q3TJ48, Q3TLZ5, Q3TTA6, Q80UT8, Q91VM0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: February 10, 2021
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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