UniProtKB - Q80TA9 (EPG5_MOUSE)
Protein
Ectopic P granules protein 5 homolog
Gene
Epg5
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located.By similarity
GO - Biological processi
- autophagosome maturation Source: MGI
- autophagy Source: MGI
- cellular response to dsDNA Source: UniProtKB
- endocytic recycling Source: MGI
- endosome to lysosome transport Source: UniProtKB
- nucleotide transport Source: UniProtKB
- toll-like receptor 9 signaling pathway Source: UniProtKB
Keywordsi
Biological process | Autophagy |
Names & Taxonomyi
Protein namesi | Recommended name: Ectopic P granules protein 5 homolog |
Gene namesi | Name:Epg5 Synonyms:Kiaa1632 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1918673, Epg5 |
Subcellular locationi
Lysosome
- Lysosome By similarity
Other locations
- perinuclear region By similarity
Lysosome
- lysosome Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
- perinuclear region of cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, LysosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000306256 | 1 – 2572 | Ectopic P granules protein 5 homologAdd BLAST | 2572 |
Proteomic databases
EPDi | Q80TA9 |
MaxQBi | Q80TA9 |
PaxDbi | Q80TA9 |
PeptideAtlasi | Q80TA9 |
PRIDEi | Q80TA9 |
PTM databases
iPTMneti | Q80TA9 |
PhosphoSitePlusi | Q80TA9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000039840, Expressed in quadriceps femoris and 250 other tissues |
Genevisiblei | Q80TA9, MM |
Interactioni
Subunit structurei
Interacts with RAN.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000038681 |
Miscellaneous databases
RNActi | Q80TA9, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1600 – 1626 | Sequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Belongs to the EPG5 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3622, Eukaryota |
GeneTreei | ENSGT00390000007354 |
HOGENOMi | CLU_000773_0_0_1 |
InParanoidi | Q80TA9 |
OMAi | FFEMAND |
OrthoDBi | 42984at2759 |
PhylomeDBi | Q80TA9 |
TreeFami | TF313847 |
Family and domain databases
InterProi | View protein in InterPro IPR029651, EPG-5 |
PANTHERi | PTHR31139:SF4, PTHR31139:SF4, 1 hit |
i Sequence
Sequence statusi: Complete.
Q80TA9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEAVKPRRA KAKASRTKGK EKKKHEALQT CDAGPLPETC REQESPCPAS
60 70 80 90 100
ELKGDDLKSS ADPQLHSDVC GWNESEMFDI PLTSLTIGDE GPPVQDTEDL
110 120 130 140 150
KERGEVTAGD GDDEMELKVD PGDNVIAKGE PCKNFPEVED HTLIQCGPPE
160 170 180 190 200
STLQPDFPCT QQAVEGSHAR EHPTRKQDEA ALGCSKVFQN VSLHSSYEAK
210 220 230 240 250
EVSQPPRVKK LYPELPAEIA EVPALVAVKP LLRSERLYPE LPSQPEVTPF
260 270 280 290 300
TKEQLKLLEP GSWLENVASY VEEFDNIAHQ DRHEFYELLL NYSRCRKQLL
310 320 330 340 350
LAEAELLTLM SDCHSAKSRL WHFKDEQMAV QGICADQVKV YGHHHYQRVE
360 370 380 390 400
MNENVLGELK KLFDAKSEHL HQTLTLHSYT SVLSRLQVES YIFTLLNSSA
410 420 430 440 450
