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Protein

Myotubularin-related protein 12

Gene

Mtmr12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location.By similarity

Caution

Lacks the phosphocysteine intermediate Cys active site in position 391 that is replaced by a Glu residue, preventing the hydrolase activity.Curated

GO - Molecular functioni

GO - Biological processi

  • toxin transport Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-1660516 Synthesis of PIPs at the early endosome membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 12
Gene namesi
Name:Mtmr12
Synonyms:Kiaa1682
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2443034 Mtmr12

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003158261 – 747Myotubularin-related protein 12Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei564PhosphoserineBy similarity1
Modified residuei601PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80TA6
PaxDbiQ80TA6
PeptideAtlasiQ80TA6
PRIDEiQ80TA6

PTM databases

iPTMnetiQ80TA6
PhosphoSitePlusiQ80TA6

Expressioni

Gene expression databases

BgeeiENSMUSG00000039458 Expressed in 233 organ(s), highest expression level in thymus
CleanExiMM_MTMR12
ExpressionAtlasiQ80TA6 baseline and differential
GenevisibleiQ80TA6 MM

Interactioni

Subunit structurei

Interacts with myotubularin MTM1 and myotubularin-related MTMR2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041227

Structurei

3D structure databases

ProteinModelPortaliQ80TA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini205 – 643Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST439

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni449 – 558Interaction with MTM1By similarityAdd BLAST110

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1089 Eukaryota
ENOG410XPTU LUCA
GeneTreeiENSGT00920000149050
HOGENOMiHOG000113684
HOVERGENiHBG108154
InParanoidiQ80TA6
KOiK18085
OMAiSDKDKMF
OrthoDBiEOG091G0DYN
PhylomeDBiQ80TA6
TreeFamiTF315197

Family and domain databases

InterProiView protein in InterPro
IPR030576 MTMR12
IPR022587 MTMR12-like_C
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR029021 Prot-tyrosine_phosphatase-like
PANTHERiPTHR10807 PTHR10807, 1 hit
PTHR10807:SF37 PTHR10807:SF37, 1 hit
PfamiView protein in Pfam
PF12578 3-PAP, 1 hit
PF06602 Myotub-related, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q80TA6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGKGGVGGG GGTKAPKPSF VSYVRPEEIH TDEKEVTEKE VTLHLLPGEQ
60 70 80 90 100
LLCEASTVLK YVQEDSCQRG VYGRLVCTDF KISFLGDEDS ALDNGGEAQF
110 120 130 140 150
KNKIIGVNDV PLHCVDQIYG VFDEKKKPLF GQLKKYPEKL VIHCKDLRVL
160 170 180 190 200
HFCLRYTKEE EVKRIVSGII HHTQSPKLLK RLFLFSYAAA VHGTATDSRN
210 220 230 240 250
CTVMFDTPKD WCWELERTKG SVKYRTVSVN EGYRVSDRLP AYFVVPTPLP
260 270 280 290 300
EDDVRRFQGH GIPIWCWSCH NGSALLKMSA LPKEQDDGAL QVQKSFLDGI
310 320 330 340 350
YKTIHRPPYE MVKTEDLSSN FLSLQEIQSA YCKFKQLFLI DNSSEFWDTD
360 370 380 390 400
IKWFSLLESS SWLDIIRRCL KKAIEITECL EAQNVNVLLL EENASDLCCL
410 420 430 440 450
LSSLVQVMMD AHCRTRTGFQ SLIQKEWVMG GHSFLDRCNH LHQSDKEEVP
460 470 480 490 500
IFLLFLDCVW QLVHQYPPAF EFTETYLTVL SDSLYIPIFS TFFFNSPHQK
510 520 530 540 550
DTNMGRENLD AQSKPLTLLT VWDWSVQFEP KAQTLLRNPL YVEKPKLDRG
560 570 580 590 600
QQKGSRFKHQ RQLSLPLTQS KSSPKRGFFR EETDHLIKNL LGKRISKLIN
610 620 630 640 650
SSDDLQDSSR EFYDSWHSKP TDYHGLLLPH IEGPEIKVWA QRYLRWIPEA
660 670 680 690 700
QILGGGRVAT MGKLLEMMEE VQSLQEKIEA RHHRQEAVHA EAPGLLRNSV
710 720 730 740
RLSSLFPFAL LQRHSAKPVL PTSGWKALGG EDDLAKREDE FVDLGDV
Length:747
Mass (Da):85,516
Last modified:January 15, 2008 - v2
Checksum:iD4D2AE2E8772500E
GO
Isoform 2 (identifier: Q80TA6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-357: Missing.