ALRSLAVYQA DQVPKLTESI PSDVCQLKEC ISVLFMFTRR VSEDAQFHED
460 470 480 490 500
ILLWLQKLVS VLQRVGCPGD HFFLLNHVLR CPAGIRKWAV PFIQIKVLNN
510 520 530 540 550
PSGVFHFMQS LALLMSPVKN RAEFMCHMKP SEWKPSSSGP ASGNWTLVDE
560 570 580 590 600
AGEEDEDPET SWILLNEDDL VTLLSQFPFQ ELFQHLLGFK AKGDYLPETT
610 620 630 640 650
RPQEMMKIFA FANSLVELLA VGLDTFNRAR YRQFVKRIGY LIRMTLGYVS
660 670 680 690 700
DHWAQYVSHS TGAGLTPQPY SMEKLQVEFD ELFLRAVLHV LKAKRLGIWL
710 720 730 740 750
FMSEMPFGTL SVQMLWKLLY LMHQVESGDL QQLCASLQPA ECKRRLQDPE
760 770 780 790 800
HFASFEKCLS SINSSEEICL LTAFAQMARA RRTNVDEDFI KIIVLEIYEV
810 820 830 840 850
SYVTLSTRET FSKVGRELLG AIAAVHPEII SVLLDRVQET IDQVGMVSLY
860 870 880 890 900
LFKELPLYLW RPSAPEIAVI RDWLLNNNLT AVKNKLACVI LEGLNWGFTE
910 920 930 940 950
QGTLHLDQAL HTEVALLVLE AYQKYLAQKP YTGLISESMK QVSYLASIVR
960 970 980 990 1000
YGETPETSFN QWAWNLILRL KLHKNDFGRQ NFPVIPFCST VPDMTESSMF
1010 1020 1030 1040 1050
HPLLKAVKSG LPIGCYLALA VTAVGHSLEK FCAEGIPLLG VLVQSRHLRA
1060 1070 1080 1090 1100
VVHALDKILP VFYPYQCYLL KNEQFLSNLL LFLQLDSGVP QGVTQQVTHR
1110 1120 1130 1140 1150
VAQHLTGAVH GDNVKLLSSM IQAHICVSTQ PDGVGPVAVL EFWVQALISQ
1160 1170 1180 1190 1200
HLWYREQPIL FLMDHLCKTA FHLMQEDCVQ KLLYQQHKNA LGYHCDRSLL
1210 1220 1230 1240 1250
SSLVNWIVAG NITPSFVEGL STSTQVWFAW TVLNMESIFE EDSQLRRVVE
1260 1270 1280 1290 1300
RELVINAFSP DQALKKAQVQ LKLPIVPSLQ RLLIYRWAHQ ALVTPSDHPL
1310 1320 1330 1340 1350
LPLIWQKFFL LYLHRPGPQY GLPVDGCIGR RFFQSPSHVN LLKDMKRRLT
1360 1370 1380 1390 1400
EVADFHYAAS KALRVPAEGS EGTPEGQAGT PGFLTSPELH RELVRLFNVY
1410 1420 1430 1440 1450
VLWLEDENFQ KGDTYIPSLP KHYDVHRLAK VMQNQQDLWM EYVNMERIQH
1460 1470 1480 1490 1500
EFQETVALWT QAKLESHAAP CSSSAQLDFT DPLLAKARVL SNLEKHEAPH
1510 1520 1530 1540 1550
PPLLLHPVRP PVPLIPSAAL LTQKDSTQLM CTDLNLLQQQ ARSATLRESQ
1560 1570 1580 1590 1600
QVALDGELLE TMPKQYVNRE DQATLHLECR GSSGKKCQGA AVVTVQFEGM
1610 1620 1630 1640 1650
NKNEAVSQQI HVLQKEVRQL QAEAAQPPAL NVVEAAVHAE NLITALVNTY
1660 1670 1680 1690 1700
KLQPTPGVQK LGISLFFTVV DHVSDETQRH PPTRQFFTSC IEILGQVFVS
1710 1720 1730 1740 1750
GTKSECRKLL QTILKNRRLC SLLAPFFTPN AAPAEFIQLY ERVVTCLRED
1760 1770 1780 1790 1800
NSDVIFMLLT KFDIQQWLNS TKPPLSDRTR LLESIHLALT AWGLEPEEDI
1810 1820 1830 1840 1850
LMPFNLFCKH WTHLLLYQFP DQYSDVLRLL VQSSAEQLLS PECWKATLRA
1860 1870 1880 1890 1900
LGCYAPSSQQ GAASVESSGL HSASRVLLSD KQVMETVQWL SDFFYKLRLS
1910 1920 1930 1940 1950
KLDFKSFGLF SKWSPYMADV KTFLGYLVKR LTDLEIASLS QDPTASSKEV
1960 1970 1980 1990 2000
LRSLHAQIIQ LFKPWILVLE DAESSHQRHY PWLESDTAVA SSIVQLFSDC
2010 2020 2030 2040 2050
VGSLHTSFKD RLLPGDEGAL RLHLLHYCET CTAPKMPEFI LYAFHSAYQR
2060 2070 2080 2090 2100
LEWKDLHPDQ RLMEAFFKVE RGSPKSCFLF LGSVLCRVNW VSVLSDAWNP
2110 2120 2130 2140 2150
SPLPETQSMA VCLLFMMVLL AKEAQLVDEP DSPLLSLLGQ TSSLSWHLVD
2160 2170 2180 2190 2200
LVSYQSVLGY FSSHYPPSVV LANDCSSELI VKLLKVSAGL SAHADGRKHV
2210 2220 2230 2240 2250
DIVPKCQAFT HQMVQFLSAL EQTGKITFPA LEREISKLLD DIIIFNPPDM
2260 2270 2280 2290 2300
DSQTRHMALS SFFVEVLMMM NNAAVPTAEF LAVSIRTWIG QRVHGLIVLP
2310 2320 2330 2340 2350
LLTAACQSLA SVRHMAEITE ACIMAYFKES SLDQNLGWGP VLVSLQVPQL
2360 2370 2380 2390 2400
TARDFLEECL ALGSCLTLYV YLLQCLNSEQ TVKNDMKMLL VVSGWLEQVY
2410 2420 2430 2440 2450
PSSAQEEAKL FLWWHQILQL SLIQLEQNDS VLTESVIRIL LMLQSRQSLM
2460 2470 2480 2490 2500
AEERLSSGIL GAIGLGRRSP LSNRFRVAAR SMAAFLLVQV PAEDQIRLKP
2510 2520 2530 2540 2550
SSELHLAPKA QQVLTALESM TLSKQYVEYQ DQILHALQFI RHPGHCLQNG
2560 2570
KSFLALLVNR LYPEVHYLDN IR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC126553 Genomic DNA No translation available. AK122536 mRNA Translation: BAC65818.1 |
CCDSi | CCDS57126.1 |
RefSeqi | NP_001182562.1, NM_001195633.1 |
Genome annotation databases
Ensembli | ENSMUST00000044622; ENSMUSP00000038681; ENSMUSG00000039840 ENSMUST00000230263; ENSMUSP00000155113; ENSMUSG00000116023 |
GeneIDi | 100502841 |
KEGGi | mmu:100502841 |
UCSCi | uc008fsa.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC126553 Genomic DNA No translation available. AK122536 mRNA Translation: BAC65818.1 |
CCDSi | CCDS57126.1 |
RefSeqi | NP_001182562.1, NM_001195633.1 |
3D structure databases
SMRi | Q80TA9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000038681 |
PTM databases
iPTMneti | Q80TA9 |
PhosphoSitePlusi | Q80TA9 |
Proteomic databases
EPDi | Q80TA9 |
MaxQBi | Q80TA9 |
PaxDbi | Q80TA9 |
PeptideAtlasi | Q80TA9 |
PRIDEi | Q80TA9 |
Protocols and materials databases
Antibodypediai | 22425, 72 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000044622; ENSMUSP00000038681; ENSMUSG00000039840 ENSMUST00000230263; ENSMUSP00000155113; ENSMUSG00000116023 |
GeneIDi | 100502841 |
KEGGi | mmu:100502841 |
UCSCi | uc008fsa.2, mouse |
Organism-specific databases
CTDi | 57724 |
MGIi | MGI:1918673, Epg5 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG3622, Eukaryota |
GeneTreei | ENSGT00390000007354 |
HOGENOMi | CLU_000773_0_0_1 |
InParanoidi | Q80TA9 |
OMAi | FFEMAND |
OrthoDBi | 42984at2759 |
PhylomeDBi | Q80TA9 |
TreeFami | TF313847 |
Miscellaneous databases
BioGRID-ORCSi | 100502841, 5 hits in 19 CRISPR screens |
ChiTaRSi | Epg5, mouse |
PROi | PR:Q80TA9 |
RNActi | Q80TA9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039840, Expressed in quadriceps femoris and 250 other tissues |
Genevisiblei | Q80TA9, MM |
Family and domain databases
InterProi | View protein in InterPro IPR029651, EPG-5 |
PANTHERi | PTHR31139:SF4, PTHR31139:SF4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EPG5_MOUSE | |
Accessioni | Q80TA9Primary (citable) accession number: Q80TA9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | December 2, 2020 | |
This is version 93 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families