Show »
Length:437
Mass (Da):49,893
Checksum:i463C81470DE9B400
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZ04G3UZ04_MOUSE
Myotubularin-related protein 12
Mtmr12
526Annotation score:
G3XA69G3XA69_MOUSE
Myotubularin-related protein 12
Mtmr12
159Annotation score:

Sequence cautioni

The sequence BAC36227 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC65821 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03072348 – 357Missing in isoform 2. 1 PublicationAdd BLAST310

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122539 mRNA Translation: BAC65821.1 Different initiation.
AK030139 mRNA Translation: BAC26803.1
AK076161 mRNA Translation: BAC36227.1 Different initiation.
BC054352 mRNA Translation: AAH54352.1
CCDSiCCDS27388.1 [Q80TA6-1]
RefSeqiNP_766546.1, NM_172958.3 [Q80TA6-1]
UniGeneiMm.54460

Genome annotation databases

EnsembliENSMUST00000038172; ENSMUSP00000041227; ENSMUSG00000039458 [Q80TA6-1]
ENSMUST00000071993; ENSMUSP00000071883; ENSMUSG00000039458 [Q80TA6-2]
GeneIDi268783
KEGGimmu:268783
UCSCiuc007vhl.1 mouse [Q80TA6-1]
uc011zrl.1 mouse [Q80TA6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122539 mRNA Translation: BAC65821.1 Different initiation.
AK030139 mRNA Translation: BAC26803.1
AK076161 mRNA Translation: BAC36227.1 Different initiation.
BC054352 mRNA Translation: AAH54352.1
CCDSiCCDS27388.1 [Q80TA6-1]
RefSeqiNP_766546.1, NM_172958.3 [Q80TA6-1]
UniGeneiMm.54460

3D structure databases

ProteinModelPortaliQ80TA6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041227

PTM databases

iPTMnetiQ80TA6
PhosphoSitePlusiQ80TA6

Proteomic databases

EPDiQ80TA6
PaxDbiQ80TA6
PeptideAtlasiQ80TA6
PRIDEiQ80TA6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038172; ENSMUSP00000041227; ENSMUSG00000039458 [Q80TA6-1]
ENSMUST00000071993; ENSMUSP00000071883; ENSMUSG00000039458 [Q80TA6-2]
GeneIDi268783
KEGGimmu:268783
UCSCiuc007vhl.1 mouse [Q80TA6-1]
uc011zrl.1 mouse [Q80TA6-2]

Organism-specific databases

CTDi54545
MGIiMGI:2443034 Mtmr12
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1089 Eukaryota
ENOG410XPTU LUCA
GeneTreeiENSGT00920000149050
HOGENOMiHOG000113684
HOVERGENiHBG108154
InParanoidiQ80TA6
KOiK18085
OMAiSDKDKMF
OrthoDBiEOG091G0DYN
PhylomeDBiQ80TA6
TreeFamiTF315197

Enzyme and pathway databases

ReactomeiR-MMU-1660516 Synthesis of PIPs at the early endosome membrane

Miscellaneous databases

ChiTaRSiMtmr12 mouse
PROiPR:Q80TA6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039458 Expressed in 233 organ(s), highest expression level in thymus
CleanExiMM_MTMR12
ExpressionAtlasiQ80TA6 baseline and differential
GenevisibleiQ80TA6 MM

Family and domain databases

InterProiView protein in InterPro
IPR030576 MTMR12
IPR022587 MTMR12-like_C
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR029021 Prot-tyrosine_phosphatase-like
PANTHERiPTHR10807 PTHR10807, 1 hit
PTHR10807:SF37 PTHR10807:SF37, 1 hit
PfamiView protein in Pfam
PF12578 3-PAP, 1 hit
PF06602 Myotub-related, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTMRC_MOUSE
AccessioniPrimary (citable) accession number: Q80TA6
Secondary accession number(s): Q8BVX4, Q8C0P1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 7, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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